Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6S7_LEIBR

TriTrypDb:

LbrM.12.0140 , LBRM2903_120006200

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6S7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.552
CLV_C14_Caspase3-7	267	271	PF00656	0.618
CLV_C14_Caspase3-7	407	411	PF00656	0.574
CLV_C14_Caspase3-7	645	649	PF00656	0.635
CLV_NRD_NRD_1	211	213	PF00675	0.573
CLV_NRD_NRD_1	264	266	PF00675	0.616
CLV_NRD_NRD_1	336	338	PF00675	0.423
CLV_NRD_NRD_1	428	430	PF00675	0.464
CLV_NRD_NRD_1	461	463	PF00675	0.558
CLV_NRD_NRD_1	498	500	PF00675	0.592
CLV_NRD_NRD_1	560	562	PF00675	0.450
CLV_NRD_NRD_1	721	723	PF00675	0.503
CLV_NRD_NRD_1	787	789	PF00675	0.628
CLV_PCSK_FUR_1	426	430	PF00082	0.433
CLV_PCSK_FUR_1	498	502	PF00082	0.463
CLV_PCSK_FUR_1	719	723	PF00082	0.501
CLV_PCSK_FUR_1	762	766	PF00082	0.507
CLV_PCSK_KEX2_1	124	126	PF00082	0.561
CLV_PCSK_KEX2_1	160	162	PF00082	0.433
CLV_PCSK_KEX2_1	210	212	PF00082	0.580
CLV_PCSK_KEX2_1	264	266	PF00082	0.646
CLV_PCSK_KEX2_1	336	338	PF00082	0.423
CLV_PCSK_KEX2_1	428	430	PF00082	0.548
CLV_PCSK_KEX2_1	477	479	PF00082	0.427
CLV_PCSK_KEX2_1	498	500	PF00082	0.594
CLV_PCSK_KEX2_1	559	561	PF00082	0.476
CLV_PCSK_KEX2_1	7	9	PF00082	0.479
CLV_PCSK_KEX2_1	721	723	PF00082	0.503
CLV_PCSK_KEX2_1	764	766	PF00082	0.586
CLV_PCSK_KEX2_1	771	773	PF00082	0.612
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.561
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.433
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.427
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.430
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.479
CLV_PCSK_PC1ET2_1	764	766	PF00082	0.615
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.662
CLV_PCSK_PC7_1	556	562	PF00082	0.447
CLV_PCSK_SKI1_1	130	134	PF00082	0.552
CLV_PCSK_SKI1_1	135	139	PF00082	0.503
CLV_PCSK_SKI1_1	152	156	PF00082	0.421
CLV_PCSK_SKI1_1	160	164	PF00082	0.499
CLV_PCSK_SKI1_1	236	240	PF00082	0.532
CLV_PCSK_SKI1_1	392	396	PF00082	0.513
CLV_PCSK_SKI1_1	399	403	PF00082	0.548
CLV_PCSK_SKI1_1	4	8	PF00082	0.492
CLV_PCSK_SKI1_1	445	449	PF00082	0.559
CLV_PCSK_SKI1_1	474	478	PF00082	0.550
CLV_PCSK_SKI1_1	49	53	PF00082	0.545
CLV_PCSK_SKI1_1	561	565	PF00082	0.505
CLV_PCSK_SKI1_1	670	674	PF00082	0.423
CLV_PCSK_SKI1_1	678	682	PF00082	0.388
DEG_APCC_DBOX_1	177	185	PF00400	0.414
DEG_APCC_DBOX_1	246	254	PF00400	0.539
DEG_Nend_UBRbox_4	1	3	PF02207	0.460
DEG_SCF_FBW7_1	84	90	PF00400	0.610
DOC_CKS1_1	84	89	PF01111	0.557
DOC_CYCLIN_RxL_1	4	14	PF00134	0.415
DOC_CYCLIN_RxL_1	667	676	PF00134	0.430
DOC_MAPK_gen_1	122	129	PF00069	0.415
DOC_MAPK_gen_1	392	400	PF00069	0.424
DOC_MAPK_gen_1	769	775	PF00069	0.588
DOC_PP1_RVXF_1	350	357	PF00149	0.400
DOC_USP7_MATH_1	106	110	PF00917	0.508
DOC_USP7_MATH_1	338	342	PF00917	0.556
DOC_USP7_MATH_1	552	556	PF00917	0.442
DOC_USP7_MATH_1	639	643	PF00917	0.481
DOC_USP7_MATH_1	649	653	PF00917	0.520
DOC_USP7_UBL2_3	135	139	PF12436	0.550
DOC_USP7_UBL2_3	55	59	PF12436	0.545
DOC_WW_Pin1_4	83	88	PF00397	0.675
DOC_WW_Pin1_4	91	96	PF00397	0.646
LIG_14-3-3_CanoR_1	224	232	PF00244	0.418
LIG_14-3-3_CanoR_1	302	312	PF00244	0.560
LIG_14-3-3_CanoR_1	501	511	PF00244	0.475
LIG_14-3-3_CanoR_1	638	644	PF00244	0.479
LIG_14-3-3_CanoR_1	662	669	PF00244	0.484
LIG_14-3-3_CanoR_1	700	709	PF00244	0.433
LIG_14-3-3_CanoR_1	778	784	PF00244	0.611
LIG_CaM_IQ_9	189	205	PF13499	0.417
LIG_Clathr_ClatBox_1	672	676	PF01394	0.558
LIG_Dynein_DLC8_1	302	308	PF01221	0.560
LIG_eIF4E_1	511	517	PF01652	0.408
LIG_FHA_1	161	167	PF00498	0.485
LIG_FHA_1	224	230	PF00498	0.416
LIG_FHA_1	311	317	PF00498	0.616
LIG_FHA_1	562	568	PF00498	0.580
LIG_FHA_1	701	707	PF00498	0.590
LIG_FHA_1	708	714	PF00498	0.678
LIG_FHA_1	733	739	PF00498	0.562
LIG_FHA_2	131	137	PF00498	0.549
LIG_FHA_2	193	199	PF00498	0.418
LIG_FHA_2	304	310	PF00498	0.568
LIG_FHA_2	455	461	PF00498	0.478
LIG_FHA_2	567	573	PF00498	0.568
LIG_FHA_2	578	584	PF00498	0.457
LIG_FHA_2	628	634	PF00498	0.554
LIG_FHA_2	735	741	PF00498	0.554
LIG_FHA_2	797	803	PF00498	0.618
LIG_LIR_Gen_1	309	316	PF02991	0.556
LIG_LIR_Gen_1	701	709	PF02991	0.549
LIG_LIR_Nem_3	309	315	PF02991	0.556
LIG_LIR_Nem_3	666	672	PF02991	0.726
LIG_PCNA_yPIPBox_3	336	346	PF02747	0.525
LIG_PCNA_yPIPBox_3	790	804	PF02747	0.496
LIG_SH2_CRK	331	335	PF00017	0.438
LIG_SH2_CRK	669	673	PF00017	0.573
LIG_SH2_CRK	695	699	PF00017	0.548
LIG_SH2_NCK_1	695	699	PF00017	0.548
LIG_SH2_SRC	214	217	PF00017	0.419
LIG_SH2_STAP1	214	218	PF00017	0.559
LIG_SH2_STAP1	690	694	PF00017	0.549
LIG_SH3_3	638	644	PF00018	0.516
LIG_SH3_3	81	87	PF00018	0.611
LIG_TRAF2_1	115	118	PF00917	0.526
LIG_TRAF2_1	154	157	PF00917	0.572
LIG_TRAF2_1	278	281	PF00917	0.664
LIG_TRAF2_1	284	287	PF00917	0.661
LIG_TRAF2_1	574	577	PF00917	0.569
LIG_TRAF2_1	799	802	PF00917	0.495
LIG_UBA3_1	345	352	PF00899	0.401
MOD_CDK_SPxK_1	91	97	PF00069	0.562
MOD_CK1_1	109	115	PF00069	0.565
MOD_CK1_1	512	518	PF00069	0.406
MOD_CK1_1	642	648	PF00069	0.531
MOD_CK1_1	779	785	PF00069	0.545
MOD_CK1_1	93	99	PF00069	0.628
MOD_CK2_1	169	175	PF00069	0.567
MOD_CK2_1	192	198	PF00069	0.420
MOD_CK2_1	281	287	PF00069	0.596
MOD_CK2_1	387	393	PF00069	0.532
MOD_CK2_1	450	456	PF00069	0.460
MOD_CK2_1	552	558	PF00069	0.480
MOD_CK2_1	566	572	PF00069	0.541
MOD_CK2_1	577	583	PF00069	0.455
MOD_CK2_1	627	633	PF00069	0.629
MOD_CK2_1	649	655	PF00069	0.542
MOD_CK2_1	734	740	PF00069	0.557
MOD_CK2_1	796	802	PF00069	0.622
MOD_Cter_Amidation	460	463	PF01082	0.419
MOD_GlcNHglycan	106	109	PF01048	0.610
MOD_GlcNHglycan	141	144	PF01048	0.460
MOD_GlcNHglycan	368	371	PF01048	0.527
MOD_GlcNHglycan	406	409	PF01048	0.549
MOD_GlcNHglycan	511	514	PF01048	0.518
MOD_GlcNHglycan	601	605	PF01048	0.554
MOD_GlcNHglycan	641	644	PF01048	0.524
MOD_GlcNHglycan	725	729	PF01048	0.454
MOD_GlcNHglycan	805	808	PF01048	0.624
MOD_GSK3_1	160	167	PF00069	0.555
MOD_GSK3_1	255	262	PF00069	0.479
MOD_GSK3_1	450	457	PF00069	0.432
MOD_GSK3_1	505	512	PF00069	0.434
MOD_GSK3_1	54	61	PF00069	0.542
MOD_GSK3_1	649	656	PF00069	0.542
MOD_GSK3_1	720	727	PF00069	0.524
MOD_GSK3_1	792	799	PF00069	0.503
MOD_GSK3_1	83	90	PF00069	0.671
MOD_N-GLC_1	104	109	PF02516	0.635
MOD_N-GLC_1	255	260	PF02516	0.447
MOD_N-GLC_1	502	507	PF02516	0.412
MOD_N-GLC_1	732	737	PF02516	0.545
MOD_NEK2_1	192	197	PF00069	0.418
MOD_NEK2_1	571	576	PF00069	0.460
MOD_NEK2_1	58	63	PF00069	0.537
MOD_NEK2_1	709	714	PF00069	0.579
MOD_NEK2_1	731	736	PF00069	0.572
MOD_PIKK_1	272	278	PF00454	0.698
MOD_PIKK_1	303	309	PF00454	0.596
MOD_PIKK_1	387	393	PF00454	0.466
MOD_PIKK_1	399	405	PF00454	0.540
MOD_PIKK_1	411	417	PF00454	0.463
MOD_PIKK_1	561	567	PF00454	0.583
MOD_PIKK_1	700	706	PF00454	0.557
MOD_PKA_1	139	145	PF00069	0.549
MOD_PKA_1	160	166	PF00069	0.430
MOD_PKA_1	450	456	PF00069	0.497
MOD_PKA_2	160	166	PF00069	0.430
MOD_PKA_2	223	229	PF00069	0.418
MOD_PKA_2	263	269	PF00069	0.602
MOD_PKA_2	303	309	PF00069	0.579
MOD_PKA_2	404	410	PF00069	0.571
MOD_PKA_2	577	583	PF00069	0.597
MOD_PKA_2	661	667	PF00069	0.495
MOD_PKA_2	707	713	PF00069	0.449
MOD_PKA_2	720	726	PF00069	0.475
MOD_PKB_1	559	567	PF00069	0.588
MOD_PKB_1	722	730	PF00069	0.498
MOD_Plk_1	130	136	PF00069	0.535
MOD_Plk_1	255	261	PF00069	0.455
MOD_Plk_1	664	670	PF00069	0.525
MOD_Plk_2-3	281	287	PF00069	0.570
MOD_Plk_2-3	796	802	PF00069	0.622
MOD_Plk_4	169	175	PF00069	0.567
MOD_Plk_4	512	518	PF00069	0.406
MOD_Plk_4	709	715	PF00069	0.435
MOD_ProDKin_1	83	89	PF00069	0.680
MOD_ProDKin_1	91	97	PF00069	0.647
MOD_SUMO_for_1	476	479	PF00179	0.503
MOD_SUMO_rev_2	274	284	PF00179	0.629
MOD_SUMO_rev_2	389	397	PF00179	0.417
MOD_SUMO_rev_2	43	51	PF00179	0.573
MOD_SUMO_rev_2	479	485	PF00179	0.516
TRG_DiLeu_BaEn_1	46	51	PF01217	0.571
TRG_DiLeu_BaEn_4	176	182	PF01217	0.550
TRG_DiLeu_BaEn_4	280	286	PF01217	0.565
TRG_DiLeu_BaEn_4	46	52	PF01217	0.547
TRG_DiLeu_BaEn_4	601	607	PF01217	0.549
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.382
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.420
TRG_ENDOCYTIC_2	214	217	PF00928	0.561
TRG_ENDOCYTIC_2	331	334	PF00928	0.464
TRG_ENDOCYTIC_2	669	672	PF00928	0.614
TRG_ENDOCYTIC_2	695	698	PF00928	0.547
TRG_ER_diArg_1	178	181	PF00400	0.548
TRG_ER_diArg_1	19	22	PF00400	0.409
TRG_ER_diArg_1	210	212	PF00400	0.580
TRG_ER_diArg_1	426	429	PF00400	0.496
TRG_ER_diArg_1	498	501	PF00400	0.528
TRG_ER_diArg_1	559	561	PF00400	0.460
TRG_ER_diArg_1	719	722	PF00400	0.572
TRG_ER_diArg_1	745	748	PF00400	0.561
TRG_NES_CRM1_1	56	70	PF08389	0.543
TRG_NLS_Bipartite_1	770	792	PF00514	0.441
TRG_NLS_MonoCore_2	121	126	PF00514	0.558
TRG_NLS_MonoExtC_3	122	128	PF00514	0.558
TRG_NLS_MonoExtC_3	787	793	PF00514	0.504
TRG_NLS_MonoExtN_4	122	127	PF00514	0.560
TRG_NLS_MonoExtN_4	498	503	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRW5	Leishmania donovani	69%	100%
A4HV55	Leishmania infantum	69%	90%
E9ANT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QGT2	Leishmania major	69%	100%