ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6M1_LEIBR

TriTrypDb:

LbrM.11.0750 , LBRM2903_110014200

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.605
CLV_NRD_NRD_1	138	140	PF00675	0.586
CLV_NRD_NRD_1	291	293	PF00675	0.502
CLV_NRD_NRD_1	304	306	PF00675	0.584
CLV_NRD_NRD_1	313	315	PF00675	0.577
CLV_PCSK_KEX2_1	138	140	PF00082	0.586
CLV_PCSK_KEX2_1	304	306	PF00082	0.584
CLV_PCSK_KEX2_1	313	315	PF00082	0.577
CLV_PCSK_KEX2_1	414	416	PF00082	0.665
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.710
CLV_PCSK_SKI1_1	145	149	PF00082	0.686
CLV_PCSK_SKI1_1	314	318	PF00082	0.564
DEG_Nend_UBRbox_1	1	4	PF02207	0.513
DEG_ODPH_VHL_1	360	372	PF01847	0.517
DEG_SPOP_SBC_1	102	106	PF00917	0.664
DEG_SPOP_SBC_1	117	121	PF00917	0.562
DEG_SPOP_SBC_1	40	44	PF00917	0.531
DOC_MAPK_gen_1	292	300	PF00069	0.547
DOC_MAPK_gen_1	310	320	PF00069	0.546
DOC_MAPK_MEF2A_6	13	20	PF00069	0.490
DOC_USP7_MATH_1	102	106	PF00917	0.654
DOC_USP7_MATH_1	118	122	PF00917	0.636
DOC_USP7_MATH_1	335	339	PF00917	0.705
DOC_USP7_MATH_1	40	44	PF00917	0.577
DOC_USP7_MATH_1	50	54	PF00917	0.517
DOC_USP7_MATH_2	153	159	PF00917	0.552
DOC_USP7_MATH_2	271	277	PF00917	0.392
DOC_WW_Pin1_4	189	194	PF00397	0.527
DOC_WW_Pin1_4	240	245	PF00397	0.657
LIG_CAP-Gly_1	511	516	PF01302	0.594
LIG_EH_1	173	177	PF12763	0.509
LIG_FHA_1	320	326	PF00498	0.514
LIG_FHA_1	481	487	PF00498	0.714
LIG_FHA_1	70	76	PF00498	0.493
LIG_FHA_2	118	124	PF00498	0.536
LIG_FHA_2	442	448	PF00498	0.553
LIG_LIR_Nem_3	180	185	PF02991	0.586
LIG_PDZ_Class_3	511	516	PF00595	0.679
LIG_Pex14_2	147	151	PF04695	0.558
LIG_RPA_C_Fungi	278	290	PF08784	0.415
LIG_SH2_NCK_1	11	15	PF00017	0.497
LIG_SH2_NCK_1	23	27	PF00017	0.479
LIG_SH2_NCK_1	377	381	PF00017	0.674
LIG_SH2_SRC	23	26	PF00017	0.483
LIG_SH2_STAT3	35	38	PF00017	0.507
LIG_SH2_STAT5	109	112	PF00017	0.515
LIG_SH2_STAT5	146	149	PF00017	0.557
LIG_SH2_STAT5	64	67	PF00017	0.512
LIG_SH3_1	305	311	PF00018	0.557
LIG_SH3_2	308	313	PF14604	0.553
LIG_SH3_3	169	175	PF00018	0.681
LIG_SH3_3	187	193	PF00018	0.475
LIG_SH3_3	303	309	PF00018	0.568
LIG_SH3_3	315	321	PF00018	0.530
LIG_SUMO_SIM_par_1	275	281	PF11976	0.536
LIG_SUMO_SIM_par_1	346	351	PF11976	0.525
LIG_WW_3	140	144	PF00397	0.579
LIG_WW_3	28	32	PF00397	0.501
LIG_WW_3	307	311	PF00397	0.550
MOD_CDC14_SPxK_1	243	246	PF00782	0.642
MOD_CDK_SPxK_1	240	246	PF00069	0.655
MOD_CK1_1	113	119	PF00069	0.609
MOD_CK1_1	405	411	PF00069	0.551
MOD_CK1_1	59	65	PF00069	0.571
MOD_CK1_1	91	97	PF00069	0.565
MOD_CK1_1	98	104	PF00069	0.590
MOD_CK2_1	117	123	PF00069	0.565
MOD_CK2_1	159	165	PF00069	0.538
MOD_GlcNHglycan	100	103	PF01048	0.641
MOD_GlcNHglycan	112	115	PF01048	0.711
MOD_GlcNHglycan	220	224	PF01048	0.638
MOD_GlcNHglycan	227	231	PF01048	0.656
MOD_GlcNHglycan	248	251	PF01048	0.484
MOD_GlcNHglycan	280	283	PF01048	0.536
MOD_GlcNHglycan	285	288	PF01048	0.528
MOD_GlcNHglycan	322	325	PF01048	0.542
MOD_GlcNHglycan	337	340	PF01048	0.546
MOD_GlcNHglycan	373	376	PF01048	0.724
MOD_GlcNHglycan	404	407	PF01048	0.714
MOD_GlcNHglycan	43	46	PF01048	0.642
MOD_GlcNHglycan	434	437	PF01048	0.618
MOD_GlcNHglycan	443	447	PF01048	0.674
MOD_GlcNHglycan	48	51	PF01048	0.572
MOD_GlcNHglycan	53	56	PF01048	0.532
MOD_GlcNHglycan	58	61	PF01048	0.559
MOD_GlcNHglycan	90	93	PF01048	0.536
MOD_GSK3_1	112	119	PF00069	0.595
MOD_GSK3_1	155	162	PF00069	0.558
MOD_GSK3_1	371	378	PF00069	0.677
MOD_GSK3_1	401	408	PF00069	0.593
MOD_GSK3_1	449	456	PF00069	0.794
MOD_GSK3_1	46	53	PF00069	0.600
MOD_GSK3_1	56	63	PF00069	0.559
MOD_GSK3_1	91	98	PF00069	0.545
MOD_N-GLC_1	155	160	PF02516	0.455
MOD_N-GLC_1	51	56	PF02516	0.537
MOD_N-GLC_1	60	65	PF02516	0.528
MOD_NEK2_1	226	231	PF00069	0.563
MOD_NEK2_1	261	266	PF00069	0.473
MOD_NEK2_1	348	353	PF00069	0.626
MOD_NEK2_1	402	407	PF00069	0.566
MOD_NEK2_1	432	437	PF00069	0.605
MOD_NEK2_1	88	93	PF00069	0.550
MOD_PK_1	379	385	PF00069	0.510
MOD_PKA_2	110	116	PF00069	0.775
MOD_PKA_2	216	222	PF00069	0.664
MOD_PKA_2	288	294	PF00069	0.492
MOD_Plk_1	226	232	PF00069	0.615
MOD_Plk_1	24	30	PF00069	0.487
MOD_Plk_1	272	278	PF00069	0.463
MOD_Plk_1	348	354	PF00069	0.629
MOD_Plk_1	60	66	PF00069	0.546
MOD_Plk_2-3	159	165	PF00069	0.545
MOD_Plk_4	273	279	PF00069	0.370
MOD_Plk_4	379	385	PF00069	0.645
MOD_Plk_4	461	467	PF00069	0.559
MOD_ProDKin_1	189	195	PF00069	0.530
MOD_ProDKin_1	240	246	PF00069	0.655
MOD_SUMO_for_1	201	204	PF00179	0.634
MOD_SUMO_for_1	231	234	PF00179	0.618
MOD_SUMO_rev_2	393	402	PF00179	0.622
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.599
TRG_ENDOCYTIC_2	178	181	PF00928	0.536
TRG_ER_diArg_1	138	140	PF00400	0.593
TRG_ER_diArg_1	142	145	PF00400	0.552
TRG_ER_diArg_1	298	301	PF00400	0.554
TRG_ER_diArg_1	304	306	PF00400	0.584
TRG_ER_diArg_1	312	314	PF00400	0.575
TRG_ER_diArg_1	415	418	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I1	Leptomonas seymouri	48%	99%
A0A3Q8IHH5	Leishmania donovani	71%	100%
A4HV04	Leishmania infantum	72%	100%
E9ANN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QGY4	Leishmania major	74%	100%