Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H6Q9_LEIBR

TriTrypDb:

LbrM.11.1130 , LBRM2903_110019600

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H6Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Q9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	36	38	PF00675	0.261
CLV_PCSK_KEX2_1	36	38	PF00082	0.249
CLV_PCSK_KEX2_1	44	46	PF00082	0.251
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.268
CLV_PCSK_SKI1_1	231	235	PF00082	0.270
CLV_PCSK_SKI1_1	238	242	PF00082	0.270
CLV_PCSK_SKI1_1	56	60	PF00082	0.211
DEG_APCC_DBOX_1	230	238	PF00400	0.453
DOC_CKS1_1	105	110	PF01111	0.240
DOC_CKS1_1	128	133	PF01111	0.463
DOC_CKS1_1	250	255	PF01111	0.549
DOC_MAPK_DCC_7	126	136	PF00069	0.471
DOC_MAPK_gen_1	126	136	PF00069	0.575
DOC_MAPK_gen_1	44	52	PF00069	0.462
DOC_MAPK_MEF2A_6	129	138	PF00069	0.465
DOC_MAPK_MEF2A_6	222	229	PF00069	0.240
DOC_PP1_RVXF_1	163	170	PF00149	0.457
DOC_PP1_RVXF_1	46	53	PF00149	0.456
DOC_PP1_RVXF_1	72	78	PF00149	0.251
DOC_PP4_FxxP_1	160	163	PF00568	0.480
DOC_WW_Pin1_4	104	109	PF00397	0.240
DOC_WW_Pin1_4	127	132	PF00397	0.462
DOC_WW_Pin1_4	249	254	PF00397	0.545
LIG_14-3-3_CanoR_1	231	237	PF00244	0.471
LIG_Actin_WH2_2	121	137	PF00022	0.460
LIG_CSL_BTD_1	254	257	PF09270	0.552
LIG_eIF4E_1	236	242	PF01652	0.456
LIG_FHA_1	118	124	PF00498	0.483
LIG_FHA_1	70	76	PF00498	0.312
LIG_LIR_Apic_2	159	163	PF02991	0.488
LIG_LIR_Apic_2	252	258	PF02991	0.552
LIG_LIR_Gen_1	175	186	PF02991	0.410
LIG_LIR_Gen_1	194	201	PF02991	0.234
LIG_LIR_Gen_1	235	244	PF02991	0.476
LIG_LIR_Nem_3	142	147	PF02991	0.454
LIG_LIR_Nem_3	154	160	PF02991	0.436
LIG_LIR_Nem_3	175	181	PF02991	0.494
LIG_LIR_Nem_3	194	198	PF02991	0.217
LIG_LIR_Nem_3	200	205	PF02991	0.268
LIG_LIR_Nem_3	213	217	PF02991	0.153
LIG_LIR_Nem_3	235	239	PF02991	0.473
LIG_LIR_Nem_3	243	248	PF02991	0.485
LIG_PCNA_yPIPBox_3	218	231	PF02747	0.211
LIG_Pex14_1	166	170	PF04695	0.473
LIG_PTB_Apo_2	65	72	PF02174	0.240
LIG_REV1ctd_RIR_1	242	251	PF16727	0.502
LIG_SH2_CRK	193	197	PF00017	0.204
LIG_SH2_CRK	9	13	PF00017	0.210
LIG_SH2_CRK	95	99	PF00017	0.303
LIG_SH2_PTP2	224	227	PF00017	0.211
LIG_SH2_STAP1	170	174	PF00017	0.578
LIG_SH2_STAP1	193	197	PF00017	0.240
LIG_SH2_STAP1	69	73	PF00017	0.237
LIG_SH2_STAT5	224	227	PF00017	0.225
LIG_SH2_STAT5	236	239	PF00017	0.434
LIG_SH2_STAT5	248	251	PF00017	0.510
LIG_SH2_STAT5	69	72	PF00017	0.262
LIG_SH3_3	198	204	PF00018	0.284
LIG_SH3_3	250	256	PF00018	0.576
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.240
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.240
LIG_SUMO_SIM_par_1	187	194	PF11976	0.394
LIG_TYR_ITIM	191	196	PF00017	0.240
LIG_TYR_ITIM	234	239	PF00017	0.292
LIG_WRC_WIRS_1	192	197	PF05994	0.240
LIG_WRC_WIRS_1	211	216	PF05994	0.240
LIG_WW_3	45	49	PF00397	0.315
MOD_CDC14_SPxK_1	132	135	PF00782	0.316
MOD_CDK_SPxK_1	129	135	PF00069	0.332
MOD_CMANNOS	166	169	PF00535	0.281
MOD_GlcNHglycan	186	189	PF01048	0.196
MOD_GlcNHglycan	9	12	PF01048	0.392
MOD_GSK3_1	168	175	PF00069	0.378
MOD_GSK3_1	69	76	PF00069	0.315
MOD_N-GLC_1	117	122	PF02516	0.311
MOD_N-GLC_1	67	72	PF02516	0.240
MOD_NEK2_1	134	139	PF00069	0.299
MOD_NEK2_1	182	187	PF00069	0.357
MOD_NEK2_1	197	202	PF00069	0.271
MOD_NEK2_1	229	234	PF00069	0.344
MOD_NEK2_1	28	33	PF00069	0.318
MOD_NEK2_1	62	67	PF00069	0.362
MOD_NEK2_1	7	12	PF00069	0.442
MOD_NEK2_2	80	85	PF00069	0.349
MOD_PIKK_1	168	174	PF00454	0.262
MOD_PIKK_1	246	252	PF00454	0.404
MOD_Plk_1	67	73	PF00069	0.240
MOD_Plk_4	139	145	PF00069	0.292
MOD_Plk_4	191	197	PF00069	0.265
MOD_Plk_4	232	238	PF00069	0.306
MOD_Plk_4	29	35	PF00069	0.353
MOD_ProDKin_1	104	110	PF00069	0.240
MOD_ProDKin_1	127	133	PF00069	0.316
MOD_ProDKin_1	249	255	PF00069	0.434
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.320
TRG_ENDOCYTIC_2	157	160	PF00928	0.496
TRG_ENDOCYTIC_2	193	196	PF00928	0.240
TRG_ENDOCYTIC_2	224	227	PF00928	0.225
TRG_ENDOCYTIC_2	236	239	PF00928	0.274
TRG_ENDOCYTIC_2	9	12	PF00928	0.370
TRG_ENDOCYTIC_2	95	98	PF00928	0.303
TRG_ER_diArg_1	35	37	PF00400	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III3	Leptomonas seymouri	70%	100%
A0A0S4JVZ4	Bodo saltans	26%	82%