Sec16_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein SEC31, putative

Species:

Leishmania braziliensis

UniProt:

A4H6N8_LEIBR

TriTrypDb:

LbrM.11.0920 , LBRM2903_110016100

Length:

1154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	6
GO:0030117	membrane coat	3	1
GO:0030120	vesicle coat	4	1
GO:0030127	COPII vesicle coat	5	1
GO:0032991	protein-containing complex	1	1
GO:0070971	endoplasmic reticulum exit site	2	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H6N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6N8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	5
GO:0009987	cellular process	1	6
GO:0016192	vesicle-mediated transport	4	5
GO:0046907	intracellular transport	3	6
GO:0048193	Golgi vesicle transport	5	5
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0035459	vesicle cargo loading	4	1
GO:0045184	establishment of protein localization	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090110	COPII-coated vesicle cargo loading	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.470
CLV_C14_Caspase3-7	896	900	PF00656	0.531
CLV_NRD_NRD_1	1090	1092	PF00675	0.446
CLV_NRD_NRD_1	310	312	PF00675	0.354
CLV_NRD_NRD_1	534	536	PF00675	0.304
CLV_PCSK_FUR_1	739	743	PF00082	0.409
CLV_PCSK_KEX2_1	1089	1091	PF00082	0.459
CLV_PCSK_KEX2_1	1139	1141	PF00082	0.323
CLV_PCSK_KEX2_1	552	554	PF00082	0.298
CLV_PCSK_KEX2_1	741	743	PF00082	0.492
CLV_PCSK_PC1ET2_1	1139	1141	PF00082	0.323
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.298
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.408
CLV_PCSK_SKI1_1	120	124	PF00082	0.592
CLV_PCSK_SKI1_1	215	219	PF00082	0.420
CLV_PCSK_SKI1_1	278	282	PF00082	0.200
CLV_PCSK_SKI1_1	458	462	PF00082	0.443
CLV_PCSK_SKI1_1	553	557	PF00082	0.298
CLV_PCSK_SKI1_1	577	581	PF00082	0.298
CLV_PCSK_SKI1_1	669	673	PF00082	0.494
CLV_PCSK_SKI1_1	702	706	PF00082	0.577
CLV_Separin_Metazoa	532	536	PF03568	0.391
DEG_APCC_DBOX_1	119	127	PF00400	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.385
DEG_SPOP_SBC_1	861	865	PF00917	0.535
DOC_CYCLIN_yCln2_LP_2	853	859	PF00134	0.619
DOC_MAPK_HePTP_8	502	514	PF00069	0.391
DOC_MAPK_MEF2A_6	505	514	PF00069	0.298
DOC_PP1_RVXF_1	118	125	PF00149	0.416
DOC_PP1_RVXF_1	71	77	PF00149	0.353
DOC_PP2B_LxvP_1	853	856	PF13499	0.562
DOC_PP4_FxxP_1	1066	1069	PF00568	0.439
DOC_PP4_FxxP_1	705	708	PF00568	0.528
DOC_PP4_MxPP_1	881	884	PF00568	0.526
DOC_USP7_MATH_1	1044	1048	PF00917	0.626
DOC_USP7_MATH_1	106	110	PF00917	0.335
DOC_USP7_MATH_1	1069	1073	PF00917	0.360
DOC_USP7_MATH_1	26	30	PF00917	0.355
DOC_USP7_MATH_1	337	341	PF00917	0.355
DOC_USP7_MATH_1	421	425	PF00917	0.434
DOC_USP7_MATH_1	441	445	PF00917	0.413
DOC_USP7_MATH_1	560	564	PF00917	0.298
DOC_USP7_MATH_1	782	786	PF00917	0.574
DOC_USP7_MATH_1	819	823	PF00917	0.732
DOC_USP7_MATH_1	835	839	PF00917	0.543
DOC_USP7_MATH_1	847	851	PF00917	0.745
DOC_USP7_MATH_1	859	863	PF00917	0.552
DOC_USP7_MATH_1	888	892	PF00917	0.558
DOC_USP7_MATH_1	917	921	PF00917	0.643
DOC_USP7_MATH_1	935	939	PF00917	0.603
DOC_USP7_MATH_1	967	971	PF00917	0.754
DOC_USP7_UBL2_3	227	231	PF12436	0.393
DOC_USP7_UBL2_3	366	370	PF12436	0.473
DOC_WW_Pin1_4	1047	1052	PF00397	0.769
DOC_WW_Pin1_4	1065	1070	PF00397	0.394
DOC_WW_Pin1_4	1124	1129	PF00397	0.426
DOC_WW_Pin1_4	12	17	PF00397	0.332
DOC_WW_Pin1_4	339	344	PF00397	0.292
DOC_WW_Pin1_4	401	406	PF00397	0.508
DOC_WW_Pin1_4	723	728	PF00397	0.516
DOC_WW_Pin1_4	74	79	PF00397	0.362
DOC_WW_Pin1_4	810	815	PF00397	0.552
DOC_WW_Pin1_4	836	841	PF00397	0.566
DOC_WW_Pin1_4	862	867	PF00397	0.613
DOC_WW_Pin1_4	947	952	PF00397	0.609
DOC_WW_Pin1_4	953	958	PF00397	0.549
DOC_WW_Pin1_4	970	975	PF00397	0.505
DOC_WW_Pin1_4	991	996	PF00397	0.630
LIG_14-3-3_CanoR_1	157	162	PF00244	0.523
LIG_14-3-3_CanoR_1	174	178	PF00244	0.332
LIG_14-3-3_CanoR_1	2	12	PF00244	0.444
LIG_14-3-3_CanoR_1	219	225	PF00244	0.393
LIG_14-3-3_CanoR_1	496	502	PF00244	0.391
LIG_Actin_WH2_2	201	217	PF00022	0.358
LIG_AP2alpha_1	519	523	PF02296	0.298
LIG_AP2alpha_2	480	482	PF02296	0.519
LIG_BRCT_BRCA1_1	562	566	PF00533	0.308
LIG_BRCT_BRCA1_1	899	903	PF00533	0.536
LIG_CSL_BTD_1	13	16	PF09270	0.322
LIG_CtBP_PxDLS_1	1111	1115	PF00389	0.417
LIG_CtBP_PxDLS_1	831	835	PF00389	0.560
LIG_deltaCOP1_diTrp_1	152	159	PF00928	0.525
LIG_FHA_1	164	170	PF00498	0.457
LIG_FHA_1	200	206	PF00498	0.344
LIG_FHA_1	243	249	PF00498	0.381
LIG_FHA_1	263	269	PF00498	0.422
LIG_FHA_1	275	281	PF00498	0.458
LIG_FHA_1	340	346	PF00498	0.291
LIG_FHA_1	426	432	PF00498	0.424
LIG_FHA_1	495	501	PF00498	0.525
LIG_FHA_1	641	647	PF00498	0.395
LIG_FHA_1	691	697	PF00498	0.416
LIG_FHA_1	911	917	PF00498	0.711
LIG_FHA_1	985	991	PF00498	0.563
LIG_FHA_2	147	153	PF00498	0.458
LIG_FHA_2	158	164	PF00498	0.521
LIG_FHA_2	347	353	PF00498	0.423
LIG_FHA_2	387	393	PF00498	0.466
LIG_FHA_2	405	411	PF00498	0.470
LIG_FHA_2	432	438	PF00498	0.432
LIG_LIR_Apic_2	302	307	PF02991	0.458
LIG_LIR_Apic_2	77	82	PF02991	0.494
LIG_LIR_Apic_2	808	814	PF02991	0.545
LIG_LIR_Gen_1	1131	1142	PF02991	0.498
LIG_LIR_Gen_1	40	51	PF02991	0.369
LIG_LIR_Gen_1	479	488	PF02991	0.531
LIG_LIR_Gen_1	937	947	PF02991	0.621
LIG_LIR_LC3C_4	245	249	PF02991	0.356
LIG_LIR_LC3C_4	379	382	PF02991	0.335
LIG_LIR_Nem_3	1131	1137	PF02991	0.499
LIG_LIR_Nem_3	325	331	PF02991	0.429
LIG_LIR_Nem_3	338	344	PF02991	0.293
LIG_LIR_Nem_3	40	46	PF02991	0.365
LIG_LIR_Nem_3	479	485	PF02991	0.523
LIG_LIR_Nem_3	563	569	PF02991	0.308
LIG_LIR_Nem_3	610	616	PF02991	0.298
LIG_LIR_Nem_3	75	79	PF02991	0.364
LIG_LIR_Nem_3	994	1000	PF02991	0.532
LIG_LYPXL_yS_3	997	1000	PF13949	0.533
LIG_MYND_1	929	933	PF01753	0.623
LIG_Pex14_1	192	196	PF04695	0.355
LIG_Pex14_2	519	523	PF04695	0.298
LIG_PROFILIN_1	1024	1030	PF00235	0.526
LIG_SH2_CRK	79	83	PF00017	0.505
LIG_SH2_CRK	811	815	PF00017	0.716
LIG_SH2_NCK_1	196	200	PF00017	0.354
LIG_SH2_NCK_1	716	720	PF00017	0.509
LIG_SH2_SRC	196	199	PF00017	0.361
LIG_SH2_SRC	716	719	PF00017	0.687
LIG_SH2_SRC	805	808	PF00017	0.724
LIG_SH2_STAP1	196	200	PF00017	0.354
LIG_SH2_STAP1	980	984	PF00017	0.717
LIG_SH2_STAT5	322	325	PF00017	0.351
LIG_SH2_STAT5	541	544	PF00017	0.299
LIG_SH2_STAT5	616	619	PF00017	0.298
LIG_SH2_STAT5	658	661	PF00017	0.348
LIG_SH2_STAT5	682	685	PF00017	0.438
LIG_SH2_STAT5	703	706	PF00017	0.491
LIG_SH2_STAT5	805	808	PF00017	0.724
LIG_SH2_STAT5	811	814	PF00017	0.644
LIG_SH2_STAT5	96	99	PF00017	0.470
LIG_SH3_1	1022	1028	PF00018	0.686
LIG_SH3_1	837	843	PF00018	0.577
LIG_SH3_2	1027	1032	PF14604	0.568
LIG_SH3_3	1021	1027	PF00018	0.626
LIG_SH3_3	1036	1042	PF00018	0.644
LIG_SH3_3	1048	1054	PF00018	0.559
LIG_SH3_3	138	144	PF00018	0.458
LIG_SH3_3	166	172	PF00018	0.442
LIG_SH3_3	327	333	PF00018	0.352
LIG_SH3_3	399	405	PF00018	0.611
LIG_SH3_3	62	68	PF00018	0.388
LIG_SH3_3	712	718	PF00018	0.599
LIG_SH3_3	721	727	PF00018	0.547
LIG_SH3_3	772	778	PF00018	0.592
LIG_SH3_3	792	798	PF00018	0.529
LIG_SH3_3	821	827	PF00018	0.600
LIG_SH3_3	837	843	PF00018	0.678
LIG_SH3_3	853	859	PF00018	0.636
LIG_SH3_3	877	883	PF00018	0.754
LIG_SH3_3	955	961	PF00018	0.738
LIG_SH3_3	983	989	PF00018	0.673
LIG_SH3_3	992	998	PF00018	0.590
LIG_SH3_3	999	1005	PF00018	0.511
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.416
LIG_SUMO_SIM_par_1	642	650	PF11976	0.400
LIG_SUMO_SIM_par_1	693	699	PF11976	0.459
LIG_SUMO_SIM_par_1	987	994	PF11976	0.548
LIG_TRAF2_1	286	289	PF00917	0.458
LIG_TRAF2_1	735	738	PF00917	0.470
LIG_TRAF2_2	1005	1010	PF00917	0.707
LIG_UBA3_1	452	458	PF00899	0.344
LIG_WW_3	1029	1033	PF00397	0.569
MOD_CDK_SPK_2	401	406	PF00069	0.418
MOD_CK1_1	1047	1053	PF00069	0.620
MOD_CK1_1	109	115	PF00069	0.417
MOD_CK1_1	176	182	PF00069	0.520
MOD_CK1_1	226	232	PF00069	0.461
MOD_CK1_1	339	345	PF00069	0.287
MOD_CK1_1	355	361	PF00069	0.419
MOD_CK1_1	404	410	PF00069	0.539
MOD_CK1_1	462	468	PF00069	0.704
MOD_CK1_1	486	492	PF00069	0.432
MOD_CK1_1	769	775	PF00069	0.605
MOD_CK1_1	838	844	PF00069	0.553
MOD_CK1_1	862	868	PF00069	0.536
MOD_CK1_1	937	943	PF00069	0.623
MOD_CK1_1	956	962	PF00069	0.742
MOD_CK1_1	970	976	PF00069	0.612
MOD_CK1_1	978	984	PF00069	0.599
MOD_CK2_1	283	289	PF00069	0.298
MOD_CK2_1	30	36	PF00069	0.345
MOD_CK2_1	386	392	PF00069	0.401
MOD_CK2_1	431	437	PF00069	0.526
MOD_CK2_1	526	532	PF00069	0.298
MOD_CK2_1	96	102	PF00069	0.433
MOD_CMANNOS	156	159	PF00535	0.298
MOD_Cter_Amidation	309	312	PF01082	0.529
MOD_GlcNHglycan	1013	1016	PF01048	0.556
MOD_GlcNHglycan	1046	1049	PF01048	0.631
MOD_GlcNHglycan	108	111	PF01048	0.454
MOD_GlcNHglycan	131	134	PF01048	0.391
MOD_GlcNHglycan	183	186	PF01048	0.398
MOD_GlcNHglycan	30	33	PF01048	0.404
MOD_GlcNHglycan	355	358	PF01048	0.461
MOD_GlcNHglycan	421	424	PF01048	0.420
MOD_GlcNHglycan	443	446	PF01048	0.441
MOD_GlcNHglycan	464	467	PF01048	0.622
MOD_GlcNHglycan	502	505	PF01048	0.298
MOD_GlcNHglycan	528	531	PF01048	0.298
MOD_GlcNHglycan	562	565	PF01048	0.298
MOD_GlcNHglycan	580	583	PF01048	0.298
MOD_GlcNHglycan	654	657	PF01048	0.414
MOD_GlcNHglycan	807	810	PF01048	0.648
MOD_GlcNHglycan	840	843	PF01048	0.731
MOD_GlcNHglycan	874	877	PF01048	0.619
MOD_GlcNHglycan	958	961	PF01048	0.721
MOD_GlcNHglycan	964	967	PF01048	0.675
MOD_GlcNHglycan	98	101	PF01048	0.336
MOD_GSK3_1	1053	1060	PF00069	0.582
MOD_GSK3_1	1065	1072	PF00069	0.382
MOD_GSK3_1	109	116	PF00069	0.418
MOD_GSK3_1	1124	1131	PF00069	0.514
MOD_GSK3_1	24	31	PF00069	0.357
MOD_GSK3_1	274	281	PF00069	0.298
MOD_GSK3_1	283	290	PF00069	0.302
MOD_GSK3_1	335	342	PF00069	0.264
MOD_GSK3_1	351	358	PF00069	0.393
MOD_GSK3_1	372	379	PF00069	0.450
MOD_GSK3_1	401	408	PF00069	0.586
MOD_GSK3_1	415	422	PF00069	0.355
MOD_GSK3_1	425	432	PF00069	0.423
MOD_GSK3_1	441	448	PF00069	0.418
MOD_GSK3_1	458	465	PF00069	0.540
MOD_GSK3_1	719	726	PF00069	0.570
MOD_GSK3_1	765	772	PF00069	0.544
MOD_GSK3_1	805	812	PF00069	0.548
MOD_GSK3_1	861	868	PF00069	0.587
MOD_GSK3_1	893	900	PF00069	0.624
MOD_GSK3_1	934	941	PF00069	0.623
MOD_GSK3_1	970	977	PF00069	0.592
MOD_GSK3_1	980	987	PF00069	0.633
MOD_LATS_1	276	282	PF00433	0.216
MOD_N-GLC_1	1128	1133	PF02516	0.335
MOD_N-GLC_1	223	228	PF02516	0.420
MOD_N-GLC_1	36	41	PF02516	0.438
MOD_N-GLC_1	376	381	PF02516	0.437
MOD_N-GLC_2	92	94	PF02516	0.348
MOD_NEK2_1	1057	1062	PF00069	0.555
MOD_NEK2_1	146	151	PF00069	0.298
MOD_NEK2_1	223	228	PF00069	0.420
MOD_NEK2_1	24	29	PF00069	0.350
MOD_NEK2_1	292	297	PF00069	0.312
MOD_NEK2_1	3	8	PF00069	0.361
MOD_NEK2_1	345	350	PF00069	0.414
MOD_NEK2_1	431	436	PF00069	0.561
MOD_NEK2_1	500	505	PF00069	0.298
MOD_NEK2_1	646	651	PF00069	0.409
MOD_PIKK_1	1069	1075	PF00454	0.321
MOD_PIKK_1	1128	1134	PF00454	0.504
MOD_PIKK_1	242	248	PF00454	0.373
MOD_PIKK_1	415	421	PF00454	0.483
MOD_PIKK_1	425	431	PF00454	0.419
MOD_PIKK_1	486	492	PF00454	0.432
MOD_PIKK_1	647	653	PF00454	0.421
MOD_PIKK_1	782	788	PF00454	0.715
MOD_PIKK_1	888	894	PF00454	0.554
MOD_PIKK_1	984	990	PF00454	0.596
MOD_PKA_2	173	179	PF00069	0.364
MOD_PKA_2	218	224	PF00069	0.399
MOD_PKA_2	495	501	PF00069	0.432
MOD_PKA_2	633	639	PF00069	0.402
MOD_Plk_1	1128	1134	PF00069	0.329
MOD_Plk_1	288	294	PF00069	0.299
MOD_Plk_1	376	382	PF00069	0.431
MOD_Plk_1	425	431	PF00069	0.430
MOD_Plk_4	1008	1014	PF00069	0.621
MOD_Plk_4	1053	1059	PF00069	0.630
MOD_Plk_4	288	294	PF00069	0.298
MOD_Plk_4	376	382	PF00069	0.349
MOD_Plk_4	640	646	PF00069	0.424
MOD_Plk_4	692	698	PF00069	0.463
MOD_Plk_4	899	905	PF00069	0.536
MOD_Plk_4	975	981	PF00069	0.598
MOD_Plk_4	996	1002	PF00069	0.531
MOD_ProDKin_1	1047	1053	PF00069	0.768
MOD_ProDKin_1	1065	1071	PF00069	0.386
MOD_ProDKin_1	1124	1130	PF00069	0.417
MOD_ProDKin_1	12	18	PF00069	0.344
MOD_ProDKin_1	339	345	PF00069	0.287
MOD_ProDKin_1	401	407	PF00069	0.498
MOD_ProDKin_1	723	729	PF00069	0.513
MOD_ProDKin_1	74	80	PF00069	0.369
MOD_ProDKin_1	810	816	PF00069	0.552
MOD_ProDKin_1	836	842	PF00069	0.563
MOD_ProDKin_1	862	868	PF00069	0.614
MOD_ProDKin_1	947	953	PF00069	0.611
MOD_ProDKin_1	970	976	PF00069	0.594
MOD_ProDKin_1	991	997	PF00069	0.631
MOD_SUMO_rev_2	45	54	PF00179	0.387
TRG_DiLeu_BaEn_3	1112	1118	PF01217	0.412
TRG_DiLeu_BaEn_4	507	513	PF01217	0.298
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.374
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.376
TRG_ENDOCYTIC_2	196	199	PF00928	0.361
TRG_ENDOCYTIC_2	939	942	PF00928	0.718
TRG_ENDOCYTIC_2	997	1000	PF00928	0.533
TRG_ER_diArg_1	1088	1091	PF00400	0.464
TRG_ER_diArg_1	64	67	PF00400	0.382
TRG_NES_CRM1_1	578	591	PF08389	0.391
TRG_NES_CRM1_1	58	69	PF08389	0.392
TRG_NLS_Bipartite_1	535	555	PF00514	0.208
TRG_NLS_MonoExtN_4	550	555	PF00514	0.208
TRG_Pf-PMV_PEXEL_1	1103	1107	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	742	746	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K3	Leptomonas seymouri	62%	96%
A0A3S5H6J7	Leishmania donovani	81%	99%
E9ANQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
F4ICD9	Arabidopsis thaliana	25%	100%
P38968	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	91%
Q3UPL0	Mus musculus	24%	94%
Q4QGW6	Leishmania major	81%	99%
Q5F3X8	Gallus gallus	25%	94%
Q6CL75	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	94%