Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6K4_LEIBR

TriTrypDb:

LbrM.11.0580 , LBRM2903_110010800

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.601
CLV_PCSK_KEX2_1	21	23	PF00082	0.532
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.542
CLV_PCSK_SKI1_1	8	12	PF00082	0.604
DEG_SCF_FBW7_1	133	140	PF00400	0.428
DOC_CKS1_1	134	139	PF01111	0.429
DOC_MAPK_FxFP_2	118	121	PF00069	0.521
DOC_PP4_FxxP_1	118	121	PF00568	0.486
DOC_PP4_FxxP_1	134	137	PF00568	0.547
DOC_USP7_MATH_1	137	141	PF00917	0.582
DOC_USP7_MATH_1	67	71	PF00917	0.584
DOC_USP7_MATH_1	86	90	PF00917	0.448
DOC_WW_Pin1_4	133	138	PF00397	0.427
LIG_14-3-3_CanoR_1	22	30	PF00244	0.528
LIG_14-3-3_CanoR_1	52	57	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_FHA_1	7	13	PF00498	0.618
LIG_FHA_1	70	76	PF00498	0.410
LIG_LIR_Apic_2	116	121	PF02991	0.482
LIG_LIR_Gen_1	59	69	PF02991	0.494
LIG_LIR_Gen_1	89	98	PF02991	0.487
LIG_LIR_Nem_3	16	20	PF02991	0.483
LIG_LIR_Nem_3	59	64	PF02991	0.497
LIG_LIR_Nem_3	89	94	PF02991	0.446
LIG_LIR_Nem_3	96	102	PF02991	0.443
LIG_NRP_CendR_1	144	147	PF00754	0.470
LIG_PTB_Apo_2	104	111	PF02174	0.359
LIG_SH2_NCK_1	54	58	PF00017	0.602
LIG_SH2_PTP2	91	94	PF00017	0.493
LIG_SH2_STAP1	54	58	PF00017	0.488
LIG_SH2_STAT5	19	22	PF00017	0.587
LIG_SH2_STAT5	54	57	PF00017	0.513
LIG_SH2_STAT5	91	94	PF00017	0.635
LIG_SH3_3	39	45	PF00018	0.528
LIG_WRC_WIRS_1	7	12	PF05994	0.472
MOD_CK2_1	136	142	PF00069	0.580
MOD_CK2_1	68	74	PF00069	0.642
MOD_GlcNHglycan	129	132	PF01048	0.486
MOD_GlcNHglycan	65	68	PF01048	0.554
MOD_GlcNHglycan	82	85	PF01048	0.365
MOD_GlcNHglycan	95	98	PF01048	0.449
MOD_GSK3_1	133	140	PF00069	0.445
MOD_GSK3_1	63	70	PF00069	0.518
MOD_NEK2_2	113	118	PF00069	0.357
MOD_NEK2_2	86	91	PF00069	0.495
MOD_PKA_1	52	58	PF00069	0.606
MOD_PKB_1	50	58	PF00069	0.603
MOD_Plk_4	113	119	PF00069	0.448
MOD_Plk_4	86	92	PF00069	0.479
MOD_ProDKin_1	133	139	PF00069	0.427
MOD_SUMO_for_1	143	146	PF00179	0.460
MOD_SUMO_rev_2	139	145	PF00179	0.585
MOD_SUMO_rev_2	2	7	PF00179	0.404
TRG_ENDOCYTIC_2	91	94	PF00928	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P635	Leptomonas seymouri	71%	98%
A0A0S4JUP0	Bodo saltans	28%	100%
A0A1X0NV26	Trypanosomatidae	47%	100%
A0A3S7WRP0	Leishmania donovani	82%	100%
A0A422NQB2	Trypanosoma rangeli	46%	97%
A4HUY9	Leishmania infantum	82%	100%
D0A7G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ANM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QGZ9	Leishmania major	82%	100%