LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family, putative
Species:
Leishmania braziliensis
UniProt:
A4H6L0_LEIBR
TriTrypDb:
LbrM.11.0640 , LBRM2903_110011600 *
Length:
490

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 26
NetGPI no yes: 0, no: 26
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4H6L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6L0

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044255 cellular lipid metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016298 lipase activity 4 3
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0034338 short-chain carboxylesterase activity 5 3
GO:0047372 acylglycerol lipase activity 5 3
GO:0052689 carboxylic ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 97 101 PF00656 0.421
CLV_MEL_PAP_1 73 79 PF00089 0.472
CLV_NRD_NRD_1 192 194 PF00675 0.506
CLV_NRD_NRD_1 251 253 PF00675 0.653
CLV_NRD_NRD_1 54 56 PF00675 0.428
CLV_PCSK_KEX2_1 192 194 PF00082 0.506
CLV_PCSK_KEX2_1 251 253 PF00082 0.681
CLV_PCSK_KEX2_1 54 56 PF00082 0.429
CLV_PCSK_SKI1_1 125 129 PF00082 0.479
CLV_PCSK_SKI1_1 196 200 PF00082 0.476
CLV_PCSK_SKI1_1 340 344 PF00082 0.556
CLV_PCSK_SKI1_1 351 355 PF00082 0.523
CLV_PCSK_SKI1_1 44 48 PF00082 0.554
CLV_PCSK_SKI1_1 466 470 PF00082 0.488
CLV_PCSK_SKI1_1 484 488 PF00082 0.537
DEG_APCC_DBOX_1 30 38 PF00400 0.318
DEG_APCC_DBOX_1 315 323 PF00400 0.400
DEG_APCC_DBOX_1 432 440 PF00400 0.320
DEG_APCC_DBOX_1 465 473 PF00400 0.273
DEG_Nend_Nbox_1 1 3 PF02207 0.504
DEG_SPOP_SBC_1 94 98 PF00917 0.323
DOC_CKS1_1 420 425 PF01111 0.241
DOC_CYCLIN_RxL_1 122 129 PF00134 0.241
DOC_CYCLIN_RxL_1 192 201 PF00134 0.167
DOC_CYCLIN_RxL_1 421 430 PF00134 0.262
DOC_MAPK_DCC_7 263 271 PF00069 0.422
DOC_MAPK_FxFP_2 380 383 PF00069 0.210
DOC_MAPK_gen_1 431 439 PF00069 0.326
DOC_MAPK_gen_1 51 61 PF00069 0.252
DOC_MAPK_MEF2A_6 125 132 PF00069 0.353
DOC_MAPK_MEF2A_6 200 207 PF00069 0.168
DOC_MAPK_MEF2A_6 263 271 PF00069 0.344
DOC_MAPK_MEF2A_6 433 441 PF00069 0.285
DOC_PP2B_LxvP_1 130 133 PF13499 0.294
DOC_PP2B_LxvP_1 315 318 PF13499 0.219
DOC_PP2B_PxIxI_1 266 272 PF00149 0.347
DOC_PP4_FxxP_1 380 383 PF00568 0.313
DOC_SPAK_OSR1_1 76 80 PF12202 0.317
DOC_USP7_MATH_1 290 294 PF00917 0.357
DOC_USP7_MATH_1 390 394 PF00917 0.195
DOC_USP7_MATH_1 94 98 PF00917 0.364
DOC_USP7_UBL2_3 484 488 PF12436 0.335
DOC_WW_Pin1_4 213 218 PF00397 0.275
DOC_WW_Pin1_4 250 255 PF00397 0.490
DOC_WW_Pin1_4 301 306 PF00397 0.273
DOC_WW_Pin1_4 400 405 PF00397 0.348
DOC_WW_Pin1_4 419 424 PF00397 0.286
DOC_WW_Pin1_4 65 70 PF00397 0.316
DOC_WW_Pin1_4 99 104 PF00397 0.332
LIG_14-3-3_CanoR_1 364 369 PF00244 0.346
LIG_14-3-3_CanoR_1 76 84 PF00244 0.324
LIG_Actin_WH2_1 220 235 PF00022 0.208
LIG_BIR_III_2 100 104 PF00653 0.294
LIG_BRCT_BRCA1_1 185 189 PF00533 0.319
LIG_BRCT_BRCA1_1 224 228 PF00533 0.355
LIG_BRCT_BRCA1_1 292 296 PF00533 0.421
LIG_BRCT_BRCA1_2 224 230 PF00533 0.205
LIG_Clathr_ClatBox_1 436 440 PF01394 0.337
LIG_Clathr_ClatBox_2 452 457 PF01394 0.235
LIG_CSL_BTD_1 150 153 PF09270 0.348
LIG_deltaCOP1_diTrp_1 149 152 PF00928 0.283
LIG_FHA_1 227 233 PF00498 0.234
LIG_FHA_1 251 257 PF00498 0.417
LIG_FHA_1 279 285 PF00498 0.236
LIG_FHA_1 401 407 PF00498 0.256
LIG_FHA_2 144 150 PF00498 0.285
LIG_FHA_2 152 158 PF00498 0.351
LIG_FHA_2 214 220 PF00498 0.352
LIG_FHA_2 365 371 PF00498 0.285
LIG_FXI_DFP_1 368 372 PF00024 0.512
LIG_LIR_Apic_2 149 153 PF02991 0.349
LIG_LIR_Gen_1 293 302 PF02991 0.352
LIG_LIR_Gen_1 370 378 PF02991 0.326
LIG_LIR_Gen_1 4 14 PF02991 0.415
LIG_LIR_Gen_1 422 429 PF02991 0.272
LIG_LIR_Nem_3 102 108 PF02991 0.245
LIG_LIR_Nem_3 293 299 PF02991 0.358
LIG_LIR_Nem_3 370 374 PF02991 0.332
LIG_LIR_Nem_3 393 398 PF02991 0.288
LIG_LIR_Nem_3 4 10 PF02991 0.402
LIG_LIR_Nem_3 422 428 PF02991 0.335
LIG_NRBOX 36 42 PF00104 0.332
LIG_Pex14_2 224 228 PF04695 0.320
LIG_SH2_CRK 108 112 PF00017 0.272
LIG_SH2_CRK 19 23 PF00017 0.242
LIG_SH2_NCK_1 3 7 PF00017 0.341
LIG_SH2_NCK_1 389 393 PF00017 0.234
LIG_SH2_STAP1 3 7 PF00017 0.341
LIG_SH2_STAT5 190 193 PF00017 0.266
LIG_SH2_STAT5 283 286 PF00017 0.276
LIG_SH2_STAT5 3 6 PF00017 0.542
LIG_SH2_STAT5 438 441 PF00017 0.277
LIG_SH3_3 174 180 PF00018 0.279
LIG_SH3_3 27 33 PF00018 0.315
LIG_SH3_3 415 421 PF00018 0.332
LIG_SH3_3 436 442 PF00018 0.262
LIG_SH3_CIN85_PxpxPR_1 419 424 PF14604 0.269
LIG_TRAF2_2 255 260 PF00917 0.342
LIG_UBA3_1 223 230 PF00899 0.425
MOD_CDK_SPK_2 419 424 PF00069 0.296
MOD_CDK_SPK_2 65 70 PF00069 0.375
MOD_CDK_SPxxK_3 213 220 PF00069 0.346
MOD_CK1_1 301 307 PF00069 0.345
MOD_CK1_1 455 461 PF00069 0.477
MOD_CK1_1 478 484 PF00069 0.381
MOD_CK1_1 65 71 PF00069 0.460
MOD_CK1_1 95 101 PF00069 0.531
MOD_CK2_1 182 188 PF00069 0.431
MOD_CK2_1 213 219 PF00069 0.442
MOD_CMANNOS 454 457 PF00535 0.363
MOD_GlcNHglycan 163 166 PF01048 0.482
MOD_GlcNHglycan 224 227 PF01048 0.350
MOD_GlcNHglycan 293 296 PF01048 0.423
MOD_GlcNHglycan 310 313 PF01048 0.394
MOD_GlcNHglycan 325 328 PF01048 0.357
MOD_GlcNHglycan 477 480 PF01048 0.453
MOD_GlcNHglycan 64 67 PF01048 0.455
MOD_GlcNHglycan 97 100 PF01048 0.617
MOD_GSK3_1 151 158 PF00069 0.412
MOD_GSK3_1 222 229 PF00069 0.338
MOD_GSK3_1 278 285 PF00069 0.299
MOD_GSK3_1 61 68 PF00069 0.373
MOD_GSK3_1 90 97 PF00069 0.553
MOD_LATS_1 90 96 PF00433 0.415
MOD_N-GLC_1 306 311 PF02516 0.366
MOD_NEK2_1 1 6 PF00069 0.446
MOD_NEK2_1 10 15 PF00069 0.307
MOD_NEK2_1 182 187 PF00069 0.360
MOD_NEK2_1 198 203 PF00069 0.379
MOD_NEK2_1 278 283 PF00069 0.261
MOD_NEK2_1 323 328 PF00069 0.440
MOD_NEK2_1 398 403 PF00069 0.359
MOD_NEK2_1 59 64 PF00069 0.440
MOD_PIKK_1 455 461 PF00454 0.442
MOD_PIKK_1 478 484 PF00454 0.565
MOD_PKA_2 134 140 PF00069 0.420
MOD_Plk_1 356 362 PF00069 0.384
MOD_Plk_4 116 122 PF00069 0.305
MOD_Plk_4 35 41 PF00069 0.354
MOD_Plk_4 356 362 PF00069 0.382
MOD_Plk_4 391 397 PF00069 0.232
MOD_Plk_4 468 474 PF00069 0.385
MOD_ProDKin_1 213 219 PF00069 0.344
MOD_ProDKin_1 250 256 PF00069 0.640
MOD_ProDKin_1 301 307 PF00069 0.336
MOD_ProDKin_1 400 406 PF00069 0.435
MOD_ProDKin_1 419 425 PF00069 0.341
MOD_ProDKin_1 65 71 PF00069 0.387
MOD_ProDKin_1 99 105 PF00069 0.405
MOD_SUMO_for_1 50 53 PF00179 0.455
TRG_DiLeu_BaEn_2 462 468 PF01217 0.331
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.294
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.462
TRG_DiLeu_BaLyEn_6 318 323 PF01217 0.242
TRG_ENDOCYTIC_2 438 441 PF00928 0.290
TRG_ER_diArg_1 191 193 PF00400 0.380
TRG_ER_diArg_1 250 252 PF00400 0.590
TRG_ER_diArg_1 54 56 PF00400 0.306
TRG_ER_diLys_1 487 490 PF00400 0.516
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.413
TRG_Pf-PMV_PEXEL_1 233 237 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.280

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 27% 100%
A0A0N1HZ60 Leptomonas seymouri 34% 100%
A0A0N1I523 Leptomonas seymouri 28% 100%
A0A0N1I5Q2 Leptomonas seymouri 62% 97%
A0A0N1I7U8 Leptomonas seymouri 33% 100%
A0A0S4JMS7 Bodo saltans 32% 100%
A0A0S4JTS9 Bodo saltans 30% 100%
A0A1X0NEW5 Trypanosomatidae 35% 100%
A0A1X0NSK7 Trypanosomatidae 36% 100%
A0A1X0NUZ6 Trypanosomatidae 33% 100%
A0A3S5H6J1 Leishmania donovani 35% 100%
A0A3S7X2V6 Leishmania donovani 33% 100%
A0A422NB49 Trypanosoma rangeli 35% 100%
A0A422NQC5 Trypanosoma rangeli 38% 100%
A4HHU6 Leishmania braziliensis 33% 100%
A4HUZ4 Leishmania infantum 35% 100%
A4I4Z6 Leishmania infantum 34% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q0VC00 Bos taurus 26% 100%
Q24093 Drosophila melanogaster 23% 100%
Q3T0A0 Bos taurus 28% 100%
Q40863 Picea glauca 28% 100%
Q4Q7V8 Leishmania major 33% 100%
Q4QGZ4 Leishmania major 34% 96%
Q4QGZ5 Leishmania major 77% 100%
Q54H38 Dictyostelium discoideum 27% 100%
Q5RK23 Rattus norvegicus 27% 100%
Q8WU67 Homo sapiens 27% 100%
Q91ZH7 Mus musculus 26% 100%
Q96SE0 Homo sapiens 27% 100%
Q9QZC8 Mus musculus 27% 100%
V5AZF4 Trypanosoma cruzi 36% 100%
V5BBC2 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS