Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H6S6_LEIBR

TriTrypDb:

LbrM.12.0130 , LBRM2903_120006100

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6S6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003677	DNA binding	4	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.485
CLV_NRD_NRD_1	167	169	PF00675	0.648
CLV_NRD_NRD_1	204	206	PF00675	0.677
CLV_NRD_NRD_1	59	61	PF00675	0.401
CLV_PCSK_KEX2_1	167	169	PF00082	0.642
CLV_PCSK_KEX2_1	188	190	PF00082	0.669
CLV_PCSK_KEX2_1	204	206	PF00082	0.658
CLV_PCSK_KEX2_1	59	61	PF00082	0.397
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.673
CLV_PCSK_SKI1_1	222	226	PF00082	0.481
CLV_PCSK_SKI1_1	240	244	PF00082	0.329
CLV_PCSK_SKI1_1	47	51	PF00082	0.367
DEG_APCC_DBOX_1	221	229	PF00400	0.494
DOC_CDC14_PxL_1	141	149	PF14671	0.587
DOC_CYCLIN_RxL_1	204	216	PF00134	0.634
DOC_CYCLIN_RxL_1	42	54	PF00134	0.369
DOC_PP1_RVXF_1	135	142	PF00149	0.656
DOC_USP7_MATH_1	55	59	PF00917	0.391
DOC_USP7_MATH_1	6	10	PF00917	0.676
DOC_USP7_UBL2_3	263	267	PF12436	0.568
DOC_WW_Pin1_4	116	121	PF00397	0.402
DOC_WW_Pin1_4	59	64	PF00397	0.492
LIG_14-3-3_CanoR_1	103	111	PF00244	0.377
LIG_14-3-3_CanoR_1	247	255	PF00244	0.466
LIG_14-3-3_CanoR_1	25	29	PF00244	0.406
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_deltaCOP1_diTrp_1	33	37	PF00928	0.397
LIG_FHA_1	134	140	PF00498	0.673
LIG_FHA_1	175	181	PF00498	0.594
LIG_FHA_1	209	215	PF00498	0.495
LIG_LIR_Gen_1	64	74	PF02991	0.500
LIG_LIR_Gen_1	89	100	PF02991	0.387
LIG_LIR_Nem_3	138	144	PF02991	0.602
LIG_LIR_Nem_3	285	289	PF02991	0.488
LIG_LIR_Nem_3	33	37	PF02991	0.384
LIG_LIR_Nem_3	64	70	PF02991	0.463
LIG_LIR_Nem_3	89	95	PF02991	0.388
LIG_PTB_Apo_2	115	122	PF02174	0.386
LIG_SH2_GRB2like	126	129	PF00017	0.500
LIG_SH2_PTP2	45	48	PF00017	0.415
LIG_SH2_PTP2	67	70	PF00017	0.500
LIG_SH2_STAP1	284	288	PF00017	0.592
LIG_SH2_STAT5	284	287	PF00017	0.588
LIG_SH2_STAT5	45	48	PF00017	0.415
LIG_SH2_STAT5	67	70	PF00017	0.382
LIG_SH3_3	139	145	PF00018	0.629
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.607
LIG_SUMO_SIM_par_1	210	216	PF11976	0.568
LIG_SUMO_SIM_par_1	223	229	PF11976	0.589
LIG_TRAF2_1	184	187	PF00917	0.564
LIG_TRAF2_1	54	57	PF00917	0.502
MOD_CDC14_SPxK_1	119	122	PF00782	0.402
MOD_CDK_SPxK_1	116	122	PF00069	0.402
MOD_CK1_1	140	146	PF00069	0.628
MOD_CK1_1	81	87	PF00069	0.402
MOD_CK2_1	51	57	PF00069	0.498
MOD_GlcNHglycan	53	56	PF01048	0.460
MOD_GlcNHglycan	8	11	PF01048	0.550
MOD_GlcNHglycan	80	83	PF01048	0.400
MOD_GSK3_1	112	119	PF00069	0.362
MOD_GSK3_1	133	140	PF00069	0.630
MOD_GSK3_1	51	58	PF00069	0.395
MOD_LATS_1	245	251	PF00433	0.491
MOD_N-GLC_1	35	40	PF02516	0.502
MOD_NEK2_1	102	107	PF00069	0.377
MOD_NEK2_1	23	28	PF00069	0.386
MOD_NEK2_1	277	282	PF00069	0.501
MOD_PIKK_1	102	108	PF00454	0.402
MOD_PKA_2	102	108	PF00069	0.377
MOD_PKA_2	24	30	PF00069	0.415
MOD_Plk_1	137	143	PF00069	0.652
MOD_Plk_4	24	30	PF00069	0.402
MOD_ProDKin_1	116	122	PF00069	0.402
MOD_ProDKin_1	59	65	PF00069	0.492
MOD_SUMO_for_1	192	195	PF00179	0.468
TRG_DiLeu_BaEn_1	223	228	PF01217	0.609
TRG_ENDOCYTIC_2	45	48	PF00928	0.415
TRG_ENDOCYTIC_2	67	70	PF00928	0.428
TRG_ENDOCYTIC_2	80	83	PF00928	0.283
TRG_ER_diArg_1	166	168	PF00400	0.656
TRG_ER_diArg_1	189	192	PF00400	0.664
TRG_ER_diArg_1	203	205	PF00400	0.663
TRG_NES_CRM1_1	223	237	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T3	Leptomonas seymouri	85%	99%
A0A0S4JCN1	Bodo saltans	26%	90%
A0A0S4JLV2	Bodo saltans	52%	100%
A0A1X0NMT4	Trypanosomatidae	69%	99%
A0A3R7KK47	Trypanosoma rangeli	68%	99%
A0A3S5H6K3	Leishmania donovani	93%	100%
A4HV54	Leishmania infantum	92%	99%
C9ZQD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9ANT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGT3	Leishmania major	92%	100%
V5BHW6	Trypanosoma cruzi	66%	99%