RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6N0_LEIBR

TriTrypDb:

LbrM.11.0840 , LBRM2903_110015100

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6N0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.709
CLV_NRD_NRD_1	731	733	PF00675	0.362
CLV_NRD_NRD_1	775	777	PF00675	0.629
CLV_PCSK_SKI1_1	202	206	PF00082	0.547
CLV_PCSK_SKI1_1	365	369	PF00082	0.582
CLV_PCSK_SKI1_1	539	543	PF00082	0.631
CLV_PCSK_SKI1_1	747	751	PF00082	0.653
CLV_PCSK_SKI1_1	780	784	PF00082	0.627
DEG_Nend_UBRbox_1	1	4	PF02207	0.534
DEG_SCF_FBW7_1	585	592	PF00400	0.599
DEG_SCF_FBW7_2	712	719	PF00400	0.501
DEG_SPOP_SBC_1	208	212	PF00917	0.733
DEG_SPOP_SBC_1	54	58	PF00917	0.553
DEG_SPOP_SBC_1	624	628	PF00917	0.583
DOC_CKS1_1	296	301	PF01111	0.573
DOC_CKS1_1	617	622	PF01111	0.758
DOC_CKS1_1	664	669	PF01111	0.595
DOC_CKS1_1	713	718	PF01111	0.498
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.550
DOC_MAPK_gen_1	173	182	PF00069	0.562
DOC_MAPK_gen_1	280	287	PF00069	0.461
DOC_MAPK_gen_1	776	784	PF00069	0.635
DOC_PP1_RVXF_1	176	183	PF00149	0.646
DOC_PP1_RVXF_1	284	290	PF00149	0.456
DOC_PP1_RVXF_1	768	775	PF00149	0.615
DOC_PP2B_LxvP_1	370	373	PF13499	0.697
DOC_PP2B_LxvP_1	397	400	PF13499	0.557
DOC_PP2B_LxvP_1	608	611	PF13499	0.622
DOC_PP2B_LxvP_1	684	687	PF13499	0.694
DOC_PP2B_LxvP_1	750	753	PF13499	0.705
DOC_PP4_FxxP_1	213	216	PF00568	0.687
DOC_PP4_FxxP_1	393	396	PF00568	0.568
DOC_PP4_FxxP_1	549	552	PF00568	0.735
DOC_PP4_FxxP_1	749	752	PF00568	0.681
DOC_USP7_MATH_1	218	222	PF00917	0.823
DOC_USP7_MATH_1	252	256	PF00917	0.690
DOC_USP7_MATH_1	308	312	PF00917	0.803
DOC_USP7_MATH_1	507	511	PF00917	0.587
DOC_USP7_MATH_1	535	539	PF00917	0.702
DOC_USP7_MATH_1	54	58	PF00917	0.806
DOC_USP7_MATH_1	641	645	PF00917	0.596
DOC_USP7_MATH_1	672	676	PF00917	0.700
DOC_USP7_MATH_1	687	691	PF00917	0.603
DOC_USP7_MATH_2	272	278	PF00917	0.454
DOC_WW_Pin1_4	111	116	PF00397	0.614
DOC_WW_Pin1_4	128	133	PF00397	0.765
DOC_WW_Pin1_4	19	24	PF00397	0.582
DOC_WW_Pin1_4	248	253	PF00397	0.808
DOC_WW_Pin1_4	295	300	PF00397	0.591
DOC_WW_Pin1_4	313	318	PF00397	0.753
DOC_WW_Pin1_4	320	325	PF00397	0.695
DOC_WW_Pin1_4	345	350	PF00397	0.591
DOC_WW_Pin1_4	381	386	PF00397	0.791
DOC_WW_Pin1_4	387	392	PF00397	0.750
DOC_WW_Pin1_4	429	434	PF00397	0.772
DOC_WW_Pin1_4	460	465	PF00397	0.602
DOC_WW_Pin1_4	5	10	PF00397	0.641
DOC_WW_Pin1_4	585	590	PF00397	0.596
DOC_WW_Pin1_4	616	621	PF00397	0.756
DOC_WW_Pin1_4	654	659	PF00397	0.802
DOC_WW_Pin1_4	663	668	PF00397	0.713
DOC_WW_Pin1_4	679	684	PF00397	0.581
DOC_WW_Pin1_4	691	696	PF00397	0.542
DOC_WW_Pin1_4	712	717	PF00397	0.771
DOC_WW_Pin1_4	785	790	PF00397	0.367
LIG_14-3-3_CanoR_1	126	132	PF00244	0.816
LIG_14-3-3_CanoR_1	171	180	PF00244	0.589
LIG_14-3-3_CanoR_1	24	30	PF00244	0.588
LIG_14-3-3_CanoR_1	280	285	PF00244	0.614
LIG_14-3-3_CanoR_1	437	447	PF00244	0.836
LIG_14-3-3_CanoR_1	613	622	PF00244	0.718
LIG_14-3-3_CanoR_1	623	633	PF00244	0.597
LIG_14-3-3_CanoR_1	685	695	PF00244	0.579
LIG_14-3-3_CanoR_1	725	731	PF00244	0.611
LIG_14-3-3_CanoR_1	87	91	PF00244	0.694
LIG_BIR_III_4	37	41	PF00653	0.811
LIG_BRCT_BRCA1_1	244	248	PF00533	0.817
LIG_BRCT_BRCA1_1	389	393	PF00533	0.579
LIG_BRCT_BRCA1_1	6	10	PF00533	0.799
LIG_BRCT_BRCA1_1	736	740	PF00533	0.602
LIG_FHA_1	128	134	PF00498	0.683
LIG_FHA_1	138	144	PF00498	0.519
LIG_FHA_1	266	272	PF00498	0.577
LIG_FHA_1	412	418	PF00498	0.586
LIG_FHA_1	538	544	PF00498	0.639
LIG_FHA_1	56	62	PF00498	0.552
LIG_FHA_1	664	670	PF00498	0.851
LIG_FHA_1	74	80	PF00498	0.655
LIG_FHA_1	94	100	PF00498	0.553
LIG_Integrin_RGD_1	352	354	PF01839	0.577
LIG_LIR_Apic_2	210	216	PF02991	0.672
LIG_LIR_Apic_2	390	396	PF02991	0.569
LIG_LIR_Apic_2	425	431	PF02991	0.629
LIG_LIR_Apic_2	463	469	PF02991	0.598
LIG_LIR_Apic_2	748	752	PF02991	0.674
LIG_LIR_Gen_1	196	204	PF02991	0.398
LIG_LIR_Gen_1	274	279	PF02991	0.439
LIG_LIR_Gen_1	540	549	PF02991	0.657
LIG_LIR_Gen_1	579	585	PF02991	0.600
LIG_LIR_Gen_1	7	18	PF02991	0.555
LIG_LIR_Nem_3	110	116	PF02991	0.828
LIG_LIR_Nem_3	274	278	PF02991	0.441
LIG_LIR_Nem_3	473	478	PF02991	0.592
LIG_LIR_Nem_3	497	502	PF02991	0.603
LIG_LIR_Nem_3	540	545	PF02991	0.625
LIG_LIR_Nem_3	579	583	PF02991	0.604
LIG_LIR_Nem_3	7	13	PF02991	0.804
LIG_LIR_Nem_3	720	726	PF02991	0.657
LIG_LIR_Nem_3	737	743	PF02991	0.331
LIG_Pex14_2	736	740	PF04695	0.602
LIG_REV1ctd_RIR_1	721	729	PF16727	0.640
LIG_SH2_CRK	185	189	PF00017	0.638
LIG_SH2_CRK	428	432	PF00017	0.622
LIG_SH2_CRK	655	659	PF00017	0.704
LIG_SH2_CRK	681	685	PF00017	0.707
LIG_SH2_NCK_1	185	189	PF00017	0.638
LIG_SH2_STAP1	185	189	PF00017	0.638
LIG_SH2_STAP1	262	266	PF00017	0.699
LIG_SH2_STAT5	265	268	PF00017	0.693
LIG_SH2_STAT5	554	557	PF00017	0.801
LIG_SH2_STAT5	735	738	PF00017	0.596
LIG_SH3_1	333	339	PF00018	0.565
LIG_SH3_1	466	472	PF00018	0.593
LIG_SH3_1	655	661	PF00018	0.700
LIG_SH3_2	321	326	PF14604	0.560
LIG_SH3_2	534	539	PF14604	0.744
LIG_SH3_3	129	135	PF00018	0.780
LIG_SH3_3	157	163	PF00018	0.643
LIG_SH3_3	233	239	PF00018	0.650
LIG_SH3_3	311	317	PF00018	0.708
LIG_SH3_3	318	324	PF00018	0.785
LIG_SH3_3	329	335	PF00018	0.625
LIG_SH3_3	375	381	PF00018	0.699
LIG_SH3_3	385	391	PF00018	0.610
LIG_SH3_3	393	399	PF00018	0.748
LIG_SH3_3	466	472	PF00018	0.721
LIG_SH3_3	501	507	PF00018	0.816
LIG_SH3_3	531	537	PF00018	0.808
LIG_SH3_3	572	578	PF00018	0.719
LIG_SH3_3	603	609	PF00018	0.679
LIG_SH3_3	655	661	PF00018	0.700
LIG_SH3_3	680	686	PF00018	0.587
LIG_SH3_3	708	714	PF00018	0.572
LIG_SUMO_SIM_par_1	383	390	PF11976	0.585
LIG_UBA3_1	167	173	PF00899	0.409
LIG_WW_1	752	755	PF00397	0.711
LIG_WW_2	534	537	PF00397	0.779
MOD_CDC14_SPxK_1	323	326	PF00782	0.569
MOD_CDC14_SPxK_1	682	685	PF00782	0.586
MOD_CDC14_SPxK_1	788	791	PF00782	0.389
MOD_CDK_SPK_2	19	24	PF00069	0.569
MOD_CDK_SPK_2	387	392	PF00069	0.583
MOD_CDK_SPK_2	691	696	PF00069	0.589
MOD_CDK_SPxK_1	295	301	PF00069	0.539
MOD_CDK_SPxK_1	320	326	PF00069	0.562
MOD_CDK_SPxK_1	679	685	PF00069	0.591
MOD_CDK_SPxK_1	785	791	PF00069	0.375
MOD_CDK_SPxxK_3	345	352	PF00069	0.585
MOD_CDK_SPxxK_3	616	623	PF00069	0.603
MOD_CDK_SPxxK_3	663	670	PF00069	0.849
MOD_CK1_1	103	109	PF00069	0.808
MOD_CK1_1	131	137	PF00069	0.551
MOD_CK1_1	19	25	PF00069	0.824
MOD_CK1_1	221	227	PF00069	0.610
MOD_CK1_1	312	318	PF00069	0.569
MOD_CK1_1	32	38	PF00069	0.631
MOD_CK1_1	432	438	PF00069	0.756
MOD_CK1_1	442	448	PF00069	0.586
MOD_CK1_1	456	462	PF00069	0.623
MOD_CK1_1	52	58	PF00069	0.482
MOD_CK1_1	579	585	PF00069	0.600
MOD_CK1_1	587	593	PF00069	0.571
MOD_CK1_1	616	622	PF00069	0.810
MOD_CK1_1	625	631	PF00069	0.723
MOD_CK1_1	690	696	PF00069	0.800
MOD_CK1_1	75	81	PF00069	0.682
MOD_CK2_1	248	254	PF00069	0.806
MOD_GlcNHglycan	103	106	PF01048	0.551
MOD_GlcNHglycan	122	125	PF01048	0.516
MOD_GlcNHglycan	220	223	PF01048	0.828
MOD_GlcNHglycan	239	242	PF01048	0.490
MOD_GlcNHglycan	244	247	PF01048	0.682
MOD_GlcNHglycan	34	37	PF01048	0.848
MOD_GlcNHglycan	441	444	PF01048	0.751
MOD_GlcNHglycan	458	461	PF01048	0.576
MOD_GlcNHglycan	569	572	PF01048	0.803
MOD_GlcNHglycan	589	592	PF01048	0.599
MOD_GlcNHglycan	62	65	PF01048	0.712
MOD_GlcNHglycan	633	636	PF01048	0.744
MOD_GlcNHglycan	701	704	PF01048	0.593
MOD_GSK3_1	103	110	PF00069	0.810
MOD_GSK3_1	116	123	PF00069	0.613
MOD_GSK3_1	127	134	PF00069	0.782
MOD_GSK3_1	135	142	PF00069	0.563
MOD_GSK3_1	218	225	PF00069	0.827
MOD_GSK3_1	237	244	PF00069	0.512
MOD_GSK3_1	248	255	PF00069	0.578
MOD_GSK3_1	25	32	PF00069	0.680
MOD_GSK3_1	308	315	PF00069	0.810
MOD_GSK3_1	316	323	PF00069	0.684
MOD_GSK3_1	435	442	PF00069	0.703
MOD_GSK3_1	452	459	PF00069	0.605
MOD_GSK3_1	49	56	PF00069	0.569
MOD_GSK3_1	561	568	PF00069	0.827
MOD_GSK3_1	585	592	PF00069	0.852
MOD_GSK3_1	609	616	PF00069	0.804
MOD_GSK3_1	618	625	PF00069	0.748
MOD_GSK3_1	659	666	PF00069	0.791
MOD_GSK3_1	668	675	PF00069	0.664
MOD_GSK3_1	686	693	PF00069	0.609
MOD_GSK3_1	75	82	PF00069	0.780
MOD_N-GLC_1	116	121	PF02516	0.569
MOD_N-GLC_1	791	796	PF02516	0.684
MOD_NEK2_1	116	121	PF00069	0.569
MOD_NEK2_1	209	214	PF00069	0.500
MOD_NEK2_1	422	427	PF00069	0.693
MOD_NEK2_1	453	458	PF00069	0.596
MOD_NEK2_1	49	54	PF00069	0.572
MOD_NEK2_1	560	565	PF00069	0.593
MOD_NEK2_1	622	627	PF00069	0.600
MOD_NEK2_1	66	71	PF00069	0.551
MOD_NEK2_1	726	731	PF00069	0.572
MOD_NEK2_1	73	78	PF00069	0.691
MOD_NEK2_1	79	84	PF00069	0.759
MOD_NEK2_2	423	428	PF00069	0.594
MOD_NEK2_2	537	542	PF00069	0.654
MOD_PIKK_1	116	122	PF00454	0.572
MOD_PIKK_1	265	271	PF00454	0.707
MOD_PIKK_1	613	619	PF00454	0.758
MOD_PIKK_1	687	693	PF00454	0.693
MOD_PIKK_1	73	79	PF00454	0.564
MOD_PKA_1	280	286	PF00069	0.620
MOD_PKA_2	125	131	PF00069	0.683
MOD_PKA_2	32	38	PF00069	0.846
MOD_PKA_2	453	459	PF00069	0.597
MOD_PKA_2	560	566	PF00069	0.833
MOD_PKA_2	622	628	PF00069	0.592
MOD_PKA_2	698	704	PF00069	0.593
MOD_PKA_2	86	92	PF00069	0.795
MOD_PKB_1	613	621	PF00069	0.600
MOD_Plk_1	791	797	PF00069	0.705
MOD_Plk_2-3	86	92	PF00069	0.795
MOD_Plk_4	139	145	PF00069	0.513
MOD_Plk_4	193	199	PF00069	0.497
MOD_Plk_4	274	280	PF00069	0.699
MOD_Plk_4	309	315	PF00069	0.558
MOD_Plk_4	423	429	PF00069	0.595
MOD_Plk_4	443	449	PF00069	0.497
MOD_Plk_4	57	63	PF00069	0.550
MOD_Plk_4	641	647	PF00069	0.552
MOD_Plk_4	659	665	PF00069	0.502
MOD_Plk_4	726	732	PF00069	0.606
MOD_Plk_4	79	85	PF00069	0.554
MOD_ProDKin_1	111	117	PF00069	0.613
MOD_ProDKin_1	128	134	PF00069	0.762
MOD_ProDKin_1	19	25	PF00069	0.585
MOD_ProDKin_1	248	254	PF00069	0.806
MOD_ProDKin_1	295	301	PF00069	0.594
MOD_ProDKin_1	313	319	PF00069	0.754
MOD_ProDKin_1	320	326	PF00069	0.699
MOD_ProDKin_1	345	351	PF00069	0.585
MOD_ProDKin_1	381	387	PF00069	0.793
MOD_ProDKin_1	429	435	PF00069	0.772
MOD_ProDKin_1	460	466	PF00069	0.604
MOD_ProDKin_1	5	11	PF00069	0.643
MOD_ProDKin_1	585	591	PF00069	0.596
MOD_ProDKin_1	616	622	PF00069	0.757
MOD_ProDKin_1	654	660	PF00069	0.802
MOD_ProDKin_1	663	669	PF00069	0.715
MOD_ProDKin_1	679	685	PF00069	0.609
MOD_ProDKin_1	691	697	PF00069	0.542
MOD_ProDKin_1	712	718	PF00069	0.761
MOD_ProDKin_1	785	791	PF00069	0.375
MOD_SUMO_for_1	260	263	PF00179	0.448
TRG_AP2beta_CARGO_1	738	747	PF09066	0.615
TRG_DiLeu_BaEn_1	274	279	PF01217	0.439
TRG_DiLeu_BaEn_4	550	556	PF01217	0.526
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.638
TRG_ENDOCYTIC_2	185	188	PF00928	0.631
TRG_ENDOCYTIC_2	681	684	PF00928	0.709
TRG_ENDOCYTIC_2	746	749	PF00928	0.623
TRG_ER_diArg_1	30	33	PF00400	0.844
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBB5	Leishmania donovani	65%	98%
A4HV13	Leishmania infantum	64%	98%
E9ANP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	98%
Q4QGX5	Leishmania major	63%	100%