Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6S5_LEIBR

TriTrypDb:

LbrM.12.0120 , LBRM2903_120005900

Length:

428

Annotations

LeishMANIAdb annotations

Consists of a solenoid domain with LRR-like helical repeats. Certainly not TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6S5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.430
CLV_NRD_NRD_1	170	172	PF00675	0.386
CLV_NRD_NRD_1	279	281	PF00675	0.539
CLV_PCSK_KEX2_1	170	172	PF00082	0.507
CLV_PCSK_SKI1_1	246	250	PF00082	0.446
CLV_PCSK_SKI1_1	76	80	PF00082	0.344
DEG_APCC_DBOX_1	98	106	PF00400	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.348
DOC_MAPK_HePTP_8	322	334	PF00069	0.267
DOC_MAPK_MEF2A_6	325	334	PF00069	0.473
DOC_USP7_MATH_2	415	421	PF00917	0.544
DOC_WW_Pin1_4	371	376	PF00397	0.511
DOC_WW_Pin1_4	392	397	PF00397	0.546
LIG_14-3-3_CanoR_1	318	322	PF00244	0.327
LIG_14-3-3_CanoR_1	337	342	PF00244	0.218
LIG_Actin_WH2_2	294	309	PF00022	0.507
LIG_Actin_WH2_2	323	339	PF00022	0.269
LIG_Actin_WH2_2	4	19	PF00022	0.535
LIG_CtBP_PxDLS_1	267	272	PF00389	0.462
LIG_FHA_1	1	7	PF00498	0.586
LIG_FHA_1	51	57	PF00498	0.556
LIG_LIR_Gen_1	329	338	PF02991	0.471
LIG_LIR_Gen_1	363	373	PF02991	0.456
LIG_LIR_Gen_1	419	428	PF02991	0.459
LIG_LIR_Nem_3	155	159	PF02991	0.365
LIG_LIR_Nem_3	329	334	PF02991	0.491
LIG_LIR_Nem_3	363	368	PF02991	0.493
LIG_LIR_Nem_3	419	424	PF02991	0.448
LIG_NRBOX	346	352	PF00104	0.419
LIG_PCNA_yPIPBox_3	337	351	PF02747	0.388
LIG_SH2_CRK	365	369	PF00017	0.290
LIG_SH2_STAP1	116	120	PF00017	0.273
LIG_SH2_STAP1	243	247	PF00017	0.370
LIG_SH2_STAT5	384	387	PF00017	0.384
LIG_SH2_STAT5	39	42	PF00017	0.543
LIG_Sin3_3	237	244	PF02671	0.307
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.510
LIG_SUMO_SIM_anti_2	192	197	PF11976	0.500
LIG_TRAF2_1	326	329	PF00917	0.475
LIG_TRFH_1	304	308	PF08558	0.498
MOD_CK1_1	101	107	PF00069	0.284
MOD_CK1_1	320	326	PF00069	0.426
MOD_CK1_1	50	56	PF00069	0.531
MOD_CK1_1	81	87	PF00069	0.659
MOD_GlcNHglycan	117	120	PF01048	0.321
MOD_GlcNHglycan	182	185	PF01048	0.369
MOD_GlcNHglycan	253	256	PF01048	0.528
MOD_GlcNHglycan	388	391	PF01048	0.419
MOD_GSK3_1	317	324	PF00069	0.484
MOD_GSK3_1	6	13	PF00069	0.448
MOD_NEK2_1	1	6	PF00069	0.498
MOD_NEK2_1	120	125	PF00069	0.409
MOD_NEK2_1	174	179	PF00069	0.414
MOD_NEK2_1	290	295	PF00069	0.499
MOD_NEK2_1	336	341	PF00069	0.372
MOD_NEK2_1	350	355	PF00069	0.367
MOD_NEK2_1	368	373	PF00069	0.297
MOD_NEK2_1	47	52	PF00069	0.479
MOD_NEK2_1	78	83	PF00069	0.571
MOD_PK_1	189	195	PF00069	0.460
MOD_PKA_2	317	323	PF00069	0.480
MOD_PKA_2	336	342	PF00069	0.215
MOD_PKA_2	98	104	PF00069	0.505
MOD_Plk_1	147	153	PF00069	0.570
MOD_Plk_4	317	323	PF00069	0.500
MOD_Plk_4	417	423	PF00069	0.525
MOD_Plk_4	66	72	PF00069	0.391
MOD_ProDKin_1	371	377	PF00069	0.508
MOD_ProDKin_1	392	398	PF00069	0.542
MOD_SUMO_for_1	88	91	PF00179	0.431
TRG_DiLeu_BaEn_1	346	351	PF01217	0.423
TRG_DiLeu_BaEn_2	299	305	PF01217	0.487
TRG_ENDOCYTIC_2	365	368	PF00928	0.495
TRG_ER_diArg_1	169	171	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK8	Leptomonas seymouri	48%	88%
A0A1X0NM47	Trypanosomatidae	28%	94%
A0A3S5IQL9	Trypanosoma rangeli	29%	94%
A0A3S7WRW4	Leishmania donovani	82%	89%
A4HV53	Leishmania infantum	82%	89%
C9ZQD2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	91%
E9ANT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	80%
Q4QGT4	Leishmania major	80%	100%
V5BDA8	Trypanosoma cruzi	28%	94%