LeishMANIAdb
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Putative tatD related deoxyribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative tatD related deoxyribonuclease
Gene product:
tatD related deoxyribonuclease, putative
Species:
Leishmania braziliensis
UniProt:
A4H6P9_LEIBR
TriTrypDb:
LbrM.11.1030 , LBRM2903_110018400 *
Length:
336

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H6P9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6P9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0004518 nuclease activity 4 1
GO:0004527 exonuclease activity 5 1
GO:0004529 DNA exonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0008296 3'-5'-DNA exonuclease activity 7 1
GO:0008408 3'-5' exonuclease activity 6 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0140097 catalytic activity, acting on DNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 199 203 PF00656 0.471
CLV_C14_Caspase3-7 264 268 PF00656 0.355
CLV_NRD_NRD_1 257 259 PF00675 0.155
CLV_NRD_NRD_1 276 278 PF00675 0.224
CLV_NRD_NRD_1 32 34 PF00675 0.272
CLV_NRD_NRD_1 325 327 PF00675 0.256
CLV_PCSK_KEX2_1 154 156 PF00082 0.323
CLV_PCSK_KEX2_1 257 259 PF00082 0.253
CLV_PCSK_KEX2_1 32 34 PF00082 0.197
CLV_PCSK_PC1ET2_1 154 156 PF00082 0.324
CLV_PCSK_SKI1_1 133 137 PF00082 0.222
CLV_PCSK_SKI1_1 230 234 PF00082 0.315
CLV_PCSK_SKI1_1 249 253 PF00082 0.257
CLV_PCSK_SKI1_1 326 330 PF00082 0.238
CLV_PCSK_SKI1_1 45 49 PF00082 0.194
CLV_PCSK_SKI1_1 52 56 PF00082 0.194
DOC_MAPK_gen_1 154 162 PF00069 0.483
DOC_MAPK_gen_1 32 39 PF00069 0.380
DOC_MAPK_MEF2A_6 12 20 PF00069 0.380
DOC_MAPK_MEF2A_6 154 162 PF00069 0.480
DOC_MAPK_NFAT4_5 155 163 PF00069 0.515
DOC_PP1_RVXF_1 131 137 PF00149 0.417
DOC_USP7_UBL2_3 139 143 PF12436 0.471
DOC_USP7_UBL2_3 278 282 PF12436 0.543
LIG_14-3-3_CanoR_1 243 251 PF00244 0.389
LIG_14-3-3_CanoR_1 257 262 PF00244 0.496
LIG_14-3-3_CanoR_1 32 38 PF00244 0.471
LIG_14-3-3_CanoR_1 73 82 PF00244 0.510
LIG_Actin_WH2_2 202 217 PF00022 0.486
LIG_Actin_WH2_2 47 64 PF00022 0.417
LIG_CtBP_PxDLS_1 17 23 PF00389 0.434
LIG_DLG_GKlike_1 257 265 PF00625 0.355
LIG_eIF4E_1 145 151 PF01652 0.471
LIG_FHA_1 110 116 PF00498 0.461
LIG_FHA_1 323 329 PF00498 0.413
LIG_FHA_1 34 40 PF00498 0.523
LIG_FHA_2 165 171 PF00498 0.413
LIG_FHA_2 191 197 PF00498 0.394
LIG_FHA_2 73 79 PF00498 0.513
LIG_Integrin_isoDGR_2 30 32 PF01839 0.315
LIG_LIR_Gen_1 130 136 PF02991 0.413
LIG_LIR_Gen_1 170 179 PF02991 0.356
LIG_LIR_Gen_1 236 247 PF02991 0.413
LIG_LIR_Nem_3 130 134 PF02991 0.413
LIG_LIR_Nem_3 170 174 PF02991 0.414
LIG_LIR_Nem_3 22 28 PF02991 0.438
LIG_LIR_Nem_3 236 242 PF02991 0.424
LIG_REV1ctd_RIR_1 133 143 PF16727 0.363
LIG_SH2_CRK 131 135 PF00017 0.413
LIG_SH2_CRK 25 29 PF00017 0.480
LIG_SH2_PTP2 206 209 PF00017 0.438
LIG_SH2_SRC 200 203 PF00017 0.515
LIG_SH2_STAP1 131 135 PF00017 0.363
LIG_SH2_STAT5 102 105 PF00017 0.480
LIG_SH2_STAT5 145 148 PF00017 0.413
LIG_SH2_STAT5 200 203 PF00017 0.454
LIG_SH2_STAT5 206 209 PF00017 0.421
LIG_SH2_STAT5 74 77 PF00017 0.451
LIG_SH3_3 174 180 PF00018 0.471
LIG_SH3_3 93 99 PF00018 0.515
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.355
LIG_SUMO_SIM_par_1 35 41 PF11976 0.355
LIG_TYR_ITIM 129 134 PF00017 0.413
LIG_WRC_WIRS_1 187 192 PF05994 0.413
MOD_CK1_1 213 219 PF00069 0.438
MOD_CK1_1 271 277 PF00069 0.477
MOD_CK1_1 72 78 PF00069 0.476
MOD_CK2_1 120 126 PF00069 0.489
MOD_CK2_1 190 196 PF00069 0.438
MOD_CK2_1 72 78 PF00069 0.448
MOD_Cter_Amidation 30 33 PF01082 0.234
MOD_GlcNHglycan 193 196 PF01048 0.155
MOD_GlcNHglycan 25 28 PF01048 0.234
MOD_GlcNHglycan 270 273 PF01048 0.357
MOD_GlcNHglycan 292 296 PF01048 0.155
MOD_GlcNHglycan 333 336 PF01048 0.411
MOD_GSK3_1 186 193 PF00069 0.426
MOD_GSK3_1 257 264 PF00069 0.496
MOD_GSK3_1 268 275 PF00069 0.443
MOD_GSK3_1 69 76 PF00069 0.468
MOD_N-GLC_1 18 23 PF02516 0.224
MOD_N-GLC_2 210 212 PF02516 0.239
MOD_NEK2_1 109 114 PF00069 0.441
MOD_NEK2_1 190 195 PF00069 0.456
MOD_NEK2_1 261 266 PF00069 0.426
MOD_NEK2_1 322 327 PF00069 0.467
MOD_NEK2_1 331 336 PF00069 0.471
MOD_NEK2_1 54 59 PF00069 0.424
MOD_NEK2_1 61 66 PF00069 0.456
MOD_NEK2_2 272 277 PF00069 0.373
MOD_PKA_1 257 263 PF00069 0.453
MOD_PKA_2 164 170 PF00069 0.429
MOD_PKA_2 242 248 PF00069 0.389
MOD_PKA_2 257 263 PF00069 0.507
MOD_PKA_2 72 78 PF00069 0.431
MOD_Plk_1 309 315 PF00069 0.515
MOD_Plk_4 38 44 PF00069 0.515
TRG_DiLeu_BaEn_1 292 297 PF01217 0.377
TRG_DiLeu_BaLyEn_6 9 14 PF01217 0.415
TRG_ENDOCYTIC_2 131 134 PF00928 0.413
TRG_ENDOCYTIC_2 206 209 PF00928 0.438
TRG_ENDOCYTIC_2 25 28 PF00928 0.503
TRG_ER_diArg_1 155 158 PF00400 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3Q2 Leptomonas seymouri 67% 100%
A0A0N1IL51 Leptomonas seymouri 34% 93%
A0A0S4IY84 Bodo saltans 49% 99%
A0A0S4JNN8 Bodo saltans 33% 91%
A0A1X0NWJ2 Trypanosomatidae 58% 100%
A0A1X0P426 Trypanosomatidae 34% 86%
A0A3R7K0P4 Trypanosoma rangeli 33% 94%
A0A3R7LLG2 Trypanosoma rangeli 59% 100%
A0A3S5H6J9 Leishmania donovani 82% 100%
A0A3S7X0L2 Leishmania donovani 30% 89%
A4HFM3 Leishmania braziliensis 31% 89%
A4HV34 Leishmania infantum 82% 100%
A4I2Q1 Leishmania infantum 30% 89%
A4WFX9 Enterobacter sp. (strain 638) 34% 100%
A7MQN1 Cronobacter sakazakii (strain ATCC BAA-894) 34% 100%
A8ACY8 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 35% 100%
A8G8C4 Serratia proteamaculans (strain 568) 35% 100%
B1JP69 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 34% 100%
B2VG45 Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99) 35% 100%
B5XYH5 Klebsiella pneumoniae (strain 342) 38% 100%
B7LTZ5 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 33% 100%
C6C4V4 Musicola paradisiaca (strain Ech703) 35% 100%
C6DI71 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 35% 100%
C9XTA5 Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032) 34% 100%
D0A5V3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 88%
D0A7B6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0KC77 Pectobacterium parmentieri (strain WPP163) 34% 100%
D0Z9R0 Edwardsiella tarda (strain EIB202) 36% 100%
D2TUZ4 Citrobacter rodentium (strain ICC168) 37% 100%
D4GGR2 Pantoea ananatis (strain LMG 20103) 36% 100%
D4ICL5 Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3) 36% 100%
D8MKW4 Erwinia billingiae (strain Eb661) 31% 100%
E0SLH6 Dickeya dadantii (strain 3937) 37% 100%
E1SKR8 Pantoea vagans (strain C9-1) 35% 100%
E3G381 Enterobacter lignolyticus (strain SCF1) 35% 100%
E6WHK1 Pantoea sp. (strain At-9b) 37% 100%
E8XYF5 Rahnella sp. (strain Y9602) 37% 100%
E9AD77 Leishmania major 30% 98%
E9ANR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9AZ01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 89%
P27859 Escherichia coli (strain K12) 34% 100%
P34220 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 80%
P39408 Escherichia coli (strain K12) 29% 100%
P57436 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 26% 100%
Q0SZ31 Shigella flexneri serotype 5b (strain 8401) 34% 100%
Q148G4 Bos taurus 42% 100%
Q4QGV4 Leishmania major 82% 100%
Q640V9 Xenopus laevis 44% 100%
Q6DAQ1 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 36% 100%
Q6GML7 Danio rerio 44% 100%
Q6P1N9 Homo sapiens 42% 100%
Q6P8M1 Mus musculus 41% 100%
Q8K9J1 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 28% 100%
Q8SW70 Encephalitozoon cuniculi (strain GB-M1) 32% 100%
Q9L6M2 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 30% 100%
Q9UUF1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 100%
V5BRW2 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS