Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Q1_LEIBR

TriTrypDb:

LbrM.11.1050 , LBRM2903_110018600

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.459
CLV_NRD_NRD_1	166	168	PF00675	0.452
CLV_NRD_NRD_1	171	173	PF00675	0.472
CLV_NRD_NRD_1	51	53	PF00675	0.406
CLV_NRD_NRD_1	63	65	PF00675	0.415
CLV_PCSK_KEX2_1	125	127	PF00082	0.459
CLV_PCSK_KEX2_1	50	52	PF00082	0.423
CLV_PCSK_KEX2_1	62	64	PF00082	0.404
CLV_PCSK_KEX2_1	87	89	PF00082	0.538
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.538
DOC_ANK_TNKS_1	42	49	PF00023	0.485
DOC_MAPK_gen_1	112	120	PF00069	0.420
DOC_USP7_MATH_1	185	189	PF00917	0.599
DOC_WW_Pin1_4	181	186	PF00397	0.590
DOC_WW_Pin1_4	2	7	PF00397	0.638
DOC_WW_Pin1_4	76	81	PF00397	0.477
DOC_WW_Pin1_4	96	101	PF00397	0.422
LIG_14-3-3_CanoR_1	31	36	PF00244	0.461
LIG_14-3-3_CanoR_1	62	67	PF00244	0.425
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	52	56	PF00533	0.465
LIG_BRCT_BRCA1_2	52	58	PF00533	0.473
LIG_FHA_1	17	23	PF00498	0.492
LIG_FHA_1	182	188	PF00498	0.441
LIG_FHA_1	55	61	PF00498	0.360
LIG_FHA_2	149	155	PF00498	0.389
LIG_FHA_2	79	85	PF00498	0.596
LIG_FHA_2	8	14	PF00498	0.567
LIG_LIR_Gen_1	99	109	PF02991	0.479
LIG_LIR_Nem_3	99	105	PF02991	0.646
LIG_PDZ_Class_1	187	192	PF00595	0.478
LIG_SH2_STAT3	113	116	PF00017	0.428
LIG_UBA3_1	82	87	PF00899	0.371
MOD_CK1_1	2	8	PF00069	0.654
MOD_CK1_1	34	40	PF00069	0.529
MOD_CK2_1	130	136	PF00069	0.517
MOD_CK2_1	148	154	PF00069	0.302
MOD_CK2_1	15	21	PF00069	0.536
MOD_CK2_1	7	13	PF00069	0.589
MOD_CK2_1	78	84	PF00069	0.623
MOD_GlcNHglycan	187	190	PF01048	0.643
MOD_GSK3_1	148	155	PF00069	0.393
MOD_GSK3_1	181	188	PF00069	0.543
MOD_GSK3_1	27	34	PF00069	0.567
MOD_GSK3_1	50	57	PF00069	0.428
MOD_GSK3_1	78	85	PF00069	0.616
MOD_GSK3_1	96	103	PF00069	0.638
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	148	153	PF00069	0.469
MOD_NEK2_1	82	87	PF00069	0.371
MOD_NEK2_1	95	100	PF00069	0.583
MOD_PIKK_1	31	37	PF00454	0.485
MOD_PKA_1	50	56	PF00069	0.411
MOD_PKA_1	62	68	PF00069	0.505
MOD_PKA_2	27	33	PF00069	0.445
MOD_PKA_2	50	56	PF00069	0.427
MOD_PKA_2	62	68	PF00069	0.505
MOD_Plk_1	120	126	PF00069	0.512
MOD_Plk_4	34	40	PF00069	0.469
MOD_Plk_4	78	84	PF00069	0.392
MOD_ProDKin_1	181	187	PF00069	0.432
MOD_ProDKin_1	2	8	PF00069	0.629
MOD_ProDKin_1	76	82	PF00069	0.475
MOD_ProDKin_1	96	102	PF00069	0.423
MOD_SUMO_for_1	86	89	PF00179	0.434
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.412
TRG_ER_diArg_1	124	126	PF00400	0.440
TRG_ER_diArg_1	49	52	PF00400	0.390
TRG_ER_diArg_1	62	64	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	172	177	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F7	Leptomonas seymouri	57%	100%
A0A1X0NWA0	Trypanosomatidae	37%	98%
A0A3S7WRU4	Leishmania donovani	74%	100%
A0A422N1X3	Trypanosoma rangeli	33%	94%
A4HV36	Leishmania infantum	74%	100%
D0A7B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QGV2	Leishmania major	74%	100%