Putative proteasome regulatory ATPase subunittcc1l8.3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory ATPase subunittcc1l8.3, putative

Species:

Leishmania braziliensis

UniProt:

A4H6T6_LEIBR

TriTrypDb:

LbrM.12.0230 , LBRM2903_120007200

Length:

361

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	10
GO:0005737	cytoplasm	2	11
GO:0008540	proteasome regulatory particle, base subcomplex	2	1
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1905369	endopeptidase complex	4	10

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Expansion

Sequence features

A4H6T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6T6

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.321
CLV_C14_Caspase3-7	236	240	PF00656	0.319
CLV_C14_Caspase3-7	36	40	PF00656	0.493
CLV_C14_Caspase3-7	87	91	PF00656	0.564
CLV_NRD_NRD_1	186	188	PF00675	0.319
CLV_NRD_NRD_1	270	272	PF00675	0.300
CLV_NRD_NRD_1	280	282	PF00675	0.404
CLV_NRD_NRD_1	329	331	PF00675	0.333
CLV_PCSK_FUR_1	281	285	PF00082	0.391
CLV_PCSK_KEX2_1	215	217	PF00082	0.305

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E9	Leptomonas seymouri	42%	91%
A0A0N0P5B8	Leptomonas seymouri	40%	81%
A0A0N0P5V2	Leptomonas seymouri	33%	100%
A0A0N0P7K1	Leptomonas seymouri	45%	88%
A0A0N1IGY9	Leptomonas seymouri	99%	87%
A0A0N1IM81	Leptomonas seymouri	49%	82%
A0A0N1PAS8	Leptomonas seymouri	45%	83%
A0A0S4IJE6	Bodo saltans	45%	83%
A0A0S4ITX1	Bodo saltans	42%	81%
A0A0S4IY28	Bodo saltans	45%	100%

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