Adaptin-related protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adaptin-related protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H6M5_LEIBR

TriTrypDb:

LbrM.11.0790 , LBRM2903_110014500

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	11
GO:0032991	protein-containing complex	1	11
GO:0098796	membrane protein complex	2	11

Expansion

Sequence features

A4H6M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6M5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0030276	clathrin binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.168
CLV_C14_Caspase3-7	536	540	PF00656	0.325
CLV_C14_Caspase3-7	605	609	PF00656	0.192
CLV_MEL_PAP_1	423	429	PF00089	0.168
CLV_NRD_NRD_1	141	143	PF00675	0.249
CLV_NRD_NRD_1	256	258	PF00675	0.292
CLV_NRD_NRD_1	358	360	PF00675	0.294
CLV_PCSK_FUR_1	253	257	PF00082	0.271
CLV_PCSK_KEX2_1	141	143	PF00082	0.249
CLV_PCSK_KEX2_1	253	255	PF00082	0.294
CLV_PCSK_KEX2_1	256	258	PF00082	0.281
CLV_PCSK_KEX2_1	358	360	PF00082	0.282
CLV_PCSK_KEX2_1	633	635	PF00082	0.515
CLV_PCSK_KEX2_1	69	71	PF00082	0.268
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.507
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.268
CLV_PCSK_SKI1_1	111	115	PF00082	0.293
CLV_PCSK_SKI1_1	169	173	PF00082	0.448
CLV_PCSK_SKI1_1	185	189	PF00082	0.249
CLV_PCSK_SKI1_1	212	216	PF00082	0.168
CLV_PCSK_SKI1_1	359	363	PF00082	0.168
CLV_PCSK_SKI1_1	617	621	PF00082	0.290
CLV_PCSK_SKI1_1	623	627	PF00082	0.224
CLV_PCSK_SKI1_1	633	637	PF00082	0.360
CLV_PCSK_SKI1_1	731	735	PF00082	0.572
CLV_PCSK_SKI1_1	786	790	PF00082	0.327
CLV_PCSK_SKI1_1	806	810	PF00082	0.454
CLV_PCSK_SKI1_1	86	90	PF00082	0.249
DEG_APCC_DBOX_1	358	366	PF00400	0.251
DEG_COP1_1	342	351	PF00400	0.265
DEG_MDM2_SWIB_1	891	898	PF02201	0.481
DEG_SCF_FBW7_1	391	396	PF00400	0.265
DEG_SPOP_SBC_1	263	267	PF00917	0.325
DEG_SPOP_SBC_1	340	344	PF00917	0.272
DEG_SPOP_SBC_1	59	63	PF00917	0.381
DEG_SPOP_SBC_1	660	664	PF00917	0.417
DEG_SPOP_SBC_1	738	742	PF00917	0.504
DEG_SPOP_SBC_1	996	1000	PF00917	0.491
DOC_CKS1_1	16	21	PF01111	0.461
DOC_CKS1_1	390	395	PF01111	0.325
DOC_CKS1_1	765	770	PF01111	0.456
DOC_CYCLIN_RxL_1	166	175	PF00134	0.325
DOC_CYCLIN_RxL_1	207	219	PF00134	0.168
DOC_CYCLIN_RxL_1	675	686	PF00134	0.471
DOC_MAPK_gen_1	141	148	PF00069	0.381
DOC_MAPK_gen_1	355	364	PF00069	0.168
DOC_MAPK_gen_1	417	427	PF00069	0.268
DOC_MAPK_gen_1	69	76	PF00069	0.268
DOC_MAPK_gen_1	803	812	PF00069	0.461
DOC_MAPK_HePTP_8	963	975	PF00069	0.366
DOC_MAPK_JIP1_4	678	684	PF00069	0.472
DOC_MAPK_MEF2A_6	111	120	PF00069	0.293
DOC_MAPK_MEF2A_6	409	418	PF00069	0.266
DOC_MAPK_MEF2A_6	420	427	PF00069	0.293
DOC_MAPK_MEF2A_6	835	843	PF00069	0.474
DOC_MAPK_MEF2A_6	940	947	PF00069	0.465
DOC_MAPK_MEF2A_6	966	975	PF00069	0.412
DOC_PP2B_LxvP_1	346	349	PF13499	0.381
DOC_PP2B_LxvP_1	372	375	PF13499	0.381
DOC_PP2B_LxvP_1	879	882	PF13499	0.309
DOC_PP2B_LxvP_1	994	997	PF13499	0.289
DOC_PP4_FxxP_1	16	19	PF00568	0.425
DOC_PP4_FxxP_1	390	393	PF00568	0.381
DOC_PP4_FxxP_1	410	413	PF00568	0.381
DOC_USP7_MATH_1	156	160	PF00917	0.378
DOC_USP7_MATH_1	262	266	PF00917	0.280
DOC_USP7_MATH_1	340	344	PF00917	0.272
DOC_USP7_MATH_1	351	355	PF00917	0.428
DOC_USP7_MATH_1	59	63	PF00917	0.268
DOC_USP7_MATH_1	660	664	PF00917	0.422
DOC_USP7_MATH_1	720	724	PF00917	0.523
DOC_USP7_MATH_1	738	742	PF00917	0.675
DOC_USP7_UBL2_3	169	173	PF12436	0.176
DOC_USP7_UBL2_3	405	409	PF12436	0.381
DOC_WW_Pin1_4	15	20	PF00397	0.478
DOC_WW_Pin1_4	258	263	PF00397	0.168
DOC_WW_Pin1_4	274	279	PF00397	0.125
DOC_WW_Pin1_4	320	325	PF00397	0.378
DOC_WW_Pin1_4	389	394	PF00397	0.325
DOC_WW_Pin1_4	764	769	PF00397	0.505
DOC_WW_Pin1_4	847	852	PF00397	0.483
DOC_WW_Pin1_4	99	104	PF00397	0.249
LIG_14-3-3_CanoR_1	32	41	PF00244	0.268
LIG_14-3-3_CanoR_1	359	365	PF00244	0.381
LIG_14-3-3_CanoR_1	623	628	PF00244	0.325
LIG_14-3-3_CanoR_1	634	644	PF00244	0.336
LIG_14-3-3_CanoR_1	806	811	PF00244	0.396
LIG_14-3-3_CanoR_1	918	926	PF00244	0.382
LIG_Actin_WH2_2	564	579	PF00022	0.301
LIG_APCC_ABBA_1	945	950	PF00400	0.420
LIG_BRCT_BRCA1_1	50	54	PF00533	0.268
LIG_Clathr_ClatBox_1	407	411	PF01394	0.381
LIG_Clathr_ClatBox_1	624	628	PF01394	0.325
LIG_deltaCOP1_diTrp_1	777	783	PF00928	0.243
LIG_EH1_1	208	216	PF00400	0.325
LIG_FHA_1	1	7	PF00498	0.479
LIG_FHA_1	124	130	PF00498	0.337
LIG_FHA_1	16	22	PF00498	0.443
LIG_FHA_1	220	226	PF00498	0.325
LIG_FHA_1	274	280	PF00498	0.345
LIG_FHA_1	394	400	PF00498	0.373
LIG_FHA_1	480	486	PF00498	0.311
LIG_FHA_1	490	496	PF00498	0.282
LIG_FHA_1	506	512	PF00498	0.293
LIG_FHA_1	544	550	PF00498	0.248
LIG_FHA_1	605	611	PF00498	0.388
LIG_FHA_1	637	643	PF00498	0.566
LIG_FHA_1	803	809	PF00498	0.484
LIG_FHA_1	850	856	PF00498	0.503
LIG_FHA_1	918	924	PF00498	0.457
LIG_FHA_2	304	310	PF00498	0.168
LIG_FHA_2	442	448	PF00498	0.174
LIG_FHA_2	463	469	PF00498	0.168
LIG_FHA_2	517	523	PF00498	0.215
LIG_FHA_2	826	832	PF00498	0.492
LIG_FHA_2	882	888	PF00498	0.463
LIG_FHA_2	96	102	PF00498	0.288
LIG_LIR_Apic_2	901	906	PF02991	0.370
LIG_LIR_Gen_1	208	216	PF02991	0.393
LIG_LIR_Gen_1	35	46	PF02991	0.352
LIG_LIR_Gen_1	378	388	PF02991	0.249
LIG_LIR_Gen_1	412	423	PF02991	0.249
LIG_LIR_Gen_1	51	60	PF02991	0.161
LIG_LIR_Gen_1	546	556	PF02991	0.334
LIG_LIR_Gen_1	646	656	PF02991	0.518
LIG_LIR_Gen_1	759	769	PF02991	0.496
LIG_LIR_Nem_3	35	41	PF02991	0.381
LIG_LIR_Nem_3	378	384	PF02991	0.301
LIG_LIR_Nem_3	392	398	PF02991	0.213
LIG_LIR_Nem_3	51	57	PF02991	0.157
LIG_LIR_Nem_3	546	551	PF02991	0.360
LIG_LIR_Nem_3	608	614	PF02991	0.386
LIG_LIR_Nem_3	646	652	PF02991	0.568
LIG_LIR_Nem_3	759	765	PF02991	0.514
LIG_LIR_Nem_3	893	898	PF02991	0.423
LIG_LYPXL_S_1	610	614	PF13949	0.265
LIG_LYPXL_yS_3	611	614	PF13949	0.265
LIG_NRBOX	167	173	PF00104	0.381
LIG_NRBOX	941	947	PF00104	0.377
LIG_PCNA_APIM_2	403	409	PF02747	0.381
LIG_PCNA_PIPBox_1	568	577	PF02747	0.381
LIG_Pex14_1	220	224	PF04695	0.249
LIG_Pex14_2	12	16	PF04695	0.426
LIG_Pex14_2	406	410	PF04695	0.366
LIG_Pex14_2	652	656	PF04695	0.380
LIG_Pex14_2	891	895	PF04695	0.360
LIG_PTB_Apo_2	10	17	PF02174	0.416
LIG_REV1ctd_RIR_1	617	627	PF16727	0.328
LIG_SH2_CRK	321	325	PF00017	0.381
LIG_SH2_CRK	38	42	PF00017	0.325
LIG_SH2_GRB2like	11	14	PF00017	0.423
LIG_SH2_NCK_1	152	156	PF00017	0.325
LIG_SH2_PTP2	381	384	PF00017	0.325
LIG_SH2_SRC	152	155	PF00017	0.168
LIG_SH2_STAP1	360	364	PF00017	0.433
LIG_SH2_STAT5	11	14	PF00017	0.541
LIG_SH2_STAT5	139	142	PF00017	0.249
LIG_SH2_STAT5	199	202	PF00017	0.381
LIG_SH2_STAT5	224	227	PF00017	0.249
LIG_SH2_STAT5	304	307	PF00017	0.381
LIG_SH2_STAT5	381	384	PF00017	0.301
LIG_SH2_STAT5	398	401	PF00017	0.184
LIG_SH2_STAT5	415	418	PF00017	0.152
LIG_SH2_STAT5	443	446	PF00017	0.381
LIG_SH2_STAT5	548	551	PF00017	0.411
LIG_SH2_STAT5	575	578	PF00017	0.249
LIG_SH2_STAT5	73	76	PF00017	0.249
LIG_SH2_STAT5	868	871	PF00017	0.358
LIG_SH2_STAT5	878	881	PF00017	0.335
LIG_SH2_STAT5	948	951	PF00017	0.366
LIG_SH2_STAT5	985	988	PF00017	0.404
LIG_SH3_1	256	262	PF00018	0.168
LIG_SH3_3	122	128	PF00018	0.263
LIG_SH3_3	256	262	PF00018	0.377
LIG_SH3_3	272	278	PF00018	0.147
LIG_SH3_3	391	397	PF00018	0.325
LIG_SH3_3	673	679	PF00018	0.300
LIG_SH3_3	747	753	PF00018	0.670
LIG_SH3_3	762	768	PF00018	0.442
LIG_SH3_3	866	872	PF00018	0.329
LIG_SH3_5	797	801	PF00018	0.424
LIG_SUMO_SIM_anti_2	323	329	PF11976	0.378
LIG_SUMO_SIM_anti_2	446	454	PF11976	0.310
LIG_SUMO_SIM_anti_2	517	522	PF11976	0.332
LIG_SUMO_SIM_anti_2	546	554	PF11976	0.379
LIG_SUMO_SIM_anti_2	838	843	PF11976	0.477
LIG_SUMO_SIM_anti_2	860	865	PF11976	0.261
LIG_SUMO_SIM_par_1	323	329	PF11976	0.381
LIG_TRAF2_1	444	447	PF00917	0.195
LIG_TRFH_1	878	882	PF08558	0.429
LIG_TYR_ITAM	608	624	PF00017	0.265
LIG_TYR_ITIM	71	76	PF00017	0.249
LIG_TYR_ITSM	544	551	PF00017	0.263
LIG_UBA3_1	164	173	PF00899	0.293
LIG_UBA3_1	778	786	PF00899	0.264
MOD_CDK_SPxxK_3	15	22	PF00069	0.297
MOD_CDK_SPxxK_3	274	281	PF00069	0.168
MOD_CDK_SPxxK_3	99	106	PF00069	0.249
MOD_CK1_1	159	165	PF00069	0.356
MOD_CK1_1	273	279	PF00069	0.306
MOD_CK1_1	58	64	PF00069	0.342
MOD_CK1_1	604	610	PF00069	0.298
MOD_CK1_1	674	680	PF00069	0.432
MOD_CK1_1	739	745	PF00069	0.643
MOD_CK1_1	755	761	PF00069	0.630
MOD_CK1_1	826	832	PF00069	0.371
MOD_CK1_1	959	965	PF00069	0.429
MOD_CK1_1	974	980	PF00069	0.555
MOD_CK2_1	24	30	PF00069	0.328
MOD_CK2_1	241	247	PF00069	0.168
MOD_CK2_1	268	274	PF00069	0.332
MOD_CK2_1	303	309	PF00069	0.168
MOD_CK2_1	425	431	PF00069	0.447
MOD_CK2_1	441	447	PF00069	0.169
MOD_CK2_1	462	468	PF00069	0.426
MOD_CK2_1	516	522	PF00069	0.249
MOD_CK2_1	537	543	PF00069	0.375
MOD_CK2_1	645	651	PF00069	0.635
MOD_CK2_1	697	703	PF00069	0.445
MOD_CK2_1	825	831	PF00069	0.553
MOD_CK2_1	881	887	PF00069	0.504
MOD_CMANNOS	780	783	PF00535	0.260
MOD_Cter_Amidation	251	254	PF01082	0.168
MOD_GlcNHglycan	134	139	PF01048	0.415
MOD_GlcNHglycan	181	184	PF01048	0.293
MOD_GlcNHglycan	328	331	PF01048	0.277
MOD_GlcNHglycan	34	37	PF01048	0.286
MOD_GlcNHglycan	49	53	PF01048	0.224
MOD_GlcNHglycan	56	60	PF01048	0.309
MOD_GlcNHglycan	588	591	PF01048	0.406
MOD_GlcNHglycan	663	666	PF01048	0.488
MOD_GlcNHglycan	722	725	PF01048	0.640
MOD_GlcNHglycan	825	828	PF01048	0.289
MOD_GlcNHglycan	976	979	PF01048	0.569
MOD_GSK3_1	258	265	PF00069	0.385
MOD_GSK3_1	269	276	PF00069	0.407
MOD_GSK3_1	389	396	PF00069	0.360
MOD_GSK3_1	397	404	PF00069	0.349
MOD_GSK3_1	510	517	PF00069	0.195
MOD_GSK3_1	537	544	PF00069	0.388
MOD_GSK3_1	547	554	PF00069	0.368
MOD_GSK3_1	55	62	PF00069	0.295
MOD_GSK3_1	736	743	PF00069	0.610
MOD_GSK3_1	752	759	PF00069	0.590
MOD_GSK3_1	760	767	PF00069	0.499
MOD_GSK3_1	778	785	PF00069	0.367
MOD_GSK3_1	802	809	PF00069	0.457
MOD_GSK3_1	914	921	PF00069	0.527
MOD_GSK3_1	95	102	PF00069	0.249
MOD_LATS_1	804	810	PF00433	0.473
MOD_N-GLC_1	156	161	PF02516	0.325
MOD_N-GLC_1	269	274	PF02516	0.168
MOD_N-GLC_1	64	69	PF02516	0.298
MOD_NEK2_1	172	177	PF00069	0.338
MOD_NEK2_1	451	456	PF00069	0.381
MOD_NEK2_1	462	467	PF00069	0.333
MOD_NEK2_1	480	485	PF00069	0.231
MOD_NEK2_1	514	519	PF00069	0.381
MOD_NEK2_1	60	65	PF00069	0.249
MOD_NEK2_1	778	783	PF00069	0.350
MOD_NEK2_1	802	807	PF00069	0.426
MOD_NEK2_1	825	830	PF00069	0.471
MOD_NEK2_1	898	903	PF00069	0.484
MOD_NEK2_1	971	976	PF00069	0.388
MOD_NEK2_2	606	611	PF00069	0.325
MOD_PIKK_1	24	30	PF00454	0.249
MOD_PIKK_1	551	557	PF00454	0.217
MOD_PIKK_1	654	660	PF00454	0.549
MOD_PIKK_1	956	962	PF00454	0.235
MOD_PKA_2	425	431	PF00069	0.447
MOD_PKA_2	654	660	PF00069	0.423
MOD_PKA_2	802	808	PF00069	0.423
MOD_PKA_2	917	923	PF00069	0.389
MOD_Plk_1	134	140	PF00069	0.381
MOD_Plk_1	308	314	PF00069	0.381
MOD_Plk_1	351	357	PF00069	0.325
MOD_Plk_1	489	495	PF00069	0.381
MOD_Plk_1	55	61	PF00069	0.286
MOD_Plk_1	64	70	PF00069	0.210
MOD_Plk_1	837	843	PF00069	0.475
MOD_Plk_1	84	90	PF00069	0.282
MOD_Plk_1	914	920	PF00069	0.463
MOD_Plk_4	195	201	PF00069	0.381
MOD_Plk_4	360	366	PF00069	0.324
MOD_Plk_4	489	495	PF00069	0.287
MOD_Plk_4	516	522	PF00069	0.381
MOD_Plk_4	547	553	PF00069	0.270
MOD_Plk_4	606	612	PF00069	0.270
MOD_Plk_4	671	677	PF00069	0.329
MOD_Plk_4	761	767	PF00069	0.469
MOD_Plk_4	898	904	PF00069	0.575
MOD_Plk_4	90	96	PF00069	0.381
MOD_Plk_4	966	972	PF00069	0.416
MOD_ProDKin_1	15	21	PF00069	0.470
MOD_ProDKin_1	258	264	PF00069	0.168
MOD_ProDKin_1	274	280	PF00069	0.125
MOD_ProDKin_1	320	326	PF00069	0.378
MOD_ProDKin_1	389	395	PF00069	0.325
MOD_ProDKin_1	764	770	PF00069	0.507
MOD_ProDKin_1	847	853	PF00069	0.485
MOD_ProDKin_1	99	105	PF00069	0.249
MOD_SUMO_for_1	408	411	PF00179	0.282
MOD_SUMO_for_1	416	419	PF00179	0.217
MOD_SUMO_rev_2	522	529	PF00179	0.179
MOD_SUMO_rev_2	829	837	PF00179	0.508
TRG_DiLeu_BaEn_1	352	357	PF01217	0.356
TRG_DiLeu_BaEn_1	419	424	PF01217	0.293
TRG_DiLeu_BaEn_1	447	452	PF01217	0.168
TRG_DiLeu_BaEn_1	558	563	PF01217	0.298
TRG_DiLeu_BaEn_1	838	843	PF01217	0.427
TRG_DiLeu_BaEn_2	489	495	PF01217	0.168
TRG_DiLeu_LyEn_5	352	357	PF01217	0.265
TRG_ENDOCYTIC_2	38	41	PF00928	0.385
TRG_ENDOCYTIC_2	381	384	PF00928	0.254
TRG_ENDOCYTIC_2	415	418	PF00928	0.261
TRG_ENDOCYTIC_2	43	46	PF00928	0.331
TRG_ENDOCYTIC_2	548	551	PF00928	0.381
TRG_ENDOCYTIC_2	611	614	PF00928	0.346
TRG_ENDOCYTIC_2	621	624	PF00928	0.196
TRG_ENDOCYTIC_2	73	76	PF00928	0.267
TRG_ENDOCYTIC_2	878	881	PF00928	0.434
TRG_ER_diArg_1	140	142	PF00400	0.249
TRG_ER_diArg_1	253	256	PF00400	0.241
TRG_ER_diArg_1	345	348	PF00400	0.451
TRG_ER_diArg_1	357	359	PF00400	0.282
TRG_ER_diArg_1	792	795	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.168
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.192
TRG_Pf-PMV_PEXEL_1	806	811	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P942	Leptomonas seymouri	63%	100%
A0A0S4IS43	Bodo saltans	32%	100%
A0A1X0NUY1	Trypanosomatidae	34%	100%
A0A3Q8I939	Leishmania donovani	82%	100%
A0A3R7L5L0	Trypanosoma rangeli	36%	100%
A0A422NM75	Trypanosoma rangeli	22%	100%
A4HV08	Leishmania infantum	82%	100%
E9ANP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGY0	Leishmania major	81%	99%
Q54X82	Dictyostelium discoideum	29%	100%
V5BRU9	Trypanosoma cruzi	34%	100%