Leucine_Rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6L5_LEIBR

TriTrypDb:

LbrM.11.0690 , LBRM2903_110012900

Length:

1008

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A4H6L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.709
CLV_C14_Caspase3-7	363	367	PF00656	0.470
CLV_C14_Caspase3-7	552	556	PF00656	0.405
CLV_C14_Caspase3-7	69	73	PF00656	0.607
CLV_C14_Caspase3-7	966	970	PF00656	0.650
CLV_NRD_NRD_1	572	574	PF00675	0.455
CLV_NRD_NRD_1	618	620	PF00675	0.652
CLV_NRD_NRD_1	708	710	PF00675	0.533
CLV_NRD_NRD_1	715	717	PF00675	0.393
CLV_NRD_NRD_1	872	874	PF00675	0.504
CLV_PCSK_KEX2_1	572	574	PF00082	0.681
CLV_PCSK_KEX2_1	617	619	PF00082	0.717
CLV_PCSK_KEX2_1	622	624	PF00082	0.651
CLV_PCSK_KEX2_1	708	710	PF00082	0.558
CLV_PCSK_KEX2_1	715	717	PF00082	0.427
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.682
CLV_PCSK_PC7_1	568	574	PF00082	0.393
CLV_PCSK_PC7_1	618	624	PF00082	0.696
CLV_PCSK_SKI1_1	146	150	PF00082	0.715
CLV_PCSK_SKI1_1	391	395	PF00082	0.445
CLV_PCSK_SKI1_1	527	531	PF00082	0.564
CLV_PCSK_SKI1_1	568	572	PF00082	0.469
CLV_PCSK_SKI1_1	618	622	PF00082	0.597
CLV_PCSK_SKI1_1	626	630	PF00082	0.458
CLV_PCSK_SKI1_1	983	987	PF00082	0.561
DEG_APCC_DBOX_1	145	153	PF00400	0.704
DEG_APCC_DBOX_1	91	99	PF00400	0.531
DEG_APCC_DBOX_1	982	990	PF00400	0.568
DEG_SCF_FBW7_2	335	342	PF00400	0.657
DEG_SCF_TRCP1_1	72	78	PF00400	0.599
DOC_CDC14_PxL_1	835	843	PF14671	0.608
DOC_CKS1_1	17	22	PF01111	0.719
DOC_CKS1_1	336	341	PF01111	0.671
DOC_CYCLIN_RxL_1	319	327	PF00134	0.454
DOC_CYCLIN_RxL_1	445	457	PF00134	0.532
DOC_CYCLIN_RxL_1	516	526	PF00134	0.526
DOC_CYCLIN_RxL_1	980	988	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.535
DOC_MAPK_gen_1	445	455	PF00069	0.457
DOC_MAPK_gen_1	516	525	PF00069	0.561
DOC_MAPK_MEF2A_6	898	905	PF00069	0.637
DOC_PP1_RVXF_1	278	285	PF00149	0.616
DOC_PP1_RVXF_1	713	720	PF00149	0.582
DOC_PP2B_LxvP_1	331	334	PF13499	0.287
DOC_PP2B_LxvP_1	466	469	PF13499	0.758
DOC_PP4_FxxP_1	430	433	PF00568	0.658
DOC_PP4_MxPP_1	467	470	PF00568	0.537
DOC_USP7_MATH_1	207	211	PF00917	0.707
DOC_USP7_MATH_1	233	237	PF00917	0.751
DOC_USP7_MATH_1	360	364	PF00917	0.539
DOC_USP7_MATH_1	367	371	PF00917	0.590
DOC_USP7_MATH_1	631	635	PF00917	0.351
DOC_USP7_MATH_1	910	914	PF00917	0.668
DOC_USP7_MATH_1	921	925	PF00917	0.729
DOC_USP7_MATH_1	964	968	PF00917	0.710
DOC_USP7_MATH_1	992	996	PF00917	0.678
DOC_USP7_UBL2_3	391	395	PF12436	0.445
DOC_USP7_UBL2_3	622	626	PF12436	0.688
DOC_WW_Pin1_4	12	17	PF00397	0.721
DOC_WW_Pin1_4	205	210	PF00397	0.595
DOC_WW_Pin1_4	229	234	PF00397	0.616
DOC_WW_Pin1_4	335	340	PF00397	0.674
DOC_WW_Pin1_4	485	490	PF00397	0.800
DOC_WW_Pin1_4	509	514	PF00397	0.540
DOC_WW_Pin1_4	707	712	PF00397	0.595
DOC_WW_Pin1_4	817	822	PF00397	0.713
DOC_WW_Pin1_4	877	882	PF00397	0.639
LIG_14-3-3_CanoR_1	1000	1004	PF00244	0.560
LIG_14-3-3_CanoR_1	359	365	PF00244	0.349
LIG_14-3-3_CanoR_1	572	576	PF00244	0.474
LIG_14-3-3_CanoR_1	752	756	PF00244	0.599
LIG_Actin_WH2_2	559	574	PF00022	0.277
LIG_Actin_WH2_2	699	717	PF00022	0.410
LIG_BRCT_BRCA1_1	525	529	PF00533	0.472
LIG_BRCT_BRCA1_1	859	863	PF00533	0.504
LIG_Clathr_ClatBox_1	949	953	PF01394	0.615
LIG_deltaCOP1_diTrp_1	500	508	PF00928	0.483
LIG_FHA_1	190	196	PF00498	0.677
LIG_FHA_1	347	353	PF00498	0.454
LIG_FHA_1	392	398	PF00498	0.451
LIG_FHA_1	413	419	PF00498	0.717
LIG_FHA_1	590	596	PF00498	0.459
LIG_FHA_1	659	665	PF00498	0.338
LIG_FHA_1	728	734	PF00498	0.604
LIG_FHA_1	78	84	PF00498	0.715
LIG_FHA_1	785	791	PF00498	0.354
LIG_FHA_1	878	884	PF00498	0.642
LIG_FHA_1	898	904	PF00498	0.305
LIG_FHA_1	972	978	PF00498	0.453
LIG_FHA_2	544	550	PF00498	0.530
LIG_FHA_2	67	73	PF00498	0.605
LIG_FHA_2	742	748	PF00498	0.503
LIG_FHA_2	772	778	PF00498	0.391
LIG_FHA_2	92	98	PF00498	0.787
LIG_IRF3_LxIS_1	773	779	PF10401	0.465
LIG_IRF3_LxIS_1	841	847	PF10401	0.590
LIG_LIR_Apic_2	15	20	PF02991	0.745
LIG_LIR_Apic_2	427	433	PF02991	0.663
LIG_LIR_Apic_2	653	657	PF02991	0.567
LIG_LIR_Gen_1	215	226	PF02991	0.534
LIG_LIR_Gen_1	325	336	PF02991	0.524
LIG_LIR_Gen_1	370	381	PF02991	0.569
LIG_LIR_Gen_1	658	667	PF02991	0.558
LIG_LIR_Gen_1	777	786	PF02991	0.497
LIG_LIR_Gen_1	931	939	PF02991	0.584
LIG_LIR_Nem_3	215	221	PF02991	0.629
LIG_LIR_Nem_3	325	331	PF02991	0.524
LIG_LIR_Nem_3	370	376	PF02991	0.571
LIG_LIR_Nem_3	432	437	PF02991	0.552
LIG_LIR_Nem_3	500	505	PF02991	0.502
LIG_LIR_Nem_3	658	662	PF02991	0.597
LIG_LIR_Nem_3	777	783	PF02991	0.497
LIG_LIR_Nem_3	931	935	PF02991	0.589
LIG_MLH1_MIPbox_1	859	863	PF16413	0.504
LIG_MYND_1	16	20	PF01753	0.516
LIG_NRBOX	761	767	PF00104	0.621
LIG_NRBOX	887	893	PF00104	0.620
LIG_PCNA_APIM_2	566	572	PF02747	0.346
LIG_PCNA_yPIPBox_3	587	596	PF02747	0.627
LIG_Pex14_1	214	218	PF04695	0.639
LIG_SH2_CRK	328	332	PF00017	0.530
LIG_SH2_CRK	517	521	PF00017	0.448
LIG_SH2_CRK	560	564	PF00017	0.497
LIG_SH2_CRK	780	784	PF00017	0.442
LIG_SH2_GRB2like	373	376	PF00017	0.564
LIG_SH2_NCK_1	780	784	PF00017	0.433
LIG_SH2_STAP1	272	276	PF00017	0.559
LIG_SH2_STAP1	285	289	PF00017	0.389
LIG_SH2_STAT3	515	518	PF00017	0.611
LIG_SH2_STAT3	704	707	PF00017	0.687
LIG_SH2_STAT5	17	20	PF00017	0.760
LIG_SH2_STAT5	296	299	PF00017	0.585
LIG_SH2_STAT5	354	357	PF00017	0.628
LIG_SH2_STAT5	373	376	PF00017	0.552
LIG_SH2_STAT5	569	572	PF00017	0.481
LIG_SH2_STAT5	654	657	PF00017	0.457
LIG_SH2_STAT5	894	897	PF00017	0.567
LIG_SH3_1	878	884	PF00018	0.642
LIG_SH3_3	133	139	PF00018	0.620
LIG_SH3_3	154	160	PF00018	0.674
LIG_SH3_3	197	203	PF00018	0.631
LIG_SH3_3	333	339	PF00018	0.630
LIG_SH3_3	415	421	PF00018	0.647
LIG_SH3_3	736	742	PF00018	0.601
LIG_SH3_3	878	884	PF00018	0.642
LIG_SUMO_SIM_anti_2	546	552	PF11976	0.432
LIG_SUMO_SIM_par_1	322	327	PF11976	0.458
LIG_SUMO_SIM_par_1	521	526	PF11976	0.393
LIG_SUMO_SIM_par_1	549	555	PF11976	0.385
LIG_SUMO_SIM_par_1	660	666	PF11976	0.339
LIG_SUMO_SIM_par_1	946	953	PF11976	0.609
LIG_TRAF2_1	470	473	PF00917	0.762
LIG_TRAF2_1	478	481	PF00917	0.815
LIG_TRAF2_1	497	500	PF00917	0.523
LIG_TRAF2_1	672	675	PF00917	0.457
LIG_TRAF2_1	695	698	PF00917	0.605
LIG_TRAF2_1	822	825	PF00917	0.651
LIG_TYR_ITIM	326	331	PF00017	0.530
LIG_TYR_ITIM	371	376	PF00017	0.571
LIG_TYR_ITIM	558	563	PF00017	0.497
LIG_TYR_ITIM	778	783	PF00017	0.458
LIG_UBA3_1	985	991	PF00899	0.707
LIG_WRC_WIRS_1	632	637	PF05994	0.356
MOD_CDK_SPK_2	877	882	PF00069	0.555
MOD_CDK_SPxxK_3	16	23	PF00069	0.737
MOD_CDK_SPxxK_3	509	516	PF00069	0.554
MOD_CK1_1	208	214	PF00069	0.668
MOD_CK1_1	232	238	PF00069	0.752
MOD_CK1_1	239	245	PF00069	0.763
MOD_CK1_1	412	418	PF00069	0.600
MOD_CK1_1	543	549	PF00069	0.530
MOD_CK1_1	634	640	PF00069	0.354
MOD_CK1_1	73	79	PF00069	0.599
MOD_CK1_1	751	757	PF00069	0.533
MOD_CK1_1	784	790	PF00069	0.427
MOD_CK1_1	805	811	PF00069	0.547
MOD_CK1_1	817	823	PF00069	0.407
MOD_CK1_1	897	903	PF00069	0.615
MOD_CK1_1	971	977	PF00069	0.712
MOD_CK2_1	46	52	PF00069	0.552
MOD_CK2_1	543	549	PF00069	0.530
MOD_CK2_1	634	640	PF00069	0.607
MOD_CK2_1	741	747	PF00069	0.432
MOD_CK2_1	91	97	PF00069	0.570
MOD_CK2_1	945	951	PF00069	0.648
MOD_GlcNHglycan	126	129	PF01048	0.705
MOD_GlcNHglycan	187	190	PF01048	0.699
MOD_GlcNHglycan	235	238	PF01048	0.801
MOD_GlcNHglycan	403	407	PF01048	0.561
MOD_GlcNHglycan	411	414	PF01048	0.703
MOD_GlcNHglycan	580	583	PF01048	0.691
MOD_GlcNHglycan	587	590	PF01048	0.412
MOD_GlcNHglycan	610	613	PF01048	0.728
MOD_GlcNHglycan	636	639	PF01048	0.475
MOD_GlcNHglycan	72	75	PF01048	0.603
MOD_GlcNHglycan	816	819	PF01048	0.478
MOD_GlcNHglycan	859	862	PF01048	0.548
MOD_GlcNHglycan	966	969	PF01048	0.756
MOD_GlcNHglycan	995	998	PF01048	0.653
MOD_GSK3_1	12	19	PF00069	0.730
MOD_GSK3_1	185	192	PF00069	0.700
MOD_GSK3_1	229	236	PF00069	0.712
MOD_GSK3_1	248	255	PF00069	0.670
MOD_GSK3_1	297	304	PF00069	0.556
MOD_GSK3_1	540	547	PF00069	0.610
MOD_GSK3_1	585	592	PF00069	0.632
MOD_GSK3_1	608	615	PF00069	0.458
MOD_GSK3_1	62	69	PF00069	0.727
MOD_GSK3_1	73	80	PF00069	0.597
MOD_GSK3_1	857	864	PF00069	0.592
MOD_GSK3_1	964	971	PF00069	0.703
MOD_LATS_1	616	622	PF00433	0.507
MOD_N-GLC_1	367	372	PF02516	0.471
MOD_N-GLC_1	409	414	PF02516	0.611
MOD_N-GLC_1	544	549	PF02516	0.385
MOD_N-GLC_1	722	727	PF02516	0.585
MOD_N-GLC_1	781	786	PF02516	0.463
MOD_N-GLC_1	802	807	PF02516	0.544
MOD_N-GLC_1	844	849	PF02516	0.371
MOD_NEK2_1	196	201	PF00069	0.604
MOD_NEK2_1	324	329	PF00069	0.530
MOD_NEK2_1	37	42	PF00069	0.671
MOD_NEK2_1	523	528	PF00069	0.472
MOD_NEK2_1	571	576	PF00069	0.521
MOD_NEK2_1	650	655	PF00069	0.522
MOD_NEK2_1	676	681	PF00069	0.454
MOD_NEK2_1	691	696	PF00069	0.517
MOD_NEK2_1	724	729	PF00069	0.521
MOD_NEK2_1	748	753	PF00069	0.504
MOD_NEK2_1	776	781	PF00069	0.460
MOD_NEK2_1	802	807	PF00069	0.449
MOD_NEK2_1	844	849	PF00069	0.594
MOD_NEK2_1	863	868	PF00069	0.461
MOD_NEK2_1	904	909	PF00069	0.535
MOD_NEK2_1	985	990	PF00069	0.498
MOD_NEK2_2	367	372	PF00069	0.490
MOD_PIKK_1	252	258	PF00454	0.741
MOD_PIKK_1	73	79	PF00454	0.851
MOD_PIKK_1	760	766	PF00454	0.580
MOD_PKA_1	618	624	PF00069	0.624
MOD_PKA_2	571	577	PF00069	0.462
MOD_PKA_2	618	624	PF00069	0.663
MOD_PKA_2	62	68	PF00069	0.593
MOD_PKA_2	751	757	PF00069	0.598
MOD_PKA_2	897	903	PF00069	0.609
MOD_PKA_2	91	97	PF00069	0.687
MOD_PKA_2	999	1005	PF00069	0.562
MOD_Plk_1	324	330	PF00069	0.530
MOD_Plk_1	367	373	PF00069	0.470
MOD_Plk_1	544	550	PF00069	0.385
MOD_Plk_1	676	682	PF00069	0.415
MOD_Plk_1	746	752	PF00069	0.442
MOD_Plk_1	776	782	PF00069	0.470
MOD_Plk_1	968	974	PF00069	0.750
MOD_Plk_2-3	248	254	PF00069	0.709
MOD_Plk_4	190	196	PF00069	0.424
MOD_Plk_4	360	366	PF00069	0.458
MOD_Plk_4	589	595	PF00069	0.469
MOD_Plk_4	650	656	PF00069	0.565
MOD_Plk_4	658	664	PF00069	0.558
MOD_Plk_4	887	893	PF00069	0.620
MOD_Plk_4	904	910	PF00069	0.373
MOD_Plk_4	945	951	PF00069	0.496
MOD_Plk_4	985	991	PF00069	0.577
MOD_ProDKin_1	12	18	PF00069	0.713
MOD_ProDKin_1	205	211	PF00069	0.599
MOD_ProDKin_1	229	235	PF00069	0.619
MOD_ProDKin_1	335	341	PF00069	0.678
MOD_ProDKin_1	485	491	PF00069	0.796
MOD_ProDKin_1	509	515	PF00069	0.543
MOD_ProDKin_1	707	713	PF00069	0.593
MOD_ProDKin_1	817	823	PF00069	0.707
MOD_ProDKin_1	877	883	PF00069	0.633
TRG_DiLeu_BaEn_1	698	703	PF01217	0.616
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.564
TRG_DiLeu_BaLyEn_6	980	985	PF01217	0.551
TRG_ENDOCYTIC_2	218	221	PF00928	0.616
TRG_ENDOCYTIC_2	31	34	PF00928	0.556
TRG_ENDOCYTIC_2	328	331	PF00928	0.530
TRG_ENDOCYTIC_2	373	376	PF00928	0.564
TRG_ENDOCYTIC_2	434	437	PF00928	0.523
TRG_ENDOCYTIC_2	517	520	PF00928	0.452
TRG_ENDOCYTIC_2	560	563	PF00928	0.497
TRG_ENDOCYTIC_2	780	783	PF00928	0.442
TRG_ER_diArg_1	519	522	PF00400	0.400
TRG_ER_diArg_1	571	573	PF00400	0.404
TRG_ER_diArg_1	617	619	PF00400	0.717
TRG_ER_diArg_1	714	716	PF00400	0.482
TRG_NES_CRM1_1	837	850	PF08389	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE6	Leptomonas seymouri	53%	96%
A0A1X0NWD9	Trypanosomatidae	34%	100%
A0A3S7WRP9	Leishmania donovani	83%	100%
A0A422MZT7	Trypanosoma rangeli	32%	100%
A4HUZ8	Leishmania infantum	83%	100%
D0A7F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ANN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGZ0	Leishmania major	81%	100%
V5C1B4	Trypanosoma cruzi	33%	100%