Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6T0_LEIBR

TriTrypDb:

LbrM.12.0170 , LBRM2903_120006500

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070765	gamma-secretase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H6T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6T0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0016485	protein processing	5	7
GO:0019538	protein metabolic process	3	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044093	positive regulation of molecular function	3	7
GO:0044238	primary metabolic process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0051604	protein maturation	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.646
CLV_NRD_NRD_1	342	344	PF00675	0.488
CLV_NRD_NRD_1	414	416	PF00675	0.594
CLV_PCSK_KEX2_1	414	416	PF00082	0.594
CLV_PCSK_SKI1_1	334	338	PF00082	0.476
DEG_APCC_DBOX_1	105	113	PF00400	0.272
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DEG_SPOP_SBC_1	150	154	PF00917	0.636
DOC_CDC14_PxL_1	388	396	PF14671	0.235
DOC_CKS1_1	346	351	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	25	31	PF00134	0.377
DOC_MAPK_DCC_7	104	114	PF00069	0.255
DOC_MAPK_gen_1	104	112	PF00069	0.365
DOC_MAPK_MEF2A_6	104	112	PF00069	0.345
DOC_MAPK_MEF2A_6	81	89	PF00069	0.337
DOC_PP1_RVXF_1	91	97	PF00149	0.343
DOC_PP2B_LxvP_1	12	15	PF13499	0.377
DOC_PP4_FxxP_1	389	392	PF00568	0.364
DOC_USP7_MATH_1	121	125	PF00917	0.452
DOC_USP7_MATH_1	150	154	PF00917	0.663
DOC_USP7_MATH_1	311	315	PF00917	0.644
DOC_USP7_MATH_1	329	333	PF00917	0.736
DOC_USP7_MATH_1	336	340	PF00917	0.784
DOC_USP7_MATH_1	398	402	PF00917	0.396
DOC_USP7_MATH_1	413	417	PF00917	0.438
DOC_USP7_MATH_1	61	65	PF00917	0.293
DOC_WW_Pin1_4	241	246	PF00397	0.725
DOC_WW_Pin1_4	327	332	PF00397	0.644
DOC_WW_Pin1_4	345	350	PF00397	0.725
LIG_14-3-3_CanoR_1	174	184	PF00244	0.593
LIG_14-3-3_CanoR_1	338	343	PF00244	0.748
LIG_14-3-3_CanoR_1	405	409	PF00244	0.460
LIG_14-3-3_CanoR_1	414	423	PF00244	0.262
LIG_14-3-3_CanoR_1	445	451	PF00244	0.658
LIG_Actin_WH2_2	40	58	PF00022	0.377
LIG_AP_GAE_1	265	271	PF02883	0.620
LIG_Clathr_ClatBox_1	261	265	PF01394	0.679
LIG_FHA_1	120	126	PF00498	0.230
LIG_FHA_1	2	8	PF00498	0.489
LIG_FHA_1	225	231	PF00498	0.729
LIG_FHA_1	372	378	PF00498	0.420
LIG_FHA_1	447	453	PF00498	0.680
LIG_FHA_1	46	52	PF00498	0.364
LIG_FHA_1	58	64	PF00498	0.454
LIG_FHA_1	70	76	PF00498	0.245
LIG_FHA_2	295	301	PF00498	0.677
LIG_GBD_Chelix_1	383	391	PF00786	0.261
LIG_IRF3_LxIS_1	28	34	PF10401	0.220
LIG_IRF3_LxIS_1	5	10	PF10401	0.235
LIG_LIR_Gen_1	38	47	PF02991	0.281
LIG_LIR_Gen_1	448	454	PF02991	0.638
LIG_LIR_Nem_3	105	110	PF02991	0.396
LIG_LIR_Nem_3	257	261	PF02991	0.603
LIG_LIR_Nem_3	265	271	PF02991	0.604
LIG_LIR_Nem_3	38	42	PF02991	0.303
LIG_LIR_Nem_3	448	453	PF02991	0.634
LIG_Pex14_2	180	184	PF04695	0.506
LIG_SH2_CRK	450	454	PF00017	0.660
LIG_SH2_SRC	13	16	PF00017	0.377
LIG_SH2_STAP1	200	204	PF00017	0.583
LIG_SH2_STAP1	3	7	PF00017	0.345
LIG_SH2_STAT5	3	6	PF00017	0.235
LIG_SH2_STAT5	306	309	PF00017	0.655
LIG_SH3_3	105	111	PF00018	0.406
LIG_SH3_3	346	352	PF00018	0.652
LIG_SH3_3	387	393	PF00018	0.277
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.377
LIG_SUMO_SIM_par_1	260	267	PF11976	0.676
LIG_SUMO_SIM_par_1	28	34	PF11976	0.379
LIG_SUMO_SIM_par_1	427	433	PF11976	0.283
LIG_SUMO_SIM_par_1	43	48	PF11976	0.244
LIG_SUMO_SIM_par_1	439	444	PF11976	0.425
LIG_SxIP_EBH_1	402	415	PF03271	0.375
LIG_TRAF2_1	156	159	PF00917	0.624
LIG_TRAF2_1	297	300	PF00917	0.737
LIG_TRFH_1	107	111	PF08558	0.322
LIG_TRFH_1	389	393	PF08558	0.308
LIG_TRFH_1	450	454	PF08558	0.595
LIG_WRC_WIRS_1	36	41	PF05994	0.320
MOD_CDK_SPxxK_3	327	334	PF00069	0.647
MOD_CK1_1	151	157	PF00069	0.674
MOD_CK1_1	213	219	PF00069	0.601
MOD_CK1_1	241	247	PF00069	0.639
MOD_CK1_1	283	289	PF00069	0.642
MOD_CK1_1	350	356	PF00069	0.663
MOD_CK2_1	294	300	PF00069	0.753
MOD_CK2_1	329	335	PF00069	0.744
MOD_CMANNOS	436	439	PF00535	0.228
MOD_GlcNHglycan	127	130	PF01048	0.296
MOD_GlcNHglycan	165	168	PF01048	0.443
MOD_GlcNHglycan	212	215	PF01048	0.393
MOD_GlcNHglycan	240	243	PF01048	0.498
MOD_GlcNHglycan	285	288	PF01048	0.485
MOD_GlcNHglycan	309	312	PF01048	0.564
MOD_GlcNHglycan	315	318	PF01048	0.549
MOD_GlcNHglycan	327	330	PF01048	0.638
MOD_GlcNHglycan	400	403	PF01048	0.601
MOD_GlcNHglycan	411	414	PF01048	0.634
MOD_GSK3_1	121	128	PF00069	0.293
MOD_GSK3_1	146	153	PF00069	0.681
MOD_GSK3_1	276	283	PF00069	0.723
MOD_GSK3_1	307	314	PF00069	0.636
MOD_GSK3_1	31	38	PF00069	0.325
MOD_GSK3_1	325	332	PF00069	0.839
MOD_GSK3_1	334	341	PF00069	0.639
MOD_GSK3_1	371	378	PF00069	0.420
MOD_GSK3_1	400	407	PF00069	0.435
MOD_GSK3_1	409	416	PF00069	0.492
MOD_GSK3_1	57	64	PF00069	0.558
MOD_N-GLC_1	77	82	PF02516	0.548
MOD_N-GLC_2	417	419	PF02516	0.420
MOD_N-GLC_2	86	88	PF02516	0.466
MOD_NEK2_1	1	6	PF00069	0.470
MOD_NEK2_1	102	107	PF00069	0.385
MOD_NEK2_1	120	125	PF00069	0.196
MOD_NEK2_1	162	167	PF00069	0.581
MOD_NEK2_1	175	180	PF00069	0.521
MOD_NEK2_1	210	215	PF00069	0.589
MOD_NEK2_1	31	36	PF00069	0.304
MOD_NEK2_1	45	50	PF00069	0.312
MOD_NEK2_1	55	60	PF00069	0.528
MOD_NEK2_1	7	12	PF00069	0.249
MOD_NEK2_2	250	255	PF00069	0.707
MOD_PKA_2	337	343	PF00069	0.817
MOD_PKA_2	404	410	PF00069	0.451
MOD_PKA_2	413	419	PF00069	0.385
MOD_PKA_2	55	61	PF00069	0.496
MOD_Plk_1	1	7	PF00069	0.468
MOD_Plk_1	250	256	PF00069	0.706
MOD_Plk_1	77	83	PF00069	0.352
MOD_Plk_4	121	127	PF00069	0.308
MOD_Plk_4	14	20	PF00069	0.252
MOD_Plk_4	180	186	PF00069	0.553
MOD_Plk_4	35	41	PF00069	0.349
MOD_Plk_4	363	369	PF00069	0.574
MOD_Plk_4	404	410	PF00069	0.389
MOD_Plk_4	427	433	PF00069	0.308
MOD_Plk_4	446	452	PF00069	0.621
MOD_ProDKin_1	241	247	PF00069	0.724
MOD_ProDKin_1	327	333	PF00069	0.645
MOD_ProDKin_1	345	351	PF00069	0.722
TRG_ENDOCYTIC_2	200	203	PF00928	0.583
TRG_ENDOCYTIC_2	450	453	PF00928	0.644
TRG_ER_diArg_1	103	106	PF00400	0.390
TRG_NES_CRM1_1	252	267	PF08389	0.606
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY04	Leptomonas seymouri	41%	96%
A0A3S7WRT9	Leishmania donovani	66%	100%
A4HV58	Leishmania infantum	66%	68%
E9ANU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QGS9	Leishmania major	66%	100%