Putative inositol-1,4,5-trisphosphate (IP3) 5-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6M7_LEIBR

TriTrypDb:

LbrM.11.0810 , LBRM2903_110014700

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6M7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	3
GO:0016311	dephosphorylation	5	3
GO:0019637	organophosphate metabolic process	3	3
GO:0019751	polyol metabolic process	4	1
GO:0019932	second-messenger-mediated signaling	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0048016	inositol phosphate-mediated signaling	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:0071704	organic substance metabolic process	2	3
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046488	phosphatidylinositol metabolic process	6	2
GO:0046839	phospholipid dephosphorylation	5	2
GO:0046856	phosphatidylinositol dephosphorylation	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0046030	inositol trisphosphate phosphatase activity	7	11
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	8	9
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	8	9
GO:0052743	inositol tetrakisphosphate phosphatase activity	7	9
GO:0052745	inositol phosphate phosphatase activity	6	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.572
CLV_MEL_PAP_1	143	149	PF00089	0.250
CLV_NRD_NRD_1	136	138	PF00675	0.350
CLV_NRD_NRD_1	179	181	PF00675	0.461
CLV_NRD_NRD_1	28	30	PF00675	0.769
CLV_PCSK_KEX2_1	179	181	PF00082	0.461
CLV_PCSK_KEX2_1	233	235	PF00082	0.530
CLV_PCSK_KEX2_1	28	30	PF00082	0.769
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.515
CLV_PCSK_PC7_1	229	235	PF00082	0.444
CLV_PCSK_SKI1_1	138	142	PF00082	0.385
CLV_PCSK_SKI1_1	166	170	PF00082	0.491
CLV_PCSK_SKI1_1	182	186	PF00082	0.472
CLV_PCSK_SKI1_1	396	400	PF00082	0.462
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DEG_SPOP_SBC_1	10	14	PF00917	0.544
DOC_AGCK_PIF_3	464	467	PF00069	0.457
DOC_CYCLIN_RxL_1	25	35	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.361
DOC_MAPK_gen_1	135	145	PF00069	0.470
DOC_MAPK_MEF2A_6	137	145	PF00069	0.437
DOC_MAPK_NFAT4_5	138	146	PF00069	0.375
DOC_PP1_RVXF_1	26	33	PF00149	0.505
DOC_PP1_RVXF_1	394	400	PF00149	0.311
DOC_PP2B_LxvP_1	100	103	PF13499	0.514
DOC_PP2B_LxvP_1	358	361	PF13499	0.521
DOC_PP4_FxxP_1	245	248	PF00568	0.421
DOC_PP4_FxxP_1	88	91	PF00568	0.561
DOC_USP7_MATH_1	133	137	PF00917	0.412
DOC_USP7_MATH_1	168	172	PF00917	0.447
DOC_USP7_MATH_1	189	193	PF00917	0.472
DOC_USP7_MATH_1	300	304	PF00917	0.509
DOC_USP7_MATH_1	305	309	PF00917	0.500
DOC_USP7_MATH_1	421	425	PF00917	0.647
DOC_USP7_MATH_1	449	453	PF00917	0.559
DOC_USP7_MATH_1	82	86	PF00917	0.417
DOC_WW_Pin1_4	169	174	PF00397	0.372
DOC_WW_Pin1_4	292	297	PF00397	0.517
DOC_WW_Pin1_4	376	381	PF00397	0.596
DOC_WW_Pin1_4	87	92	PF00397	0.592
LIG_14-3-3_CanoR_1	28	33	PF00244	0.570
LIG_14-3-3_CanoR_1	355	361	PF00244	0.658
LIG_APCC_ABBA_1	157	162	PF00400	0.327
LIG_APCC_ABBA_1	201	206	PF00400	0.302
LIG_BRCT_BRCA1_1	126	130	PF00533	0.467
LIG_BRCT_BRCA1_1	143	147	PF00533	0.228
LIG_BRCT_BRCA1_1	84	88	PF00533	0.439
LIG_deltaCOP1_diTrp_1	239	245	PF00928	0.368
LIG_eIF4E_1	450	456	PF01652	0.420
LIG_eIF4E_1	63	69	PF01652	0.450
LIG_FHA_1	19	25	PF00498	0.718
LIG_FHA_1	313	319	PF00498	0.689
LIG_FHA_1	347	353	PF00498	0.806
LIG_FHA_1	64	70	PF00498	0.571
LIG_FHA_2	244	250	PF00498	0.431
LIG_FHA_2	254	260	PF00498	0.583
LIG_FHA_2	456	462	PF00498	0.513
LIG_FHA_2	62	68	PF00498	0.559
LIG_LIR_Apic_2	243	248	PF02991	0.423
LIG_LIR_Apic_2	85	91	PF02991	0.554
LIG_LIR_Gen_1	239	248	PF02991	0.415
LIG_LIR_Gen_1	461	467	PF02991	0.565
LIG_LIR_Gen_1	77	88	PF02991	0.504
LIG_LIR_Nem_3	106	110	PF02991	0.393
LIG_LIR_Nem_3	144	150	PF02991	0.355
LIG_LIR_Nem_3	239	245	PF02991	0.414
LIG_LIR_Nem_3	287	291	PF02991	0.488
LIG_LIR_Nem_3	445	450	PF02991	0.626
LIG_LIR_Nem_3	461	467	PF02991	0.477
LIG_LIR_Nem_3	77	83	PF02991	0.508
LIG_PDZ_Class_2	462	467	PF00595	0.305
LIG_Pex14_2	241	245	PF04695	0.378
LIG_Rb_LxCxE_1	231	253	PF01857	0.438
LIG_SH2_NCK_1	450	454	PF00017	0.559
LIG_SH2_PTP2	107	110	PF00017	0.506
LIG_SH2_SRC	107	110	PF00017	0.506
LIG_SH2_STAT5	107	110	PF00017	0.532
LIG_SH2_STAT5	176	179	PF00017	0.495
LIG_SH2_STAT5	288	291	PF00017	0.460
LIG_SH2_STAT5	63	66	PF00017	0.725
LIG_SH3_3	108	114	PF00018	0.516
LIG_SH3_3	351	357	PF00018	0.783
LIG_SH3_3	358	364	PF00018	0.707
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.411
LIG_SUMO_SIM_anti_2	452	459	PF11976	0.505
LIG_SUMO_SIM_par_1	192	199	PF11976	0.390
LIG_SUMO_SIM_par_1	339	345	PF11976	0.488
LIG_TRAF2_1	342	345	PF00917	0.489
LIG_WW_2	361	364	PF00397	0.467
MOD_CDC14_SPxK_1	379	382	PF00782	0.573
MOD_CDK_SPK_2	87	92	PF00069	0.565
MOD_CDK_SPxK_1	376	382	PF00069	0.586
MOD_CK1_1	11	17	PF00069	0.725
MOD_CK1_1	171	177	PF00069	0.432
MOD_CK1_1	442	448	PF00069	0.588
MOD_CK1_1	59	65	PF00069	0.683
MOD_CK1_1	98	104	PF00069	0.355
MOD_CK2_1	247	253	PF00069	0.523
MOD_CK2_1	270	276	PF00069	0.367
MOD_CK2_1	339	345	PF00069	0.488
MOD_Cter_Amidation	177	180	PF01082	0.397
MOD_GlcNHglycan	126	129	PF01048	0.378
MOD_GlcNHglycan	190	194	PF01048	0.480
MOD_GlcNHglycan	302	305	PF01048	0.656
MOD_GlcNHglycan	307	310	PF01048	0.639
MOD_GlcNHglycan	328	331	PF01048	0.590
MOD_GlcNHglycan	358	361	PF01048	0.647
MOD_GlcNHglycan	413	416	PF01048	0.550
MOD_GlcNHglycan	430	433	PF01048	0.565
MOD_GlcNHglycan	48	51	PF01048	0.737
MOD_GSK3_1	243	250	PF00069	0.443
MOD_GSK3_1	28	35	PF00069	0.803
MOD_GSK3_1	300	307	PF00069	0.608
MOD_GSK3_1	321	328	PF00069	0.570
MOD_GSK3_1	416	423	PF00069	0.572
MOD_GSK3_1	59	66	PF00069	0.699
MOD_GSK3_1	78	85	PF00069	0.424
MOD_N-GLC_1	35	40	PF02516	0.700
MOD_N-GLC_1	59	64	PF02516	0.522
MOD_N-GLC_2	153	155	PF02516	0.428
MOD_N-GLC_2	384	386	PF02516	0.459
MOD_NEK2_1	124	129	PF00069	0.502
MOD_NEK2_1	141	146	PF00069	0.320
MOD_NEK2_1	224	229	PF00069	0.472
MOD_NEK2_1	32	37	PF00069	0.630
MOD_NEK2_1	9	14	PF00069	0.775
MOD_OFUCOSY	441	446	PF10250	0.415
MOD_PIKK_1	247	253	PF00454	0.591
MOD_PIKK_1	312	318	PF00454	0.489
MOD_PIKK_1	321	327	PF00454	0.489
MOD_PIKK_1	416	422	PF00454	0.579
MOD_PKA_1	28	34	PF00069	0.651
MOD_PKA_2	18	24	PF00069	0.545
MOD_PKA_2	28	34	PF00069	0.596
MOD_PKA_2	56	62	PF00069	0.710
MOD_Plk_1	189	195	PF00069	0.468
MOD_Plk_1	442	448	PF00069	0.488
MOD_Plk_1	59	65	PF00069	0.464
MOD_Plk_2-3	243	249	PF00069	0.300
MOD_Plk_2-3	339	345	PF00069	0.488
MOD_Plk_2-3	67	73	PF00069	0.431
MOD_Plk_4	284	290	PF00069	0.391
MOD_Plk_4	421	427	PF00069	0.581
MOD_Plk_4	82	88	PF00069	0.417
MOD_ProDKin_1	169	175	PF00069	0.375
MOD_ProDKin_1	292	298	PF00069	0.518
MOD_ProDKin_1	376	382	PF00069	0.586
MOD_ProDKin_1	87	93	PF00069	0.586
MOD_SUMO_rev_2	206	216	PF00179	0.413
MOD_SUMO_rev_2	218	224	PF00179	0.342
TRG_DiLeu_BaEn_1	261	266	PF01217	0.334
TRG_ENDOCYTIC_2	107	110	PF00928	0.530
TRG_ENDOCYTIC_2	288	291	PF00928	0.508
TRG_ENDOCYTIC_2	450	453	PF00928	0.450
TRG_ER_diArg_1	16	19	PF00400	0.612
TRG_ER_diArg_1	179	182	PF00400	0.419
TRG_ER_diArg_1	254	257	PF00400	0.523
TRG_ER_diArg_1	28	30	PF00400	0.695
TRG_ER_diArg_1	352	355	PF00400	0.653
TRG_NLS_MonoExtN_4	230	237	PF00514	0.506
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E4	Leptomonas seymouri	53%	70%
A0A1X0NVI9	Trypanosomatidae	37%	80%
A0A3S5H6J4	Leishmania donovani	75%	68%
A0A422NRL6	Trypanosoma rangeli	39%	81%
A4HV10	Leishmania infantum	75%	68%
D0A7D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	83%
E9ANP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	68%
Q4QGX8	Leishmania major	73%	100%
V5DT49	Trypanosoma cruzi	41%	100%