Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 7, putative

Species:

Leishmania braziliensis

UniProt:

A4H6N3_LEIBR

TriTrypDb:

LbrM.11.0870 , LBRM2903_110015500

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H6N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6N3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.663
CLV_C14_Caspase3-7	118	122	PF00656	0.666
CLV_C14_Caspase3-7	179	183	PF00656	0.661
CLV_NRD_NRD_1	199	201	PF00675	0.492
CLV_NRD_NRD_1	212	214	PF00675	0.418
CLV_NRD_NRD_1	301	303	PF00675	0.426
CLV_PCSK_FUR_1	210	214	PF00082	0.408
CLV_PCSK_KEX2_1	127	129	PF00082	0.471
CLV_PCSK_KEX2_1	199	201	PF00082	0.497
CLV_PCSK_KEX2_1	212	214	PF00082	0.429
CLV_PCSK_KEX2_1	301	303	PF00082	0.435
CLV_PCSK_KEX2_1	420	422	PF00082	0.502
CLV_PCSK_KEX2_1	438	440	PF00082	0.361
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.471
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.502
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.361
CLV_PCSK_SKI1_1	213	217	PF00082	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.624
DOC_MAPK_MEF2A_6	378	386	PF00069	0.321
DOC_PP2B_LxvP_1	157	160	PF13499	0.677
DOC_PP4_FxxP_1	216	219	PF00568	0.722
DOC_SPAK_OSR1_1	163	167	PF12202	0.627
DOC_USP7_MATH_1	109	113	PF00917	0.636
DOC_USP7_MATH_1	131	135	PF00917	0.701
DOC_USP7_MATH_1	191	195	PF00917	0.737
DOC_USP7_MATH_1	219	223	PF00917	0.701
DOC_USP7_MATH_1	28	32	PF00917	0.725
DOC_USP7_MATH_1	288	292	PF00917	0.505
DOC_USP7_MATH_1	55	59	PF00917	0.676
DOC_USP7_MATH_1	95	99	PF00917	0.662
DOC_USP7_UBL2_3	123	127	PF12436	0.664
DOC_USP7_UBL2_3	312	316	PF12436	0.635
DOC_USP7_UBL2_3	431	435	PF12436	0.538
DOC_WW_Pin1_4	11	16	PF00397	0.703
DOC_WW_Pin1_4	29	34	PF00397	0.723
DOC_WW_Pin1_4	4	9	PF00397	0.738
DOC_WW_Pin1_4	88	93	PF00397	0.656
LIG_14-3-3_CanoR_1	218	224	PF00244	0.637
LIG_14-3-3_CanoR_1	334	340	PF00244	0.440
LIG_Actin_WH2_2	396	412	PF00022	0.369
LIG_BIR_III_4	121	125	PF00653	0.661
LIG_BRCT_BRCA1_1	160	164	PF00533	0.619
LIG_BRCT_BRCA1_1	239	243	PF00533	0.529
LIG_eIF4E_1	276	282	PF01652	0.359
LIG_FHA_1	270	276	PF00498	0.347
LIG_FHA_1	291	297	PF00498	0.474
LIG_FHA_1	422	428	PF00498	0.595
LIG_FHA_1	77	83	PF00498	0.647
LIG_Integrin_RGD_1	50	52	PF01839	0.451
LIG_LIR_Apic_2	31	37	PF02991	0.654
LIG_LIR_Gen_1	244	250	PF02991	0.241
LIG_LIR_Gen_1	263	273	PF02991	0.242
LIG_LIR_Gen_1	338	349	PF02991	0.456
LIG_LIR_Gen_1	350	359	PF02991	0.295
LIG_LIR_Gen_1	411	418	PF02991	0.590
LIG_LIR_Gen_1	422	433	PF02991	0.542
LIG_LIR_Nem_3	240	246	PF02991	0.511
LIG_LIR_Nem_3	263	269	PF02991	0.279
LIG_LIR_Nem_3	338	344	PF02991	0.463
LIG_LIR_Nem_3	350	355	PF02991	0.307
LIG_LIR_Nem_3	422	428	PF02991	0.549
LIG_PDZ_Class_2	438	443	PF00595	0.571
LIG_Pex14_1	239	243	PF04695	0.529
LIG_SH2_CRK	230	234	PF00017	0.362
LIG_SH2_CRK	276	280	PF00017	0.399
LIG_SH2_CRK	34	38	PF00017	0.657
LIG_SH2_PTP2	246	249	PF00017	0.529
LIG_SH2_SRC	223	226	PF00017	0.521
LIG_SH2_STAP1	337	341	PF00017	0.428
LIG_SH2_STAT5	230	233	PF00017	0.401
LIG_SH2_STAT5	246	249	PF00017	0.393
LIG_SH2_STAT5	250	253	PF00017	0.370
LIG_SH2_STAT5	337	340	PF00017	0.521
LIG_SH2_STAT5	376	379	PF00017	0.350
LIG_SH2_STAT5	397	400	PF00017	0.428
LIG_SH2_STAT5	404	407	PF00017	0.625
LIG_SH3_3	153	159	PF00018	0.706
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.393
LIG_SUMO_SIM_par_1	278	283	PF11976	0.393
LIG_SUMO_SIM_par_1	78	84	PF11976	0.664
LIG_WRC_WIRS_1	261	266	PF05994	0.279
LIG_WRC_WIRS_1	281	286	PF05994	0.367
MOD_CDC14_SPxK_1	36	39	PF00782	0.653
MOD_CDK_SPxK_1	33	39	PF00069	0.653
MOD_CK1_1	241	247	PF00069	0.239
MOD_CK2_1	133	139	PF00069	0.657
MOD_CK2_1	4	10	PF00069	0.630
MOD_CK2_1	65	71	PF00069	0.738
MOD_CK2_1	88	94	PF00069	0.672
MOD_Cter_Amidation	418	421	PF01082	0.384
MOD_GlcNHglycan	129	134	PF01048	0.556
MOD_GlcNHglycan	144	147	PF01048	0.474
MOD_GlcNHglycan	243	246	PF01048	0.239
MOD_GlcNHglycan	344	347	PF01048	0.529
MOD_GlcNHglycan	47	50	PF01048	0.469
MOD_GlcNHglycan	65	68	PF01048	0.475
MOD_GSK3_1	129	136	PF00069	0.647
MOD_GSK3_1	202	209	PF00069	0.740
MOD_GSK3_1	237	244	PF00069	0.239
MOD_GSK3_1	29	36	PF00069	0.664
MOD_GSK3_1	301	308	PF00069	0.635
MOD_GSK3_1	347	354	PF00069	0.350
MOD_N-GLC_1	335	340	PF02516	0.228
MOD_N-GLC_2	315	317	PF02516	0.435
MOD_N-GLC_2	329	331	PF02516	0.270
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	142	147	PF00069	0.766
MOD_NEK2_1	237	242	PF00069	0.529
MOD_NEK2_1	269	274	PF00069	0.422
MOD_NEK2_1	275	280	PF00069	0.473
MOD_NEK2_1	409	414	PF00069	0.584
MOD_PIKK_1	248	254	PF00454	0.622
MOD_PIKK_1	433	439	PF00454	0.556
MOD_PKA_1	301	307	PF00069	0.635
MOD_PKA_2	206	212	PF00069	0.756
MOD_PKA_2	301	307	PF00069	0.635
MOD_Plk_1	335	341	PF00069	0.428
MOD_Plk_1	421	427	PF00069	0.593
MOD_Plk_4	238	244	PF00069	0.529
MOD_Plk_4	269	275	PF00069	0.454
MOD_Plk_4	335	341	PF00069	0.494
MOD_Plk_4	354	360	PF00069	0.393
MOD_Plk_4	55	61	PF00069	0.701
MOD_ProDKin_1	11	17	PF00069	0.701
MOD_ProDKin_1	29	35	PF00069	0.724
MOD_ProDKin_1	4	10	PF00069	0.739
MOD_ProDKin_1	88	94	PF00069	0.655
TRG_DiLeu_BaEn_3	422	428	PF01217	0.502
TRG_ENDOCYTIC_2	230	233	PF00928	0.394
TRG_ENDOCYTIC_2	246	249	PF00928	0.393
TRG_ENDOCYTIC_2	276	279	PF00928	0.529
TRG_ENDOCYTIC_2	337	340	PF00928	0.635
TRG_ENDOCYTIC_2	376	379	PF00928	0.257
TRG_ENDOCYTIC_2	404	407	PF00928	0.635
TRG_ENDOCYTIC_2	414	417	PF00928	0.517
TRG_ER_diArg_1	210	213	PF00400	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6J6	Leishmania donovani	68%	100%
A0A3S7WRS6	Leishmania donovani	47%	85%
A4H6N2	Leishmania braziliensis	55%	100%
A4HV16	Leishmania infantum	47%	85%
A4HV17	Leishmania infantum	64%	95%
E9ANQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	71%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	94%
Q4QGX1	Leishmania major	70%	100%