Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6N6_LEIBR

TriTrypDb:

LbrM.11.0900 , LBRM2903_110015800

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	241	248	PF00400	0.793
DEG_SPOP_SBC_1	134	138	PF00917	0.609
DOC_PP2B_LxvP_1	190	193	PF13499	0.490
DOC_PP4_FxxP_1	209	212	PF00568	0.535
DOC_USP7_MATH_1	134	138	PF00917	0.609
DOC_USP7_MATH_1	212	216	PF00917	0.707
DOC_USP7_MATH_1	261	265	PF00917	0.662
DOC_USP7_MATH_1	283	287	PF00917	0.597
DOC_USP7_MATH_2	254	260	PF00917	0.679
DOC_WW_Pin1_4	137	142	PF00397	0.710
DOC_WW_Pin1_4	241	246	PF00397	0.793
DOC_WW_Pin1_4	56	61	PF00397	0.619
LIG_14-3-3_CanoR_1	189	193	PF00244	0.749
LIG_14-3-3_CanoR_1	30	39	PF00244	0.705
LIG_14-3-3_CanoR_1	48	58	PF00244	0.479
LIG_Actin_WH2_2	176	191	PF00022	0.722
LIG_Actin_WH2_2	303	321	PF00022	0.625
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BIR_III_2	227	231	PF00653	0.521
LIG_BIR_III_4	216	220	PF00653	0.542
LIG_BIR_III_4	7	11	PF00653	0.437
LIG_BIR_III_4	78	82	PF00653	0.573
LIG_BRCT_BRCA1_1	1	5	PF00533	0.482
LIG_BRCT_BRCA1_1	166	170	PF00533	0.645
LIG_Clathr_ClatBox_1	292	296	PF01394	0.496
LIG_Clathr_ClatBox_1	3	7	PF01394	0.464
LIG_FHA_1	104	110	PF00498	0.489
LIG_FHA_1	311	317	PF00498	0.457
LIG_FHA_1	33	39	PF00498	0.452
LIG_FHA_1	53	59	PF00498	0.478
LIG_FHA_1	80	86	PF00498	0.568
LIG_FHA_2	171	177	PF00498	0.612
LIG_GBD_Chelix_1	184	192	PF00786	0.476
LIG_LIR_Apic_2	206	212	PF02991	0.537
LIG_LIR_Apic_2	321	326	PF02991	0.633
LIG_LIR_Gen_1	168	176	PF02991	0.712
LIG_LIR_Gen_1	22	32	PF02991	0.518
LIG_LIR_Nem_3	140	146	PF02991	0.544
LIG_LIR_Nem_3	168	174	PF02991	0.601
LIG_LIR_Nem_3	22	27	PF02991	0.595
LIG_LIR_Nem_3	279	284	PF02991	0.700
LIG_LYPXL_SIV_4	8	16	PF13949	0.696
LIG_LYPXL_yS_3	143	146	PF13949	0.484
LIG_PCNA_yPIPBox_3	67	75	PF02747	0.490
LIG_PDZ_Class_2	322	327	PF00595	0.640
LIG_SH2_CRK	281	285	PF00017	0.524
LIG_SH2_CRK	323	327	PF00017	0.641
LIG_SH2_NCK_1	281	285	PF00017	0.782
LIG_SH2_SRC	281	284	PF00017	0.794
LIG_SH2_STAT5	323	326	PF00017	0.516
LIG_SH2_STAT5	37	40	PF00017	0.458
LIG_SH2_STAT5	92	95	PF00017	0.619
LIG_SH3_3	138	144	PF00018	0.715
LIG_SH3_3	243	249	PF00018	0.606
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.586
LIG_SUMO_SIM_anti_2	311	319	PF11976	0.627
LIG_SUMO_SIM_par_1	157	162	PF11976	0.564
LIG_SUMO_SIM_par_1	197	204	PF11976	0.527
LIG_WRC_WIRS_1	102	107	PF05994	0.618
MOD_CK1_1	133	139	PF00069	0.758
MOD_CK1_1	175	181	PF00069	0.583
MOD_CK1_1	321	327	PF00069	0.544
MOD_CK1_1	54	60	PF00069	0.558
MOD_CK1_1	69	75	PF00069	0.475
MOD_CK2_1	170	176	PF00069	0.615
MOD_CK2_1	200	206	PF00069	0.679
MOD_CK2_1	256	262	PF00069	0.803
MOD_CK2_1	37	43	PF00069	0.460
MOD_GlcNHglycan	110	114	PF01048	0.641
MOD_GlcNHglycan	116	119	PF01048	0.667
MOD_GlcNHglycan	132	135	PF01048	0.458
MOD_GlcNHglycan	150	154	PF01048	0.409
MOD_GlcNHglycan	161	164	PF01048	0.678
MOD_GlcNHglycan	180	183	PF01048	0.406
MOD_GlcNHglycan	269	272	PF01048	0.618
MOD_GlcNHglycan	320	323	PF01048	0.475
MOD_GSK3_1	130	137	PF00069	0.676
MOD_GSK3_1	170	177	PF00069	0.611
MOD_GSK3_1	188	195	PF00069	0.648
MOD_GSK3_1	240	247	PF00069	0.801
MOD_GSK3_1	283	290	PF00069	0.502
MOD_GSK3_1	52	59	PF00069	0.538
MOD_NEK2_1	109	114	PF00069	0.544
MOD_NEK2_1	154	159	PF00069	0.599
MOD_NEK2_1	164	169	PF00069	0.548
MOD_NEK2_1	170	175	PF00069	0.523
MOD_NEK2_1	188	193	PF00069	0.487
MOD_NEK2_1	318	323	PF00069	0.502
MOD_NEK2_1	32	37	PF00069	0.535
MOD_NEK2_1	84	89	PF00069	0.629
MOD_NEK2_1	93	98	PF00069	0.601
MOD_PIKK_1	103	109	PF00454	0.594
MOD_PKA_2	188	194	PF00069	0.749
MOD_PKA_2	212	218	PF00069	0.606
MOD_PKA_2	318	324	PF00069	0.629
MOD_PKA_2	93	99	PF00069	0.670
MOD_Plk_1	122	128	PF00069	0.714
MOD_Plk_1	149	155	PF00069	0.658
MOD_Plk_1	175	181	PF00069	0.614
MOD_Plk_1	261	267	PF00069	0.541
MOD_Plk_1	42	48	PF00069	0.744
MOD_Plk_4	154	160	PF00069	0.578
MOD_Plk_4	69	75	PF00069	0.606
MOD_ProDKin_1	137	143	PF00069	0.709
MOD_ProDKin_1	241	247	PF00069	0.793
MOD_ProDKin_1	56	62	PF00069	0.619
TRG_ENDOCYTIC_2	143	146	PF00928	0.484
TRG_ENDOCYTIC_2	281	284	PF00928	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ79	Leptomonas seymouri	31%	91%
A0A3Q8I948	Leishmania donovani	62%	97%
A4HV20	Leishmania infantum	62%	97%
E8NHE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	97%
Q4QGW8	Leishmania major	63%	100%