GPI-anchored surface protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Q3_LEIBR

TriTrypDb:

LbrM.11.1070 , LBRM2903_110018800

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H6Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Q3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.308
CLV_PCSK_KEX2_1	283	285	PF00082	0.377
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.397
CLV_PCSK_SKI1_1	130	134	PF00082	0.454
CLV_PCSK_SKI1_1	193	197	PF00082	0.487
DOC_CYCLIN_RxL_1	127	136	PF00134	0.480
DOC_CYCLIN_RxL_1	190	200	PF00134	0.464
DOC_PP1_RVXF_1	128	134	PF00149	0.324
DOC_PP4_FxxP_1	380	383	PF00568	0.588
DOC_PP4_FxxP_1	66	69	PF00568	0.447
DOC_USP7_MATH_1	135	139	PF00917	0.454
DOC_USP7_MATH_1	205	209	PF00917	0.655
DOC_USP7_MATH_1	52	56	PF00917	0.443
DOC_WW_Pin1_4	14	19	PF00397	0.699
LIG_14-3-3_CanoR_1	111	116	PF00244	0.400
LIG_14-3-3_CanoR_1	206	214	PF00244	0.591
LIG_14-3-3_CanoR_1	385	392	PF00244	0.602
LIG_14-3-3_CanoR_1	400	405	PF00244	0.497
LIG_14-3-3_CanoR_1	413	421	PF00244	0.474
LIG_BIR_III_4	354	358	PF00653	0.486
LIG_BRCT_BRCA1_1	113	117	PF00533	0.421
LIG_Clathr_ClatBox_1	334	338	PF01394	0.480
LIG_eIF4E_1	401	407	PF01652	0.531
LIG_FHA_1	142	148	PF00498	0.632
LIG_FHA_1	190	196	PF00498	0.330
LIG_FHA_1	198	204	PF00498	0.680
LIG_FHA_1	365	371	PF00498	0.586
LIG_FHA_1	372	378	PF00498	0.639
LIG_FHA_1	406	412	PF00498	0.521
LIG_FHA_1	414	420	PF00498	0.575
LIG_FHA_1	432	438	PF00498	0.335
LIG_FHA_1	71	77	PF00498	0.464
LIG_FHA_1	79	85	PF00498	0.593
LIG_FHA_1	99	105	PF00498	0.298
LIG_FHA_2	366	372	PF00498	0.461
LIG_LIR_Gen_1	223	234	PF02991	0.570
LIG_LIR_Gen_1	408	414	PF02991	0.582
LIG_LIR_Nem_3	408	412	PF02991	0.524
LIG_MLH1_MIPbox_1	113	117	PF16413	0.421
LIG_Pex14_2	117	121	PF04695	0.333
LIG_PTB_Apo_2	120	127	PF02174	0.313
LIG_RPA_C_Fungi	194	206	PF08784	0.623
LIG_SH2_CRK	253	257	PF00017	0.517
LIG_SH2_NCK_1	421	425	PF00017	0.424
LIG_SH2_PTP2	401	404	PF00017	0.484
LIG_SH2_PTP2	409	412	PF00017	0.461
LIG_SH2_STAP1	226	230	PF00017	0.227
LIG_SH2_STAT5	211	214	PF00017	0.544
LIG_SH2_STAT5	257	260	PF00017	0.377
LIG_SH2_STAT5	401	404	PF00017	0.484
LIG_SH2_STAT5	409	412	PF00017	0.461
LIG_SH3_3	241	247	PF00018	0.455
LIG_SH3_3	325	331	PF00018	0.473
LIG_SH3_3	334	340	PF00018	0.427
LIG_SH3_3	48	54	PF00018	0.527
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.354
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.441
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.475
LIG_SUMO_SIM_par_1	100	107	PF11976	0.421
LIG_SUMO_SIM_par_1	198	204	PF11976	0.615
LIG_SUMO_SIM_par_1	333	338	PF11976	0.446
LIG_TRAF2_1	207	210	PF00917	0.546
LIG_TYR_ITIM	399	404	PF00017	0.412
LIG_WRC_WIRS_1	437	442	PF05994	0.683
MOD_CK1_1	109	115	PF00069	0.406
MOD_CK1_1	435	441	PF00069	0.650
MOD_CK2_1	435	441	PF00069	0.612
MOD_GlcNHglycan	137	140	PF01048	0.412
MOD_GlcNHglycan	161	164	PF01048	0.434
MOD_GlcNHglycan	185	188	PF01048	0.374
MOD_GlcNHglycan	226	229	PF01048	0.458
MOD_GlcNHglycan	359	362	PF01048	0.598
MOD_GlcNHglycan	38	41	PF01048	0.400
MOD_GlcNHglycan	54	57	PF01048	0.541
MOD_GlcNHglycan	6	9	PF01048	0.421
MOD_GlcNHglycan	84	87	PF01048	0.548
MOD_GSK3_1	197	204	PF00069	0.585
MOD_GSK3_1	216	223	PF00069	0.474
MOD_GSK3_1	431	438	PF00069	0.387
MOD_GSK3_1	78	85	PF00069	0.480
MOD_GSK3_1	90	97	PF00069	0.274
MOD_NEK2_1	106	111	PF00069	0.291
MOD_NEK2_1	116	121	PF00069	0.335
MOD_NEK2_1	133	138	PF00069	0.333
MOD_NEK2_1	140	145	PF00069	0.546
MOD_NEK2_1	159	164	PF00069	0.399
MOD_NEK2_1	189	194	PF00069	0.347
MOD_NEK2_1	195	200	PF00069	0.534
MOD_NEK2_1	237	242	PF00069	0.345
MOD_NEK2_1	370	375	PF00069	0.351
MOD_NEK2_1	426	431	PF00069	0.413
MOD_NEK2_1	432	437	PF00069	0.413
MOD_NEK2_1	71	76	PF00069	0.363
MOD_NEK2_1	82	87	PF00069	0.411
MOD_NEK2_1	90	95	PF00069	0.150
MOD_PIKK_1	106	112	PF00454	0.534
MOD_PIKK_1	205	211	PF00454	0.540
MOD_PK_1	400	406	PF00069	0.506
MOD_PKA_2	205	211	PF00069	0.515
MOD_PKA_2	301	307	PF00069	0.227
MOD_PKA_2	390	396	PF00069	0.487
MOD_Plk_1	370	376	PF00069	0.281
MOD_Plk_4	111	117	PF00069	0.465
MOD_Plk_4	220	226	PF00069	0.403
MOD_Plk_4	27	33	PF00069	0.395
MOD_Plk_4	301	307	PF00069	0.382
MOD_Plk_4	313	319	PF00069	0.311
MOD_Plk_4	330	336	PF00069	0.225
MOD_Plk_4	365	371	PF00069	0.429
MOD_Plk_4	405	411	PF00069	0.480
MOD_Plk_4	426	432	PF00069	0.456
MOD_Plk_4	71	77	PF00069	0.372
MOD_ProDKin_1	14	20	PF00069	0.633
TRG_DiLeu_BaEn_3	300	306	PF01217	0.208
TRG_ENDOCYTIC_2	153	156	PF00928	0.408
TRG_ENDOCYTIC_2	226	229	PF00928	0.423
TRG_ENDOCYTIC_2	401	404	PF00928	0.484
TRG_ENDOCYTIC_2	409	412	PF00928	0.461
TRG_ER_diArg_1	412	415	PF00400	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ5	Leptomonas seymouri	52%	100%
A0A1X0NUV1	Trypanosomatidae	25%	95%
A0A3Q8I960	Leishmania donovani	72%	100%
A0A3R7NA95	Trypanosoma rangeli	24%	100%
A4HV38	Leishmania infantum	72%	100%
D0A7B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9ANR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QGV0	Leishmania major	74%	100%
V5C1D7	Trypanosoma cruzi	24%	95%