Protein phosphatase 2C-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6K7_LEIBR

TriTrypDb:

LbrM.11.0610 , LBRM2903_110020500

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.562
CLV_C14_Caspase3-7	462	466	PF00656	0.565
CLV_NRD_NRD_1	265	267	PF00675	0.309
CLV_NRD_NRD_1	426	428	PF00675	0.368
CLV_NRD_NRD_1	50	52	PF00675	0.599
CLV_NRD_NRD_1	67	69	PF00675	0.634
CLV_PCSK_KEX2_1	163	165	PF00082	0.664
CLV_PCSK_KEX2_1	265	267	PF00082	0.330
CLV_PCSK_KEX2_1	426	428	PF00082	0.536
CLV_PCSK_KEX2_1	50	52	PF00082	0.547
CLV_PCSK_KEX2_1	67	69	PF00082	0.779
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.648
CLV_PCSK_SKI1_1	108	112	PF00082	0.541
CLV_PCSK_SKI1_1	265	269	PF00082	0.358
DEG_APCC_DBOX_1	264	272	PF00400	0.297
DEG_APCC_DBOX_1	412	420	PF00400	0.474
DEG_APCC_DBOX_1	425	433	PF00400	0.346
DEG_SCF_FBW7_2	217	223	PF00400	0.455
DEG_SPOP_SBC_1	380	384	PF00917	0.555
DEG_SPOP_SBC_1	56	60	PF00917	0.560
DEG_SPOP_SBC_1	96	100	PF00917	0.491
DOC_CKS1_1	217	222	PF01111	0.469
DOC_CKS1_1	334	339	PF01111	0.709
DOC_CYCLIN_RxL_1	263	270	PF00134	0.303
DOC_MAPK_gen_1	265	271	PF00069	0.299
DOC_MAPK_gen_1	426	434	PF00069	0.550
DOC_MAPK_gen_1	504	514	PF00069	0.477
DOC_MAPK_JIP1_4	533	539	PF00069	0.387
DOC_MAPK_MEF2A_6	298	305	PF00069	0.390
DOC_MAPK_MEF2A_6	507	514	PF00069	0.569
DOC_PP2B_LxvP_1	537	540	PF13499	0.369
DOC_SPAK_OSR1_1	298	302	PF12202	0.388
DOC_USP7_MATH_1	121	125	PF00917	0.465
DOC_USP7_MATH_1	132	136	PF00917	0.542
DOC_USP7_MATH_1	25	29	PF00917	0.539
DOC_USP7_MATH_1	310	314	PF00917	0.501
DOC_USP7_MATH_1	381	385	PF00917	0.670
DOC_USP7_MATH_1	421	425	PF00917	0.515
DOC_USP7_MATH_1	446	450	PF00917	0.614
DOC_USP7_MATH_1	452	456	PF00917	0.676
DOC_USP7_MATH_1	459	463	PF00917	0.579
DOC_USP7_MATH_1	481	485	PF00917	0.565
DOC_USP7_MATH_1	56	60	PF00917	0.631
DOC_USP7_MATH_1	75	79	PF00917	0.639
DOC_USP7_UBL2_3	504	508	PF12436	0.495
DOC_WW_Pin1_4	134	139	PF00397	0.543
DOC_WW_Pin1_4	216	221	PF00397	0.492
DOC_WW_Pin1_4	26	31	PF00397	0.691
DOC_WW_Pin1_4	292	297	PF00397	0.634
DOC_WW_Pin1_4	317	322	PF00397	0.792
DOC_WW_Pin1_4	333	338	PF00397	0.755
DOC_WW_Pin1_4	417	422	PF00397	0.564
DOC_WW_Pin1_4	438	443	PF00397	0.571
DOC_WW_Pin1_4	493	498	PF00397	0.532
DOC_WW_Pin1_4	506	511	PF00397	0.644
LIG_14-3-3_CanoR_1	188	196	PF00244	0.641
LIG_14-3-3_CanoR_1	413	419	PF00244	0.473
LIG_Actin_WH2_2	256	274	PF00022	0.327
LIG_BIR_III_2	515	519	PF00653	0.397
LIG_BIR_III_4	408	412	PF00653	0.630
LIG_BRCT_BRCA1_1	447	451	PF00533	0.565
LIG_FHA_1	241	247	PF00498	0.569
LIG_FHA_1	298	304	PF00498	0.534
LIG_FHA_1	328	334	PF00498	0.709
LIG_FHA_1	359	365	PF00498	0.391
LIG_FHA_1	374	380	PF00498	0.533
LIG_FHA_1	451	457	PF00498	0.563
LIG_FHA_1	493	499	PF00498	0.500
LIG_FHA_1	507	513	PF00498	0.374
LIG_FHA_1	539	545	PF00498	0.319
LIG_FHA_1	96	102	PF00498	0.406
LIG_FHA_2	206	212	PF00498	0.597
LIG_LIR_Apic_2	361	366	PF02991	0.410
LIG_LIR_Apic_2	417	421	PF02991	0.497
LIG_LIR_Gen_1	376	381	PF02991	0.434
LIG_LIR_Nem_3	376	380	PF02991	0.432
LIG_LIR_Nem_3	423	428	PF02991	0.408
LIG_PCNA_yPIPBox_3	184	196	PF02747	0.552
LIG_PDZ_Class_2	560	565	PF00595	0.474
LIG_RPA_C_Fungi	150	162	PF08784	0.552
LIG_SH2_SRC	103	106	PF00017	0.419
LIG_SH2_SRC	428	431	PF00017	0.463
LIG_SH2_STAP1	275	279	PF00017	0.285
LIG_SH2_STAT5	103	106	PF00017	0.447
LIG_SH2_STAT5	109	112	PF00017	0.414
LIG_SH2_STAT5	279	282	PF00017	0.388
LIG_SH2_STAT5	358	361	PF00017	0.438
LIG_SH2_STAT5	428	431	PF00017	0.409
LIG_SH3_1	436	442	PF00018	0.549
LIG_SH3_3	24	30	PF00018	0.560
LIG_SH3_3	300	306	PF00018	0.496
LIG_SH3_3	334	340	PF00018	0.688
LIG_SH3_3	436	442	PF00018	0.606
LIG_SH3_3	517	523	PF00018	0.431
LIG_SH3_3	558	564	PF00018	0.277
LIG_Sin3_3	226	233	PF02671	0.492
LIG_SUMO_SIM_par_1	2	8	PF11976	0.350
LIG_SUMO_SIM_par_1	299	304	PF11976	0.387
MOD_CDK_SPxK_1	292	298	PF00069	0.625
MOD_CK1_1	10	16	PF00069	0.327
MOD_CK1_1	166	172	PF00069	0.550
MOD_CK1_1	29	35	PF00069	0.504
MOD_CK1_1	484	490	PF00069	0.616
MOD_CK1_1	496	502	PF00069	0.460
MOD_CK1_1	506	512	PF00069	0.479
MOD_CK1_1	60	66	PF00069	0.613
MOD_CK1_1	69	75	PF00069	0.696
MOD_CK2_1	205	211	PF00069	0.650
MOD_CK2_1	29	35	PF00069	0.489
MOD_CK2_1	417	423	PF00069	0.481
MOD_CK2_1	457	463	PF00069	0.548
MOD_GlcNHglycan	123	126	PF01048	0.387
MOD_GlcNHglycan	168	171	PF01048	0.673
MOD_GlcNHglycan	201	204	PF01048	0.663
MOD_GlcNHglycan	205	208	PF01048	0.617
MOD_GlcNHglycan	312	315	PF01048	0.689
MOD_GlcNHglycan	404	407	PF01048	0.686
MOD_GlcNHglycan	45	49	PF01048	0.682
MOD_GlcNHglycan	483	486	PF01048	0.723
MOD_GlcNHglycan	71	74	PF01048	0.721
MOD_GlcNHglycan	77	80	PF01048	0.549
MOD_GSK3_1	117	124	PF00069	0.414
MOD_GSK3_1	162	169	PF00069	0.552
MOD_GSK3_1	187	194	PF00069	0.664
MOD_GSK3_1	199	206	PF00069	0.633
MOD_GSK3_1	25	32	PF00069	0.518
MOD_GSK3_1	297	304	PF00069	0.381
MOD_GSK3_1	310	317	PF00069	0.629
MOD_GSK3_1	417	424	PF00069	0.521
MOD_GSK3_1	446	453	PF00069	0.554
MOD_GSK3_1	46	53	PF00069	0.518
MOD_GSK3_1	492	499	PF00069	0.501
MOD_GSK3_1	506	513	PF00069	0.398
MOD_GSK3_1	56	63	PF00069	0.563
MOD_LATS_1	115	121	PF00433	0.343
MOD_NEK2_1	297	302	PF00069	0.379
MOD_NEK2_1	503	508	PF00069	0.481
MOD_NEK2_1	552	557	PF00069	0.398
MOD_NEK2_1	97	102	PF00069	0.468
MOD_NEK2_2	446	451	PF00069	0.539
MOD_PIKK_1	314	320	PF00454	0.562
MOD_PIKK_1	382	388	PF00454	0.629
MOD_PIKK_1	466	472	PF00454	0.565
MOD_PKA_1	163	169	PF00069	0.643
MOD_PKA_1	50	56	PF00069	0.538
MOD_PKA_1	67	73	PF00069	0.557
MOD_PKA_2	163	169	PF00069	0.663
MOD_PKA_2	187	193	PF00069	0.648
MOD_PKA_2	297	303	PF00069	0.390
MOD_PKA_2	50	56	PF00069	0.578
MOD_PKA_2	63	69	PF00069	0.685
MOD_Plk_1	34	40	PF00069	0.376
MOD_Plk_1	56	62	PF00069	0.558
MOD_Plk_2-3	57	63	PF00069	0.556
MOD_Plk_4	191	197	PF00069	0.613
MOD_Plk_4	34	40	PF00069	0.402
MOD_Plk_4	414	420	PF00069	0.518
MOD_Plk_4	446	452	PF00069	0.703
MOD_Plk_4	539	545	PF00069	0.394
MOD_ProDKin_1	134	140	PF00069	0.543
MOD_ProDKin_1	216	222	PF00069	0.479
MOD_ProDKin_1	26	32	PF00069	0.691
MOD_ProDKin_1	292	298	PF00069	0.625
MOD_ProDKin_1	317	323	PF00069	0.791
MOD_ProDKin_1	333	339	PF00069	0.751
MOD_ProDKin_1	417	423	PF00069	0.558
MOD_ProDKin_1	438	444	PF00069	0.575
MOD_ProDKin_1	493	499	PF00069	0.526
MOD_ProDKin_1	506	512	PF00069	0.633
TRG_ER_diArg_1	265	267	PF00400	0.306
TRG_ER_diArg_1	285	288	PF00400	0.544
TRG_ER_diArg_1	425	427	PF00400	0.361
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH30	Leptomonas seymouri	32%	100%
A0A3Q8I7W7	Leishmania donovani	64%	100%
A4HUV0	Leishmania infantum	63%	100%
E9ANI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QH41	Leishmania major	63%	100%