Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome beta-1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H6R7_LEIBR

TriTrypDb:

LbrM.12.0040 , LBRM2903_120005200

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H6R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6R7

PDB structure(s): 6qm7_H , 6qm7_V , 6qm8_H , 6qm8_V

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004298	threonine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0070003	threonine-type peptidase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	109	115	PF00089	0.389
CLV_PCSK_SKI1_1	229	233	PF00082	0.561
CLV_PCSK_SKI1_1	33	37	PF00082	0.599
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DOC_CYCLIN_RxL_1	30	39	PF00134	0.644
DOC_USP7_MATH_1	199	203	PF00917	0.564
DOC_USP7_MATH_1	69	73	PF00917	0.503
DOC_USP7_UBL2_3	90	94	PF12436	0.514
LIG_14-3-3_CanoR_1	145	154	PF00244	0.618
LIG_14-3-3_CanoR_1	20	28	PF00244	0.505
LIG_14-3-3_CanoR_1	229	234	PF00244	0.563
LIG_14-3-3_CanoR_1	73	81	PF00244	0.503
LIG_FHA_1	104	110	PF00498	0.467
LIG_FHA_1	228	234	PF00498	0.538
LIG_FHA_1	53	59	PF00498	0.589
LIG_FHA_1	76	82	PF00498	0.523
LIG_FHA_1	90	96	PF00498	0.482
LIG_LIR_Apic_2	164	169	PF02991	0.514
LIG_Pex14_2	188	192	PF04695	0.514
LIG_SH2_CRK	157	161	PF00017	0.508
LIG_SH2_CRK	166	170	PF00017	0.495
LIG_SH2_GRB2like	142	145	PF00017	0.514
LIG_SH2_NCK_1	157	161	PF00017	0.525
LIG_SH2_NCK_1	166	170	PF00017	0.476
LIG_SH2_SRC	157	160	PF00017	0.585
LIG_SH2_STAT3	258	261	PF00017	0.602
LIG_SH2_STAT5	116	119	PF00017	0.372
LIG_SH2_STAT5	250	253	PF00017	0.448
LIG_SH2_STAT5	79	82	PF00017	0.495
LIG_SH2_STAT5	96	99	PF00017	0.503
LIG_SH3_3	10	16	PF00018	0.624
LIG_SH3_3	39	45	PF00018	0.589
LIG_SUMO_SIM_par_1	229	234	PF11976	0.501
LIG_SUMO_SIM_par_1	55	61	PF11976	0.572
LIG_WRC_WIRS_1	189	194	PF05994	0.514
MOD_CK1_1	119	125	PF00069	0.528
MOD_CK1_1	164	170	PF00069	0.504
MOD_CK1_1	267	273	PF00069	0.467
MOD_CK1_1	52	58	PF00069	0.503
MOD_CK1_1	72	78	PF00069	0.503
MOD_CK2_1	199	205	PF00069	0.503
MOD_GlcNHglycan	148	151	PF01048	0.314
MOD_GlcNHglycan	169	172	PF01048	0.307
MOD_GlcNHglycan	183	186	PF01048	0.262
MOD_GlcNHglycan	223	226	PF01048	0.303
MOD_GlcNHglycan	270	273	PF01048	0.510
MOD_GlcNHglycan	75	78	PF01048	0.378
MOD_GlcNHglycan	99	102	PF01048	0.295
MOD_GSK3_1	119	126	PF00069	0.576
MOD_GSK3_1	216	223	PF00069	0.509
MOD_GSK3_1	264	271	PF00069	0.614
MOD_GSK3_1	45	52	PF00069	0.559
MOD_GSK3_1	69	76	PF00069	0.503
MOD_GSK3_1	82	89	PF00069	0.503
MOD_GSK3_1	99	106	PF00069	0.503
MOD_N-GLC_1	146	151	PF02516	0.300
MOD_NEK2_1	181	186	PF00069	0.499
MOD_NEK2_1	188	193	PF00069	0.492
MOD_NEK2_1	227	232	PF00069	0.556
MOD_NEK2_1	264	269	PF00069	0.383
MOD_NEK2_1	53	58	PF00069	0.499
MOD_NEK2_2	183	188	PF00069	0.503
MOD_PIKK_1	103	109	PF00454	0.511
MOD_PKA_2	111	117	PF00069	0.589
MOD_PKA_2	72	78	PF00069	0.503
MOD_PKA_2	82	88	PF00069	0.503
MOD_Plk_1	5	11	PF00069	0.773
MOD_Plk_4	161	167	PF00069	0.507
MOD_Plk_4	183	189	PF00069	0.500
MOD_Plk_4	5	11	PF00069	0.661
MOD_Plk_4	53	59	PF00069	0.503
MOD_Plk_4	75	81	PF00069	0.514
TRG_ENDOCYTIC_2	157	160	PF00928	0.514
TRG_ENDOCYTIC_2	190	193	PF00928	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILF0	Leptomonas seymouri	25%	100%
A0A0N1PB37	Leptomonas seymouri	87%	100%
A0A0S4J7A1	Bodo saltans	27%	100%
A0A0S4KNR5	Bodo saltans	70%	92%
A0A1X0NNS8	Trypanosomatidae	77%	100%
A0A3Q8IVH0	Leishmania donovani	32%	100%
A0A3R7M7V4	Trypanosoma rangeli	77%	100%
A0A3S5H6K1	Leishmania donovani	89%	100%
A0A3S7WPD8	Leishmania donovani	29%	100%
A0LU50	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	28%	98%
A0PQT3	Mycobacterium ulcerans (strain Agy99)	27%	98%
A0QFB5	Mycobacterium avium (strain 104)	29%	93%
A0QZ47	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	93%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	31%	100%
A1RX71	Thermofilum pendens (strain DSM 2475 / Hrk 5)	31%	100%
A1SK13	Nocardioides sp. (strain ATCC BAA-499 / JS614)	25%	100%
A1TAP4	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	27%	92%
A1UHS7	Mycobacterium sp. (strain KMS)	26%	93%
A1XQU1	Sus scrofa	33%	100%
A2BN24	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	26%	100%
A3CUS9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	28%	100%
A3Q193	Mycobacterium sp. (strain JLS)	26%	93%
A4FBY1	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	29%	100%
A4HN55	Leishmania braziliensis	31%	100%
A4HSQ5	Leishmania infantum	28%	100%
A4HV47	Leishmania infantum	89%	100%
A4IBS2	Leishmania infantum	32%	100%
A4TB64	Mycolicibacterium gilvum (strain PYR-GCK)	28%	93%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	28%	100%
A4X744	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)	26%	100%
A4YIE0	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
A5UM14	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	26%	100%
A7I841	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	29%	100%
A7KE01	Salmo salar	39%	100%
A7KII6	Salmo salar	39%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	28%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	27%	100%
A8LH54	Frankia sp. (strain EAN1pec)	25%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	28%	100%
A9A4A1	Nitrosopumilus maritimus (strain SCM1)	28%	100%
A9WSI1	Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)	25%	100%
B1L6X8	Korarchaeum cryptofilum (strain OPF8)	25%	100%
B1MAI2	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	29%	97%
B1W306	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	27%	100%
B1YDJ0	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	31%	100%
B2HFV6	Mycobacterium marinum (strain ATCC BAA-535 / M)	27%	98%
B8D673	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	26%	100%
B8D683	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	29%	100%
B8GG66	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	29%	100%
C1ASP7	Rhodococcus opacus (strain B4)	27%	96%
C3MRE5	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	26%	100%
C3MY41	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	26%	100%
C3MZI0	Sulfolobus islandicus (strain M.16.27)	26%	100%
C3N7K2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	26%	100%
C3NFX2	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	26%	100%
C4KIR0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	26%	100%
C6WID8	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)	28%	100%
C7LYP7	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	25%	100%
C7PVV2	Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)	26%	98%
C7R403	Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / BCRC 15368 / CIP 55.134 / JCM 11481 / NBRC 15587 / NCTC 10816 / Prevot 55134)	24%	94%
C9ZQD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A312	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	91%
D0KRX1	Saccharolobus solfataricus (strain 98/2)	27%	100%
D0LDT1	Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)	27%	97%
D2ATV1	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)	29%	100%
D2PDG6	Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)	26%	100%
D2Q4H4	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)	31%	100%
D3RX66	Ferroglobus placidus (strain DSM 10642 / AEDII12DO)	29%	100%
E9AFK8	Leishmania major	31%	100%
E9AKP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ANS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O09061	Mus musculus	26%	100%
O27270	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O35521	Mus terricolor	42%	100%
O35522	Mus musculus bactrianus	42%	100%
O35523	Mus platythrix	41%	100%
O35524	Mus spicilegus	42%	100%
O35955	Mus musculus	26%	100%
O43063	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O64464	Oryza sativa subsp. japonica	23%	100%
O82531	Petunia hybrida	26%	100%
P18421	Rattus norvegicus	26%	100%
P25043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P28062	Homo sapiens	29%	100%
P28065	Homo sapiens	45%	100%
P28072	Homo sapiens	50%	100%
P28073	Rattus norvegicus	50%	100%
P28075	Rattus norvegicus	27%	100%
P28076	Mus musculus	42%	100%
P28077	Rattus norvegicus	42%	100%
P34286	Caenorhabditis elegans	23%	100%
P38624	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P40304	Drosophila melanogaster	29%	100%
P42742	Arabidopsis thaliana	26%	100%
P70195	Mus musculus	34%	100%
Q09841	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q0RLT7	Frankia alni (strain ACN14a)	26%	100%
Q0SIF9	Rhodococcus jostii (strain RHA1)	27%	96%
Q1B797	Mycobacterium sp. (strain MCS)	26%	93%
Q2J9Q3	Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)	27%	100%
Q2TBP0	Bos taurus	34%	100%
Q32KL2	Bos taurus	27%	100%
Q3MHN0	Bos taurus	50%	100%
Q3SZC2	Bos taurus	43%	100%
Q3T112	Bos taurus	29%	100%
Q4JAA8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	30%	100%
Q4QGU1	Leishmania major	89%	100%
Q4QJ65	Leishmania major	29%	100%
Q53079	Rhodococcus erythropolis	27%	96%
Q54BC8	Dictyostelium discoideum	29%	100%
Q54QR2	Dictyostelium discoideum	36%	100%
Q55GJ6	Dictyostelium discoideum	51%	100%
Q5W416	Canis lupus familiaris	29%	100%
Q5YUX2	Nocardia farcinica (strain IFM 10152)	27%	98%
Q60692	Mus musculus	50%	100%
Q73YW8	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	29%	93%
Q82JE3	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	24%	100%
Q86A21	Dictyostelium discoideum	28%	100%
Q8LD27	Arabidopsis thaliana	46%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	24%	100%
Q8U125	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q8UW64	Oryzias latipes	42%	100%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	28%	100%
Q975D1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	100%
Q980L4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	27%	100%
Q99436	Homo sapiens	33%	100%
Q9DD33	Salmo salar	45%	100%
Q9JHW0	Rattus norvegicus	34%	100%
Q9LIP2	Arabidopsis thaliana	31%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
Q9PT26	Oncorhynchus mykiss	45%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%
Q9V247	Pyrococcus abyssi (strain GE5 / Orsay)	27%	100%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	100%
Q9YES4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	100%
V5BHX1	Trypanosoma cruzi	76%	100%