60Kd inner membrane protein-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6P4_LEIBR

TriTrypDb:

LbrM.11.0980 , LBRM2903_110016400

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H6P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6P4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0032978	protein insertion into membrane from inner side	6	1
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	12
GO:0140104	molecular carrier activity	1	12
GO:0140597	protein carrier chaperone	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	198	200	PF00675	0.452
CLV_NRD_NRD_1	345	347	PF00675	0.430
CLV_PCSK_KEX2_1	155	157	PF00082	0.252
CLV_PCSK_KEX2_1	171	173	PF00082	0.252
CLV_PCSK_KEX2_1	198	200	PF00082	0.452
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.252
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.252
CLV_PCSK_SKI1_1	110	114	PF00082	0.335
CLV_PCSK_SKI1_1	156	160	PF00082	0.252
CLV_PCSK_SKI1_1	166	170	PF00082	0.252
CLV_PCSK_SKI1_1	179	183	PF00082	0.239
CLV_PCSK_SKI1_1	216	220	PF00082	0.476
CLV_PCSK_SKI1_1	303	307	PF00082	0.331
CLV_PCSK_SKI1_1	55	59	PF00082	0.557
CLV_Separin_Metazoa	80	84	PF03568	0.346
DOC_CDC14_PxL_1	112	120	PF14671	0.361
DOC_CDC14_PxL_1	207	215	PF14671	0.263
DOC_CYCLIN_RxL_1	107	117	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.320
DOC_MAPK_FxFP_2	306	309	PF00069	0.538
DOC_MAPK_gen_1	247	257	PF00069	0.452
DOC_MAPK_gen_1	83	93	PF00069	0.372
DOC_MAPK_MEF2A_6	262	271	PF00069	0.361
DOC_MAPK_MEF2A_6	86	95	PF00069	0.364
DOC_PP1_RVXF_1	8	15	PF00149	0.411
DOC_PP2B_LxvP_1	185	188	PF13499	0.347
DOC_PP2B_LxvP_1	218	221	PF13499	0.242
DOC_PP4_FxxP_1	306	309	PF00568	0.526
DOC_PP4_FxxP_1	71	74	PF00568	0.339
DOC_USP7_MATH_1	132	136	PF00917	0.386
DOC_USP7_MATH_1	274	278	PF00917	0.295
DOC_USP7_MATH_1	314	318	PF00917	0.652
DOC_USP7_MATH_1	53	57	PF00917	0.366
DOC_USP7_UBL2_3	155	159	PF12436	0.452
LIG_14-3-3_CanoR_1	10	15	PF00244	0.361
LIG_14-3-3_CanoR_1	110	115	PF00244	0.304
LIG_14-3-3_CanoR_1	122	126	PF00244	0.452
LIG_14-3-3_CanoR_1	148	158	PF00244	0.466
LIG_14-3-3_CanoR_1	247	257	PF00244	0.452
LIG_14-3-3_CanoR_1	262	267	PF00244	0.304
LIG_14-3-3_CanoR_1	350	358	PF00244	0.677
LIG_AP2alpha_1	302	306	PF02296	0.543
LIG_BRCT_BRCA1_1	276	280	PF00533	0.259
LIG_Clathr_ClatBox_1	236	240	PF01394	0.339
LIG_deltaCOP1_diTrp_1	62	71	PF00928	0.334
LIG_EVH1_1	308	312	PF00568	0.543
LIG_FHA_1	184	190	PF00498	0.304
LIG_FHA_1	222	228	PF00498	0.252
LIG_FHA_1	286	292	PF00498	0.320
LIG_FHA_2	203	209	PF00498	0.271
LIG_FHA_2	217	223	PF00498	0.246
LIG_FHA_2	333	339	PF00498	0.612
LIG_FHA_2	358	364	PF00498	0.685
LIG_FHA_2	43	49	PF00498	0.473
LIG_LIR_Apic_2	222	228	PF02991	0.252
LIG_LIR_Apic_2	304	309	PF02991	0.543
LIG_LIR_Apic_2	48	53	PF02991	0.413
LIG_LIR_Apic_2	70	74	PF02991	0.350
LIG_LIR_Gen_1	160	169	PF02991	0.463
LIG_LIR_Gen_1	180	189	PF02991	0.120
LIG_LIR_Gen_1	192	202	PF02991	0.361
LIG_LIR_Gen_1	327	337	PF02991	0.630
LIG_LIR_Gen_1	362	372	PF02991	0.638
LIG_LIR_Gen_1	56	64	PF02991	0.335
LIG_LIR_Gen_1	88	95	PF02991	0.441
LIG_LIR_Nem_3	13	17	PF02991	0.479
LIG_LIR_Nem_3	180	184	PF02991	0.418
LIG_LIR_Nem_3	192	197	PF02991	0.304
LIG_LIR_Nem_3	304	308	PF02991	0.543
LIG_LIR_Nem_3	327	332	PF02991	0.634
LIG_LIR_Nem_3	362	367	PF02991	0.637
LIG_LIR_Nem_3	56	61	PF02991	0.338
LIG_LIR_Nem_3	88	93	PF02991	0.398
LIG_NRP_CendR_1	379	381	PF00754	0.578
LIG_Pex14_1	67	71	PF04695	0.337
LIG_Pex14_1	98	102	PF04695	0.252
LIG_Pex14_2	235	239	PF04695	0.304
LIG_Pex14_2	302	306	PF04695	0.519
LIG_REV1ctd_RIR_1	303	308	PF16727	0.490
LIG_SH2_CRK	225	229	PF00017	0.337
LIG_SH2_NCK_1	225	229	PF00017	0.452
LIG_SH2_NCK_1	364	368	PF00017	0.694
LIG_SH2_PTP2	50	53	PF00017	0.472
LIG_SH2_STAP1	203	207	PF00017	0.252
LIG_SH2_STAP1	329	333	PF00017	0.645
LIG_SH2_STAP1	364	368	PF00017	0.632
LIG_SH2_STAT3	6	9	PF00017	0.356
LIG_SH2_STAT5	256	259	PF00017	0.452
LIG_SH2_STAT5	270	273	PF00017	0.304
LIG_SH2_STAT5	50	53	PF00017	0.467
LIG_SH2_STAT5	6	9	PF00017	0.356
LIG_SH3_3	306	312	PF00018	0.541
LIG_SH3_3	320	326	PF00018	0.584
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.213
LIG_SxIP_EBH_1	108	122	PF03271	0.339
MOD_CK1_1	117	123	PF00069	0.452
MOD_CK1_1	135	141	PF00069	0.452
MOD_CK1_1	180	186	PF00069	0.322
MOD_CK1_1	251	257	PF00069	0.482
MOD_CK2_1	148	154	PF00069	0.447
MOD_CK2_1	202	208	PF00069	0.254
MOD_CK2_1	324	330	PF00069	0.559
MOD_CK2_1	332	338	PF00069	0.553
MOD_CK2_1	53	59	PF00069	0.359
MOD_GlcNHglycan	151	154	PF01048	0.292
MOD_GlcNHglycan	191	194	PF01048	0.297
MOD_GlcNHglycan	250	253	PF01048	0.275
MOD_GlcNHglycan	276	279	PF01048	0.462
MOD_GlcNHglycan	353	356	PF01048	0.485
MOD_GlcNHglycan	376	379	PF01048	0.542
MOD_GSK3_1	110	117	PF00069	0.304
MOD_GSK3_1	183	190	PF00069	0.267
MOD_GSK3_1	314	321	PF00069	0.638
MOD_NEK2_2	193	198	PF00069	0.304
MOD_NEK2_2	53	58	PF00069	0.376
MOD_PIKK_1	137	143	PF00454	0.440
MOD_PK_1	262	268	PF00069	0.382
MOD_PKA_2	121	127	PF00069	0.486
MOD_PKA_2	25	31	PF00069	0.408
MOD_PKA_2	261	267	PF00069	0.389
MOD_PKA_2	351	357	PF00069	0.631
MOD_Plk_1	146	152	PF00069	0.452
MOD_Plk_1	216	222	PF00069	0.260
MOD_Plk_1	53	59	PF00069	0.359
MOD_Plk_4	110	116	PF00069	0.310
MOD_Plk_4	177	183	PF00069	0.465
MOD_Plk_4	251	257	PF00069	0.478
MOD_Plk_4	262	268	PF00069	0.337
MOD_Plk_4	324	330	PF00069	0.568
MOD_Plk_4	53	59	PF00069	0.371
MOD_Plk_4	67	73	PF00069	0.349
MOD_SUMO_rev_2	317	326	PF00179	0.641
MOD_SUMO_rev_2	365	375	PF00179	0.575
TRG_DiLeu_BaEn_2	207	213	PF01217	0.252
TRG_ENDOCYTIC_2	162	165	PF00928	0.463
TRG_ENDOCYTIC_2	329	332	PF00928	0.644
TRG_ENDOCYTIC_2	364	367	PF00928	0.633
TRG_ER_diArg_1	197	199	PF00400	0.252
TRG_NLS_Bipartite_1	155	175	PF00514	0.412
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.263
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y9	Leptomonas seymouri	86%	84%
A0A0S4IZY1	Bodo saltans	60%	87%
A0A1X0NWK5	Trypanosomatidae	72%	95%
A0A3R7NUU3	Trypanosoma rangeli	71%	85%
A0A3S7WRQ0	Leishmania donovani	90%	86%
A4HV25	Leishmania infantum	90%	86%
D0A7C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	91%
E9ANQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	86%
Q4QGW4	Leishmania major	89%	100%
Q5R7D0	Pongo abelii	25%	100%
Q8N8Q8	Homo sapiens	24%	100%
Q8VC74	Mus musculus	27%	100%
V5C1D0	Trypanosoma cruzi	74%	89%