Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6T2_LEIBR

TriTrypDb:

LbrM.12.0190 , LBRM2903_120006700

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.501
CLV_NRD_NRD_1	18	20	PF00675	0.448
CLV_PCSK_FUR_1	16	20	PF00082	0.447
CLV_PCSK_KEX2_1	16	18	PF00082	0.454
CLV_PCSK_SKI1_1	100	104	PF00082	0.411
CLV_PCSK_SKI1_1	122	126	PF00082	0.377
CLV_PCSK_SKI1_1	26	30	PF00082	0.385
DEG_COP1_1	186	195	PF00400	0.520
DEG_SPOP_SBC_1	60	64	PF00917	0.552
DOC_CDC14_PxL_1	149	157	PF14671	0.468
DOC_CYCLIN_RxL_1	128	140	PF00134	0.536
DOC_CYCLIN_RxL_1	94	106	PF00134	0.434
DOC_CYCLIN_yClb1_LxF_4	49	55	PF00134	0.484
DOC_MAPK_DCC_7	128	137	PF00069	0.433
DOC_MAPK_DCC_7	208	217	PF00069	0.627
DOC_MAPK_JIP1_4	133	139	PF00069	0.432
DOC_MAPK_MEF2A_6	133	141	PF00069	0.432
DOC_MAPK_MEF2A_6	208	217	PF00069	0.656
DOC_MAPK_MEF2A_6	26	33	PF00069	0.392
DOC_MAPK_NFAT4_5	26	34	PF00069	0.389
DOC_PP1_RVXF_1	98	105	PF00149	0.413
DOC_PP2B_LxvP_1	37	40	PF13499	0.449
DOC_USP7_MATH_1	264	268	PF00917	0.466
DOC_USP7_MATH_1	294	298	PF00917	0.605
DOC_USP7_MATH_1	337	341	PF00917	0.518
DOC_WW_Pin1_4	169	174	PF00397	0.497
DOC_WW_Pin1_4	224	229	PF00397	0.554
DOC_WW_Pin1_4	341	346	PF00397	0.548
DOC_WW_Pin1_4	370	375	PF00397	0.416
LIG_14-3-3_CanoR_1	115	124	PF00244	0.610
LIG_14-3-3_CanoR_1	133	138	PF00244	0.394
LIG_14-3-3_CanoR_1	180	188	PF00244	0.533
LIG_14-3-3_CanoR_1	326	332	PF00244	0.514
LIG_APCC_ABBAyCdc20_2	100	106	PF00400	0.411
LIG_BIR_III_2	336	340	PF00653	0.503
LIG_BRCT_BRCA1_1	301	305	PF00533	0.527
LIG_CaM_IQ_9	8	24	PF13499	0.454
LIG_CtBP_PxDLS_1	134	138	PF00389	0.423
LIG_eIF4E_1	23	29	PF01652	0.407
LIG_eIF4E_1	98	104	PF01652	0.498
LIG_FHA_1	179	185	PF00498	0.433
LIG_FHA_1	356	362	PF00498	0.537
LIG_FHA_1	8	14	PF00498	0.479
LIG_FHA_1	97	103	PF00498	0.394
LIG_FHA_2	160	166	PF00498	0.404
LIG_FHA_2	284	290	PF00498	0.531
LIG_FHA_2	83	89	PF00498	0.380
LIG_LIR_Gen_1	234	244	PF02991	0.741
LIG_LIR_Gen_1	76	87	PF02991	0.536
LIG_LIR_LC3C_4	311	316	PF02991	0.508
LIG_LIR_Nem_3	231	236	PF02991	0.738
LIG_LIR_Nem_3	76	82	PF02991	0.542
LIG_MYND_1	130	134	PF01753	0.440
LIG_MYND_1	339	343	PF01753	0.511
LIG_Pex14_1	233	237	PF04695	0.592
LIG_SH2_GRB2like	375	378	PF00017	0.467
LIG_SH2_SRC	334	337	PF00017	0.505
LIG_SH2_STAP1	23	27	PF00017	0.477
LIG_SH2_STAP1	250	254	PF00017	0.517
LIG_SH2_STAP1	83	87	PF00017	0.476
LIG_SH2_STAP1	89	93	PF00017	0.467
LIG_SH2_STAP1	98	102	PF00017	0.436
LIG_SH2_STAT3	98	101	PF00017	0.344
LIG_SH2_STAT5	107	110	PF00017	0.463
LIG_SH2_STAT5	170	173	PF00017	0.629
LIG_SH2_STAT5	258	261	PF00017	0.655
LIG_SH2_STAT5	334	337	PF00017	0.505
LIG_SH2_STAT5	98	101	PF00017	0.534
LIG_SH3_1	208	214	PF00018	0.674
LIG_SH3_2	211	216	PF14604	0.557
LIG_SH3_3	206	212	PF00018	0.654
LIG_SH3_3	312	318	PF00018	0.588
LIG_SH3_3	368	374	PF00018	0.468
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.433
LIG_SUMO_SIM_anti_2	308	316	PF11976	0.669
LIG_SUMO_SIM_par_1	133	138	PF11976	0.427
LIG_SUMO_SIM_par_1	344	349	PF11976	0.531
LIG_TRAF2_1	73	76	PF00917	0.592
LIG_UBA3_1	27	35	PF00899	0.406
LIG_WW_2	211	214	PF00397	0.580
MOD_CK1_1	159	165	PF00069	0.583
MOD_CK1_1	186	192	PF00069	0.634
MOD_CK1_1	373	379	PF00069	0.458
MOD_CK1_1	407	413	PF00069	0.538
MOD_CK1_1	62	68	PF00069	0.513
MOD_CK1_1	77	83	PF00069	0.588
MOD_CK2_1	159	165	PF00069	0.669
MOD_CK2_1	245	251	PF00069	0.564
MOD_CK2_1	327	333	PF00069	0.515
MOD_CK2_1	82	88	PF00069	0.372
MOD_GlcNHglycan	150	153	PF01048	0.510
MOD_GlcNHglycan	188	191	PF01048	0.668
MOD_GlcNHglycan	266	269	PF01048	0.550
MOD_GlcNHglycan	406	409	PF01048	0.546
MOD_GlcNHglycan	421	424	PF01048	0.418
MOD_GlcNHglycan	90	93	PF01048	0.610
MOD_GSK3_1	153	160	PF00069	0.489
MOD_GSK3_1	179	186	PF00069	0.498
MOD_GSK3_1	337	344	PF00069	0.713
MOD_GSK3_1	419	426	PF00069	0.463
MOD_GSK3_1	58	65	PF00069	0.596
MOD_N-GLC_1	299	304	PF02516	0.705
MOD_N-GLC_1	96	101	PF02516	0.430
MOD_NEK2_1	82	87	PF00069	0.419
MOD_NEK2_2	117	122	PF00069	0.387
MOD_NEK2_2	294	299	PF00069	0.534
MOD_NEK2_2	327	332	PF00069	0.485
MOD_PIKK_1	115	121	PF00454	0.597
MOD_PIKK_1	179	185	PF00454	0.621
MOD_PIKK_1	348	354	PF00454	0.534
MOD_PIKK_1	356	362	PF00454	0.401
MOD_PKA_2	179	185	PF00069	0.423
MOD_PKA_2	354	360	PF00069	0.623
MOD_Plk_1	157	163	PF00069	0.572
MOD_Plk_1	294	300	PF00069	0.695
MOD_Plk_1	310	316	PF00069	0.490
MOD_Plk_1	74	80	PF00069	0.586
MOD_Plk_4	183	189	PF00069	0.482
MOD_Plk_4	294	300	PF00069	0.605
MOD_Plk_4	301	307	PF00069	0.593
MOD_Plk_4	337	343	PF00069	0.507
MOD_Plk_4	74	80	PF00069	0.398
MOD_Plk_4	82	88	PF00069	0.348
MOD_ProDKin_1	169	175	PF00069	0.499
MOD_ProDKin_1	224	230	PF00069	0.552
MOD_ProDKin_1	341	347	PF00069	0.549
MOD_ProDKin_1	370	376	PF00069	0.421
TRG_DiLeu_BaEn_1	266	271	PF01217	0.476
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.409
TRG_ENDOCYTIC_2	237	240	PF00928	0.777
TRG_ENDOCYTIC_2	83	86	PF00928	0.477
TRG_ER_diArg_1	15	18	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD33	Leptomonas seymouri	30%	91%
A0A3S7WRT8	Leishmania donovani	62%	100%
E9AGA6	Leishmania infantum	62%	100%
E9ANU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4QGS6	Leishmania major	63%	100%