Tubulin-tyrsoine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrsoine ligase-like protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H6K8_LEIBR

TriTrypDb:

LbrM.11.0620 , LBRM2903_110005700

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K8

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.840
CLV_NRD_NRD_1	169	171	PF00675	0.639
CLV_NRD_NRD_1	209	211	PF00675	0.904
CLV_NRD_NRD_1	219	221	PF00675	0.714
CLV_NRD_NRD_1	617	619	PF00675	0.803
CLV_NRD_NRD_1	622	624	PF00675	0.597
CLV_NRD_NRD_1	636	638	PF00675	0.285
CLV_NRD_NRD_1	692	694	PF00675	0.678
CLV_NRD_NRD_1	705	707	PF00675	0.430
CLV_NRD_NRD_1	738	740	PF00675	0.706

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A3DC27	ACET2	35%	100%
A4Q9E8	MOUSE	28%	90%
A4Q9F0	MOUSE	38%	81%
A4Q9F6	MOUSE	31%	92%
A6NNM8	HUMAN	32%	91%
A8CVX7	DANRE	29%	95%
D3ZVV1	RAT	34%	100%
F7E540	XENTR	35%	82%
P12036	HUMAN	32%	72%
P16884	RAT	35%	69%

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