SER_THR_PHOSPHATASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6S0_LEIBR

TriTrypDb:

LbrM.12.0070 , LBRM2903_120005500

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	2
GO:0005955	calcineurin complex	3	2
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2

Expansion

Sequence features

A4H6S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6S0

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	24
GO:0009987	cellular process	1	25
GO:0019722	calcium-mediated signaling	5	24
GO:0019932	second-messenger-mediated signaling	4	24
GO:0035556	intracellular signal transduction	3	24
GO:0050789	regulation of biological process	2	24
GO:0050794	regulation of cellular process	3	24
GO:0065007	biological regulation	1	24
GO:0097720	calcineurin-mediated signaling	6	24
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	30
GO:0004721	phosphoprotein phosphatase activity	3	30
GO:0004722	protein serine/threonine phosphatase activity	4	30
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	24
GO:0016787	hydrolase activity	2	30
GO:0016788	hydrolase activity, acting on ester bonds	3	30
GO:0016791	phosphatase activity	5	30
GO:0033192	calmodulin-dependent protein phosphatase activity	6	24
GO:0042578	phosphoric ester hydrolase activity	4	30
GO:0140096	catalytic activity, acting on a protein	2	30
GO:0017018	myosin phosphatase activity	5	19
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0005516	calmodulin binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	52	58	PF00089	0.214
CLV_NRD_NRD_1	400	402	PF00675	0.393
CLV_PCSK_FUR_1	387	391	PF00082	0.459
CLV_PCSK_KEX2_1	329	331	PF00082	0.491
CLV_PCSK_KEX2_1	389	391	PF00082	0.507
CLV_PCSK_KEX2_1	400	402	PF00082	0.398
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.461
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.404
CLV_PCSK_SKI1_1	165	169	PF00082	0.343
CLV_PCSK_SKI1_1	34	38	PF00082	0.371
DOC_CDC14_PxL_1	413	421	PF14671	0.624
DOC_CKS1_1	344	349	PF01111	0.558
DOC_CYCLIN_RxL_1	233	243	PF00134	0.251
DOC_MAPK_gen_1	23	32	PF00069	0.499
DOC_MAPK_gen_1	253	260	PF00069	0.452
DOC_MAPK_gen_1	387	396	PF00069	0.586
DOC_MAPK_gen_1	398	406	PF00069	0.459
DOC_MAPK_MEF2A_6	400	408	PF00069	0.291
DOC_MAPK_NFAT4_5	401	409	PF00069	0.291
DOC_PP1_RVXF_1	234	241	PF00149	0.273
DOC_PP1_RVXF_1	368	375	PF00149	0.275
DOC_PP4_FxxP_1	275	278	PF00568	0.448
DOC_PP4_FxxP_1	308	311	PF00568	0.298
DOC_SPAK_OSR1_1	118	122	PF12202	0.414
DOC_USP7_MATH_1	100	104	PF00917	0.464
DOC_USP7_MATH_1	225	229	PF00917	0.505
DOC_USP7_UBL2_3	47	51	PF12436	0.570
DOC_WW_Pin1_4	343	348	PF00397	0.516
LIG_14-3-3_CanoR_1	165	171	PF00244	0.362
LIG_14-3-3_CanoR_1	241	245	PF00244	0.334
LIG_14-3-3_CanoR_1	25	31	PF00244	0.289
LIG_14-3-3_CanoR_1	67	77	PF00244	0.173
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BIR_III_2	379	383	PF00653	0.372
LIG_BRCT_BRCA1_1	188	192	PF00533	0.450
LIG_BRCT_BRCA1_1	283	287	PF00533	0.506
LIG_EH1_1	107	115	PF00400	0.408
LIG_eIF4E_1	108	114	PF01652	0.313
LIG_eIF4E_1	339	345	PF01652	0.504
LIG_FHA_1	110	116	PF00498	0.288
LIG_FHA_1	367	373	PF00498	0.371
LIG_FHA_1	41	47	PF00498	0.395
LIG_FHA_1	48	54	PF00498	0.368
LIG_FHA_1	77	83	PF00498	0.413
LIG_FHA_2	192	198	PF00498	0.450
LIG_LIR_Apic_2	273	278	PF02991	0.447
LIG_LIR_Apic_2	306	311	PF02991	0.349
LIG_LIR_Apic_2	355	359	PF02991	0.418
LIG_LIR_Gen_1	228	238	PF02991	0.420
LIG_LIR_Gen_1	271	278	PF02991	0.625
LIG_LIR_Gen_1	71	81	PF02991	0.410
LIG_LIR_LC3C_4	12	17	PF02991	0.517
LIG_LIR_Nem_3	117	122	PF02991	0.329
LIG_LIR_Nem_3	137	142	PF02991	0.425
LIG_LIR_Nem_3	178	184	PF02991	0.316
LIG_LIR_Nem_3	189	195	PF02991	0.320
LIG_LIR_Nem_3	228	233	PF02991	0.305
LIG_LIR_Nem_3	271	275	PF02991	0.560
LIG_LIR_Nem_3	284	290	PF02991	0.385
LIG_LIR_Nem_3	312	316	PF02991	0.482
LIG_LIR_Nem_3	60	66	PF02991	0.457
LIG_LIR_Nem_3	71	76	PF02991	0.386
LIG_MLH1_MIPbox_1	283	287	PF16413	0.522
LIG_PCNA_yPIPBox_3	75	85	PF02747	0.465
LIG_Pex14_2	240	244	PF04695	0.356
LIG_PTB_Apo_2	176	183	PF02174	0.314
LIG_PTB_Apo_2	86	93	PF02174	0.421
LIG_SH2_CRK	409	413	PF00017	0.306
LIG_SH2_GRB2like	339	342	PF00017	0.271
LIG_SH2_SRC	108	111	PF00017	0.324
LIG_SH2_SRC	96	99	PF00017	0.337
LIG_SH2_STAP1	242	246	PF00017	0.343
LIG_SH2_STAT3	132	135	PF00017	0.295
LIG_SH2_STAT5	108	111	PF00017	0.305
LIG_SH2_STAT5	242	245	PF00017	0.333
LIG_SH2_STAT5	286	289	PF00017	0.437
LIG_SH2_STAT5	290	293	PF00017	0.400
LIG_SH2_STAT5	96	99	PF00017	0.305
LIG_SH3_3	130	136	PF00018	0.408
LIG_SH3_3	411	417	PF00018	0.599
LIG_SH3_3	59	65	PF00018	0.374
LIG_SUMO_SIM_par_1	111	117	PF11976	0.347
LIG_SUMO_SIM_par_1	199	204	PF11976	0.324
LIG_SUMO_SIM_par_1	303	309	PF11976	0.256
LIG_SUMO_SIM_par_1	364	369	PF11976	0.468
LIG_TRAF2_1	194	197	PF00917	0.295
LIG_WRC_WIRS_1	272	277	PF05994	0.562
MOD_CK1_1	138	144	PF00069	0.461
MOD_CK1_1	273	279	PF00069	0.514
MOD_CK1_1	306	312	PF00069	0.359
MOD_CK1_1	4	10	PF00069	0.533
MOD_CK1_1	57	63	PF00069	0.265
MOD_CK2_1	191	197	PF00069	0.500
MOD_CK2_1	352	358	PF00069	0.288
MOD_CK2_1	38	44	PF00069	0.298
MOD_GlcNHglycan	189	192	PF01048	0.255
MOD_GlcNHglycan	227	230	PF01048	0.421
MOD_GlcNHglycan	308	311	PF01048	0.315
MOD_GlcNHglycan	40	43	PF01048	0.313
MOD_GlcNHglycan	56	59	PF01048	0.233
MOD_GSK3_1	1	8	PF00069	0.621
MOD_GSK3_1	187	194	PF00069	0.321
MOD_GSK3_1	26	33	PF00069	0.462
MOD_N-GLC_1	9	14	PF02516	0.471
MOD_N-GLC_2	320	322	PF02516	0.336
MOD_N-GLC_2	84	86	PF02516	0.320
MOD_NEK2_1	109	114	PF00069	0.353
MOD_NEK2_1	240	245	PF00069	0.316
MOD_NEK2_1	30	35	PF00069	0.369
MOD_NEK2_1	5	10	PF00069	0.603
MOD_NEK2_2	281	286	PF00069	0.625
MOD_NEK2_2	303	308	PF00069	0.383
MOD_PIKK_1	201	207	PF00454	0.422
MOD_PIKK_1	296	302	PF00454	0.492
MOD_PIKK_1	346	352	PF00454	0.585
MOD_PKA_2	240	246	PF00069	0.361
MOD_PKA_2	54	60	PF00069	0.411
MOD_Plk_1	270	276	PF00069	0.488
MOD_Plk_1	334	340	PF00069	0.387
MOD_Plk_4	109	115	PF00069	0.309
MOD_Plk_4	281	287	PF00069	0.533
MOD_Plk_4	303	309	PF00069	0.296
MOD_Plk_4	334	340	PF00069	0.395
MOD_Plk_4	57	63	PF00069	0.353
MOD_ProDKin_1	343	349	PF00069	0.523
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.362
TRG_ENDOCYTIC_2	272	275	PF00928	0.607
TRG_ER_diArg_1	399	401	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y2	Leptomonas seymouri	24%	77%
A0A0N1ILH2	Leptomonas seymouri	24%	99%
A0A0N1PD03	Leptomonas seymouri	72%	95%
A0A0S4JDD1	Bodo saltans	26%	94%
A0A0S4JKZ6	Bodo saltans	25%	85%
A0A0S4KLF4	Bodo saltans	35%	100%
A0A1X0NMS7	Trypanosomatidae	41%	100%
A0A1X0NNN6	Trypanosomatidae	24%	100%
A0A1X0NS65	Trypanosomatidae	26%	100%
A0A1X0P6J3	Trypanosomatidae	25%	100%
A0A1X0P7H9	Trypanosomatidae	25%	95%
A0A1X0P7Q5	Trypanosomatidae	25%	100%
A0A3Q8ID20	Leishmania donovani	25%	88%
A0A3Q8IH18	Leishmania donovani	24%	100%
A0A3R7LPS5	Trypanosoma rangeli	41%	100%
A0A3R7MBA3	Trypanosoma rangeli	25%	94%
A0A3S5H6K2	Leishmania donovani	81%	100%
A0A3S7X1Y0	Leishmania donovani	27%	100%
A0A3S7X8K6	Leishmania donovani	23%	100%
A0A3S7XAY3	Leishmania donovani	22%	100%
A0A422N9D5	Trypanosoma rangeli	23%	100%
A0C1E4	Paramecium tetraurelia	24%	100%
A0CCD2	Paramecium tetraurelia	24%	100%
A0CNL9	Paramecium tetraurelia	23%	100%
A4HBE2	Leishmania braziliensis	24%	100%
A4HF98	Leishmania braziliensis	24%	77%
A4HKU9	Leishmania braziliensis	24%	100%
A4HP65	Leishmania braziliensis	23%	100%
A4HV49	Leishmania infantum	81%	100%
A4I2J0	Leishmania infantum	25%	88%
A4I400	Leishmania infantum	27%	100%
A4I8C8	Leishmania infantum	24%	100%
A4IAJ0	Leishmania infantum	23%	100%
A4IDH0	Leishmania infantum	22%	100%
C9ZQD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9ANT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AYN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9B090	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B387	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B5L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
O42773	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	24%	66%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	70%
P16298	Homo sapiens	21%	81%
P20651	Rattus norvegicus	21%	80%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	76%
P48452	Bos taurus	21%	81%
P48453	Mus musculus	21%	80%
P48455	Mus musculus	20%	82%
P48456	Drosophila melanogaster	20%	68%
P48457	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	77%
P48577	Acetabularia peniculus	23%	100%
P48726	Paramecium tetraurelia	23%	100%
P63328	Mus musculus	21%	81%
P63329	Rattus norvegicus	21%	81%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	76%
Q08209	Homo sapiens	21%	81%
Q0G819	Caenorhabditis elegans	21%	78%
Q12705	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	76%
Q27889	Drosophila melanogaster	21%	74%
Q4Q1M5	Leishmania major	23%	100%
Q4Q2C2	Leishmania major	23%	100%
Q4Q4W8	Leishmania major	24%	100%
Q4Q7Z5	Leishmania major	27%	100%
Q4Q8T8	Leishmania major	25%	100%
Q4QGT8	Leishmania major	82%	100%
Q4WUR1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	22%	79%
Q6BFF6	Paramecium tetraurelia	24%	100%
Q7YSW8	Dictyostelium discoideum	21%	68%
Q9VXF1	Drosophila melanogaster	21%	72%
Q9Y0B7	Dictyostelium discoideum	22%	100%
V5B3V2	Trypanosoma cruzi	26%	100%
V5B5K9	Trypanosoma cruzi	25%	100%
V5BBR3	Trypanosoma cruzi	23%	100%