Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6S2_LEIBR

TriTrypDb:

LbrM.12.0090 , LBRM2903_120005700

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6S2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.460
CLV_C14_Caspase3-7	581	585	PF00656	0.471
CLV_NRD_NRD_1	106	108	PF00675	0.598
CLV_NRD_NRD_1	124	126	PF00675	0.610
CLV_NRD_NRD_1	183	185	PF00675	0.464
CLV_NRD_NRD_1	211	213	PF00675	0.405
CLV_NRD_NRD_1	253	255	PF00675	0.662
CLV_NRD_NRD_1	257	259	PF00675	0.754
CLV_NRD_NRD_1	281	283	PF00675	0.509
CLV_NRD_NRD_1	303	305	PF00675	0.524
CLV_NRD_NRD_1	341	343	PF00675	0.541
CLV_NRD_NRD_1	382	384	PF00675	0.553
CLV_NRD_NRD_1	445	447	PF00675	0.450
CLV_NRD_NRD_1	501	503	PF00675	0.494
CLV_NRD_NRD_1	508	510	PF00675	0.502
CLV_NRD_NRD_1	547	549	PF00675	0.472
CLV_NRD_NRD_1	551	553	PF00675	0.442
CLV_NRD_NRD_1	559	561	PF00675	0.429
CLV_NRD_NRD_1	569	571	PF00675	0.492
CLV_NRD_NRD_1	618	620	PF00675	0.497
CLV_PCSK_FUR_1	209	213	PF00082	0.446
CLV_PCSK_FUR_1	339	343	PF00082	0.641
CLV_PCSK_KEX2_1	124	126	PF00082	0.644
CLV_PCSK_KEX2_1	153	155	PF00082	0.443
CLV_PCSK_KEX2_1	183	185	PF00082	0.463
CLV_PCSK_KEX2_1	211	213	PF00082	0.360
CLV_PCSK_KEX2_1	253	255	PF00082	0.615
CLV_PCSK_KEX2_1	257	259	PF00082	0.668
CLV_PCSK_KEX2_1	280	282	PF00082	0.527
CLV_PCSK_KEX2_1	303	305	PF00082	0.650
CLV_PCSK_KEX2_1	341	343	PF00082	0.492
CLV_PCSK_KEX2_1	382	384	PF00082	0.583
CLV_PCSK_KEX2_1	409	411	PF00082	0.430
CLV_PCSK_KEX2_1	445	447	PF00082	0.441
CLV_PCSK_KEX2_1	501	503	PF00082	0.499
CLV_PCSK_KEX2_1	508	510	PF00082	0.510
CLV_PCSK_KEX2_1	514	516	PF00082	0.508
CLV_PCSK_KEX2_1	559	561	PF00082	0.525
CLV_PCSK_KEX2_1	569	571	PF00082	0.535
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.446
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.436
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.569
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.552
CLV_PCSK_PC7_1	207	213	PF00082	0.447
CLV_PCSK_PC7_1	253	259	PF00082	0.468
CLV_PCSK_SKI1_1	184	188	PF00082	0.444
CLV_PCSK_SKI1_1	20	24	PF00082	0.419
CLV_PCSK_SKI1_1	217	221	PF00082	0.446
CLV_PCSK_SKI1_1	77	81	PF00082	0.609
CLV_Separin_Metazoa	185	189	PF03568	0.358
DEG_APCC_DBOX_1	183	191	PF00400	0.445
DOC_ANK_TNKS_1	569	576	PF00023	0.405
DOC_CDC14_PxL_1	368	376	PF14671	0.458
DOC_CYCLIN_RxL_1	15	24	PF00134	0.371
DOC_CYCLIN_RxL_1	178	189	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.457
DOC_MAPK_DCC_7	474	483	PF00069	0.506
DOC_MAPK_gen_1	124	131	PF00069	0.572
DOC_MAPK_gen_1	445	453	PF00069	0.440
DOC_MAPK_gen_1	474	483	PF00069	0.579
DOC_USP7_MATH_1	346	350	PF00917	0.414
DOC_USP7_UBL2_3	549	553	PF12436	0.351
DOC_WW_Pin1_4	160	165	PF00397	0.547
DOC_WW_Pin1_4	486	491	PF00397	0.586
LIG_14-3-3_CanoR_1	20	26	PF00244	0.371
LIG_14-3-3_CanoR_1	360	368	PF00244	0.584
LIG_14-3-3_CanoR_1	474	479	PF00244	0.437
LIG_14-3-3_CanoR_1	526	530	PF00244	0.431
LIG_14-3-3_CanoR_1	559	563	PF00244	0.467
LIG_14-3-3_CanoR_1	587	597	PF00244	0.433
LIG_APCC_ABBAyCdc20_2	235	241	PF00400	0.415
LIG_FHA_1	116	122	PF00498	0.395
LIG_FHA_1	287	293	PF00498	0.525
LIG_FHA_1	600	606	PF00498	0.463
LIG_FHA_1	97	103	PF00498	0.726
LIG_FHA_2	250	256	PF00498	0.653
LIG_FHA_2	579	585	PF00498	0.616
LIG_LIR_Gen_1	375	384	PF02991	0.589
LIG_LIR_Gen_1	447	456	PF02991	0.351
LIG_LIR_Gen_1	49	58	PF02991	0.478
LIG_LIR_Nem_3	447	451	PF02991	0.349
LIG_LIR_Nem_3	49	53	PF02991	0.466
LIG_NRBOX	186	192	PF00104	0.357
LIG_NRBOX	21	27	PF00104	0.369
LIG_Pex14_2	37	41	PF04695	0.396
LIG_PTB_Apo_2	108	115	PF02174	0.448
LIG_PTB_Phospho_1	108	114	PF10480	0.454
LIG_Rb_pABgroove_1	371	379	PF01858	0.491
LIG_RPA_C_Fungi	336	348	PF08784	0.582
LIG_SH2_CRK	33	37	PF00017	0.383
LIG_SH2_CRK	597	601	PF00017	0.478
LIG_SH2_NCK_1	114	118	PF00017	0.608
LIG_SH2_NCK_1	222	226	PF00017	0.386
LIG_SH2_NCK_1	427	431	PF00017	0.505
LIG_SH2_SRC	114	117	PF00017	0.603
LIG_SH2_STAT5	33	36	PF00017	0.455
LIG_SH2_STAT5	55	58	PF00017	0.409
LIG_SH3_3	245	251	PF00018	0.433
LIG_SH3_3	79	85	PF00018	0.561
LIG_SUMO_SIM_anti_2	267	273	PF11976	0.460
LIG_SUMO_SIM_par_1	267	273	PF11976	0.460
LIG_SUMO_SIM_par_1	372	379	PF11976	0.521
LIG_TRAF2_1	349	352	PF00917	0.357
LIG_TRAF2_1	519	522	PF00917	0.547
LIG_TRAF2_1	539	542	PF00917	0.303
LIG_TRAF2_1	95	98	PF00917	0.651
LIG_TYR_ITIM	53	58	PF00017	0.404
LIG_WRC_WIRS_1	432	437	PF05994	0.444
MOD_CDK_SPK_2	486	491	PF00069	0.429
MOD_CK1_1	7	13	PF00069	0.520
MOD_CK1_1	72	78	PF00069	0.481
MOD_CK2_1	249	255	PF00069	0.694
MOD_CK2_1	346	352	PF00069	0.499
MOD_CK2_1	536	542	PF00069	0.518
MOD_CK2_1	586	592	PF00069	0.495
MOD_Cter_Amidation	617	620	PF01082	0.475
MOD_GlcNHglycan	348	351	PF01048	0.445
MOD_GlcNHglycan	538	541	PF01048	0.443
MOD_GlcNHglycan	588	591	PF01048	0.505
MOD_GlcNHglycan	608	611	PF01048	0.496
MOD_GlcNHglycan	64	68	PF01048	0.733
MOD_GlcNHglycan	70	74	PF01048	0.610
MOD_GSK3_1	135	142	PF00069	0.532
MOD_GSK3_1	372	379	PF00069	0.434
MOD_GSK3_1	68	75	PF00069	0.538
MOD_GSK3_1	7	14	PF00069	0.420
MOD_NEK2_1	21	26	PF00069	0.369
MOD_NEK2_1	41	46	PF00069	0.506
MOD_NEK2_1	69	74	PF00069	0.594
MOD_NEK2_2	372	377	PF00069	0.625
MOD_OFUCOSY	93	100	PF10250	0.652
MOD_PIKK_1	83	89	PF00454	0.636
MOD_PK_1	139	145	PF00069	0.482
MOD_PK_1	474	480	PF00069	0.503
MOD_PKA_2	359	365	PF00069	0.632
MOD_PKA_2	525	531	PF00069	0.526
MOD_PKA_2	558	564	PF00069	0.467
MOD_PKA_2	586	592	PF00069	0.454
MOD_PKB_1	419	427	PF00069	0.365
MOD_PKB_1	472	480	PF00069	0.591
MOD_Plk_1	48	54	PF00069	0.506
MOD_Plk_1	583	589	PF00069	0.622
MOD_Plk_1	69	75	PF00069	0.480
MOD_Plk_2-3	431	437	PF00069	0.348
MOD_Plk_4	139	145	PF00069	0.505
MOD_Plk_4	372	378	PF00069	0.500
MOD_Plk_4	4	10	PF00069	0.424
MOD_ProDKin_1	160	166	PF00069	0.550
MOD_ProDKin_1	486	492	PF00069	0.579
MOD_SUMO_for_1	200	203	PF00179	0.389
MOD_SUMO_for_1	428	431	PF00179	0.504
MOD_SUMO_rev_2	301	309	PF00179	0.550
MOD_SUMO_rev_2	489	498	PF00179	0.456
MOD_SUMO_rev_2	542	551	PF00179	0.561
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.468
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.542
TRG_ENDOCYTIC_2	33	36	PF00928	0.382
TRG_ENDOCYTIC_2	448	451	PF00928	0.350
TRG_ENDOCYTIC_2	55	58	PF00928	0.409
TRG_ER_diArg_1	123	125	PF00400	0.591
TRG_ER_diArg_1	209	212	PF00400	0.391
TRG_ER_diArg_1	280	282	PF00400	0.547
TRG_ER_diArg_1	339	342	PF00400	0.499
TRG_ER_diArg_1	501	503	PF00400	0.499
TRG_ER_diArg_1	507	509	PF00400	0.503
TRG_ER_diArg_1	558	560	PF00400	0.533
TRG_NLS_Bipartite_1	552	573	PF00514	0.582
TRG_NLS_MonoExtC_3	568	574	PF00514	0.396
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	560	565	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK43	Leptomonas seymouri	46%	100%
A0A1X0NM25	Trypanosomatidae	26%	100%
A0A3Q8I971	Leishmania donovani	72%	100%
A0A422N6D2	Trypanosoma rangeli	28%	100%
A4HV51	Leishmania infantum	72%	100%
E9ANT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QGT6	Leishmania major	70%	100%