EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6K5_LEIBR

TriTrypDb:

LbrM.11.0590 , LBRM2903_110010900

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.342
CLV_C14_Caspase3-7	703	707	PF00656	0.501
CLV_C14_Caspase3-7	875	879	PF00656	0.478
CLV_C14_Caspase3-7	89	93	PF00656	0.494
CLV_NRD_NRD_1	12	14	PF00675	0.463
CLV_NRD_NRD_1	136	138	PF00675	0.501
CLV_NRD_NRD_1	171	173	PF00675	0.422
CLV_NRD_NRD_1	22	24	PF00675	0.383
CLV_NRD_NRD_1	425	427	PF00675	0.495
CLV_NRD_NRD_1	460	462	PF00675	0.480
CLV_NRD_NRD_1	542	544	PF00675	0.465
CLV_NRD_NRD_1	778	780	PF00675	0.459
CLV_NRD_NRD_1	860	862	PF00675	0.525
CLV_NRD_NRD_1	870	872	PF00675	0.593
CLV_NRD_NRD_1	919	921	PF00675	0.541
CLV_PCSK_KEX2_1	136	138	PF00082	0.558
CLV_PCSK_KEX2_1	171	173	PF00082	0.422
CLV_PCSK_KEX2_1	21	23	PF00082	0.445
CLV_PCSK_KEX2_1	542	544	PF00082	0.504
CLV_PCSK_KEX2_1	778	780	PF00082	0.585
CLV_PCSK_KEX2_1	860	862	PF00082	0.524
CLV_PCSK_KEX2_1	870	872	PF00082	0.597
CLV_PCSK_KEX2_1	899	901	PF00082	0.366
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.537
CLV_PCSK_PC1ET2_1	899	901	PF00082	0.423
CLV_PCSK_SKI1_1	136	140	PF00082	0.560
CLV_PCSK_SKI1_1	22	26	PF00082	0.544
CLV_PCSK_SKI1_1	27	31	PF00082	0.507
CLV_PCSK_SKI1_1	352	356	PF00082	0.515
CLV_PCSK_SKI1_1	48	52	PF00082	0.416
CLV_PCSK_SKI1_1	534	538	PF00082	0.384
CLV_PCSK_SKI1_1	602	606	PF00082	0.505
CLV_PCSK_SKI1_1	845	849	PF00082	0.536
CLV_PCSK_SKI1_1	871	875	PF00082	0.616
CLV_PCSK_SKI1_1	900	904	PF00082	0.550
DEG_APCC_DBOX_1	351	359	PF00400	0.511
DEG_APCC_DBOX_1	411	419	PF00400	0.428
DEG_APCC_DBOX_1	533	541	PF00400	0.283
DEG_COP1_1	504	512	PF00400	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.466
DEG_SCF_FBW7_2	122	129	PF00400	0.469
DOC_CKS1_1	673	678	PF01111	0.487
DOC_CYCLIN_RxL_1	169	179	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	658	664	PF00134	0.406
DOC_MAPK_gen_1	289	297	PF00069	0.433
DOC_MAPK_gen_1	563	570	PF00069	0.435
DOC_MAPK_gen_1	647	654	PF00069	0.517
DOC_MAPK_MEF2A_6	117	124	PF00069	0.386
DOC_MAPK_MEF2A_6	563	570	PF00069	0.413
DOC_MAPK_MEF2A_6	653	662	PF00069	0.426
DOC_MAPK_RevD_3	449	462	PF00069	0.415
DOC_PP1_RVXF_1	714	721	PF00149	0.466
DOC_PP2B_LxvP_1	150	153	PF13499	0.470
DOC_PP2B_LxvP_1	507	510	PF13499	0.590
DOC_PP2B_LxvP_1	658	661	PF13499	0.423
DOC_PP4_MxPP_1	450	453	PF00568	0.459
DOC_USP7_MATH_1	224	228	PF00917	0.570
DOC_USP7_MATH_1	519	523	PF00917	0.700
DOC_USP7_MATH_1	555	559	PF00917	0.439
DOC_USP7_MATH_1	588	592	PF00917	0.462
DOC_USP7_MATH_1	739	743	PF00917	0.600
DOC_USP7_MATH_1	75	79	PF00917	0.571
DOC_USP7_MATH_1	825	829	PF00917	0.603
DOC_USP7_MATH_1	855	859	PF00917	0.663
DOC_USP7_MATH_1	86	90	PF00917	0.689
DOC_USP7_MATH_1	865	869	PF00917	0.644
DOC_USP7_UBL2_3	899	903	PF12436	0.299
DOC_WW_Pin1_4	122	127	PF00397	0.581
DOC_WW_Pin1_4	413	418	PF00397	0.509
DOC_WW_Pin1_4	468	473	PF00397	0.507
DOC_WW_Pin1_4	55	60	PF00397	0.601
DOC_WW_Pin1_4	672	677	PF00397	0.485
DOC_WW_Pin1_4	706	711	PF00397	0.622
DOC_WW_Pin1_4	795	800	PF00397	0.555
DOC_WW_Pin1_4	828	833	PF00397	0.347
LIG_14-3-3_CanoR_1	112	116	PF00244	0.603
LIG_14-3-3_CanoR_1	164	168	PF00244	0.597
LIG_14-3-3_CanoR_1	259	266	PF00244	0.496
LIG_14-3-3_CanoR_1	40	46	PF00244	0.369
LIG_14-3-3_CanoR_1	442	452	PF00244	0.463
LIG_14-3-3_CanoR_1	461	466	PF00244	0.477
LIG_14-3-3_CanoR_1	500	510	PF00244	0.595
LIG_14-3-3_CanoR_1	779	787	PF00244	0.480
LIG_14-3-3_CanoR_1	803	809	PF00244	0.543
LIG_14-3-3_CanoR_1	870	880	PF00244	0.481
LIG_14-3-3_CanoR_1	905	913	PF00244	0.407
LIG_Actin_WH2_2	600	617	PF00022	0.440
LIG_Actin_WH2_2	926	943	PF00022	0.357
LIG_BIR_III_4	220	224	PF00653	0.443
LIG_BIR_III_4	87	91	PF00653	0.523
LIG_BRCT_BRCA1_1	65	69	PF00533	0.442
LIG_CtBP_PxDLS_1	4	8	PF00389	0.376
LIG_CtBP_PxDLS_1	579	583	PF00389	0.290
LIG_EH1_1	841	849	PF00400	0.303
LIG_FHA_1	143	149	PF00498	0.567
LIG_FHA_1	160	166	PF00498	0.577
LIG_FHA_1	241	247	PF00498	0.687
LIG_FHA_1	290	296	PF00498	0.387
LIG_FHA_1	444	450	PF00498	0.408
LIG_FHA_1	502	508	PF00498	0.726
LIG_FHA_1	598	604	PF00498	0.418
LIG_FHA_1	710	716	PF00498	0.563
LIG_FHA_1	905	911	PF00498	0.467
LIG_FHA_1	92	98	PF00498	0.411
LIG_FHA_2	123	129	PF00498	0.515
LIG_FHA_2	214	220	PF00498	0.444
LIG_FHA_2	387	393	PF00498	0.610
LIG_FHA_2	49	55	PF00498	0.547
LIG_FHA_2	603	609	PF00498	0.562
LIG_FHA_2	689	695	PF00498	0.526
LIG_FXI_DFP_1	30	34	PF00024	0.356
LIG_FXI_DFP_1	419	423	PF00024	0.392
LIG_FXI_DFP_1	550	554	PF00024	0.293
LIG_FXI_DFP_1	663	667	PF00024	0.375
LIG_LIR_Gen_1	28	36	PF02991	0.400
LIG_LIR_Gen_1	286	295	PF02991	0.411
LIG_LIR_Gen_1	421	430	PF02991	0.508
LIG_LIR_Gen_1	95	105	PF02991	0.381
LIG_LIR_Nem_3	28	33	PF02991	0.375
LIG_LIR_Nem_3	281	287	PF02991	0.438
LIG_LIR_Nem_3	350	354	PF02991	0.403
LIG_LIR_Nem_3	421	425	PF02991	0.467
LIG_LIR_Nem_3	475	481	PF02991	0.358
LIG_LIR_Nem_3	551	556	PF02991	0.329
LIG_LIR_Nem_3	834	840	PF02991	0.363
LIG_LIR_Nem_3	95	101	PF02991	0.378
LIG_NRBOX	935	941	PF00104	0.277
LIG_PCNA_PIPBox_1	681	690	PF02747	0.535
LIG_Pex14_2	25	29	PF04695	0.412
LIG_Pex14_2	549	553	PF04695	0.298
LIG_Pex14_2	662	666	PF04695	0.381
LIG_RPA_C_Fungi	11	23	PF08784	0.466
LIG_SH2_CRK	463	467	PF00017	0.515
LIG_SH2_NCK_1	463	467	PF00017	0.533
LIG_SH2_NCK_1	733	737	PF00017	0.516
LIG_SH2_SRC	280	283	PF00017	0.511
LIG_SH2_STAP1	842	846	PF00017	0.305
LIG_SH2_STAP1	98	102	PF00017	0.505
LIG_SH2_STAT5	326	329	PF00017	0.556
LIG_SH2_STAT5	387	390	PF00017	0.622
LIG_SH2_STAT5	463	466	PF00017	0.408
LIG_SH2_STAT5	479	482	PF00017	0.277
LIG_SH2_STAT5	717	720	PF00017	0.396
LIG_SH2_STAT5	842	845	PF00017	0.455
LIG_SH2_STAT5	923	926	PF00017	0.410
LIG_SH2_STAT5	961	964	PF00017	0.356
LIG_SH3_3	338	344	PF00018	0.706
LIG_SH3_3	462	468	PF00018	0.541
LIG_SH3_3	670	676	PF00018	0.515
LIG_SUMO_SIM_anti_2	580	587	PF11976	0.330
LIG_SUMO_SIM_par_1	3	9	PF11976	0.382
LIG_SUMO_SIM_par_1	969	977	PF11976	0.586
LIG_TRAF2_1	126	129	PF00917	0.511
LIG_TRAF2_1	216	219	PF00917	0.565
LIG_TRAF2_1	58	61	PF00917	0.446
LIG_TRFH_1	312	316	PF08558	0.459
LIG_TRFH_1	575	579	PF08558	0.296
LIG_WRC_WIRS_1	26	31	PF05994	0.425
LIG_WRC_WIRS_1	509	514	PF05994	0.460
MOD_CDK_SPxK_1	795	801	PF00069	0.558
MOD_CDK_SPxxK_3	413	420	PF00069	0.508
MOD_CK1_1	111	117	PF00069	0.392
MOD_CK1_1	118	124	PF00069	0.511
MOD_CK1_1	3	9	PF00069	0.524
MOD_CK1_1	471	477	PF00069	0.453
MOD_CK1_1	511	517	PF00069	0.678
MOD_CK1_1	597	603	PF00069	0.299
MOD_CK1_1	700	706	PF00069	0.514
MOD_CK1_1	740	746	PF00069	0.648
MOD_CK1_1	828	834	PF00069	0.415
MOD_CK1_1	879	885	PF00069	0.641
MOD_CK1_1	91	97	PF00069	0.565
MOD_CK2_1	122	128	PF00069	0.439
MOD_CK2_1	176	182	PF00069	0.556
MOD_CK2_1	208	214	PF00069	0.375
MOD_CK2_1	258	264	PF00069	0.521
MOD_CK2_1	55	61	PF00069	0.439
MOD_CK2_1	602	608	PF00069	0.423
MOD_CK2_1	688	694	PF00069	0.418
MOD_CK2_1	778	784	PF00069	0.362
MOD_CK2_1	817	823	PF00069	0.420
MOD_Cter_Amidation	19	22	PF01082	0.483
MOD_Cter_Amidation	868	871	PF01082	0.485
MOD_GlcNHglycan	117	120	PF01048	0.508
MOD_GlcNHglycan	176	179	PF01048	0.567
MOD_GlcNHglycan	226	229	PF01048	0.654
MOD_GlcNHglycan	260	263	PF01048	0.463
MOD_GlcNHglycan	328	331	PF01048	0.624
MOD_GlcNHglycan	332	335	PF01048	0.670
MOD_GlcNHglycan	344	347	PF01048	0.630
MOD_GlcNHglycan	497	500	PF01048	0.638
MOD_GlcNHglycan	513	516	PF01048	0.646
MOD_GlcNHglycan	557	560	PF01048	0.374
MOD_GlcNHglycan	586	589	PF01048	0.521
MOD_GlcNHglycan	702	705	PF01048	0.523
MOD_GlcNHglycan	727	732	PF01048	0.500
MOD_GlcNHglycan	739	742	PF01048	0.627
MOD_GlcNHglycan	750	753	PF01048	0.635
MOD_GlcNHglycan	77	80	PF01048	0.556
MOD_GlcNHglycan	819	822	PF01048	0.524
MOD_GlcNHglycan	827	830	PF01048	0.513
MOD_GlcNHglycan	867	870	PF01048	0.624
MOD_GlcNHglycan	87	91	PF01048	0.685
MOD_GSK3_1	111	118	PF00069	0.616
MOD_GSK3_1	142	149	PF00069	0.518
MOD_GSK3_1	159	166	PF00069	0.442
MOD_GSK3_1	174	181	PF00069	0.440
MOD_GSK3_1	240	247	PF00069	0.609
MOD_GSK3_1	251	258	PF00069	0.476
MOD_GSK3_1	289	296	PF00069	0.394
MOD_GSK3_1	326	333	PF00069	0.498
MOD_GSK3_1	383	390	PF00069	0.579
MOD_GSK3_1	431	438	PF00069	0.410
MOD_GSK3_1	510	517	PF00069	0.676
MOD_GSK3_1	584	591	PF00069	0.475
MOD_GSK3_1	693	700	PF00069	0.421
MOD_GSK3_1	735	742	PF00069	0.622
MOD_GSK3_1	872	879	PF00069	0.518
MOD_N-GLC_1	330	335	PF02516	0.444
MOD_N-GLC_1	493	498	PF02516	0.642
MOD_N-GLC_1	502	507	PF02516	0.536
MOD_NEK2_1	176	181	PF00069	0.555
MOD_NEK2_1	25	30	PF00069	0.432
MOD_NEK2_1	255	260	PF00069	0.433
MOD_NEK2_1	377	382	PF00069	0.483
MOD_NEK2_1	407	412	PF00069	0.425
MOD_NEK2_1	589	594	PF00069	0.535
MOD_NEK2_1	614	619	PF00069	0.503
MOD_NEK2_1	65	70	PF00069	0.517
MOD_NEK2_1	735	740	PF00069	0.484
MOD_NEK2_1	750	755	PF00069	0.623
MOD_NEK2_1	840	845	PF00069	0.425
MOD_NEK2_1	872	877	PF00069	0.641
MOD_PIKK_1	358	364	PF00454	0.577
MOD_PIKK_1	399	405	PF00454	0.439
MOD_PIKK_1	443	449	PF00454	0.499
MOD_PIKK_1	485	491	PF00454	0.572
MOD_PIKK_1	597	603	PF00454	0.420
MOD_PIKK_1	674	680	PF00454	0.391
MOD_PIKK_1	688	694	PF00454	0.548
MOD_PIKK_1	855	861	PF00454	0.501
MOD_PKA_1	461	467	PF00069	0.482
MOD_PKA_1	778	784	PF00069	0.362
MOD_PKA_2	111	117	PF00069	0.493
MOD_PKA_2	163	169	PF00069	0.596
MOD_PKA_2	258	264	PF00069	0.552
MOD_PKA_2	39	45	PF00069	0.372
MOD_PKA_2	594	600	PF00069	0.387
MOD_PKA_2	614	620	PF00069	0.429
MOD_PKA_2	778	784	PF00069	0.378
MOD_PKA_2	904	910	PF00069	0.396
MOD_Plk_1	502	508	PF00069	0.595
MOD_Plk_1	693	699	PF00069	0.394
MOD_Plk_1	969	975	PF00069	0.476
MOD_Plk_4	245	251	PF00069	0.703
MOD_Plk_4	25	31	PF00069	0.412
MOD_Plk_4	299	305	PF00069	0.574
MOD_Plk_4	383	389	PF00069	0.556
MOD_Plk_4	396	402	PF00069	0.543
MOD_Plk_4	527	533	PF00069	0.527
MOD_Plk_4	697	703	PF00069	0.510
MOD_Plk_4	906	912	PF00069	0.377
MOD_Plk_4	969	975	PF00069	0.476
MOD_ProDKin_1	122	128	PF00069	0.574
MOD_ProDKin_1	413	419	PF00069	0.504
MOD_ProDKin_1	468	474	PF00069	0.505
MOD_ProDKin_1	55	61	PF00069	0.595
MOD_ProDKin_1	672	678	PF00069	0.486
MOD_ProDKin_1	706	712	PF00069	0.619
MOD_ProDKin_1	795	801	PF00069	0.558
MOD_ProDKin_1	828	834	PF00069	0.337
TRG_DiLeu_BaEn_1	454	459	PF01217	0.392
TRG_DiLeu_BaEn_1	944	949	PF01217	0.481
TRG_DiLeu_BaEn_2	349	355	PF01217	0.419
TRG_DiLeu_BaEn_4	580	586	PF01217	0.269
TRG_DiLeu_BaEn_4	60	66	PF01217	0.308
TRG_DiLeu_BaLyEn_6	868	873	PF01217	0.485
TRG_ENDOCYTIC_2	287	290	PF00928	0.424
TRG_ENDOCYTIC_2	351	354	PF00928	0.354
TRG_ENDOCYTIC_2	478	481	PF00928	0.359
TRG_ENDOCYTIC_2	717	720	PF00928	0.374
TRG_ENDOCYTIC_2	837	840	PF00928	0.360
TRG_ENDOCYTIC_2	961	964	PF00928	0.341
TRG_ENDOCYTIC_2	98	101	PF00928	0.363
TRG_ER_diArg_1	135	137	PF00400	0.545
TRG_ER_diArg_1	170	172	PF00400	0.403
TRG_ER_diArg_1	22	24	PF00400	0.431
TRG_ER_diArg_1	276	279	PF00400	0.399
TRG_ER_diArg_1	437	440	PF00400	0.453
TRG_ER_diArg_1	542	544	PF00400	0.507
TRG_ER_diArg_1	778	780	PF00400	0.514
TRG_ER_diArg_1	860	862	PF00400	0.545
TRG_ER_diArg_1	870	872	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ9	Leptomonas seymouri	58%	100%
A0A0S4JMU3	Bodo saltans	30%	100%
A0A1X0NV98	Trypanosomatidae	37%	98%
A0A3Q8I908	Leishmania donovani	83%	100%
A0A3R7KQI0	Trypanosoma rangeli	37%	100%
A4HUZ0	Leishmania infantum	83%	100%
D0A7F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGZ8	Leishmania major	84%	99%
V5DT33	Trypanosoma cruzi	39%	100%