Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 7, putative

Species:

Leishmania braziliensis

UniProt:

A4H6N2_LEIBR

TriTrypDb:

LbrM.11.0860 , LBRM2903_110015400

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H6N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6N2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016409	palmitoyltransferase activity	5	12
GO:0016417	S-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	12
GO:0019707	protein-cysteine S-acyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.635
CLV_NRD_NRD_1	157	159	PF00675	0.499
CLV_NRD_NRD_1	276	278	PF00675	0.398
CLV_NRD_NRD_1	284	286	PF00675	0.384
CLV_NRD_NRD_1	289	291	PF00675	0.364
CLV_NRD_NRD_1	378	380	PF00675	0.365
CLV_NRD_NRD_1	513	515	PF00675	0.384
CLV_NRD_NRD_1	517	519	PF00675	0.442
CLV_PCSK_FUR_1	511	515	PF00082	0.407
CLV_PCSK_KEX2_1	157	159	PF00082	0.496
CLV_PCSK_KEX2_1	284	286	PF00082	0.398
CLV_PCSK_KEX2_1	289	291	PF00082	0.365
CLV_PCSK_KEX2_1	378	380	PF00082	0.370
CLV_PCSK_KEX2_1	496	498	PF00082	0.362
CLV_PCSK_KEX2_1	513	515	PF00082	0.519
CLV_PCSK_KEX2_1	516	518	PF00082	0.438
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.362
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.451
CLV_PCSK_PC7_1	285	291	PF00082	0.305
CLV_PCSK_PC7_1	511	517	PF00082	0.425
CLV_PCSK_SKI1_1	290	294	PF00082	0.339
DOC_CKS1_1	47	52	PF01111	0.607
DOC_MAPK_gen_1	496	503	PF00069	0.620
DOC_PP1_RVXF_1	497	504	PF00149	0.583
DOC_PP2B_LxvP_1	21	24	PF13499	0.604
DOC_PP4_FxxP_1	293	296	PF00568	0.552
DOC_USP7_MATH_1	125	129	PF00917	0.627
DOC_USP7_MATH_1	152	156	PF00917	0.620
DOC_USP7_MATH_1	249	253	PF00917	0.632
DOC_USP7_MATH_1	268	272	PF00917	0.630
DOC_USP7_MATH_1	296	300	PF00917	0.580
DOC_USP7_MATH_1	35	39	PF00917	0.653
DOC_USP7_MATH_1	365	369	PF00917	0.490
DOC_USP7_MATH_1	58	62	PF00917	0.636
DOC_USP7_MATH_1	95	99	PF00917	0.662
DOC_USP7_UBL2_3	389	393	PF12436	0.475
DOC_WW_Pin1_4	137	142	PF00397	0.708
DOC_WW_Pin1_4	19	24	PF00397	0.719
DOC_WW_Pin1_4	31	36	PF00397	0.708
DOC_WW_Pin1_4	46	51	PF00397	0.630
LIG_14-3-3_CanoR_1	284	288	PF00244	0.624
LIG_14-3-3_CanoR_1	295	301	PF00244	0.579
LIG_BIR_III_2	218	222	PF00653	0.605
LIG_BRCT_BRCA1_1	128	132	PF00533	0.631
LIG_BRCT_BRCA1_1	316	320	PF00533	0.308
LIG_eIF4E_1	353	359	PF01652	0.288
LIG_FHA_1	133	139	PF00498	0.617
LIG_FHA_1	338	344	PF00498	0.279
LIG_FHA_1	347	353	PF00498	0.328
LIG_FHA_1	368	374	PF00498	0.425
LIG_FHA_2	192	198	PF00498	0.628
LIG_FHA_2	7	13	PF00498	0.660
LIG_LIR_Gen_1	225	234	PF02991	0.600
LIG_LIR_Gen_1	340	347	PF02991	0.242
LIG_LIR_Gen_1	411	421	PF02991	0.538
LIG_LIR_Gen_1	480	485	PF02991	0.530
LIG_LIR_Gen_1	488	494	PF02991	0.500
LIG_LIR_Nem_3	225	229	PF02991	0.603
LIG_LIR_Nem_3	317	323	PF02991	0.511
LIG_LIR_Nem_3	340	344	PF02991	0.295
LIG_LIR_Nem_3	411	417	PF02991	0.502
LIG_LIR_Nem_3	480	484	PF02991	0.526
LIG_LIR_Nem_3	488	493	PF02991	0.495
LIG_Pex14_1	316	320	PF04695	0.368
LIG_SH2_CRK	353	357	PF00017	0.319
LIG_SH2_PTP2	323	326	PF00017	0.338
LIG_SH2_SRC	226	229	PF00017	0.603
LIG_SH2_SRC	490	493	PF00017	0.524
LIG_SH2_STAT5	226	229	PF00017	0.603
LIG_SH2_STAT5	323	326	PF00017	0.287
LIG_SH2_STAT5	327	330	PF00017	0.293
LIG_SH2_STAT5	438	441	PF00017	0.382
LIG_SH2_STAT5	453	456	PF00017	0.241
LIG_SH2_STAT5	481	484	PF00017	0.503
LIG_SH3_3	101	107	PF00018	0.639
LIG_SH3_3	115	121	PF00018	0.660
LIG_SH3_3	167	173	PF00018	0.652
LIG_SH3_3	44	50	PF00018	0.667
LIG_SH3_3	498	504	PF00018	0.583
LIG_SUMO_SIM_anti_2	308	313	PF11976	0.295
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.315
LIG_SUMO_SIM_par_1	134	140	PF11976	0.753
LIG_SUMO_SIM_par_1	355	360	PF11976	0.414
LIG_TYR_ITSM	486	493	PF00017	0.500
LIG_WRC_WIRS_1	338	343	PF05994	0.239
LIG_WRC_WIRS_1	358	363	PF05994	0.332
LIG_WRC_WIRS_1	417	422	PF05994	0.395
MOD_CK1_1	128	134	PF00069	0.623
MOD_CK1_1	140	146	PF00069	0.642
MOD_CK1_1	419	425	PF00069	0.326
MOD_CK1_1	505	511	PF00069	0.659
MOD_CK2_1	128	134	PF00069	0.733
MOD_CK2_1	140	146	PF00069	0.672
MOD_CK2_1	6	12	PF00069	0.623
MOD_CK2_1	99	105	PF00069	0.643
MOD_GlcNHglycan	101	104	PF01048	0.576
MOD_GlcNHglycan	142	145	PF01048	0.433
MOD_GlcNHglycan	264	267	PF01048	0.430
MOD_GlcNHglycan	421	424	PF01048	0.344
MOD_GlcNHglycan	504	507	PF01048	0.423
MOD_GlcNHglycan	51	54	PF01048	0.398
MOD_GlcNHglycan	60	63	PF01048	0.498
MOD_GlcNHglycan	79	82	PF01048	0.438
MOD_GSK3_1	128	135	PF00069	0.653
MOD_GSK3_1	13	20	PF00069	0.687
MOD_GSK3_1	27	34	PF00069	0.653
MOD_GSK3_1	378	385	PF00069	0.480
MOD_GSK3_1	505	512	PF00069	0.581
MOD_GSK3_1	77	84	PF00069	0.612
MOD_GSK3_1	95	102	PF00069	0.640
MOD_N-GLC_1	181	186	PF02516	0.424
MOD_N-GLC_1	71	76	PF02516	0.404
MOD_N-GLC_2	392	394	PF02516	0.281
MOD_N-GLC_2	406	408	PF02516	0.327
MOD_NEK2_1	14	19	PF00069	0.635
MOD_NEK2_1	166	171	PF00069	0.652
MOD_NEK2_1	222	227	PF00069	0.678
MOD_NEK2_1	314	319	PF00069	0.317
MOD_NEK2_1	346	351	PF00069	0.290
MOD_NEK2_1	352	357	PF00069	0.352
MOD_NEK2_1	416	421	PF00069	0.368
MOD_NEK2_1	477	482	PF00069	0.369
MOD_NEK2_1	88	93	PF00069	0.708
MOD_PIKK_1	283	289	PF00454	0.584
MOD_PIKK_1	325	331	PF00454	0.322
MOD_PKA_1	378	384	PF00069	0.517
MOD_PKA_2	210	216	PF00069	0.667
MOD_PKA_2	283	289	PF00069	0.637
MOD_PKA_2	378	384	PF00069	0.475
MOD_Plk_1	14	20	PF00069	0.620
MOD_Plk_1	181	187	PF00069	0.660
MOD_Plk_2-3	6	12	PF00069	0.617
MOD_Plk_4	222	228	PF00069	0.616
MOD_Plk_4	315	321	PF00069	0.308
MOD_Plk_4	346	352	PF00069	0.314
MOD_Plk_4	434	440	PF00069	0.331
MOD_Plk_4	477	483	PF00069	0.215
MOD_ProDKin_1	137	143	PF00069	0.707
MOD_ProDKin_1	19	25	PF00069	0.721
MOD_ProDKin_1	31	37	PF00069	0.709
MOD_ProDKin_1	46	52	PF00069	0.628
MOD_SUMO_rev_2	253	263	PF00179	0.632
MOD_SUMO_rev_2	3	9	PF00179	0.660
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.614
TRG_ENDOCYTIC_2	226	229	PF00928	0.603
TRG_ENDOCYTIC_2	323	326	PF00928	0.368
TRG_ENDOCYTIC_2	353	356	PF00928	0.308
TRG_ENDOCYTIC_2	414	417	PF00928	0.495
TRG_ENDOCYTIC_2	453	456	PF00928	0.221
TRG_ENDOCYTIC_2	481	484	PF00928	0.560
TRG_ENDOCYTIC_2	490	493	PF00928	0.465
TRG_ER_diArg_1	156	158	PF00400	0.691
TRG_ER_diArg_1	283	285	PF00400	0.586
TRG_ER_diArg_1	288	290	PF00400	0.570
TRG_ER_diArg_1	511	514	PF00400	0.627
TRG_ER_diArg_1	516	518	PF00400	0.653
TRG_NLS_Bipartite_1	496	518	PF00514	0.604
TRG_NLS_MonoCore_2	513	518	PF00514	0.640
TRG_NLS_MonoExtC_3	513	518	PF00514	0.600
TRG_NLS_MonoExtN_4	511	518	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I382	Leptomonas seymouri	38%	100%
A0A3S7WRS6	Leishmania donovani	65%	100%
A0A3S7WX91	Leishmania donovani	33%	100%
A4H6N3	Leishmania braziliensis	55%	100%
A4HV16	Leishmania infantum	65%	100%
A4HV17	Leishmania infantum	41%	100%
E9AH03	Leishmania infantum	33%	100%
E9ANQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	83%
E9ANQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4QGX2	Leishmania major	63%	100%