DUF1421 multi-domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6K6_LEIBR

TriTrypDb:

LbrM.11.0600 , LBRM2903_110011000

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.494
CLV_PCSK_KEX2_1	226	228	PF00082	0.484
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.473
CLV_PCSK_SKI1_1	115	119	PF00082	0.699
CLV_PCSK_SKI1_1	219	223	PF00082	0.453
CLV_PCSK_SKI1_1	54	58	PF00082	0.498
DEG_SIAH_1	300	308	PF03145	0.678
DOC_PP1_RVXF_1	193	200	PF00149	0.527
DOC_PP2B_LxvP_1	311	314	PF13499	0.546
DOC_PP4_FxxP_1	199	202	PF00568	0.553
DOC_PP4_MxPP_1	325	328	PF00568	0.667
DOC_PP4_MxPP_1	413	416	PF00568	0.798
DOC_USP7_MATH_1	393	397	PF00917	0.542
DOC_USP7_MATH_1	456	460	PF00917	0.646
DOC_USP7_MATH_1	52	56	PF00917	0.494
DOC_USP7_MATH_1	59	63	PF00917	0.552
DOC_USP7_MATH_1	73	77	PF00917	0.660
DOC_USP7_UBL2_3	16	20	PF12436	0.561
DOC_WW_Pin1_4	115	120	PF00397	0.693
DOC_WW_Pin1_4	297	302	PF00397	0.614
DOC_WW_Pin1_4	303	308	PF00397	0.620
DOC_WW_Pin1_4	447	452	PF00397	0.561
DOC_WW_Pin1_4	91	96	PF00397	0.794
LIG_14-3-3_CanoR_1	294	301	PF00244	0.621
LIG_14-3-3_CanoR_1	442	448	PF00244	0.688
LIG_14-3-3_CanoR_1	74	78	PF00244	0.649
LIG_deltaCOP1_diTrp_1	349	357	PF00928	0.608
LIG_FHA_1	141	147	PF00498	0.578
LIG_FHA_1	207	213	PF00498	0.436
LIG_FHA_1	256	262	PF00498	0.455
LIG_FHA_1	91	97	PF00498	0.571
LIG_SH2_STAP1	181	185	PF00017	0.543
LIG_SH2_STAP1	419	423	PF00017	0.628
LIG_SH2_STAT3	345	348	PF00017	0.655
LIG_SH3_2	425	430	PF14604	0.537
LIG_SH3_3	123	129	PF00018	0.591
LIG_SH3_3	422	428	PF00018	0.685
LIG_SH3_3	63	69	PF00018	0.519
LIG_SH3_3	72	78	PF00018	0.583
LIG_SH3_3	89	95	PF00018	0.579
LIG_SH3_4	16	23	PF00018	0.568
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.535
LIG_TRAF2_1	111	114	PF00917	0.723
LIG_TRAF2_1	130	133	PF00917	0.563
LIG_TRAF2_1	150	153	PF00917	0.677
LIG_TRAF2_1	82	85	PF00917	0.549
MOD_CK1_1	293	299	PF00069	0.593
MOD_CK1_1	306	312	PF00069	0.540
MOD_CK1_1	443	449	PF00069	0.749
MOD_CK2_1	103	109	PF00069	0.680
MOD_CK2_1	122	128	PF00069	0.560
MOD_CK2_1	146	152	PF00069	0.700
MOD_CK2_1	185	191	PF00069	0.511
MOD_CK2_1	207	213	PF00069	0.513
MOD_Cter_Amidation	62	65	PF01082	0.505
MOD_GlcNHglycan	105	108	PF01048	0.591
MOD_GlcNHglycan	132	136	PF01048	0.556
MOD_GlcNHglycan	148	151	PF01048	0.671
MOD_GlcNHglycan	209	212	PF01048	0.512
MOD_GlcNHglycan	308	311	PF01048	0.562
MOD_GlcNHglycan	335	338	PF01048	0.674
MOD_GlcNHglycan	395	398	PF01048	0.687
MOD_GlcNHglycan	46	49	PF01048	0.675
MOD_GlcNHglycan	61	64	PF01048	0.507
MOD_GSK3_1	127	134	PF00069	0.635
MOD_GSK3_1	288	295	PF00069	0.620
MOD_GSK3_1	443	450	PF00069	0.551
MOD_NEK2_1	131	136	PF00069	0.550
MOD_NEK2_1	270	275	PF00069	0.518
MOD_NEK2_1	341	346	PF00069	0.584
MOD_PIKK_1	270	276	PF00454	0.467
MOD_PIKK_1	288	294	PF00454	0.575
MOD_PIKK_1	295	301	PF00454	0.548
MOD_PIKK_1	39	45	PF00454	0.546
MOD_PIKK_1	440	446	PF00454	0.778
MOD_PKA_2	293	299	PF00069	0.600
MOD_PKA_2	73	79	PF00069	0.648
MOD_Plk_1	243	249	PF00069	0.456
MOD_Plk_1	30	36	PF00069	0.552
MOD_Plk_2-3	127	133	PF00069	0.551
MOD_Plk_4	185	191	PF00069	0.542
MOD_Plk_4	5	11	PF00069	0.530
MOD_Plk_4	52	58	PF00069	0.505
MOD_ProDKin_1	115	121	PF00069	0.646
MOD_ProDKin_1	297	303	PF00069	0.614
MOD_ProDKin_1	447	453	PF00069	0.559
MOD_ProDKin_1	91	97	PF00069	0.779
MOD_SUMO_for_1	111	114	PF00179	0.585
MOD_SUMO_for_1	28	31	PF00179	0.578
TRG_DiLeu_BaEn_1	264	269	PF01217	0.516
TRG_DiLeu_BaEn_3	152	158	PF01217	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL54	Leptomonas seymouri	54%	97%
A0A3S7WRM1	Leishmania donovani	83%	100%
A4HUZ1	Leishmania infantum	83%	100%
E9ANM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QGZ7	Leishmania major	82%	100%