Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cell division protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6S9_LEIBR

TriTrypDb:

LbrM.12.0160 , LBRM2903_120006400

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H6S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6S9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0051301	cell division	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.394
CLV_NRD_NRD_1	139	141	PF00675	0.513
CLV_NRD_NRD_1	258	260	PF00675	0.522
CLV_PCSK_KEX2_1	139	141	PF00082	0.513
CLV_PCSK_KEX2_1	258	260	PF00082	0.522
CLV_PCSK_SKI1_1	139	143	PF00082	0.465
CLV_PCSK_SKI1_1	160	164	PF00082	0.515
CLV_PCSK_SKI1_1	418	422	PF00082	0.339
CLV_PCSK_SKI1_1	42	46	PF00082	0.254
CLV_PCSK_SKI1_1	83	87	PF00082	0.408
CLV_PCSK_SKI1_1	96	100	PF00082	0.318
DEG_APCC_DBOX_1	138	146	PF00400	0.465
DEG_COP1_1	315	323	PF00400	0.423
DEG_SCF_FBW7_1	349	354	PF00400	0.411
DOC_CKS1_1	126	131	PF01111	0.261
DOC_CKS1_1	353	358	PF01111	0.411
DOC_CKS1_1	423	428	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.530
DOC_MAPK_gen_1	160	169	PF00069	0.411
DOC_MAPK_gen_1	415	423	PF00069	0.261
DOC_MAPK_MEF2A_6	131	138	PF00069	0.261
DOC_MAPK_MEF2A_6	415	423	PF00069	0.261
DOC_PP2B_PxIxI_1	133	139	PF00149	0.513
DOC_PP4_FxxP_1	574	577	PF00568	0.635
DOC_SPAK_OSR1_1	8	12	PF12202	0.411
DOC_USP7_MATH_1	107	111	PF00917	0.513
DOC_USP7_MATH_1	184	188	PF00917	0.775
DOC_USP7_MATH_1	505	509	PF00917	0.315
DOC_USP7_MATH_1	512	516	PF00917	0.365
DOC_USP7_MATH_1	518	522	PF00917	0.491
DOC_USP7_MATH_1	531	535	PF00917	0.199
DOC_WW_Pin1_4	125	130	PF00397	0.444
DOC_WW_Pin1_4	201	206	PF00397	0.766
DOC_WW_Pin1_4	313	318	PF00397	0.698
DOC_WW_Pin1_4	347	352	PF00397	0.404
DOC_WW_Pin1_4	422	427	PF00397	0.353
DOC_WW_Pin1_4	462	467	PF00397	0.392
DOC_WW_Pin1_4	501	506	PF00397	0.272
DOC_WW_Pin1_4	64	69	PF00397	0.513
LIG_14-3-3_CanoR_1	106	112	PF00244	0.290
LIG_14-3-3_CanoR_1	563	570	PF00244	0.357
LIG_14-3-3_CanoR_1	8	12	PF00244	0.411
LIG_Actin_WH2_2	31	47	PF00022	0.290
LIG_APCC_ABBA_1	234	239	PF00400	0.587
LIG_APCC_ABBAyCdc20_2	155	161	PF00400	0.377
LIG_BRCT_BRCA1_1	224	228	PF00533	0.505
LIG_CtBP_PxDLS_1	92	96	PF00389	0.411
LIG_FAT_LD_1	549	557	PF03623	0.261
LIG_FHA_1	314	320	PF00498	0.487
LIG_FHA_1	334	340	PF00498	0.364
LIG_FHA_1	352	358	PF00498	0.411
LIG_FHA_1	39	45	PF00498	0.411
LIG_FHA_1	423	429	PF00498	0.472
LIG_FHA_2	188	194	PF00498	0.522
LIG_FHA_2	239	245	PF00498	0.556
LIG_FHA_2	31	37	PF00498	0.513
LIG_FHA_2	369	375	PF00498	0.411
LIG_FHA_2	483	489	PF00498	0.416
LIG_FHA_2	517	523	PF00498	0.367
LIG_FHA_2	563	569	PF00498	0.411
LIG_FHA_2	8	14	PF00498	0.355
LIG_LIR_Apic_2	355	361	PF02991	0.411
LIG_LIR_Apic_2	522	528	PF02991	0.261
LIG_LIR_Gen_1	389	397	PF02991	0.290
LIG_LIR_Gen_1	408	416	PF02991	0.411
LIG_LIR_Gen_1	7	15	PF02991	0.411
LIG_LIR_Nem_3	17	23	PF02991	0.411
LIG_LIR_Nem_3	389	394	PF02991	0.411
LIG_LIR_Nem_3	429	434	PF02991	0.411
LIG_LIR_Nem_3	7	12	PF02991	0.378
LIG_LIR_Nem_3	89	93	PF02991	0.411
LIG_MYND_1	317	321	PF01753	0.573
LIG_MYND_1	573	577	PF01753	0.513
LIG_NRBOX	551	557	PF00104	0.411
LIG_Pex14_2	98	102	PF04695	0.411
LIG_PTB_Apo_2	97	104	PF02174	0.411
LIG_PTB_Phospho_1	97	103	PF10480	0.411
LIG_SH2_CRK	20	24	PF00017	0.411
LIG_SH2_CRK	525	529	PF00017	0.261
LIG_SH2_NCK_1	558	562	PF00017	0.261
LIG_SH2_PTP2	90	93	PF00017	0.411
LIG_SH2_SRC	558	561	PF00017	0.513
LIG_SH2_STAT3	270	273	PF00017	0.563
LIG_SH2_STAT5	103	106	PF00017	0.411
LIG_SH2_STAT5	137	140	PF00017	0.411
LIG_SH2_STAT5	270	273	PF00017	0.563
LIG_SH2_STAT5	358	361	PF00017	0.411
LIG_SH2_STAT5	410	413	PF00017	0.411
LIG_SH2_STAT5	90	93	PF00017	0.411
LIG_SH3_1	258	264	PF00018	0.500
LIG_SH3_1	525	531	PF00018	0.261
LIG_SH3_3	123	129	PF00018	0.261
LIG_SH3_3	178	184	PF00018	0.649
LIG_SH3_3	196	202	PF00018	0.793
LIG_SH3_3	258	264	PF00018	0.500
LIG_SH3_3	315	321	PF00018	0.592
LIG_SH3_3	350	356	PF00018	0.411
LIG_SH3_3	491	497	PF00018	0.261
LIG_SH3_3	525	531	PF00018	0.261
LIG_SUMO_SIM_par_1	91	97	PF11976	0.513
LIG_TRAF2_1	207	210	PF00917	0.825
LIG_TRAF2_1	341	344	PF00917	0.513
LIG_TYR_ITIM	381	386	PF00017	0.261
LIG_TYR_ITIM	88	93	PF00017	0.411
LIG_WRC_WIRS_1	397	402	PF05994	0.411
LIG_WRC_WIRS_1	95	100	PF05994	0.513
LIG_WW_3	128	132	PF00397	0.261
MOD_CDK_SPxK_1	125	131	PF00069	0.261
MOD_CDK_SPxxK_3	462	469	PF00069	0.261
MOD_CK1_1	187	193	PF00069	0.517
MOD_CK1_1	393	399	PF00069	0.280
MOD_CK1_1	534	540	PF00069	0.261
MOD_CK1_1	7	13	PF00069	0.397
MOD_CK2_1	187	193	PF00069	0.517
MOD_CK2_1	238	244	PF00069	0.656
MOD_CK2_1	338	344	PF00069	0.411
MOD_CK2_1	424	430	PF00069	0.411
MOD_CK2_1	462	468	PF00069	0.407
MOD_CK2_1	482	488	PF00069	0.350
MOD_CK2_1	516	522	PF00069	0.367
MOD_CK2_1	562	568	PF00069	0.411
MOD_CK2_1	7	13	PF00069	0.400
MOD_GlcNHglycan	109	112	PF01048	0.438
MOD_GlcNHglycan	16	19	PF01048	0.411
MOD_GlcNHglycan	187	190	PF01048	0.632
MOD_GlcNHglycan	246	249	PF01048	0.516
MOD_GlcNHglycan	299	303	PF01048	0.672
MOD_GlcNHglycan	329	332	PF01048	0.492
MOD_GlcNHglycan	340	343	PF01048	0.411
MOD_GlcNHglycan	400	403	PF01048	0.429
MOD_GlcNHglycan	473	476	PF01048	0.513
MOD_GlcNHglycan	546	549	PF01048	0.357
MOD_GlcNHglycan	565	568	PF01048	0.513
MOD_GSK3_1	347	354	PF00069	0.390
MOD_GSK3_1	501	508	PF00069	0.313
MOD_GSK3_1	512	519	PF00069	0.261
MOD_NEK2_1	185	190	PF00069	0.629
MOD_NEK2_1	390	395	PF00069	0.290
MOD_NEK2_1	44	49	PF00069	0.513
MOD_NEK2_1	551	556	PF00069	0.411
MOD_PIKK_1	211	217	PF00454	0.716
MOD_PIKK_1	285	291	PF00454	0.708
MOD_PK_1	55	61	PF00069	0.389
MOD_PKA_2	562	568	PF00069	0.378
MOD_PKA_2	7	13	PF00069	0.411
MOD_PKB_1	217	225	PF00069	0.539
MOD_Plk_1	276	282	PF00069	0.545
MOD_Plk_1	55	61	PF00069	0.389
MOD_Plk_2-3	30	36	PF00069	0.411
MOD_Plk_4	19	25	PF00069	0.381
MOD_Plk_4	551	557	PF00069	0.261
MOD_ProDKin_1	125	131	PF00069	0.444
MOD_ProDKin_1	201	207	PF00069	0.761
MOD_ProDKin_1	313	319	PF00069	0.685
MOD_ProDKin_1	347	353	PF00069	0.404
MOD_ProDKin_1	422	428	PF00069	0.353
MOD_ProDKin_1	462	468	PF00069	0.392
MOD_ProDKin_1	501	507	PF00069	0.272
MOD_ProDKin_1	64	70	PF00069	0.513
MOD_SUMO_for_1	162	165	PF00179	0.411
MOD_SUMO_rev_2	305	313	PF00179	0.799
MOD_SUMO_rev_2	473	479	PF00179	0.438
MOD_SUMO_rev_2	482	492	PF00179	0.480
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.513
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.261
TRG_ENDOCYTIC_2	20	23	PF00928	0.411
TRG_ENDOCYTIC_2	24	27	PF00928	0.411
TRG_ENDOCYTIC_2	383	386	PF00928	0.468
TRG_ENDOCYTIC_2	410	413	PF00928	0.524
TRG_ENDOCYTIC_2	90	93	PF00928	0.411
TRG_ER_diArg_1	138	140	PF00400	0.513
TRG_ER_diArg_1	217	220	PF00400	0.690
TRG_ER_diArg_1	337	340	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4P5	Leptomonas seymouri	55%	93%
A0A3Q8ICJ0	Leishmania donovani	78%	100%
A4HV57	Leishmania infantum	78%	100%
E9ANU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QGT0	Leishmania major	77%	100%