Cytochrome c oxidase assembly factor 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6K3_LEIBR

TriTrypDb:

LbrM.11.0570 , LBRM2903_110010700

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.505
CLV_NRD_NRD_1	178	180	PF00675	0.310
CLV_NRD_NRD_1	83	85	PF00675	0.687
CLV_PCSK_KEX2_1	150	152	PF00082	0.505
CLV_PCSK_KEX2_1	178	180	PF00082	0.310
CLV_PCSK_KEX2_1	82	84	PF00082	0.635
CLV_PCSK_SKI1_1	150	154	PF00082	0.509
CLV_PCSK_SKI1_1	178	182	PF00082	0.430
CLV_PCSK_SKI1_1	194	198	PF00082	0.338
CLV_PCSK_SKI1_1	222	226	PF00082	0.515
CLV_PCSK_SKI1_1	52	56	PF00082	0.559
DEG_APCC_DBOX_1	181	189	PF00400	0.365
DEG_SPOP_SBC_1	166	170	PF00917	0.519
DEG_SPOP_SBC_1	223	227	PF00917	0.529
DOC_CKS1_1	10	15	PF01111	0.635
DOC_MAPK_MEF2A_6	15	23	PF00069	0.388
DOC_USP7_MATH_1	123	127	PF00917	0.511
DOC_USP7_MATH_1	14	18	PF00917	0.602
DOC_USP7_MATH_1	166	170	PF00917	0.534
DOC_USP7_MATH_1	252	256	PF00917	0.670
DOC_USP7_UBL2_3	111	115	PF12436	0.613
DOC_USP7_UBL2_3	66	70	PF12436	0.467
DOC_WW_Pin1_4	167	172	PF00397	0.635
DOC_WW_Pin1_4	9	14	PF00397	0.637
LIG_14-3-3_CanoR_1	118	125	PF00244	0.460
LIG_14-3-3_CanoR_1	150	155	PF00244	0.551
LIG_APCC_ABBA_1	21	26	PF00400	0.586
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_FHA_1	70	76	PF00498	0.406
LIG_FHA_2	223	229	PF00498	0.596
LIG_FHA_2	71	77	PF00498	0.558
LIG_LIR_Gen_1	153	163	PF02991	0.463
LIG_LIR_Nem_3	153	158	PF02991	0.322
LIG_LIR_Nem_3	174	180	PF02991	0.491
LIG_LIR_Nem_3	202	208	PF02991	0.490
LIG_PDZ_Class_1	252	257	PF00595	0.470
LIG_SH2_CRK	177	181	PF00017	0.407
LIG_SH2_SRC	246	249	PF00017	0.654
LIG_SH2_STAP1	71	75	PF00017	0.396
LIG_SH2_STAT5	124	127	PF00017	0.438
LIG_SH2_STAT5	220	223	PF00017	0.613
LIG_SH2_STAT5	246	249	PF00017	0.565
LIG_SH2_STAT5	62	65	PF00017	0.433
LIG_SH2_STAT5	71	74	PF00017	0.384
LIG_TRAF2_1	45	48	PF00917	0.567
LIG_TRFH_1	245	249	PF08558	0.689
LIG_TYR_ITIM	63	68	PF00017	0.427
MOD_CDK_SPxK_1	9	15	PF00069	0.638
MOD_CK1_1	126	132	PF00069	0.514
MOD_CK1_1	17	23	PF00069	0.532
MOD_CK1_1	99	105	PF00069	0.700
MOD_CK2_1	222	228	PF00069	0.558
MOD_CK2_1	70	76	PF00069	0.551
MOD_CK2_1	99	105	PF00069	0.662
MOD_GlcNHglycan	1	4	PF01048	0.707
MOD_GlcNHglycan	139	142	PF01048	0.479
MOD_GlcNHglycan	84	87	PF01048	0.738
MOD_GSK3_1	123	130	PF00069	0.488
MOD_GSK3_1	161	168	PF00069	0.539
MOD_GSK3_1	92	99	PF00069	0.727
MOD_PIKK_1	105	111	PF00454	0.509
MOD_PIKK_1	127	133	PF00454	0.502
MOD_PIKK_1	14	20	PF00454	0.533
MOD_PIKK_1	33	39	PF00454	0.497
MOD_PKA_1	150	156	PF00069	0.319
MOD_PKA_1	82	88	PF00069	0.481
MOD_PKA_2	117	123	PF00069	0.425
MOD_PKA_2	150	156	PF00069	0.441
MOD_PKA_2	82	88	PF00069	0.712
MOD_Plk_2-3	139	145	PF00069	0.333
MOD_Plk_4	150	156	PF00069	0.482
MOD_ProDKin_1	167	173	PF00069	0.622
MOD_ProDKin_1	9	15	PF00069	0.638
MOD_SUMO_rev_2	22	29	PF00179	0.579
MOD_SUMO_rev_2	76	81	PF00179	0.563
TRG_DiLeu_BaEn_1	76	81	PF01217	0.514
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.328
TRG_ENDOCYTIC_2	177	180	PF00928	0.416
TRG_ENDOCYTIC_2	65	68	PF00928	0.435
TRG_ER_diArg_1	177	179	PF00400	0.334
TRG_ER_diArg_1	81	84	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKT7	Leptomonas seymouri	71%	100%
A0A0S4JTR3	Bodo saltans	49%	100%
A0A1X0NV10	Trypanosomatidae	52%	100%
A0A3S7WRK9	Leishmania donovani	88%	100%
A4HUY8	Leishmania infantum	88%	100%
D0A7G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ANM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QH00	Leishmania major	87%	100%
V5C1A3	Trypanosoma cruzi	51%	100%