Ribosomal_L7Ae domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6M9_LEIBR

TriTrypDb:

LbrM.11.0830 , LBRM2903_110015000

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	119	123	PF00082	0.530
CLV_PCSK_SKI1_1	129	133	PF00082	0.489
CLV_PCSK_SKI1_1	141	145	PF00082	0.589
CLV_PCSK_SKI1_1	79	83	PF00082	0.394
CLV_PCSK_SKI1_1	93	97	PF00082	0.456
DOC_CKS1_1	63	68	PF01111	0.406
DOC_MAPK_gen_1	129	138	PF00069	0.491
DOC_MAPK_MEF2A_6	132	140	PF00069	0.528
DOC_USP7_MATH_1	22	26	PF00917	0.464
DOC_USP7_UBL2_3	141	145	PF12436	0.481
DOC_WW_Pin1_4	257	262	PF00397	0.571
DOC_WW_Pin1_4	62	67	PF00397	0.491
LIG_14-3-3_CanoR_1	135	139	PF00244	0.481
LIG_14-3-3_CanoR_1	186	190	PF00244	0.324
LIG_APCC_ABBA_1	180	185	PF00400	0.470
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_FHA_1	156	162	PF00498	0.482
LIG_FHA_1	73	79	PF00498	0.446
LIG_FHA_1	87	93	PF00498	0.595
LIG_FHA_2	142	148	PF00498	0.580
LIG_FHA_2	63	69	PF00498	0.435
LIG_GBD_Chelix_1	233	241	PF00786	0.513
LIG_LIR_Gen_1	144	153	PF02991	0.553
LIG_LIR_Nem_3	144	149	PF02991	0.476
LIG_LIR_Nem_3	229	233	PF02991	0.476
LIG_LIR_Nem_3	67	73	PF02991	0.503
LIG_SH2_CRK	205	209	PF00017	0.352
LIG_SH2_CRK	230	234	PF00017	0.513
LIG_SH2_CRK	56	60	PF00017	0.505
LIG_SH2_CRK	70	74	PF00017	0.375
LIG_SH2_NCK_1	217	221	PF00017	0.568
LIG_SH2_NCK_1	56	60	PF00017	0.593
LIG_SH2_SRC	203	206	PF00017	0.304
LIG_SH2_STAP1	56	60	PF00017	0.530
LIG_SH2_STAT5	217	220	PF00017	0.508
LIG_SH3_3	136	142	PF00018	0.538
LIG_SH3_3	56	62	PF00018	0.471
LIG_SH3_3	63	69	PF00018	0.526
LIG_SH3_4	141	148	PF00018	0.582
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.475
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.468
MOD_CDK_SPK_2	257	262	PF00069	0.571
MOD_CK1_1	134	140	PF00069	0.463
MOD_CK1_1	164	170	PF00069	0.546
MOD_CK1_1	229	235	PF00069	0.436
MOD_CK1_1	25	31	PF00069	0.487
MOD_CK1_1	39	45	PF00069	0.442
MOD_CK1_1	64	70	PF00069	0.577
MOD_CK2_1	141	147	PF00069	0.586
MOD_CK2_1	62	68	PF00069	0.464
MOD_GlcNHglycan	101	104	PF01048	0.522
MOD_GlcNHglycan	162	166	PF01048	0.512
MOD_GlcNHglycan	20	23	PF01048	0.471
MOD_GlcNHglycan	38	41	PF01048	0.552
MOD_GSK3_1	153	160	PF00069	0.605
MOD_GSK3_1	164	171	PF00069	0.478
MOD_GSK3_1	18	25	PF00069	0.448
MOD_GSK3_1	211	218	PF00069	0.468
MOD_GSK3_1	31	38	PF00069	0.542
MOD_N-GLC_1	115	120	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	131	136	PF00069	0.520
MOD_NEK2_1	153	158	PF00069	0.503
MOD_PIKK_1	32	38	PF00454	0.474
MOD_PKA_2	134	140	PF00069	0.487
MOD_PKA_2	153	159	PF00069	0.515
MOD_PKA_2	185	191	PF00069	0.327
MOD_Plk_4	134	140	PF00069	0.492
MOD_Plk_4	178	184	PF00069	0.571
MOD_Plk_4	212	218	PF00069	0.511
MOD_Plk_4	72	78	PF00069	0.464
MOD_ProDKin_1	257	263	PF00069	0.572
MOD_ProDKin_1	62	68	PF00069	0.498
MOD_SUMO_for_1	246	249	PF00179	0.566
MOD_SUMO_for_1	251	254	PF00179	0.572
MOD_SUMO_rev_2	239	244	PF00179	0.536
TRG_DiLeu_BaEn_4	239	245	PF01217	0.519
TRG_ENDOCYTIC_2	146	149	PF00928	0.489
TRG_ENDOCYTIC_2	205	208	PF00928	0.342
TRG_ENDOCYTIC_2	230	233	PF00928	0.504
TRG_ENDOCYTIC_2	56	59	PF00928	0.505
TRG_ENDOCYTIC_2	70	73	PF00928	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X8	Leptomonas seymouri	73%	100%
A0A0S4IPH5	Bodo saltans	46%	100%
A0A1X0NV63	Trypanosomatidae	53%	100%
A0A3Q8I815	Leishmania donovani	89%	100%
A0A3R7NL41	Trypanosoma rangeli	52%	100%
A4HV12	Leishmania infantum	89%	100%
D0A7D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ANP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QGX6	Leishmania major	89%	100%