Putative 60S ribosomal protein L28

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L28, putative

Species:

Leishmania braziliensis

UniProt:

A4H6N7_LEIBR

TriTrypDb:

LbrM.11.0890 , LBRM2903_110015700

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	14
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	10
GO:0044391	ribosomal subunit	3	1
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

A4H6N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6N7

PDB structure(s): 6az3_Z

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	10
GO:0005198	structural molecule activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.451
CLV_NRD_NRD_1	101	103	PF00675	0.299
CLV_NRD_NRD_1	112	114	PF00675	0.533
CLV_NRD_NRD_1	83	85	PF00675	0.336
CLV_NRD_NRD_1	86	88	PF00675	0.336
CLV_PCSK_FUR_1	117	121	PF00082	0.566
CLV_PCSK_FUR_1	84	88	PF00082	0.457
CLV_PCSK_KEX2_1	119	121	PF00082	0.574
CLV_PCSK_KEX2_1	14	16	PF00082	0.327
CLV_PCSK_KEX2_1	83	85	PF00082	0.336
CLV_PCSK_KEX2_1	86	88	PF00082	0.336
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.574
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.336
CLV_PCSK_SKI1_1	28	32	PF00082	0.431
DEG_APCC_DBOX_1	73	81	PF00400	0.336
DOC_MAPK_gen_1	102	111	PF00069	0.504
DOC_MAPK_gen_1	28	37	PF00069	0.352
DOC_MAPK_MEF2A_6	31	39	PF00069	0.457
DOC_MAPK_RevD_3	71	84	PF00069	0.352
DOC_PP1_RVXF_1	106	112	PF00149	0.533
LIG_14-3-3_CanoR_1	102	111	PF00244	0.563
LIG_AP2alpha_2	4	6	PF02296	0.352
LIG_BIR_II_1	1	5	PF00653	0.175
LIG_BRCT_BRCA1_1	78	82	PF00533	0.241
LIG_FHA_1	93	99	PF00498	0.567
LIG_FHA_2	36	42	PF00498	0.371
LIG_RPA_C_Fungi	108	120	PF08784	0.673
LIG_SH2_CRK	52	56	PF00017	0.316
LIG_SH3_3	23	29	PF00018	0.455
LIG_TYR_ITIM	50	55	PF00017	0.241
MOD_CK1_1	64	70	PF00069	0.352
MOD_CK1_1	93	99	PF00069	0.565
MOD_GlcNHglycan	16	19	PF01048	0.282
MOD_GSK3_1	10	17	PF00069	0.274
MOD_N-GLC_1	8	13	PF02516	0.337
MOD_PKA_1	14	20	PF00069	0.282
MOD_PKA_2	109	115	PF00069	0.543
MOD_PKA_2	14	20	PF00069	0.282
MOD_PKA_2	93	99	PF00069	0.493
TRG_ENDOCYTIC_2	52	55	PF00928	0.316
TRG_ER_diArg_1	82	84	PF00400	0.336
TRG_ER_diArg_1	86	88	PF00400	0.336
TRG_NLS_Bipartite_1	86	106	PF00514	0.560
TRG_NLS_MonoExtC_3	101	107	PF00514	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HQW7	Leptomonas seymouri	84%	83%
A0A0S4IQT0	Bodo saltans	57%	83%
A0A1X0NUX0	Trypanosomatidae	68%	83%
A0A3Q8I930	Leishmania donovani	83%	82%
A0A3Q8I959	Leishmania donovani	83%	82%
A0A3R7M2X2	Trypanosoma rangeli	65%	83%
A0A422NRH0	Trypanosoma rangeli	65%	90%
A4H6N5	Leishmania braziliensis	100%	100%
A4HV19	Leishmania infantum	83%	82%
D0A7C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	83%
E8NHE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	82%
O00822	Trypanosoma cruzi	64%	83%
Q4QGW7	Leishmania major	84%	100%