Ribosomal protein L4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L4/L1 family, putative

Species:

Leishmania braziliensis

UniProt:

A4H6Q8_LEIBR

TriTrypDb:

LbrM.11.1120 , LBRM2903_110019500

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A4H6Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Q8

PDB structure(s): 7aih_B , 7am2_B , 7ane_B

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.328
CLV_NRD_NRD_1	146	148	PF00675	0.328
CLV_NRD_NRD_1	407	409	PF00675	0.571
CLV_PCSK_SKI1_1	128	132	PF00082	0.328
CLV_PCSK_SKI1_1	159	163	PF00082	0.475
CLV_PCSK_SKI1_1	244	248	PF00082	0.328
CLV_PCSK_SKI1_1	339	343	PF00082	0.588
CLV_PCSK_SKI1_1	403	407	PF00082	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.369
DEG_SCF_FBW7_2	236	241	PF00400	0.328
DOC_CYCLIN_yClb5_NLxxxL_5	103	109	PF00134	0.444
DOC_MAPK_gen_1	178	186	PF00069	0.344
DOC_MAPK_gen_1	284	292	PF00069	0.337
DOC_MAPK_gen_1	406	415	PF00069	0.448
DOC_MAPK_MEF2A_6	178	186	PF00069	0.330
DOC_PP2B_LxvP_1	199	202	PF13499	0.449
DOC_PP2B_LxvP_1	33	36	PF13499	0.348
DOC_USP7_MATH_1	20	24	PF00917	0.545
DOC_USP7_UBL2_3	174	178	PF12436	0.363
DOC_USP7_UBL2_3	277	281	PF12436	0.363
DOC_WW_Pin1_4	234	239	PF00397	0.328
DOC_WW_Pin1_4	27	32	PF00397	0.439
LIG_14-3-3_CanoR_1	181	187	PF00244	0.328
LIG_14-3-3_CanoR_1	198	202	PF00244	0.328
LIG_14-3-3_CanoR_1	408	413	PF00244	0.556
LIG_AP2alpha_2	88	90	PF02296	0.363
LIG_APCC_ABBA_1	92	97	PF00400	0.303
LIG_Clathr_ClatBox_1	313	317	PF01394	0.385
LIG_deltaCOP1_diTrp_1	125	134	PF00928	0.328
LIG_FHA_1	168	174	PF00498	0.332
LIG_FHA_1	303	309	PF00498	0.455
LIG_FHA_1	320	326	PF00498	0.266
LIG_FHA_1	408	414	PF00498	0.323
LIG_FHA_1	42	48	PF00498	0.543
LIG_FHA_1	54	60	PF00498	0.411
LIG_FHA_1	82	88	PF00498	0.364
LIG_FHA_2	198	204	PF00498	0.328
LIG_G3BP_FGDF_1	246	251	PF02136	0.328
LIG_IBAR_NPY_1	379	381	PF08397	0.434
LIG_Integrin_isoDGR_2	253	255	PF01839	0.328
LIG_LIR_Gen_1	207	216	PF02991	0.344
LIG_LIR_Nem_3	106	110	PF02991	0.390
LIG_LIR_Nem_3	207	212	PF02991	0.328
LIG_LIR_Nem_3	410	415	PF02991	0.430
LIG_Pex14_2	115	119	PF04695	0.417
LIG_Pex14_2	247	251	PF04695	0.348
LIG_Rb_LxCxE_1	262	280	PF01857	0.385
LIG_REV1ctd_RIR_1	249	259	PF16727	0.344
LIG_SH2_CRK	298	302	PF00017	0.449
LIG_SH2_CRK	377	381	PF00017	0.555
LIG_SH2_GRB2like	121	124	PF00017	0.564
LIG_SH2_GRB2like	377	380	PF00017	0.585
LIG_SH2_NCK_1	242	246	PF00017	0.449
LIG_SH2_NCK_1	377	381	PF00017	0.555
LIG_SH2_SRC	32	35	PF00017	0.455
LIG_SH2_SRC	377	380	PF00017	0.566
LIG_SH2_STAP1	242	246	PF00017	0.449
LIG_SH2_STAP1	321	325	PF00017	0.433
LIG_SH2_STAP1	392	396	PF00017	0.485
LIG_SH2_STAT5	209	212	PF00017	0.344
LIG_SH2_STAT5	32	35	PF00017	0.452
LIG_SH2_STAT5	321	324	PF00017	0.550
LIG_SH2_STAT5	404	407	PF00017	0.532
LIG_SH2_STAT5	42	45	PF00017	0.405
LIG_SH2_STAT5	61	64	PF00017	0.421
LIG_SH3_1	377	383	PF00018	0.558
LIG_SH3_2	380	385	PF14604	0.476
LIG_SH3_3	157	163	PF00018	0.328
LIG_SH3_3	21	27	PF00018	0.458
LIG_SH3_3	28	34	PF00018	0.420
LIG_SH3_3	377	383	PF00018	0.456
LIG_SH3_3	45	51	PF00018	0.404
LIG_SUMO_SIM_par_1	304	310	PF11976	0.413
LIG_TRAF2_1	204	207	PF00917	0.331
LIG_TRFH_1	92	96	PF08558	0.278
LIG_TYR_ITIM	105	110	PF00017	0.406
LIG_UBA3_1	167	174	PF00899	0.340
LIG_UBA3_1	182	187	PF00899	0.293
LIG_WRC_WIRS_1	248	253	PF05994	0.328
MOD_CK1_1	234	240	PF00069	0.328
MOD_CK1_1	407	413	PF00069	0.497
MOD_CK2_1	197	203	PF00069	0.344
MOD_GlcNHglycan	9	12	PF01048	0.493
MOD_GSK3_1	172	179	PF00069	0.328
MOD_GSK3_1	273	280	PF00069	0.449
MOD_GSK3_1	302	309	PF00069	0.475
MOD_GSK3_1	404	411	PF00069	0.545
MOD_N-GLC_1	103	108	PF02516	0.382
MOD_N-GLC_1	113	118	PF02516	0.400
MOD_N-GLC_1	271	276	PF02516	0.344
MOD_NEK2_1	182	187	PF00069	0.328
MOD_NEK2_1	212	217	PF00069	0.385
MOD_NEK2_1	247	252	PF00069	0.336
MOD_NEK2_1	53	58	PF00069	0.416
MOD_PIKK_1	202	208	PF00454	0.328
MOD_PKA_1	408	414	PF00069	0.476
MOD_PKA_2	197	203	PF00069	0.344
MOD_PKA_2	259	265	PF00069	0.328
MOD_PKA_2	272	278	PF00069	0.328
MOD_PKA_2	407	413	PF00069	0.540
MOD_Plk_1	103	109	PF00069	0.386
MOD_Plk_1	20	26	PF00069	0.567
MOD_Plk_1	388	394	PF00069	0.510
MOD_Plk_2-3	197	203	PF00069	0.328
MOD_Plk_4	103	109	PF00069	0.402
MOD_Plk_4	247	253	PF00069	0.328
MOD_Plk_4	259	265	PF00069	0.328
MOD_Plk_4	302	308	PF00069	0.428
MOD_Plk_4	408	414	PF00069	0.439
MOD_ProDKin_1	234	240	PF00069	0.328
MOD_ProDKin_1	27	33	PF00069	0.443
TRG_DiLeu_BaEn_2	85	91	PF01217	0.362
TRG_ENDOCYTIC_2	107	110	PF00928	0.391
TRG_ENDOCYTIC_2	209	212	PF00928	0.344
TRG_ENDOCYTIC_2	298	301	PF00928	0.344
TRG_NLS_MonoExtC_3	127	132	PF00514	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F3	Leptomonas seymouri	88%	91%
A0A0S4JS84	Bodo saltans	65%	89%
A0A1X0NV94	Trypanosomatidae	74%	90%
A0A3S5H6K0	Leishmania donovani	95%	95%
A0A422N538	Trypanosoma rangeli	74%	91%
A4HV42	Leishmania infantum	94%	95%
D0A7A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	91%
E9ANS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	95%
Q4QGU6	Leishmania major	95%	100%
V5BRW7	Trypanosoma cruzi	75%	91%