Putative translation initiation factor EIF-2b alpha subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor EIF-2b alpha subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H6R5_LEIBR

TriTrypDb:

LbrM.12.0020 , LBRM2903_120005000

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H6R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6R5

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.273
CLV_NRD_NRD_1	142	144	PF00675	0.511
CLV_PCSK_KEX2_1	156	158	PF00082	0.280
CLV_PCSK_KEX2_1	44	46	PF00082	0.514
CLV_PCSK_KEX2_1	79	81	PF00082	0.528
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.280
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.514
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.528
CLV_PCSK_SKI1_1	156	160	PF00082	0.440
CLV_PCSK_SKI1_1	41	45	PF00082	0.426
CLV_PCSK_SKI1_1	62	66	PF00082	0.542
CLV_PCSK_SKI1_1	72	76	PF00082	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.453
DEG_SCF_FBW7_1	158	165	PF00400	0.287
DEG_SCF_TRCP1_1	180	185	PF00400	0.529
DOC_CKS1_1	159	164	PF01111	0.513
DOC_MAPK_gen_1	104	111	PF00069	0.239
DOC_PP4_FxxP_1	262	265	PF00568	0.434
DOC_SPAK_OSR1_1	133	137	PF12202	0.461
DOC_SPAK_OSR1_1	55	59	PF12202	0.364
DOC_USP7_MATH_1	147	151	PF00917	0.484
DOC_USP7_UBL2_3	75	79	PF12436	0.562
DOC_WW_Pin1_4	158	163	PF00397	0.444
LIG_14-3-3_CanoR_1	104	111	PF00244	0.392
LIG_14-3-3_CanoR_1	27	33	PF00244	0.459
LIG_14-3-3_CanoR_1	289	294	PF00244	0.495
LIG_14-3-3_CanoR_1	55	61	PF00244	0.487
LIG_AP2alpha_1	49	53	PF02296	0.481
LIG_BRCT_BRCA1_1	25	29	PF00533	0.414
LIG_EH1_1	7	15	PF00400	0.376
LIG_FHA_1	208	214	PF00498	0.445
LIG_FHA_1	241	247	PF00498	0.434
LIG_FHA_1	59	65	PF00498	0.521
LIG_FHA_2	29	35	PF00498	0.381
LIG_LIR_Apic_2	261	265	PF02991	0.434
LIG_LIR_Gen_1	191	200	PF02991	0.444
LIG_LIR_Gen_1	232	241	PF02991	0.445
LIG_LIR_Gen_1	26	35	PF02991	0.403
LIG_LIR_Gen_1	51	60	PF02991	0.364
LIG_LIR_Nem_3	232	238	PF02991	0.445
LIG_LIR_Nem_3	26	32	PF02991	0.394
LIG_LIR_Nem_3	51	56	PF02991	0.359
LIG_NRP_CendR_1	299	301	PF00754	0.727
LIG_Pex14_2	235	239	PF04695	0.434
LIG_Pex14_2	49	53	PF04695	0.481
LIG_PTAP_UEV_1	293	298	PF05743	0.662
LIG_PTB_Apo_2	186	193	PF02174	0.512
LIG_SH2_CRK	174	178	PF00017	0.370
LIG_SH2_STAP1	8	12	PF00017	0.375
LIG_SH2_STAT5	135	138	PF00017	0.331
LIG_SH2_STAT5	174	177	PF00017	0.370
LIG_SH2_STAT5	227	230	PF00017	0.434
LIG_SH3_2	294	299	PF14604	0.680
LIG_SH3_3	291	297	PF00018	0.649
LIG_SH3_5	4	8	PF00018	0.410
LIG_SUMO_SIM_anti_2	266	274	PF11976	0.442
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.393
LIG_SUMO_SIM_par_1	116	121	PF11976	0.442
LIG_TRAF2_1	125	128	PF00917	0.362
LIG_UBA3_1	99	105	PF00899	0.384
LIG_WRC_WIRS_1	29	34	PF05994	0.516
MOD_CK1_1	181	187	PF00069	0.529
MOD_CK1_1	209	215	PF00069	0.445
MOD_CK1_1	266	272	PF00069	0.459
MOD_CK2_1	122	128	PF00069	0.493
MOD_CK2_1	28	34	PF00069	0.405
MOD_GlcNHglycan	106	109	PF01048	0.462
MOD_GlcNHglycan	113	116	PF01048	0.433
MOD_GlcNHglycan	149	152	PF01048	0.431
MOD_GlcNHglycan	180	183	PF01048	0.299
MOD_GlcNHglycan	280	283	PF01048	0.344
MOD_GlcNHglycan	294	297	PF01048	0.673
MOD_GSK3_1	118	125	PF00069	0.477
MOD_GSK3_1	158	165	PF00069	0.287
MOD_GSK3_1	178	185	PF00069	0.529
MOD_GSK3_1	209	216	PF00069	0.451
MOD_GSK3_1	266	273	PF00069	0.434
MOD_GSK3_1	30	37	PF00069	0.447
MOD_N-GLC_1	147	152	PF02516	0.402
MOD_NEK2_1	118	123	PF00069	0.431
MOD_NEK2_1	206	211	PF00069	0.445
MOD_NEK2_1	213	218	PF00069	0.431
MOD_NEK2_1	229	234	PF00069	0.424
MOD_NEK2_1	56	61	PF00069	0.363
MOD_NEK2_1	70	75	PF00069	0.389
MOD_PIKK_1	88	94	PF00454	0.394
MOD_PKA_1	104	110	PF00069	0.244
MOD_PKA_2	103	109	PF00069	0.400
MOD_Plk_1	8	14	PF00069	0.371
MOD_Plk_2-3	2	8	PF00069	0.510
MOD_Plk_4	173	179	PF00069	0.265
MOD_Plk_4	182	188	PF00069	0.449
MOD_Plk_4	263	269	PF00069	0.441
MOD_Plk_4	8	14	PF00069	0.485
MOD_ProDKin_1	158	164	PF00069	0.438
MOD_SUMO_rev_2	244	249	PF00179	0.445
TRG_DiLeu_BaEn_1	202	207	PF01217	0.434
TRG_ENDOCYTIC_2	174	177	PF00928	0.370
TRG_ENDOCYTIC_2	46	49	PF00928	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D7	Leptomonas seymouri	87%	100%
A0A0S4KHS3	Bodo saltans	56%	98%
A0A1X0NMS5	Trypanosomatidae	68%	100%
A0A3Q8IBD6	Leishmania donovani	92%	100%
A0A3R7NDG3	Trypanosoma rangeli	65%	99%
A4HV45	Leishmania infantum	92%	100%
C9ZQE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	81%
E9ANS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P14741	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	99%
P34604	Caenorhabditis elegans	27%	99%
Q0IIF2	Bos taurus	30%	99%
Q14232	Homo sapiens	29%	99%
Q4QGU3	Leishmania major	91%	100%
Q4R4V8	Macaca fascicularis	29%	99%
Q54I81	Dictyostelium discoideum	30%	94%
Q57586	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	98%
Q5RAR0	Pongo abelii	29%	99%
Q64270	Rattus norvegicus	29%	99%
Q99LC8	Mus musculus	29%	99%
Q9USP0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	88%
V5BMF9	Trypanosoma cruzi	67%	81%