Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like/Major Facilitator Superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4H6Q5_LEIBR

TriTrypDb:

LbrM.11.1090 , LBRM2903_110019000

Length:

626

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 87
NetGPI	no	yes: 0, no: 87

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	81
GO:0110165	cellular anatomical entity	1	81
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4H6Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Q5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0022857	transmembrane transporter activity	2	41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	305	307	PF00675	0.518
CLV_NRD_NRD_1	349	351	PF00675	0.586
CLV_NRD_NRD_1	372	374	PF00675	0.512
CLV_NRD_NRD_1	488	490	PF00675	0.365
CLV_PCSK_KEX2_1	304	306	PF00082	0.475
CLV_PCSK_KEX2_1	349	351	PF00082	0.582
CLV_PCSK_KEX2_1	488	490	PF00082	0.358
CLV_PCSK_SKI1_1	157	161	PF00082	0.292
CLV_PCSK_SKI1_1	517	521	PF00082	0.501
DEG_SCF_FBW7_2	213	218	PF00400	0.369
DEG_SCF_FBW7_2	294	301	PF00400	0.501
DOC_ANK_TNKS_1	348	355	PF00023	0.687
DOC_CDC14_PxL_1	384	392	PF14671	0.581
DOC_CDC14_PxL_1	497	505	PF14671	0.275
DOC_CKS1_1	212	217	PF01111	0.570
DOC_CKS1_1	295	300	PF01111	0.365
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.273
DOC_MAPK_FxFP_2	240	243	PF00069	0.369
DOC_PP2B_LxvP_1	395	398	PF13499	0.728
DOC_PP2B_LxvP_1	498	501	PF13499	0.340
DOC_PP2B_LxvP_1	519	522	PF13499	0.308
DOC_PP2B_LxvP_1	610	613	PF13499	0.303
DOC_PP4_FxxP_1	212	215	PF00568	0.369
DOC_PP4_FxxP_1	240	243	PF00568	0.451
DOC_PP4_FxxP_1	295	298	PF00568	0.431
DOC_PP4_FxxP_1	79	82	PF00568	0.299
DOC_USP7_MATH_1	184	188	PF00917	0.254
DOC_USP7_MATH_1	611	615	PF00917	0.415
DOC_USP7_UBL2_3	332	336	PF12436	0.719
DOC_WW_Pin1_4	118	123	PF00397	0.334
DOC_WW_Pin1_4	211	216	PF00397	0.578
DOC_WW_Pin1_4	294	299	PF00397	0.363
DOC_WW_Pin1_4	376	381	PF00397	0.735
DOC_WW_Pin1_4	48	53	PF00397	0.249
DOC_WW_Pin1_4	560	565	PF00397	0.345
LIG_14-3-3_CanoR_1	319	327	PF00244	0.753
LIG_14-3-3_CanoR_1	488	498	PF00244	0.524
LIG_14-3-3_CanoR_1	60	66	PF00244	0.353
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	134	138	PF00533	0.312
LIG_BRCT_BRCA1_1	253	257	PF00533	0.328
LIG_BRCT_BRCA1_1	291	295	PF00533	0.242
LIG_deltaCOP1_diTrp_1	24	31	PF00928	0.456
LIG_deltaCOP1_diTrp_1	422	431	PF00928	0.510
LIG_EH1_1	30	38	PF00400	0.255
LIG_FHA_1	11	17	PF00498	0.601
LIG_FHA_1	113	119	PF00498	0.369
LIG_FHA_1	139	145	PF00498	0.321
LIG_FHA_1	215	221	PF00498	0.507
LIG_FHA_1	246	252	PF00498	0.300
LIG_FHA_1	254	260	PF00498	0.318
LIG_FHA_1	281	287	PF00498	0.357
LIG_FHA_1	4	10	PF00498	0.674
LIG_FHA_1	535	541	PF00498	0.253
LIG_FHA_1	69	75	PF00498	0.349
LIG_FHA_1	81	87	PF00498	0.346
LIG_FHA_1	91	97	PF00498	0.452
LIG_FHA_2	376	382	PF00498	0.662
LIG_GBD_Chelix_1	123	131	PF00786	0.380
LIG_GBD_Chelix_1	470	478	PF00786	0.192
LIG_LIR_Apic_2	265	270	PF02991	0.359
LIG_LIR_Apic_2	292	298	PF02991	0.345
LIG_LIR_Apic_2	77	82	PF02991	0.304
LIG_LIR_Apic_2	88	92	PF02991	0.471
LIG_LIR_Gen_1	254	264	PF02991	0.368
LIG_LIR_Gen_1	287	298	PF02991	0.312
LIG_LIR_Gen_1	404	414	PF02991	0.593
LIG_LIR_Gen_1	445	456	PF02991	0.327
LIG_LIR_Gen_1	46	54	PF02991	0.350
LIG_LIR_Gen_1	462	471	PF02991	0.345
LIG_LIR_Nem_3	150	154	PF02991	0.467
LIG_LIR_Nem_3	164	168	PF02991	0.366
LIG_LIR_Nem_3	199	204	PF02991	0.327
LIG_LIR_Nem_3	254	260	PF02991	0.343
LIG_LIR_Nem_3	381	387	PF02991	0.799
LIG_LIR_Nem_3	404	409	PF02991	0.624
LIG_LIR_Nem_3	413	418	PF02991	0.523
LIG_LIR_Nem_3	46	50	PF02991	0.381
LIG_LIR_Nem_3	462	467	PF02991	0.358
LIG_LIR_Nem_3	614	619	PF02991	0.343
LIG_LYPXL_S_1	482	486	PF13949	0.223
LIG_LYPXL_yS_3	483	486	PF13949	0.421
LIG_MAD2	476	484	PF02301	0.195
LIG_NRP_CendR_1	623	626	PF00754	0.300
LIG_Pex14_1	107	111	PF04695	0.286
LIG_Pex14_1	27	31	PF04695	0.454
LIG_Pex14_1	424	428	PF04695	0.340
LIG_Pex14_2	134	138	PF04695	0.213
LIG_Pex14_2	240	244	PF04695	0.478
LIG_Pex14_2	520	524	PF04695	0.297
LIG_Pex14_2	75	79	PF04695	0.405
LIG_REV1ctd_RIR_1	178	187	PF16727	0.340
LIG_SH2_CRK	406	410	PF00017	0.580
LIG_SH2_CRK	553	557	PF00017	0.247
LIG_SH2_CRK	89	93	PF00017	0.477
LIG_SH2_GRB2like	267	270	PF00017	0.220
LIG_SH2_PTP2	267	270	PF00017	0.341
LIG_SH2_SRC	267	270	PF00017	0.384
LIG_SH2_STAP1	198	202	PF00017	0.266
LIG_SH2_STAP1	553	557	PF00017	0.302
LIG_SH2_STAT5	111	114	PF00017	0.379
LIG_SH2_STAT5	177	180	PF00017	0.314
LIG_SH2_STAT5	209	212	PF00017	0.347
LIG_SH2_STAT5	21	24	PF00017	0.615
LIG_SH2_STAT5	267	270	PF00017	0.294
LIG_SH2_STAT5	406	409	PF00017	0.607
LIG_SH2_STAT5	53	56	PF00017	0.309
LIG_SH2_STAT5	557	560	PF00017	0.381
LIG_SH2_STAT5	616	619	PF00017	0.306
LIG_SH2_STAT5	78	81	PF00017	0.298
LIG_SH3_1	385	391	PF00018	0.567
LIG_SH3_3	207	213	PF00018	0.280
LIG_SH3_3	385	391	PF00018	0.694
LIG_SUMO_SIM_anti_2	368	373	PF11976	0.570
LIG_SUMO_SIM_anti_2	492	499	PF11976	0.506
LIG_SUMO_SIM_par_1	536	543	PF11976	0.275
LIG_SUMO_SIM_par_1	608	614	PF11976	0.304
LIG_SUMO_SIM_par_1	93	100	PF11976	0.335
LIG_TRAF2_1	308	311	PF00917	0.669
LIG_WRC_WIRS_1	148	153	PF05994	0.533
LIG_WRC_WIRS_1	198	203	PF05994	0.213
MOD_CDK_SPxxK_3	48	55	PF00069	0.254
MOD_CK1_1	132	138	PF00069	0.340
MOD_CK1_1	143	149	PF00069	0.350
MOD_CK1_1	289	295	PF00069	0.326
MOD_CK1_1	326	332	PF00069	0.806
MOD_CK1_1	435	441	PF00069	0.328
MOD_CK1_1	452	458	PF00069	0.363
MOD_CK1_1	543	549	PF00069	0.553
MOD_CK1_1	77	83	PF00069	0.325
MOD_CK2_1	134	140	PF00069	0.326
MOD_CK2_1	259	265	PF00069	0.289
MOD_CK2_1	375	381	PF00069	0.773
MOD_CK2_1	410	416	PF00069	0.571
MOD_CMANNOS	424	427	PF00535	0.368
MOD_Cter_Amidation	347	350	PF01082	0.413
MOD_GlcNHglycan	134	137	PF01048	0.336
MOD_GlcNHglycan	320	323	PF01048	0.461
MOD_GlcNHglycan	350	353	PF01048	0.522
MOD_GlcNHglycan	434	437	PF01048	0.284
MOD_GlcNHglycan	471	474	PF01048	0.330
MOD_GlcNHglycan	548	551	PF01048	0.317
MOD_GlcNHglycan	613	616	PF01048	0.391
MOD_GSK3_1	112	119	PF00069	0.350
MOD_GSK3_1	134	141	PF00069	0.344
MOD_GSK3_1	143	150	PF00069	0.323
MOD_GSK3_1	280	287	PF00069	0.361
MOD_GSK3_1	289	296	PF00069	0.346
MOD_GSK3_1	323	330	PF00069	0.658
MOD_GSK3_1	335	342	PF00069	0.662
MOD_GSK3_1	435	442	PF00069	0.361
MOD_GSK3_1	452	459	PF00069	0.377
MOD_GSK3_1	530	537	PF00069	0.361
MOD_GSK3_1	539	546	PF00069	0.412
MOD_GSK3_1	551	558	PF00069	0.488
MOD_GSK3_1	97	104	PF00069	0.417
MOD_N-GLC_1	102	107	PF02516	0.422
MOD_N-GLC_1	442	447	PF02516	0.427
MOD_NEK2_1	112	117	PF00069	0.270
MOD_NEK2_1	129	134	PF00069	0.349
MOD_NEK2_1	138	143	PF00069	0.343
MOD_NEK2_1	168	173	PF00069	0.360
MOD_NEK2_1	196	201	PF00069	0.301
MOD_NEK2_1	251	256	PF00069	0.350
MOD_NEK2_1	259	264	PF00069	0.325
MOD_NEK2_1	286	291	PF00069	0.327
MOD_NEK2_1	293	298	PF00069	0.336
MOD_NEK2_1	456	461	PF00069	0.346
MOD_NEK2_1	539	544	PF00069	0.375
MOD_NEK2_1	555	560	PF00069	0.327
MOD_NEK2_1	59	64	PF00069	0.295
MOD_NEK2_1	97	102	PF00069	0.266
MOD_PIKK_1	129	135	PF00454	0.293
MOD_PIKK_1	399	405	PF00454	0.583
MOD_PIKK_1	59	65	PF00454	0.267
MOD_PKA_2	318	324	PF00069	0.761
MOD_PKA_2	348	354	PF00069	0.815
MOD_PKA_2	59	65	PF00069	0.320
MOD_Plk_1	19	25	PF00069	0.444
MOD_Plk_1	367	373	PF00069	0.677
MOD_Plk_1	410	416	PF00069	0.620
MOD_Plk_1	442	448	PF00069	0.394
MOD_Plk_4	134	140	PF00069	0.330
MOD_Plk_4	161	167	PF00069	0.339
MOD_Plk_4	168	174	PF00069	0.355
MOD_Plk_4	253	259	PF00069	0.341
MOD_Plk_4	286	292	PF00069	0.352
MOD_Plk_4	367	373	PF00069	0.567
MOD_Plk_4	404	410	PF00069	0.622
MOD_Plk_4	435	441	PF00069	0.341
MOD_Plk_4	459	465	PF00069	0.281
MOD_Plk_4	491	497	PF00069	0.478
MOD_Plk_4	534	540	PF00069	0.316
MOD_Plk_4	551	557	PF00069	0.479
MOD_Plk_4	74	80	PF00069	0.343
MOD_Plk_4	92	98	PF00069	0.465
MOD_ProDKin_1	118	124	PF00069	0.334
MOD_ProDKin_1	211	217	PF00069	0.578
MOD_ProDKin_1	294	300	PF00069	0.365
MOD_ProDKin_1	376	382	PF00069	0.737
MOD_ProDKin_1	48	54	PF00069	0.249
MOD_ProDKin_1	560	566	PF00069	0.345
MOD_SUMO_for_1	54	57	PF00179	0.186
TRG_DiLeu_BaEn_1	493	498	PF01217	0.180
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.419
TRG_ENDOCYTIC_2	111	114	PF00928	0.455
TRG_ENDOCYTIC_2	177	180	PF00928	0.321
TRG_ENDOCYTIC_2	198	201	PF00928	0.330
TRG_ENDOCYTIC_2	209	212	PF00928	0.348
TRG_ENDOCYTIC_2	384	387	PF00928	0.685
TRG_ENDOCYTIC_2	406	409	PF00928	0.708
TRG_ENDOCYTIC_2	448	451	PF00928	0.298
TRG_ENDOCYTIC_2	483	486	PF00928	0.495
TRG_ENDOCYTIC_2	553	556	PF00928	0.320
TRG_ENDOCYTIC_2	61	64	PF00928	0.305
TRG_ENDOCYTIC_2	78	81	PF00928	0.292
TRG_ER_diArg_1	304	306	PF00400	0.727
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	22%	98%
A0A0N1HZC2	Leptomonas seymouri	26%	100%
A0A0N1IKC5	Leptomonas seymouri	23%	100%
A0A0N1PB63	Leptomonas seymouri	22%	95%
A0A0N1PD04	Leptomonas seymouri	60%	98%
A0A0N1PFR4	Leptomonas seymouri	25%	95%
A0A1X0NKK0	Trypanosomatidae	25%	100%
A0A1X0NM09	Trypanosomatidae	26%	100%
A0A1X0NVF9	Trypanosomatidae	47%	94%
A0A1X0NVM7	Trypanosomatidae	23%	97%
A0A1X0NZE6	Trypanosomatidae	23%	100%
A0A1X0NZU2	Trypanosomatidae	26%	97%
A0A381MMW5	Leishmania infantum	26%	95%
A0A3Q8IEC4	Leishmania donovani	26%	97%
A0A3Q8IF95	Leishmania donovani	23%	99%
A0A3Q8IIT5	Leishmania donovani	24%	93%
A0A3Q8ISY9	Leishmania donovani	23%	100%
A0A3R7JSQ9	Trypanosoma rangeli	22%	100%
A0A3R7KKN8	Trypanosoma rangeli	24%	100%
A0A3R7N3S6	Trypanosoma rangeli	48%	97%
A0A3R7N415	Trypanosoma rangeli	25%	100%
A0A3R7N921	Trypanosoma rangeli	23%	100%
A0A3S7WRJ4	Leishmania donovani	25%	98%
A0A3S7WRJ5	Leishmania donovani	24%	90%
A0A3S7WRS3	Leishmania donovani	71%	100%
A0A3S7WSR4	Leishmania donovani	24%	100%
A0A3S7WWU1	Leishmania donovani	22%	94%
A0A3S7X2G0	Leishmania donovani	26%	95%
A0A3S7X2K5	Leishmania donovani	27%	100%
A0A3S7XB11	Leishmania donovani	25%	100%
A0A422MSP6	Trypanosoma rangeli	22%	100%
A0A422MST9	Trypanosoma rangeli	24%	100%
A0A422MU68	Trypanosoma rangeli	24%	100%
A4H6J0	Leishmania braziliensis	24%	100%
A4H6J1	Leishmania braziliensis	24%	100%
A4HC19	Leishmania braziliensis	22%	97%
A4HHG2	Leishmania braziliensis	24%	93%
A4HHG3	Leishmania braziliensis	26%	97%
A4HHG4	Leishmania braziliensis	26%	96%
A4HJW3	Leishmania braziliensis	24%	98%
A4HPE2	Leishmania braziliensis	25%	100%
A4HUX5	Leishmania infantum	25%	98%
A4HUX6	Leishmania infantum	23%	90%
A4HV40	Leishmania infantum	71%	100%
A4HZF5	Leishmania infantum	23%	99%
A4HZJ4	Leishmania infantum	22%	94%
A4I4L2	Leishmania infantum	23%	93%
A4I7C5	Leishmania infantum	23%	100%
A4ICI3	Leishmania infantum	25%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AE01	Leishmania major	25%	100%
E9AE09	Leishmania major	24%	100%
E9AE10	Leishmania major	24%	100%
E9AE11	Leishmania major	26%	100%
E9AGK5	Leishmania infantum	24%	100%
E9AHJ0	Leishmania infantum	26%	97%
E9AHJ1	Leishmania infantum	27%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	93%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	95%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q1E4	Leishmania major	24%	100%
Q4Q5T8	Leishmania major	23%	100%
Q4QC27	Leishmania major	23%	100%
Q4QC28	Leishmania major	23%	100%
Q4QFY5	Leishmania major	25%	100%
Q4QGU8	Leishmania major	69%	99%
Q4QH14	Leishmania major	23%	100%
Q4QH15	Leishmania major	25%	100%
V5BFV8	Trypanosoma cruzi	21%	93%
V5BVP0	Trypanosoma cruzi	23%	100%
V5BWJ7	Trypanosoma cruzi	45%	100%
V5DT25	Trypanosoma cruzi	21%	100%