SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6L9_LEIBR

TriTrypDb:

LbrM.11.0730 , LBRM2903_110014000

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6L9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.709
CLV_NRD_NRD_1	118	120	PF00675	0.446
CLV_NRD_NRD_1	20	22	PF00675	0.600
CLV_NRD_NRD_1	341	343	PF00675	0.636
CLV_NRD_NRD_1	354	356	PF00675	0.704
CLV_NRD_NRD_1	357	359	PF00675	0.698
CLV_NRD_NRD_1	49	51	PF00675	0.565
CLV_NRD_NRD_1	83	85	PF00675	0.593
CLV_PCSK_FUR_1	338	342	PF00082	0.697
CLV_PCSK_FUR_1	355	359	PF00082	0.687
CLV_PCSK_KEX2_1	279	281	PF00082	0.494
CLV_PCSK_KEX2_1	308	310	PF00082	0.648
CLV_PCSK_KEX2_1	329	331	PF00082	0.668
CLV_PCSK_KEX2_1	340	342	PF00082	0.624
CLV_PCSK_KEX2_1	354	356	PF00082	0.701
CLV_PCSK_KEX2_1	357	359	PF00082	0.706
CLV_PCSK_KEX2_1	49	51	PF00082	0.595
CLV_PCSK_KEX2_1	83	85	PF00082	0.593
CLV_PCSK_KEX2_1	87	89	PF00082	0.530
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.494
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.648
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.668
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.490
CLV_PCSK_PC7_1	83	89	PF00082	0.506
CLV_PCSK_SKI1_1	119	123	PF00082	0.458
CLV_PCSK_SKI1_1	159	163	PF00082	0.650
CLV_PCSK_SKI1_1	172	176	PF00082	0.682
CLV_PCSK_SKI1_1	308	312	PF00082	0.647
CLV_Separin_Metazoa	64	68	PF03568	0.446
DOC_CYCLIN_yClb5_NLxxxL_5	22	30	PF00134	0.635
DOC_MAPK_gen_1	21	28	PF00069	0.627
DOC_MAPK_MEF2A_6	21	30	PF00069	0.633
DOC_MAPK_NFAT4_5	21	29	PF00069	0.574
DOC_USP7_MATH_1	20	24	PF00917	0.567
DOC_USP7_MATH_1	206	210	PF00917	0.571
DOC_USP7_MATH_1	298	302	PF00917	0.683
DOC_USP7_UBL2_3	132	136	PF12436	0.584
DOC_USP7_UBL2_3	184	188	PF12436	0.629
DOC_USP7_UBL2_3	311	315	PF12436	0.651
DOC_WW_Pin1_4	204	209	PF00397	0.724
DOC_WW_Pin1_4	233	238	PF00397	0.692
DOC_WW_Pin1_4	318	323	PF00397	0.729
DOC_WW_Pin1_4	333	338	PF00397	0.611
DOC_WW_Pin1_4	66	71	PF00397	0.485
LIG_14-3-3_CanoR_1	365	375	PF00244	0.719
LIG_Actin_WH2_2	105	121	PF00022	0.349
LIG_FHA_1	227	233	PF00498	0.558
LIG_FHA_1	234	240	PF00498	0.749
LIG_FHA_1	25	31	PF00498	0.517
LIG_FHA_1	279	285	PF00498	0.484
LIG_FHA_2	319	325	PF00498	0.640
LIG_FHA_2	367	373	PF00498	0.648
LIG_LIR_Gen_1	154	161	PF02991	0.645
LIG_LIR_Gen_1	254	265	PF02991	0.608
LIG_LIR_Gen_1	61	70	PF02991	0.581
LIG_LIR_Nem_3	154	160	PF02991	0.591
LIG_LIR_Nem_3	164	170	PF02991	0.529
LIG_LIR_Nem_3	254	260	PF02991	0.538
LIG_LIR_Nem_3	61	65	PF02991	0.503
LIG_LIR_Nem_3	69	75	PF02991	0.488
LIG_NRP_CendR_1	374	377	PF00754	0.682
LIG_SH2_PTP2	257	260	PF00017	0.596
LIG_SH2_STAT3	328	331	PF00017	0.522
LIG_SH2_STAT5	257	260	PF00017	0.535
LIG_SH2_STAT5	265	268	PF00017	0.482
LIG_SH2_STAT5	320	323	PF00017	0.739
LIG_SH3_1	150	156	PF00018	0.586
LIG_SH3_3	150	156	PF00018	0.673
LIG_SH3_3	222	228	PF00018	0.650
LIG_SH3_3	282	288	PF00018	0.511
LIG_SH3_4	311	318	PF00018	0.653
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.620
LIG_TRAF2_1	121	124	PF00917	0.525
LIG_TRAF2_1	144	147	PF00917	0.652
LIG_TRAF2_1	217	220	PF00917	0.476
LIG_TRAF2_1	261	264	PF00917	0.476
MOD_CDK_SPK_2	333	338	PF00069	0.723
MOD_CDK_SPK_2	66	71	PF00069	0.470
MOD_CDK_SPxxK_3	333	340	PF00069	0.610
MOD_CK1_1	251	257	PF00069	0.608
MOD_CK1_1	336	342	PF00069	0.625
MOD_CK1_1	34	40	PF00069	0.538
MOD_CK1_1	370	376	PF00069	0.717
MOD_CK2_1	141	147	PF00069	0.551
MOD_CK2_1	214	220	PF00069	0.529
MOD_CK2_1	345	351	PF00069	0.740
MOD_GlcNHglycan	143	146	PF01048	0.555
MOD_GlcNHglycan	163	167	PF01048	0.479
MOD_GlcNHglycan	199	202	PF01048	0.718
MOD_GlcNHglycan	204	207	PF01048	0.697
MOD_GlcNHglycan	216	219	PF01048	0.542
MOD_GlcNHglycan	268	271	PF01048	0.515
MOD_GlcNHglycan	33	36	PF01048	0.548
MOD_GlcNHglycan	51	54	PF01048	0.586
MOD_GlcNHglycan	55	58	PF01048	0.594
MOD_GSK3_1	141	148	PF00069	0.511
MOD_GSK3_1	191	198	PF00069	0.638
MOD_GSK3_1	20	27	PF00069	0.643
MOD_GSK3_1	202	209	PF00069	0.618
MOD_GSK3_1	30	37	PF00069	0.474
MOD_GSK3_1	346	353	PF00069	0.649
MOD_GSK3_1	366	373	PF00069	0.626
MOD_GSK3_1	49	56	PF00069	0.550
MOD_N-GLC_1	24	29	PF02516	0.637
MOD_N-GLC_1	303	308	PF02516	0.571
MOD_N-GLC_1	31	36	PF02516	0.598
MOD_N-GLC_1	318	323	PF02516	0.714
MOD_NEK2_1	30	35	PF00069	0.479
MOD_NEK2_1	303	308	PF00069	0.553
MOD_NEK2_1	65	70	PF00069	0.458
MOD_PIKK_1	87	93	PF00454	0.386
MOD_PK_1	272	278	PF00069	0.596
MOD_PKA_1	278	284	PF00069	0.503
MOD_PKA_1	49	55	PF00069	0.545
MOD_PKA_1	87	93	PF00069	0.526
MOD_PKA_2	20	26	PF00069	0.558
MOD_PKA_2	370	376	PF00069	0.645
MOD_PKA_2	49	55	PF00069	0.614
MOD_PKA_2	87	93	PF00069	0.423
MOD_Plk_1	162	168	PF00069	0.545
MOD_Plk_1	24	30	PF00069	0.641
MOD_Plk_1	263	269	PF00069	0.489
MOD_Plk_1	303	309	PF00069	0.521
MOD_Plk_4	253	259	PF00069	0.635
MOD_Plk_4	272	278	PF00069	0.637
MOD_ProDKin_1	204	210	PF00069	0.722
MOD_ProDKin_1	233	239	PF00069	0.690
MOD_ProDKin_1	318	324	PF00069	0.729
MOD_ProDKin_1	333	339	PF00069	0.610
MOD_ProDKin_1	66	72	PF00069	0.488
MOD_SUMO_for_1	130	133	PF00179	0.347
MOD_SUMO_for_1	161	164	PF00179	0.654
MOD_SUMO_for_1	183	186	PF00179	0.620
MOD_SUMO_for_1	187	190	PF00179	0.586
MOD_SUMO_rev_2	171	177	PF00179	0.674
MOD_SUMO_rev_2	178	185	PF00179	0.680
TRG_DiLeu_BaEn_1	220	225	PF01217	0.480
TRG_DiLeu_BaEn_2	146	152	PF01217	0.577
TRG_DiLeu_BaEn_4	123	129	PF01217	0.367
TRG_ENDOCYTIC_2	257	260	PF00928	0.615
TRG_ER_diArg_1	337	340	PF00400	0.652
TRG_ER_diArg_1	341	343	PF00400	0.648
TRG_ER_diArg_1	354	357	PF00400	0.732
TRG_ER_diArg_1	375	377	PF00400	0.536
TRG_ER_diArg_1	82	84	PF00400	0.593
TRG_NLS_MonoExtC_3	307	312	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D2	Leptomonas seymouri	53%	84%
A0A1X0NWL9	Trypanosomatidae	33%	80%
A0A3R7LWS6	Trypanosoma rangeli	33%	81%
A0A3S7WRS1	Leishmania donovani	85%	100%
A4HV02	Leishmania infantum	86%	100%
D0A7E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	80%
E9ANN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QGY6	Leishmania major	86%	100%
V5DT45	Trypanosoma cruzi	34%	81%