Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6T3_LEIBR

TriTrypDb:

LbrM.12.0200 , LBRM2903_120006800

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	608	612	PF00656	0.396
CLV_C14_Caspase3-7	622	626	PF00656	0.364
CLV_C14_Caspase3-7	732	736	PF00656	0.470
CLV_MEL_PAP_1	11	17	PF00089	0.508
CLV_MEL_PAP_1	651	657	PF00089	0.295
CLV_NRD_NRD_1	184	186	PF00675	0.635
CLV_NRD_NRD_1	260	262	PF00675	0.296
CLV_NRD_NRD_1	295	297	PF00675	0.597
CLV_NRD_NRD_1	298	300	PF00675	0.529
CLV_NRD_NRD_1	390	392	PF00675	0.794
CLV_NRD_NRD_1	510	512	PF00675	0.552
CLV_NRD_NRD_1	534	536	PF00675	0.384
CLV_NRD_NRD_1	659	661	PF00675	0.469
CLV_NRD_NRD_1	733	735	PF00675	0.646
CLV_NRD_NRD_1	737	739	PF00675	0.606
CLV_NRD_NRD_1	753	755	PF00675	0.592
CLV_NRD_NRD_1	796	798	PF00675	0.408
CLV_PCSK_FUR_1	296	300	PF00082	0.616
CLV_PCSK_FUR_1	657	661	PF00082	0.378
CLV_PCSK_KEX2_1	186	188	PF00082	0.627
CLV_PCSK_KEX2_1	260	262	PF00082	0.299
CLV_PCSK_KEX2_1	295	297	PF00082	0.597
CLV_PCSK_KEX2_1	298	300	PF00082	0.529
CLV_PCSK_KEX2_1	510	512	PF00082	0.552
CLV_PCSK_KEX2_1	534	536	PF00082	0.384
CLV_PCSK_KEX2_1	659	661	PF00082	0.410
CLV_PCSK_KEX2_1	733	735	PF00082	0.671
CLV_PCSK_KEX2_1	737	739	PF00082	0.676
CLV_PCSK_KEX2_1	753	755	PF00082	0.592
CLV_PCSK_KEX2_1	796	798	PF00082	0.408
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.684
CLV_PCSK_PC7_1	733	739	PF00082	0.487
CLV_PCSK_SKI1_1	101	105	PF00082	0.384
CLV_PCSK_SKI1_1	260	264	PF00082	0.331
CLV_PCSK_SKI1_1	273	277	PF00082	0.495
CLV_PCSK_SKI1_1	738	742	PF00082	0.609
CLV_PCSK_SKI1_1	907	911	PF00082	0.417
DEG_APCC_DBOX_1	259	267	PF00400	0.399
DEG_APCC_DBOX_1	554	562	PF00400	0.377
DEG_APCC_DBOX_1	70	78	PF00400	0.421
DEG_ODPH_VHL_1	757	769	PF01847	0.569
DEG_SPOP_SBC_1	169	173	PF00917	0.478
DEG_SPOP_SBC_1	370	374	PF00917	0.501
DEG_SPOP_SBC_1	460	464	PF00917	0.535
DOC_CDC14_PxL_1	755	763	PF14671	0.549
DOC_CYCLIN_RxL_1	902	912	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	539	545	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	741	747	PF00134	0.487
DOC_MAPK_gen_1	260	266	PF00069	0.371
DOC_MAPK_gen_1	295	306	PF00069	0.481
DOC_MAPK_gen_1	534	540	PF00069	0.424
DOC_MAPK_gen_1	657	667	PF00069	0.443
DOC_MAPK_JIP1_4	330	336	PF00069	0.421
DOC_MAPK_MEF2A_6	299	308	PF00069	0.409
DOC_MAPK_MEF2A_6	660	669	PF00069	0.461
DOC_MAPK_MEF2A_6	866	875	PF00069	0.391
DOC_PP1_RVXF_1	271	277	PF00149	0.556
DOC_PP1_RVXF_1	700	706	PF00149	0.283
DOC_PP2B_LxvP_1	334	337	PF13499	0.360
DOC_PP2B_LxvP_1	443	446	PF13499	0.572
DOC_PP2B_LxvP_1	858	861	PF13499	0.507
DOC_PP4_FxxP_1	364	367	PF00568	0.371
DOC_PP4_FxxP_1	517	520	PF00568	0.460
DOC_PP4_FxxP_1	838	841	PF00568	0.433
DOC_USP7_MATH_1	145	149	PF00917	0.651
DOC_USP7_MATH_1	151	155	PF00917	0.590
DOC_USP7_MATH_1	169	173	PF00917	0.433
DOC_USP7_MATH_1	192	196	PF00917	0.579
DOC_USP7_MATH_1	220	224	PF00917	0.388
DOC_USP7_MATH_1	286	290	PF00917	0.712
DOC_USP7_MATH_1	324	328	PF00917	0.314
DOC_USP7_MATH_1	370	374	PF00917	0.516
DOC_USP7_MATH_1	411	415	PF00917	0.753
DOC_USP7_MATH_1	42	46	PF00917	0.625
DOC_USP7_MATH_1	448	452	PF00917	0.614
DOC_USP7_MATH_1	465	469	PF00917	0.664
DOC_USP7_MATH_1	49	53	PF00917	0.607
DOC_USP7_MATH_1	554	558	PF00917	0.449
DOC_USP7_MATH_1	800	804	PF00917	0.550
DOC_USP7_MATH_1	91	95	PF00917	0.411
DOC_WW_Pin1_4	425	430	PF00397	0.634
DOC_WW_Pin1_4	466	471	PF00397	0.618
DOC_WW_Pin1_4	826	831	PF00397	0.501
LIG_14-3-3_CanoR_1	14	20	PF00244	0.526
LIG_14-3-3_CanoR_1	267	276	PF00244	0.453
LIG_14-3-3_CanoR_1	321	331	PF00244	0.352
LIG_14-3-3_CanoR_1	510	520	PF00244	0.522
LIG_14-3-3_CanoR_1	555	559	PF00244	0.412
LIG_14-3-3_CanoR_1	62	67	PF00244	0.607
LIG_14-3-3_CanoR_1	718	726	PF00244	0.460
LIG_14-3-3_CanoR_1	753	758	PF00244	0.564
LIG_14-3-3_CanoR_1	810	815	PF00244	0.490
LIG_Actin_WH2_2	643	661	PF00022	0.360
LIG_APCC_ABBA_1	643	648	PF00400	0.334
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	15	19	PF00533	0.529
LIG_BRCT_BRCA1_1	513	517	PF00533	0.498
LIG_BRCT_BRCA1_1	593	597	PF00533	0.445
LIG_FHA_1	100	106	PF00498	0.406
LIG_FHA_1	116	122	PF00498	0.354
LIG_FHA_1	489	495	PF00498	0.531
LIG_FHA_1	53	59	PF00498	0.698
LIG_FHA_1	604	610	PF00498	0.438
LIG_FHA_1	88	94	PF00498	0.455
LIG_FHA_2	20	26	PF00498	0.476
LIG_FHA_2	206	212	PF00498	0.544
LIG_FHA_2	314	320	PF00498	0.435
LIG_FHA_2	617	623	PF00498	0.329
LIG_FHA_2	730	736	PF00498	0.464
LIG_FHA_2	802	808	PF00498	0.573
LIG_FHA_2	906	912	PF00498	0.486
LIG_Integrin_RGD_1	32	34	PF01839	0.471
LIG_LIR_Apic_2	362	367	PF02991	0.353
LIG_LIR_Apic_2	514	520	PF02991	0.491
LIG_LIR_Apic_2	836	841	PF02991	0.520
LIG_LIR_Gen_1	302	313	PF02991	0.446
LIG_LIR_Nem_3	223	228	PF02991	0.286
LIG_LIR_Nem_3	302	308	PF02991	0.448
LIG_LIR_Nem_3	836	842	PF02991	0.527
LIG_MLH1_MIPbox_1	513	517	PF16413	0.498
LIG_NRBOX	258	264	PF00104	0.406
LIG_NRBOX	609	615	PF00104	0.427
LIG_PCNA_PIPBox_1	1	10	PF02747	0.517
LIG_PCNA_PIPBox_1	24	33	PF02747	0.425
LIG_Pex14_1	360	364	PF04695	0.461
LIG_Pex14_2	113	117	PF04695	0.396
LIG_PTB_Apo_2	107	114	PF02174	0.285
LIG_REV1ctd_RIR_1	105	115	PF16727	0.313
LIG_REV1ctd_RIR_1	514	519	PF16727	0.410
LIG_SH2_CRK	839	843	PF00017	0.632
LIG_SH2_GRB2like	7	10	PF00017	0.493
LIG_SH2_SRC	7	10	PF00017	0.513
LIG_SH2_STAP1	206	210	PF00017	0.530
LIG_SH2_STAP1	318	322	PF00017	0.443
LIG_SH2_STAP1	647	651	PF00017	0.375
LIG_SH2_STAT5	305	308	PF00017	0.436
LIG_SH2_STAT5	7	10	PF00017	0.513
LIG_SH2_STAT5	851	854	PF00017	0.410
LIG_SH3_3	133	139	PF00018	0.492
LIG_SH3_3	565	571	PF00018	0.320
LIG_SH3_3	67	73	PF00018	0.618
LIG_SH3_3	709	715	PF00018	0.577
LIG_SH3_3	741	747	PF00018	0.532
LIG_SH3_3	838	844	PF00018	0.423
LIG_SUMO_SIM_anti_2	118	125	PF11976	0.469
LIG_SUMO_SIM_anti_2	764	771	PF11976	0.546
LIG_SUMO_SIM_anti_2	880	888	PF11976	0.423
LIG_SUMO_SIM_par_1	194	201	PF11976	0.506
LIG_SUMO_SIM_par_1	332	341	PF11976	0.400
LIG_SUMO_SIM_par_1	441	447	PF11976	0.516
LIG_SUMO_SIM_par_1	628	634	PF11976	0.503
LIG_SUMO_SIM_par_1	667	673	PF11976	0.330
LIG_SUMO_SIM_par_1	884	890	PF11976	0.423
LIG_TRAF2_1	209	212	PF00917	0.350
LIG_TRFH_1	516	520	PF08558	0.479
LIG_TYR_ITIM	645	650	PF00017	0.341
LIG_UBA3_1	884	889	PF00899	0.418
LIG_WRC_WIRS_1	27	32	PF05994	0.413
MOD_CDK_SPxxK_3	425	432	PF00069	0.627
MOD_CDK_SPxxK_3	466	473	PF00069	0.523
MOD_CK1_1	171	177	PF00069	0.607
MOD_CK1_1	201	207	PF00069	0.619
MOD_CK1_1	290	296	PF00069	0.629
MOD_CK1_1	371	377	PF00069	0.538
MOD_CK1_1	402	408	PF00069	0.648
MOD_CK1_1	447	453	PF00069	0.632
MOD_CK1_1	468	474	PF00069	0.690
MOD_CK1_1	488	494	PF00069	0.562
MOD_CK1_1	52	58	PF00069	0.551
MOD_CK1_1	550	556	PF00069	0.434
MOD_CK1_1	575	581	PF00069	0.622
MOD_CK1_1	65	71	PF00069	0.420
MOD_CK1_1	682	688	PF00069	0.587
MOD_CK1_1	94	100	PF00069	0.496
MOD_CK2_1	205	211	PF00069	0.559
MOD_CK2_1	220	226	PF00069	0.357
MOD_CK2_1	313	319	PF00069	0.429
MOD_CK2_1	574	580	PF00069	0.556
MOD_CK2_1	616	622	PF00069	0.321
MOD_CK2_1	628	634	PF00069	0.368
MOD_CK2_1	772	778	PF00069	0.503
MOD_Cter_Amidation	293	296	PF01082	0.613
MOD_Cter_Amidation	735	738	PF01082	0.485
MOD_GlcNHglycan	147	150	PF01048	0.655
MOD_GlcNHglycan	15	18	PF01048	0.523
MOD_GlcNHglycan	175	178	PF01048	0.747
MOD_GlcNHglycan	194	197	PF01048	0.423
MOD_GlcNHglycan	290	293	PF01048	0.584
MOD_GlcNHglycan	322	325	PF01048	0.318
MOD_GlcNHglycan	373	376	PF01048	0.684
MOD_GlcNHglycan	405	408	PF01048	0.655
MOD_GlcNHglycan	413	416	PF01048	0.665
MOD_GlcNHglycan	42	45	PF01048	0.621
MOD_GlcNHglycan	446	449	PF01048	0.506
MOD_GlcNHglycan	463	466	PF01048	0.654
MOD_GlcNHglycan	475	478	PF01048	0.588
MOD_GlcNHglycan	491	494	PF01048	0.689
MOD_GlcNHglycan	574	577	PF01048	0.522
MOD_GlcNHglycan	599	602	PF01048	0.418
MOD_GlcNHglycan	614	617	PF01048	0.497
MOD_GlcNHglycan	676	679	PF01048	0.501
MOD_GlcNHglycan	681	684	PF01048	0.544
MOD_GlcNHglycan	686	690	PF01048	0.511
MOD_GlcNHglycan	833	836	PF01048	0.475
MOD_GlcNHglycan	93	96	PF01048	0.469
MOD_GlcNHglycan	97	100	PF01048	0.487
MOD_GSK3_1	117	124	PF00069	0.466
MOD_GSK3_1	15	22	PF00069	0.521
MOD_GSK3_1	169	176	PF00069	0.632
MOD_GSK3_1	187	194	PF00069	0.497
MOD_GSK3_1	201	208	PF00069	0.441
MOD_GSK3_1	286	293	PF00069	0.728
MOD_GSK3_1	320	327	PF00069	0.363
MOD_GSK3_1	338	345	PF00069	0.634
MOD_GSK3_1	399	406	PF00069	0.686
MOD_GSK3_1	444	451	PF00069	0.553
MOD_GSK3_1	461	468	PF00069	0.773
MOD_GSK3_1	47	54	PF00069	0.668
MOD_GSK3_1	485	492	PF00069	0.614
MOD_GSK3_1	550	557	PF00069	0.445
MOD_GSK3_1	575	582	PF00069	0.560
MOD_GSK3_1	58	65	PF00069	0.493
MOD_GSK3_1	588	595	PF00069	0.579
MOD_GSK3_1	612	619	PF00069	0.377
MOD_GSK3_1	806	813	PF00069	0.502
MOD_GSK3_1	824	831	PF00069	0.548
MOD_GSK3_1	87	94	PF00069	0.392
MOD_GSK3_1	896	903	PF00069	0.462
MOD_GSK3_1	905	912	PF00069	0.432
MOD_GSK3_1	95	102	PF00069	0.410
MOD_N-GLC_1	403	408	PF02516	0.510
MOD_N-GLC_1	425	430	PF02516	0.459
MOD_N-GLC_1	460	465	PF02516	0.552
MOD_N-GLC_1	466	471	PF02516	0.556
MOD_NEK2_1	117	122	PF00069	0.398
MOD_NEK2_1	163	168	PF00069	0.583
MOD_NEK2_1	322	327	PF00069	0.406
MOD_NEK2_1	572	577	PF00069	0.498
MOD_NEK2_1	761	766	PF00069	0.482
MOD_NEK2_1	772	777	PF00069	0.486
MOD_NEK2_1	833	838	PF00069	0.406
MOD_NEK2_1	896	901	PF00069	0.410
MOD_NEK2_2	313	318	PF00069	0.425
MOD_PIKK_1	129	135	PF00454	0.674
MOD_PIKK_1	163	169	PF00454	0.581
MOD_PIKK_1	47	53	PF00454	0.536
MOD_PIKK_1	499	505	PF00454	0.444
MOD_PIKK_1	828	834	PF00454	0.607
MOD_PKA_1	185	191	PF00069	0.526
MOD_PKA_1	510	516	PF00069	0.383
MOD_PKA_1	753	759	PF00069	0.585
MOD_PKA_2	13	19	PF00069	0.525
MOD_PKA_2	204	210	PF00069	0.545
MOD_PKA_2	239	245	PF00069	0.405
MOD_PKA_2	320	326	PF00069	0.318
MOD_PKA_2	510	516	PF00069	0.501
MOD_PKA_2	518	524	PF00069	0.388
MOD_PKA_2	554	560	PF00069	0.450
MOD_PKA_2	717	723	PF00069	0.402
MOD_PKA_2	753	759	PF00069	0.546
MOD_PKB_1	185	193	PF00069	0.671
MOD_PKB_1	397	405	PF00069	0.514
MOD_Plk_1	179	185	PF00069	0.538
MOD_Plk_1	198	204	PF00069	0.489
MOD_Plk_1	338	344	PF00069	0.471
MOD_Plk_1	633	639	PF00069	0.572
MOD_Plk_1	806	812	PF00069	0.517
MOD_Plk_4	117	123	PF00069	0.447
MOD_Plk_4	15	21	PF00069	0.520
MOD_Plk_4	26	32	PF00069	0.371
MOD_Plk_4	313	319	PF00069	0.397
MOD_Plk_4	342	348	PF00069	0.508
MOD_Plk_4	413	419	PF00069	0.724
MOD_Plk_4	564	570	PF00069	0.524
MOD_Plk_4	762	768	PF00069	0.539
MOD_Plk_4	772	778	PF00069	0.454
MOD_ProDKin_1	425	431	PF00069	0.630
MOD_ProDKin_1	466	472	PF00069	0.620
MOD_ProDKin_1	826	832	PF00069	0.497
TRG_DiLeu_BaEn_1	229	234	PF01217	0.487
TRG_DiLeu_BaEn_1	882	887	PF01217	0.425
TRG_DiLeu_BaEn_4	229	235	PF01217	0.489
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.411
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.725
TRG_ENDOCYTIC_2	160	163	PF00928	0.474
TRG_ENDOCYTIC_2	305	308	PF00928	0.436
TRG_ENDOCYTIC_2	647	650	PF00928	0.350
TRG_ENDOCYTIC_2	839	842	PF00928	0.645
TRG_ER_diArg_1	184	187	PF00400	0.636
TRG_ER_diArg_1	259	261	PF00400	0.405
TRG_ER_diArg_1	295	298	PF00400	0.587
TRG_ER_diArg_1	396	399	PF00400	0.541
TRG_ER_diArg_1	418	421	PF00400	0.688
TRG_ER_diArg_1	509	511	PF00400	0.552
TRG_ER_diArg_1	533	535	PF00400	0.399
TRG_ER_diArg_1	657	660	PF00400	0.468
TRG_ER_diArg_1	752	754	PF00400	0.611
TRG_ER_diArg_1	795	797	PF00400	0.413
TRG_NES_CRM1_1	608	623	PF08389	0.435
TRG_NES_CRM1_1	746	760	PF08389	0.453
TRG_NLS_MonoExtC_3	184	189	PF00514	0.684
TRG_NLS_MonoExtN_4	185	190	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	907	911	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE7	Leptomonas seymouri	49%	100%
A0A3S5H6K4	Leishmania donovani	75%	100%
C9ZQC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AGA7	Leishmania infantum	76%	100%
E9ANU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QGS5	Leishmania major	74%	99%