START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6L4_LEIBR

TriTrypDb:

LbrM.11.0680 , LBRM2903_110012700

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6L4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	22
GO:0008289	lipid binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.426
DEG_APCC_KENBOX_2	101	105	PF00400	0.347
DEG_SPOP_SBC_1	12	16	PF00917	0.484
DOC_CKS1_1	28	33	PF01111	0.463
DOC_USP7_MATH_1	56	60	PF00917	0.452
DOC_USP7_MATH_1	8	12	PF00917	0.673
DOC_WW_Pin1_4	150	155	PF00397	0.365
DOC_WW_Pin1_4	27	32	PF00397	0.409
LIG_14-3-3_CanoR_1	136	141	PF00244	0.428
LIG_BRCT_BRCA1_1	317	321	PF00533	0.328
LIG_BRCT_BRCA1_2	317	323	PF00533	0.357
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.446
LIG_FHA_1	109	115	PF00498	0.203
LIG_FHA_1	211	217	PF00498	0.310
LIG_FHA_1	248	254	PF00498	0.333
LIG_FHA_1	300	306	PF00498	0.529
LIG_FHA_2	108	114	PF00498	0.344
LIG_FHA_2	235	241	PF00498	0.298
LIG_LIR_Apic_2	286	292	PF02991	0.416
LIG_LIR_Apic_2	68	74	PF02991	0.462
LIG_LIR_Gen_1	113	123	PF02991	0.300
LIG_LIR_Gen_1	175	185	PF02991	0.343
LIG_LIR_Nem_3	113	118	PF02991	0.300
LIG_LIR_Nem_3	125	130	PF02991	0.398
LIG_LIR_Nem_3	133	138	PF02991	0.362
LIG_LIR_Nem_3	175	180	PF02991	0.347
LIG_LIR_Nem_3	53	57	PF02991	0.325
LIG_NRBOX	113	119	PF00104	0.460
LIG_Pex14_1	317	321	PF04695	0.328
LIG_Pex14_2	123	127	PF04695	0.350
LIG_Pex14_2	272	276	PF04695	0.493
LIG_PTB_Apo_2	157	164	PF02174	0.345
LIG_SH2_CRK	115	119	PF00017	0.345
LIG_SH2_CRK	28	32	PF00017	0.422
LIG_SH2_CRK	46	50	PF00017	0.383
LIG_SH2_CRK	71	75	PF00017	0.466
LIG_SH2_NCK_1	71	75	PF00017	0.552
LIG_SH2_STAP1	285	289	PF00017	0.599
LIG_SH2_STAT3	235	238	PF00017	0.324
LIG_SH2_STAT5	177	180	PF00017	0.402
LIG_SH2_STAT5	205	208	PF00017	0.369
LIG_SH2_STAT5	215	218	PF00017	0.315
LIG_SH2_STAT5	235	238	PF00017	0.298
LIG_SH2_STAT5	285	288	PF00017	0.490
LIG_SH3_1	82	88	PF00018	0.523
LIG_SH3_3	82	88	PF00018	0.523
LIG_SUMO_SIM_par_1	136	141	PF11976	0.407
LIG_WRC_WIRS_1	57	62	PF05994	0.412
MOD_CDK_SPxK_1	27	33	PF00069	0.308
MOD_CK1_1	11	17	PF00069	0.683
MOD_CK1_1	141	147	PF00069	0.404
MOD_CK1_1	20	26	PF00069	0.511
MOD_CK1_1	210	216	PF00069	0.351
MOD_CK2_1	107	113	PF00069	0.460
MOD_GlcNHglycan	10	13	PF01048	0.745
MOD_GlcNHglycan	140	143	PF01048	0.404
MOD_GlcNHglycan	224	227	PF01048	0.491
MOD_GlcNHglycan	34	37	PF01048	0.431
MOD_GSK3_1	13	20	PF00069	0.653
MOD_GSK3_1	180	187	PF00069	0.392
MOD_GSK3_1	294	301	PF00069	0.562
MOD_GSK3_1	4	11	PF00069	0.717
MOD_GSK3_1	56	63	PF00069	0.410
MOD_N-GLC_1	180	185	PF02516	0.337
MOD_N-GLC_1	306	311	PF02516	0.422
MOD_NEK2_1	118	123	PF00069	0.324
MOD_NEK2_1	180	185	PF00069	0.331
MOD_NEK2_1	252	257	PF00069	0.326
MOD_PIKK_1	17	23	PF00454	0.614
MOD_PIKK_1	184	190	PF00454	0.203
MOD_PIKK_1	234	240	PF00454	0.341
MOD_Plk_1	180	186	PF00069	0.283
MOD_Plk_1	306	312	PF00069	0.429
MOD_Plk_2-3	294	300	PF00069	0.575
MOD_Plk_4	118	124	PF00069	0.272
MOD_Plk_4	231	237	PF00069	0.320
MOD_ProDKin_1	150	156	PF00069	0.365
MOD_ProDKin_1	27	33	PF00069	0.417
MOD_SUMO_for_1	305	308	PF00179	0.517
MOD_SUMO_rev_2	76	85	PF00179	0.506
TRG_DiLeu_BaEn_1	113	118	PF01217	0.320
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.203
TRG_ENDOCYTIC_2	115	118	PF00928	0.345
TRG_ENDOCYTIC_2	177	180	PF00928	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	36%	88%
A0A0N1I4D8	Leptomonas seymouri	71%	96%
A0A0S4INS4	Bodo saltans	39%	100%
A0A0S4KH88	Bodo saltans	35%	82%
A0A1X0NV84	Trypanosomatidae	51%	100%
A0A1X0P910	Trypanosomatidae	35%	86%
A0A3Q8IBA5	Leishmania donovani	79%	100%
A0A3Q8IJ21	Leishmania donovani	35%	89%
A0A3R7KCX0	Trypanosoma rangeli	36%	89%
A0A422MZR8	Trypanosoma rangeli	50%	100%
A4HUZ7	Leishmania infantum	79%	78%
A4I4Z0	Leishmania infantum	35%	89%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	88%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AED5	Leishmania major	35%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	89%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QGZ1	Leishmania major	80%	100%
Q9JMD3	Mus musculus	33%	100%
Q9Y365	Homo sapiens	31%	100%
V5BC62	Trypanosoma cruzi	37%	89%
V5DT41	Trypanosoma cruzi	49%	100%