Radial spoke protein 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Q2_LEIBR

TriTrypDb:

LbrM.11.1060 , LBRM2903_110018700

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.501
CLV_NRD_NRD_1	6	8	PF00675	0.514
CLV_NRD_NRD_1	61	63	PF00675	0.453
CLV_PCSK_KEX2_1	278	280	PF00082	0.501
CLV_PCSK_KEX2_1	6	8	PF00082	0.535
CLV_PCSK_KEX2_1	61	63	PF00082	0.438
CLV_PCSK_KEX2_1	86	88	PF00082	0.507
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.501
CLV_PCSK_SKI1_1	133	137	PF00082	0.539
CLV_PCSK_SKI1_1	180	184	PF00082	0.465
CLV_PCSK_SKI1_1	227	231	PF00082	0.410
CLV_PCSK_SKI1_1	341	345	PF00082	0.410
CLV_PCSK_SKI1_1	393	397	PF00082	0.543
CLV_PCSK_SKI1_1	62	66	PF00082	0.503
CLV_Separin_Metazoa	373	377	PF03568	0.309
DEG_APCC_DBOX_1	340	348	PF00400	0.403
DEG_APCC_DBOX_1	364	372	PF00400	0.470
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DOC_CDC14_PxL_1	96	104	PF14671	0.498
DOC_CYCLIN_RxL_1	127	139	PF00134	0.517
DOC_CYCLIN_RxL_1	59	67	PF00134	0.532
DOC_MAPK_gen_1	115	124	PF00069	0.402
DOC_MAPK_gen_1	168	176	PF00069	0.282
DOC_MAPK_gen_1	393	402	PF00069	0.344
DOC_MAPK_HePTP_8	114	126	PF00069	0.473
DOC_MAPK_MEF2A_6	115	124	PF00069	0.461
DOC_MAPK_NFAT4_5	117	125	PF00069	0.488
DOC_MAPK_RevD_3	383	398	PF00069	0.430
DOC_USP7_UBL2_3	393	397	PF12436	0.290
DOC_WW_Pin1_4	13	18	PF00397	0.540
DOC_WW_Pin1_4	152	157	PF00397	0.632
DOC_WW_Pin1_4	19	24	PF00397	0.560
DOC_WW_Pin1_4	41	46	PF00397	0.581
LIG_14-3-3_CanoR_1	361	365	PF00244	0.503
LIG_14-3-3_CanoR_1	370	378	PF00244	0.489
LIG_Actin_WH2_2	225	243	PF00022	0.532
LIG_APCC_ABBA_1	80	85	PF00400	0.517
LIG_FHA_1	129	135	PF00498	0.469
LIG_FHA_1	152	158	PF00498	0.613
LIG_FHA_1	193	199	PF00498	0.377
LIG_FHA_1	247	253	PF00498	0.360
LIG_FHA_1	284	290	PF00498	0.450
LIG_FHA_1	298	304	PF00498	0.400
LIG_FHA_1	343	349	PF00498	0.467
LIG_FHA_1	357	363	PF00498	0.519
LIG_FHA_2	311	317	PF00498	0.390
LIG_GBD_Chelix_1	175	183	PF00786	0.472
LIG_LIR_Apic_2	39	45	PF02991	0.462
LIG_LIR_Gen_1	238	247	PF02991	0.306
LIG_LIR_Gen_1	54	65	PF02991	0.421
LIG_LIR_Gen_1	93	103	PF02991	0.497
LIG_LIR_Nem_3	238	242	PF02991	0.299
LIG_LIR_Nem_3	49	55	PF02991	0.435
LIG_LIR_Nem_3	93	99	PF02991	0.396
LIG_MAD2	393	401	PF02301	0.585
LIG_PDZ_Class_2	397	402	PF00595	0.638
LIG_Pex14_1	188	192	PF04695	0.424
LIG_SH2_CRK	42	46	PF00017	0.560
LIG_SH2_CRK	96	100	PF00017	0.502
LIG_SH2_NCK_1	306	310	PF00017	0.486
LIG_SH2_NCK_1	352	356	PF00017	0.484
LIG_SH2_PTP2	57	60	PF00017	0.425
LIG_SH2_STAP1	306	310	PF00017	0.486
LIG_SH2_STAT3	327	330	PF00017	0.533
LIG_SH2_STAT5	57	60	PF00017	0.434
LIG_SH3_3	289	295	PF00018	0.269
LIG_SH3_3	322	328	PF00018	0.529
LIG_SH3_3	35	41	PF00018	0.516
LIG_Sin3_3	257	264	PF02671	0.473
LIG_SUMO_SIM_anti_2	255	263	PF11976	0.517
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.394
LIG_SUMO_SIM_par_1	244	250	PF11976	0.442
LIG_SUMO_SIM_par_1	99	105	PF11976	0.501
LIG_TYR_ITIM	94	99	PF00017	0.401
LIG_UBA3_1	102	108	PF00899	0.538
LIG_Vh1_VBS_1	192	210	PF01044	0.255
MOD_CDC14_SPxK_1	16	19	PF00782	0.468
MOD_CDK_SPxK_1	13	19	PF00069	0.458
MOD_CK1_1	217	223	PF00069	0.438
MOD_CK1_1	22	28	PF00069	0.523
MOD_CK2_1	101	107	PF00069	0.525
MOD_CK2_1	310	316	PF00069	0.379
MOD_CK2_1	334	340	PF00069	0.482
MOD_CK2_1	386	392	PF00069	0.297
MOD_Cter_Amidation	276	279	PF01082	0.413
MOD_GlcNHglycan	148	151	PF01048	0.498
MOD_GlcNHglycan	216	219	PF01048	0.417
MOD_GlcNHglycan	223	226	PF01048	0.378
MOD_GlcNHglycan	24	27	PF01048	0.641
MOD_GlcNHglycan	306	309	PF01048	0.460
MOD_GSK3_1	188	195	PF00069	0.424
MOD_GSK3_1	210	217	PF00069	0.507
MOD_GSK3_1	356	363	PF00069	0.534
MOD_N-GLC_1	13	18	PF02516	0.456
MOD_N-GLC_1	214	219	PF02516	0.422
MOD_N-GLC_1	297	302	PF02516	0.515
MOD_NEK2_1	146	151	PF00069	0.706
MOD_NEK2_1	192	197	PF00069	0.440
MOD_NEK2_1	210	215	PF00069	0.504
MOD_NEK2_1	221	226	PF00069	0.410
MOD_NEK2_1	386	391	PF00069	0.425
MOD_NEK2_2	297	302	PF00069	0.494
MOD_NEK2_2	360	365	PF00069	0.522
MOD_PIKK_1	128	134	PF00454	0.507
MOD_PIKK_1	208	214	PF00454	0.417
MOD_PIKK_1	386	392	PF00454	0.429
MOD_PKA_2	360	366	PF00069	0.527
MOD_PKA_2	369	375	PF00069	0.388
MOD_Plk_1	109	115	PF00069	0.438
MOD_Plk_1	297	303	PF00069	0.511
MOD_Plk_2-3	334	340	PF00069	0.357
MOD_Plk_4	266	272	PF00069	0.466
MOD_ProDKin_1	13	19	PF00069	0.542
MOD_ProDKin_1	152	158	PF00069	0.630
MOD_ProDKin_1	41	47	PF00069	0.576
TRG_DiLeu_BaEn_1	266	271	PF01217	0.431
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.540
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.470
TRG_ENDOCYTIC_2	52	55	PF00928	0.454
TRG_ENDOCYTIC_2	57	60	PF00928	0.357
TRG_ENDOCYTIC_2	96	99	PF00928	0.391
TRG_ER_diArg_1	5	7	PF00400	0.526
TRG_ER_diArg_1	60	62	PF00400	0.461
TRG_NLS_MonoExtN_4	393	400	PF00514	0.457
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVS3	Leptomonas seymouri	65%	99%
A0A0S4KKN0	Bodo saltans	32%	100%
A0A1X0NUU6	Trypanosomatidae	36%	100%
A0A3R7M4V0	Trypanosoma rangeli	36%	100%
A0A3S7WRS2	Leishmania donovani	80%	100%
A4HV37	Leishmania infantum	80%	100%
D0A7B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	76%
E9ANR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGV1	Leishmania major	80%	100%
V5BWJ3	Trypanosoma cruzi	36%	100%