Tubulin-tyrsoine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrsoine ligase-like protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H6K8_LEIBR

TriTrypDb:

LbrM.11.0620 , LBRM2903_110005700

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.840
CLV_NRD_NRD_1	169	171	PF00675	0.639
CLV_NRD_NRD_1	209	211	PF00675	0.904
CLV_NRD_NRD_1	219	221	PF00675	0.714
CLV_NRD_NRD_1	617	619	PF00675	0.803
CLV_NRD_NRD_1	622	624	PF00675	0.597
CLV_NRD_NRD_1	636	638	PF00675	0.285
CLV_NRD_NRD_1	692	694	PF00675	0.678
CLV_NRD_NRD_1	705	707	PF00675	0.430
CLV_NRD_NRD_1	738	740	PF00675	0.706
CLV_PCSK_FUR_1	736	740	PF00082	0.692
CLV_PCSK_KEX2_1	155	157	PF00082	0.840
CLV_PCSK_KEX2_1	168	170	PF00082	0.656
CLV_PCSK_KEX2_1	209	211	PF00082	0.904
CLV_PCSK_KEX2_1	576	578	PF00082	0.849
CLV_PCSK_KEX2_1	617	619	PF00082	0.803
CLV_PCSK_KEX2_1	705	707	PF00082	0.657
CLV_PCSK_KEX2_1	738	740	PF00082	0.706
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.849
CLV_PCSK_PC7_1	205	211	PF00082	0.899
CLV_PCSK_SKI1_1	150	154	PF00082	0.840
CLV_PCSK_SKI1_1	155	159	PF00082	0.759
CLV_PCSK_SKI1_1	170	174	PF00082	0.532
DEG_MDM2_SWIB_1	659	667	PF02201	0.595
DEG_SCF_FBW7_1	604	609	PF00400	0.806
DOC_CKS1_1	382	387	PF01111	0.874
DOC_CKS1_1	39	44	PF01111	0.837
DOC_CKS1_1	454	459	PF01111	0.867
DOC_CKS1_1	50	55	PF01111	0.652
DOC_CKS1_1	66	71	PF01111	0.586
DOC_MAPK_gen_1	620	630	PF00069	0.658
DOC_MAPK_gen_1	637	645	PF00069	0.349
DOC_MAPK_MEF2A_6	623	630	PF00069	0.621
DOC_PP2B_LxvP_1	246	249	PF13499	0.855
DOC_PP2B_LxvP_1	298	301	PF13499	0.849
DOC_PP4_FxxP_1	136	139	PF00568	0.865
DOC_PP4_FxxP_1	185	188	PF00568	0.878
DOC_USP7_MATH_1	103	107	PF00917	0.614
DOC_USP7_MATH_1	109	113	PF00917	0.517
DOC_USP7_MATH_1	188	192	PF00917	0.865
DOC_USP7_MATH_1	287	291	PF00917	0.848
DOC_USP7_MATH_1	292	296	PF00917	0.769
DOC_USP7_MATH_1	34	38	PF00917	0.865
DOC_USP7_MATH_1	359	363	PF00917	0.856
DOC_USP7_MATH_1	555	559	PF00917	0.862
DOC_USP7_MATH_1	596	600	PF00917	0.760
DOC_USP7_MATH_1	622	626	PF00917	0.651
DOC_USP7_MATH_1	89	93	PF00917	0.853
DOC_USP7_UBL2_3	703	707	PF12436	0.657
DOC_WW_Pin1_4	10	15	PF00397	0.845
DOC_WW_Pin1_4	209	214	PF00397	0.895
DOC_WW_Pin1_4	221	226	PF00397	0.666
DOC_WW_Pin1_4	254	259	PF00397	0.878
DOC_WW_Pin1_4	316	321	PF00397	0.863
DOC_WW_Pin1_4	322	327	PF00397	0.780
DOC_WW_Pin1_4	355	360	PF00397	0.857
DOC_WW_Pin1_4	369	374	PF00397	0.618
DOC_WW_Pin1_4	375	380	PF00397	0.516
DOC_WW_Pin1_4	38	43	PF00397	0.838
DOC_WW_Pin1_4	381	386	PF00397	0.663
DOC_WW_Pin1_4	387	392	PF00397	0.555
DOC_WW_Pin1_4	393	398	PF00397	0.562
DOC_WW_Pin1_4	399	404	PF00397	0.563
DOC_WW_Pin1_4	405	410	PF00397	0.558
DOC_WW_Pin1_4	411	416	PF00397	0.555
DOC_WW_Pin1_4	417	422	PF00397	0.558
DOC_WW_Pin1_4	423	428	PF00397	0.558
DOC_WW_Pin1_4	429	434	PF00397	0.557
DOC_WW_Pin1_4	435	440	PF00397	0.548
DOC_WW_Pin1_4	441	446	PF00397	0.544
DOC_WW_Pin1_4	447	452	PF00397	0.546
DOC_WW_Pin1_4	453	458	PF00397	0.548
DOC_WW_Pin1_4	459	464	PF00397	0.553
DOC_WW_Pin1_4	465	470	PF00397	0.549
DOC_WW_Pin1_4	471	476	PF00397	0.547
DOC_WW_Pin1_4	477	482	PF00397	0.544
DOC_WW_Pin1_4	483	488	PF00397	0.549
DOC_WW_Pin1_4	489	494	PF00397	0.553
DOC_WW_Pin1_4	49	54	PF00397	0.654
DOC_WW_Pin1_4	495	500	PF00397	0.551
DOC_WW_Pin1_4	501	506	PF00397	0.550
DOC_WW_Pin1_4	507	512	PF00397	0.552
DOC_WW_Pin1_4	513	518	PF00397	0.557
DOC_WW_Pin1_4	519	524	PF00397	0.562
DOC_WW_Pin1_4	525	530	PF00397	0.556
DOC_WW_Pin1_4	531	536	PF00397	0.560
DOC_WW_Pin1_4	537	542	PF00397	0.557
DOC_WW_Pin1_4	543	548	PF00397	0.556
DOC_WW_Pin1_4	551	556	PF00397	0.521
DOC_WW_Pin1_4	602	607	PF00397	0.815
DOC_WW_Pin1_4	65	70	PF00397	0.581
LIG_14-3-3_CanoR_1	144	153	PF00244	0.852
LIG_14-3-3_CanoR_1	209	213	PF00244	0.897
LIG_14-3-3_CanoR_1	610	619	PF00244	0.807
LIG_14-3-3_CanoR_1	623	627	PF00244	0.399
LIG_14-3-3_CanoR_1	717	722	PF00244	0.644
LIG_14-3-3_CterR_2	738	742	PF00244	0.723
LIG_BIR_II_1	1	5	PF00653	0.853
LIG_BRCT_BRCA1_1	60	64	PF00533	0.868
LIG_FHA_1	124	130	PF00498	0.870
LIG_FHA_1	181	187	PF00498	0.884
LIG_FHA_1	243	249	PF00498	0.851
LIG_FHA_1	279	285	PF00498	0.856
LIG_FHA_1	286	292	PF00498	0.724
LIG_FHA_1	603	609	PF00498	0.810
LIG_FHA_1	611	617	PF00498	0.670
LIG_FHA_1	66	72	PF00498	0.867
LIG_FHA_2	261	267	PF00498	0.890
LIG_FHA_2	358	364	PF00498	0.852
LIG_FHA_2	647	653	PF00498	0.645
LIG_LIR_Apic_2	135	139	PF02991	0.867
LIG_LIR_Apic_2	183	188	PF02991	0.879
LIG_LIR_Nem_3	242	246	PF02991	0.843
LIG_LIR_Nem_3	631	636	PF02991	0.631
LIG_LIR_Nem_3	710	715	PF02991	0.636
LIG_LYPXL_yS_3	633	636	PF13949	0.634
LIG_PDZ_Class_2	737	742	PF00595	0.713
LIG_Pex14_2	659	663	PF04695	0.582
LIG_SH2_STAP1	244	248	PF00017	0.852
LIG_SH2_STAT5	244	247	PF00017	0.852
LIG_SH2_STAT5	277	280	PF00017	0.869
LIG_SH3_3	1	7	PF00018	0.846
LIG_SH3_3	156	162	PF00018	0.847
LIG_SH3_3	219	225	PF00018	0.881
LIG_SH3_3	255	261	PF00018	0.884
LIG_SH3_3	314	320	PF00018	0.865
LIG_SH3_3	358	364	PF00018	0.852
LIG_SH3_3	36	42	PF00018	0.847
LIG_SH3_3	379	385	PF00018	0.867
LIG_SH3_3	451	457	PF00018	0.863
LIG_SH3_3	60	66	PF00018	0.862
LIG_SUMO_SIM_anti_2	664	672	PF11976	0.618
LIG_TRAF2_1	649	652	PF00917	0.653
LIG_TRFH_1	602	606	PF08558	0.818
LIG_TYR_ITSM	629	636	PF00017	0.630
LIG_UBA3_1	615	624	PF00899	0.764
MOD_CDK_SPxK_1	254	260	PF00069	0.880
MOD_CK1_1	102	108	PF00069	0.861
MOD_CK1_1	254	260	PF00069	0.880
MOD_CK1_1	285	291	PF00069	0.845
MOD_CK1_1	319	325	PF00069	0.881
MOD_CK1_1	37	43	PF00069	0.843
MOD_CK1_1	554	560	PF00069	0.864
MOD_CK1_1	581	587	PF00069	0.820
MOD_CK1_1	720	726	PF00069	0.646
MOD_CK2_1	260	266	PF00069	0.890
MOD_CK2_1	646	652	PF00069	0.650
MOD_Cter_Amidation	166	169	PF01082	0.871
MOD_Cter_Amidation	207	210	PF01082	0.902
MOD_Cter_Amidation	94	97	PF01082	0.854
MOD_GlcNHglycan	101	104	PF01048	0.645
MOD_GlcNHglycan	135	139	PF01048	0.867
MOD_GlcNHglycan	146	149	PF01048	0.661
MOD_GlcNHglycan	177	180	PF01048	0.880
MOD_GlcNHglycan	190	193	PF01048	0.646
MOD_GlcNHglycan	205	208	PF01048	0.634
MOD_GlcNHglycan	22	25	PF01048	0.842
MOD_GlcNHglycan	284	287	PF01048	0.844
MOD_GlcNHglycan	294	297	PF01048	0.668
MOD_GlcNHglycan	298	301	PF01048	0.604
MOD_GlcNHglycan	36	39	PF01048	0.608
MOD_GlcNHglycan	548	551	PF01048	0.880
MOD_GlcNHglycan	557	560	PF01048	0.708
MOD_GlcNHglycan	89	92	PF01048	0.852
MOD_GlcNHglycan	93	96	PF01048	0.784
MOD_GSK3_1	144	151	PF00069	0.854
MOD_GSK3_1	188	195	PF00069	0.870
MOD_GSK3_1	196	203	PF00069	0.747
MOD_GSK3_1	20	27	PF00069	0.841
MOD_GSK3_1	278	285	PF00069	0.858
MOD_GSK3_1	292	299	PF00069	0.607
MOD_GSK3_1	312	319	PF00069	0.519
MOD_GSK3_1	332	339	PF00069	0.528
MOD_GSK3_1	34	41	PF00069	0.612
MOD_GSK3_1	355	362	PF00069	0.860
MOD_GSK3_1	365	372	PF00069	0.693
MOD_GSK3_1	389	396	PF00069	0.873
MOD_GSK3_1	425	432	PF00069	0.872
MOD_GSK3_1	461	468	PF00069	0.868
MOD_GSK3_1	491	498	PF00069	0.870
MOD_GSK3_1	515	522	PF00069	0.875
MOD_GSK3_1	527	534	PF00069	0.665
MOD_GSK3_1	542	549	PF00069	0.611
MOD_GSK3_1	551	558	PF00069	0.712
MOD_GSK3_1	578	585	PF00069	0.828
MOD_GSK3_1	602	609	PF00069	0.811
MOD_GSK3_1	73	80	PF00069	0.866
MOD_GSK3_1	83	90	PF00069	0.674
MOD_GSK3_1	99	106	PF00069	0.576
MOD_N-GLC_1	192	197	PF02516	0.877
MOD_N-GLC_1	200	205	PF02516	0.749
MOD_N-GLC_1	80	85	PF02516	0.856
MOD_N-GLC_1	99	104	PF02516	0.524
MOD_N-GLC_2	660	662	PF02516	0.575
MOD_N-GLC_2	77	79	PF02516	0.863
MOD_NEK2_1	312	317	PF00069	0.869
MOD_NEK2_1	404	409	PF00069	0.876
MOD_NEK2_1	440	445	PF00069	0.862
MOD_NEK2_1	476	481	PF00069	0.859
MOD_NEK2_1	506	511	PF00069	0.867
MOD_NEK2_1	536	541	PF00069	0.873
MOD_NEK2_1	58	63	PF00069	0.866
MOD_NEK2_1	697	702	PF00069	0.626
MOD_NEK2_1	726	731	PF00069	0.643
MOD_PIKK_1	116	122	PF00454	0.872
MOD_PIKK_1	200	206	PF00454	0.889
MOD_PIKK_1	26	32	PF00454	0.843
MOD_PIKK_1	325	331	PF00454	0.874
MOD_PKA_2	116	122	PF00069	0.872
MOD_PKA_2	123	129	PF00069	0.749
MOD_PKA_2	180	186	PF00069	0.883
MOD_PKA_2	208	214	PF00069	0.895
MOD_PKA_2	259	265	PF00069	0.890
MOD_PKA_2	572	578	PF00069	0.846
MOD_PKA_2	581	587	PF00069	0.663
MOD_PKA_2	596	602	PF00069	0.512
MOD_PKA_2	609	615	PF00069	0.578
MOD_PKA_2	622	628	PF00069	0.404
MOD_Plk_1	148	154	PF00069	0.842
MOD_Plk_4	226	232	PF00069	0.851
MOD_Plk_4	239	245	PF00069	0.603
MOD_Plk_4	302	308	PF00069	0.858
MOD_Plk_4	663	669	PF00069	0.609
MOD_ProDKin_1	10	16	PF00069	0.846
MOD_ProDKin_1	209	215	PF00069	0.894
MOD_ProDKin_1	221	227	PF00069	0.662
MOD_ProDKin_1	254	260	PF00069	0.880
MOD_ProDKin_1	316	322	PF00069	0.867
MOD_ProDKin_1	355	361	PF00069	0.858
MOD_ProDKin_1	369	375	PF00069	0.620
MOD_ProDKin_1	38	44	PF00069	0.840
MOD_ProDKin_1	381	387	PF00069	0.663
MOD_ProDKin_1	393	399	PF00069	0.667
MOD_ProDKin_1	405	411	PF00069	0.663
MOD_ProDKin_1	417	423	PF00069	0.664
MOD_ProDKin_1	429	435	PF00069	0.662
MOD_ProDKin_1	441	447	PF00069	0.648
MOD_ProDKin_1	453	459	PF00069	0.655
MOD_ProDKin_1	465	471	PF00069	0.654
MOD_ProDKin_1	477	483	PF00069	0.650
MOD_ProDKin_1	489	495	PF00069	0.659
MOD_ProDKin_1	49	55	PF00069	0.653
MOD_ProDKin_1	501	507	PF00069	0.654
MOD_ProDKin_1	513	519	PF00069	0.662
MOD_ProDKin_1	525	531	PF00069	0.661
MOD_ProDKin_1	537	543	PF00069	0.663
MOD_ProDKin_1	551	557	PF00069	0.626
MOD_ProDKin_1	602	608	PF00069	0.813
MOD_ProDKin_1	65	71	PF00069	0.583
MOD_SUMO_rev_2	570	578	PF00179	0.847
MOD_SUMO_rev_2	651	659	PF00179	0.627
TRG_DiLeu_BaLyEn_6	631	636	PF01217	0.631
TRG_ENDOCYTIC_2	633	636	PF00928	0.634
TRG_ER_diArg_1	155	157	PF00400	0.840
TRG_ER_diArg_1	168	170	PF00400	0.656
TRG_ER_diArg_1	616	618	PF00400	0.814
TRG_ER_diArg_1	674	677	PF00400	0.644
TRG_ER_diArg_1	704	706	PF00400	0.647
TRG_ER_diArg_1	735	738	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A3DC27	ACET2	35%	100%
A4Q9E8	MOUSE	28%	90%
A4Q9F0	MOUSE	38%	81%
A4Q9F6	MOUSE	31%	92%
A6NNM8	HUMAN	32%	91%
A8CVX7	DANRE	29%	95%
D3ZVV1	RAT	34%	100%
F7E540	XENTR	35%	82%
P12036	HUMAN	32%	72%
P16884	RAT	35%	69%
P19246	MOUSE	36%	68%
P29294	RABIT	28%	65%
Q01456	ASCSU	24%	100%
Q06852	ACET2	32%	32%
Q23MT7	TETTS	30%	62%
Q28824	BOVIN	25%	63%
Q6ZT98	HUMAN	37%	84%
Q8N841	HUMAN	31%	88%
Q96KM6	HUMAN	24%	83%
Q9P2P1	HUMAN	33%	39%