PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Short C-terminal domain/PUB domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6L8_LEIBR

TriTrypDb:

LbrM.11.0720 , LBRM2903_110013600

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.438
CLV_C14_Caspase3-7	25	29	PF00656	0.405
CLV_C14_Caspase3-7	307	311	PF00656	0.796
CLV_C14_Caspase3-7	342	346	PF00656	0.615
CLV_C14_Caspase3-7	554	558	PF00656	0.579
CLV_NRD_NRD_1	226	228	PF00675	0.451
CLV_NRD_NRD_1	235	237	PF00675	0.389
CLV_NRD_NRD_1	258	260	PF00675	0.542
CLV_NRD_NRD_1	299	301	PF00675	0.793
CLV_NRD_NRD_1	466	468	PF00675	0.601
CLV_NRD_NRD_1	469	471	PF00675	0.643
CLV_NRD_NRD_1	501	503	PF00675	0.647
CLV_NRD_NRD_1	526	528	PF00675	0.681
CLV_NRD_NRD_1	537	539	PF00675	0.703
CLV_NRD_NRD_1	579	581	PF00675	0.673
CLV_PCSK_FUR_1	467	471	PF00082	0.647
CLV_PCSK_FUR_1	499	503	PF00082	0.705
CLV_PCSK_KEX2_1	226	228	PF00082	0.417
CLV_PCSK_KEX2_1	258	260	PF00082	0.593
CLV_PCSK_KEX2_1	466	468	PF00082	0.528
CLV_PCSK_KEX2_1	469	471	PF00082	0.562
CLV_PCSK_KEX2_1	496	498	PF00082	0.539
CLV_PCSK_KEX2_1	501	503	PF00082	0.559
CLV_PCSK_KEX2_1	525	527	PF00082	0.683
CLV_PCSK_KEX2_1	536	538	PF00082	0.703
CLV_PCSK_KEX2_1	559	561	PF00082	0.572
CLV_PCSK_KEX2_1	579	581	PF00082	0.713
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.588
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.539
CLV_PCSK_PC7_1	492	498	PF00082	0.688
DEG_SCF_FBW7_1	448	455	PF00400	0.689
DEG_SPOP_SBC_1	539	543	PF00917	0.818
DEG_SPOP_SBC_1	583	587	PF00917	0.842
DOC_CKS1_1	414	419	PF01111	0.544
DOC_CKS1_1	66	71	PF01111	0.602
DOC_MAPK_gen_1	236	244	PF00069	0.366
DOC_MAPK_MEF2A_6	267	275	PF00069	0.600
DOC_MAPK_MEF2A_6	395	402	PF00069	0.534
DOC_PP2B_LxvP_1	289	292	PF13499	0.561
DOC_PP2B_LxvP_1	93	96	PF13499	0.808
DOC_PP4_FxxP_1	409	412	PF00568	0.712
DOC_USP7_MATH_1	109	113	PF00917	0.625
DOC_USP7_MATH_1	132	136	PF00917	0.710
DOC_USP7_MATH_1	188	192	PF00917	0.524
DOC_USP7_MATH_1	318	322	PF00917	0.691
DOC_USP7_MATH_1	365	369	PF00917	0.584
DOC_USP7_MATH_1	375	379	PF00917	0.619
DOC_USP7_MATH_1	433	437	PF00917	0.635
DOC_USP7_MATH_1	452	456	PF00917	0.686
DOC_USP7_MATH_1	487	491	PF00917	0.577
DOC_USP7_MATH_1	539	543	PF00917	0.846
DOC_USP7_MATH_1	583	587	PF00917	0.710
DOC_USP7_UBL2_3	555	559	PF12436	0.570
DOC_WW_Pin1_4	283	288	PF00397	0.725
DOC_WW_Pin1_4	322	327	PF00397	0.747
DOC_WW_Pin1_4	413	418	PF00397	0.784
DOC_WW_Pin1_4	422	427	PF00397	0.677
DOC_WW_Pin1_4	429	434	PF00397	0.623
DOC_WW_Pin1_4	448	453	PF00397	0.469
DOC_WW_Pin1_4	45	50	PF00397	0.631
DOC_WW_Pin1_4	516	521	PF00397	0.646
DOC_WW_Pin1_4	572	577	PF00397	0.674
DOC_WW_Pin1_4	584	589	PF00397	0.663
DOC_WW_Pin1_4	65	70	PF00397	0.762
DOC_WW_Pin1_4	94	99	PF00397	0.681
LIG_14-3-3_CanoR_1	329	334	PF00244	0.451
LIG_14-3-3_CanoR_1	374	382	PF00244	0.466
LIG_14-3-3_CanoR_1	383	391	PF00244	0.470
LIG_14-3-3_CanoR_1	55	65	PF00244	0.556
LIG_Actin_WH2_2	144	161	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BRCT_BRCA1_1	111	115	PF00533	0.763
LIG_BRCT_BRCA1_2	111	117	PF00533	0.507
LIG_deltaCOP1_diTrp_1	116	122	PF00928	0.646
LIG_FHA_1	122	128	PF00498	0.769
LIG_FHA_1	364	370	PF00498	0.446
LIG_FHA_1	382	388	PF00498	0.609
LIG_FHA_1	414	420	PF00498	0.800
LIG_FHA_1	441	447	PF00498	0.674
LIG_FHA_1	449	455	PF00498	0.622
LIG_FHA_2	20	26	PF00498	0.572
LIG_FHA_2	337	343	PF00498	0.553
LIG_FHA_2	552	558	PF00498	0.797
LIG_FHA_2	66	72	PF00498	0.631
LIG_GBD_Chelix_1	563	571	PF00786	0.546
LIG_LIR_Apic_2	61	67	PF02991	0.558
LIG_LIR_Gen_1	345	354	PF02991	0.508
LIG_LIR_Nem_3	116	121	PF02991	0.644
LIG_LIR_Nem_3	167	173	PF02991	0.384
LIG_LIR_Nem_3	196	200	PF02991	0.474
LIG_LIR_Nem_3	385	391	PF02991	0.542
LIG_MAD2	418	426	PF02301	0.551
LIG_NRBOX	153	159	PF00104	0.513
LIG_SH2_CRK	128	132	PF00017	0.533
LIG_SH2_CRK	170	174	PF00017	0.411
LIG_SH2_CRK	388	392	PF00017	0.513
LIG_SH2_NCK_1	128	132	PF00017	0.533
LIG_SH2_NCK_1	361	365	PF00017	0.636
LIG_SH2_STAP1	128	132	PF00017	0.533
LIG_SH2_STAP1	361	365	PF00017	0.636
LIG_SH2_STAP1	442	446	PF00017	0.672
LIG_SH2_STAT3	260	263	PF00017	0.702
LIG_SH2_STAT3	442	445	PF00017	0.678
LIG_SH2_STAT5	128	131	PF00017	0.533
LIG_SH2_STAT5	221	224	PF00017	0.390
LIG_SH2_STAT5	251	254	PF00017	0.668
LIG_SH2_STAT5	333	336	PF00017	0.487
LIG_SH2_STAT5	338	341	PF00017	0.460
LIG_SH2_STAT5	442	445	PF00017	0.576
LIG_SH2_STAT5	64	67	PF00017	0.588
LIG_SH3_3	162	168	PF00018	0.513
LIG_SH3_3	289	295	PF00018	0.667
LIG_SH3_3	411	417	PF00018	0.592
LIG_SH3_3	89	95	PF00018	0.710
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.594
LIG_SUMO_SIM_par_1	282	294	PF11976	0.550
LIG_SUMO_SIM_par_1	365	370	PF11976	0.459
LIG_TRAF2_1	22	25	PF00917	0.581
LIG_UBA3_1	9	17	PF00899	0.401
LIG_WRC_WIRS_1	194	199	PF05994	0.474
MOD_CDK_SPK_2	413	418	PF00069	0.541
MOD_CDK_SPxxK_3	322	329	PF00069	0.481
MOD_CDK_SPxxK_3	572	579	PF00069	0.654
MOD_CK1_1	311	317	PF00069	0.750
MOD_CK1_1	377	383	PF00069	0.597
MOD_CK1_1	541	547	PF00069	0.743
MOD_CK1_1	575	581	PF00069	0.734
MOD_CK1_1	59	65	PF00069	0.762
MOD_CK2_1	183	189	PF00069	0.513
MOD_CK2_1	19	25	PF00069	0.588
MOD_CK2_1	290	296	PF00069	0.677
MOD_CK2_1	336	342	PF00069	0.546
MOD_CK2_1	511	517	PF00069	0.746
MOD_CK2_1	54	60	PF00069	0.746
MOD_CK2_1	546	552	PF00069	0.707
MOD_CK2_1	65	71	PF00069	0.564
MOD_Cter_Amidation	557	560	PF01082	0.594
MOD_Cter_Amidation	571	574	PF01082	0.664
MOD_GlcNHglycan	191	194	PF01048	0.401
MOD_GlcNHglycan	306	309	PF01048	0.676
MOD_GlcNHglycan	507	510	PF01048	0.738
MOD_GlcNHglycan	60	64	PF01048	0.666
MOD_GSK3_1	103	110	PF00069	0.559
MOD_GSK3_1	189	196	PF00069	0.364
MOD_GSK3_1	207	214	PF00069	0.664
MOD_GSK3_1	279	286	PF00069	0.518
MOD_GSK3_1	304	311	PF00069	0.665
MOD_GSK3_1	318	325	PF00069	0.731
MOD_GSK3_1	377	384	PF00069	0.672
MOD_GSK3_1	40	47	PF00069	0.650
MOD_GSK3_1	429	436	PF00069	0.685
MOD_GSK3_1	448	455	PF00069	0.455
MOD_GSK3_1	538	545	PF00069	0.779
MOD_GSK3_1	54	61	PF00069	0.746
MOD_GSK3_1	582	589	PF00069	0.683
MOD_GSK3_1	94	101	PF00069	0.579
MOD_LATS_1	523	529	PF00433	0.828
MOD_N-GLC_1	211	216	PF02516	0.489
MOD_NEK2_1	1	6	PF00069	0.565
MOD_NEK2_1	103	108	PF00069	0.557
MOD_NEK2_1	121	126	PF00069	0.758
MOD_NEK2_1	211	216	PF00069	0.560
MOD_NEK2_1	265	270	PF00069	0.544
MOD_NEK2_1	347	352	PF00069	0.573
MOD_NEK2_1	58	63	PF00069	0.581
MOD_NEK2_2	487	492	PF00069	0.578
MOD_PIKK_1	19	25	PF00454	0.690
MOD_PIKK_1	308	314	PF00454	0.587
MOD_PKA_1	525	531	PF00069	0.831
MOD_PKA_2	304	310	PF00069	0.592
MOD_PKA_2	382	388	PF00069	0.458
MOD_PKA_2	525	531	PF00069	0.751
MOD_PKA_2	54	60	PF00069	0.629
MOD_PKB_1	277	285	PF00069	0.510
MOD_PKB_1	536	544	PF00069	0.593
MOD_Plk_1	211	217	PF00069	0.491
MOD_Plk_1	440	446	PF00069	0.687
MOD_Plk_1	487	493	PF00069	0.579
MOD_Plk_1	511	517	PF00069	0.608
MOD_Plk_1	59	65	PF00069	0.555
MOD_Plk_2-3	183	189	PF00069	0.513
MOD_Plk_2-3	290	296	PF00069	0.649
MOD_Plk_2-3	336	342	PF00069	0.546
MOD_Plk_2-3	511	517	PF00069	0.544
MOD_Plk_4	329	335	PF00069	0.650
MOD_Plk_4	347	353	PF00069	0.369
MOD_Plk_4	377	383	PF00069	0.598
MOD_Plk_4	511	517	PF00069	0.544
MOD_ProDKin_1	283	289	PF00069	0.724
MOD_ProDKin_1	322	328	PF00069	0.739
MOD_ProDKin_1	413	419	PF00069	0.785
MOD_ProDKin_1	422	428	PF00069	0.673
MOD_ProDKin_1	429	435	PF00069	0.625
MOD_ProDKin_1	448	454	PF00069	0.464
MOD_ProDKin_1	45	51	PF00069	0.632
MOD_ProDKin_1	516	522	PF00069	0.647
MOD_ProDKin_1	572	578	PF00069	0.677
MOD_ProDKin_1	65	71	PF00069	0.765
MOD_ProDKin_1	94	100	PF00069	0.684
MOD_SUMO_for_1	495	498	PF00179	0.585
MOD_SUMO_rev_2	24	32	PF00179	0.665
MOD_SUMO_rev_2	552	561	PF00179	0.571
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.513
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.543
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.438
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.544
TRG_ENDOCYTIC_2	128	131	PF00928	0.533
TRG_ENDOCYTIC_2	170	173	PF00928	0.411
TRG_ENDOCYTIC_2	221	224	PF00928	0.390
TRG_ENDOCYTIC_2	361	364	PF00928	0.561
TRG_ENDOCYTIC_2	388	391	PF00928	0.529
TRG_ER_diArg_1	225	227	PF00400	0.384
TRG_ER_diArg_1	258	260	PF00400	0.590
TRG_ER_diArg_1	465	467	PF00400	0.612
TRG_ER_diArg_1	468	470	PF00400	0.615
TRG_ER_diArg_1	499	502	PF00400	0.650
TRG_ER_diArg_1	525	527	PF00400	0.683
TRG_ER_diArg_1	536	538	PF00400	0.703
TRG_ER_diArg_1	579	581	PF00400	0.673
TRG_NES_CRM1_1	263	276	PF08389	0.556
TRG_NES_CRM1_1	358	370	PF08389	0.597
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ9	Leptomonas seymouri	43%	99%
A0A3S7WRQ6	Leishmania donovani	70%	95%
A4HV01	Leishmania infantum	72%	95%
E9ANN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	95%
Q4QGY7	Leishmania major	72%	100%