LeishMANIAdb
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SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SH3 domain-containing protein
Gene product:
Variant SH3 domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4H6R1_LEIBR
TriTrypDb:
LbrM.11.1150 , LBRM2903_110019900 *
Length:
386

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6R1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6R1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 355 359 PF00656 0.463
CLV_NRD_NRD_1 190 192 PF00675 0.621
CLV_NRD_NRD_1 341 343 PF00675 0.495
CLV_NRD_NRD_1 352 354 PF00675 0.416
CLV_PCSK_KEX2_1 123 125 PF00082 0.472
CLV_PCSK_KEX2_1 341 343 PF00082 0.474
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.382
CLV_PCSK_SKI1_1 123 127 PF00082 0.521
CLV_PCSK_SKI1_1 134 138 PF00082 0.362
CLV_PCSK_SKI1_1 170 174 PF00082 0.490
CLV_PCSK_SKI1_1 235 239 PF00082 0.484
CLV_PCSK_SKI1_1 299 303 PF00082 0.585
CLV_PCSK_SKI1_1 334 338 PF00082 0.435
CLV_PCSK_SKI1_1 354 358 PF00082 0.303
CLV_PCSK_SKI1_1 51 55 PF00082 0.360
CLV_PCSK_SKI1_1 76 80 PF00082 0.517
CLV_Separin_Metazoa 239 243 PF03568 0.373
DEG_APCC_DBOX_1 230 238 PF00400 0.560
DOC_CYCLIN_RxL_1 119 129 PF00134 0.587
DOC_PP1_RVXF_1 270 276 PF00149 0.549
DOC_PP4_FxxP_1 64 67 PF00568 0.531
DOC_USP7_MATH_1 229 233 PF00917 0.473
DOC_USP7_MATH_1 265 269 PF00917 0.605
DOC_USP7_MATH_1 356 360 PF00917 0.297
DOC_USP7_MATH_1 36 40 PF00917 0.410
DOC_USP7_UBL2_3 119 123 PF12436 0.378
DOC_WW_Pin1_4 108 113 PF00397 0.617
LIG_14-3-3_CanoR_1 170 175 PF00244 0.383
LIG_14-3-3_CanoR_1 228 237 PF00244 0.365
LIG_14-3-3_CanoR_1 264 270 PF00244 0.479
LIG_BRCT_BRCA1_1 174 178 PF00533 0.322
LIG_EVH1_2 112 116 PF00568 0.403
LIG_FHA_1 264 270 PF00498 0.312
LIG_FHA_1 309 315 PF00498 0.314
LIG_FHA_1 55 61 PF00498 0.410
LIG_FHA_2 145 151 PF00498 0.485
LIG_FHA_2 171 177 PF00498 0.405
LIG_FHA_2 231 237 PF00498 0.500
LIG_LIR_Apic_2 14 18 PF02991 0.383
LIG_LIR_Apic_2 56 61 PF02991 0.373
LIG_LIR_Gen_1 175 185 PF02991 0.329
LIG_LIR_Gen_1 204 215 PF02991 0.542
LIG_LIR_Nem_3 115 121 PF02991 0.405
LIG_LIR_Nem_3 175 181 PF02991 0.334
LIG_LIR_Nem_3 20 25 PF02991 0.432
LIG_LIR_Nem_3 204 210 PF02991 0.593
LIG_LIR_Nem_3 335 340 PF02991 0.539
LIG_NRBOX 318 324 PF00104 0.303
LIG_Pex14_1 206 210 PF04695 0.565
LIG_SH2_CRK 118 122 PF00017 0.385
LIG_SH2_CRK 15 19 PF00017 0.355
LIG_SH2_CRK 58 62 PF00017 0.510
LIG_SH2_NCK_1 15 19 PF00017 0.410
LIG_SH2_NCK_1 58 62 PF00017 0.510
LIG_SH2_PTP2 62 65 PF00017 0.561
LIG_SH2_SRC 10 13 PF00017 0.351
LIG_SH2_SRC 15 18 PF00017 0.317
LIG_SH2_STAP1 226 230 PF00017 0.377
LIG_SH2_STAT5 330 333 PF00017 0.309
LIG_SH2_STAT5 58 61 PF00017 0.467
LIG_SH2_STAT5 62 65 PF00017 0.534
LIG_SH3_3 107 113 PF00018 0.635
LIG_SH3_3 60 66 PF00018 0.449
LIG_SUMO_SIM_par_1 211 216 PF11976 0.610
LIG_SUMO_SIM_par_1 381 386 PF11976 0.450
LIG_TRAF2_1 161 164 PF00917 0.361
LIG_TRAF2_1 256 259 PF00917 0.461
MOD_CK1_1 216 222 PF00069 0.664
MOD_CK1_1 56 62 PF00069 0.435
MOD_CK2_1 144 150 PF00069 0.524
MOD_CK2_1 170 176 PF00069 0.606
MOD_CK2_1 265 271 PF00069 0.561
MOD_GlcNHglycan 192 195 PF01048 0.469
MOD_GlcNHglycan 203 206 PF01048 0.490
MOD_GlcNHglycan 215 218 PF01048 0.568
MOD_GlcNHglycan 345 350 PF01048 0.367
MOD_GlcNHglycan 37 41 PF01048 0.193
MOD_GlcNHglycan 89 92 PF01048 0.546
MOD_GSK3_1 108 115 PF00069 0.495
MOD_GSK3_1 186 193 PF00069 0.429
MOD_GSK3_1 211 218 PF00069 0.656
MOD_NEK2_1 142 147 PF00069 0.457
MOD_NEK2_1 181 186 PF00069 0.536
MOD_NEK2_1 251 256 PF00069 0.458
MOD_NEK2_1 314 319 PF00069 0.380
MOD_NEK2_2 186 191 PF00069 0.414
MOD_NEK2_2 230 235 PF00069 0.457
MOD_NEK2_2 265 270 PF00069 0.488
MOD_OFUCOSY 250 255 PF10250 0.299
MOD_PIKK_1 137 143 PF00454 0.479
MOD_PIKK_1 159 165 PF00454 0.356
MOD_PIKK_1 314 320 PF00454 0.354
MOD_PK_1 276 282 PF00069 0.308
MOD_PKA_2 190 196 PF00069 0.460
MOD_PKA_2 230 236 PF00069 0.552
MOD_PKA_2 263 269 PF00069 0.390
MOD_Plk_1 181 187 PF00069 0.548
MOD_Plk_1 308 314 PF00069 0.430
MOD_Plk_1 345 351 PF00069 0.308
MOD_ProDKin_1 108 114 PF00069 0.618
MOD_SUMO_rev_2 232 240 PF00179 0.511
TRG_DiLeu_BaEn_1 315 320 PF01217 0.305
TRG_DiLeu_BaEn_4 246 252 PF01217 0.466
TRG_DiLeu_BaLyEn_6 121 126 PF01217 0.594
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.487
TRG_DiLeu_BaLyEn_6 92 97 PF01217 0.539
TRG_ENDOCYTIC_2 118 121 PF00928 0.408
TRG_ENDOCYTIC_2 207 210 PF00928 0.605
TRG_ER_diArg_1 132 135 PF00400 0.540
TRG_ER_diArg_1 340 342 PF00400 0.299
TRG_Pf-PMV_PEXEL_1 124 129 PF00026 0.484
TRG_Pf-PMV_PEXEL_1 338 343 PF00026 0.362
TRG_Pf-PMV_PEXEL_1 362 366 PF00026 0.390

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ47 Leptomonas seymouri 44% 100%
A0A1X0NUT5 Trypanosomatidae 26% 100%
A0A3Q8I836 Leishmania donovani 65% 100%
A0A3R7RDU1 Trypanosoma rangeli 29% 98%
A4HV44 Leishmania infantum 64% 100%
D0A7A4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9ANS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
Q4QGU4 Leishmania major 67% 100%
V5DT68 Trypanosoma cruzi 26% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS