MIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6K0_LEIBR

TriTrypDb:

LbrM.11.0540 , LBRM2903_110010400

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.444
CLV_PCSK_KEX2_1	58	60	PF00082	0.400
CLV_PCSK_PC7_1	54	60	PF00082	0.344
CLV_PCSK_SKI1_1	188	192	PF00082	0.671
CLV_PCSK_SKI1_1	58	62	PF00082	0.410
DEG_APCC_DBOX_1	58	66	PF00400	0.416
DOC_CKS1_1	110	115	PF01111	0.507
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.659
DOC_MAPK_MEF2A_6	75	82	PF00069	0.417
DOC_MAPK_NFAT4_5	75	83	PF00069	0.413
DOC_PP2B_LxvP_1	133	136	PF13499	0.694
DOC_PP2B_LxvP_1	193	196	PF13499	0.689
DOC_USP7_MATH_1	114	118	PF00917	0.765
DOC_USP7_MATH_1	179	183	PF00917	0.565
DOC_USP7_MATH_1	83	87	PF00917	0.485
DOC_WW_Pin1_4	109	114	PF00397	0.653
DOC_WW_Pin1_4	144	149	PF00397	0.715
DOC_WW_Pin1_4	96	101	PF00397	0.606
LIG_14-3-3_CanoR_1	32	41	PF00244	0.449
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_3	1	5	PF00653	0.503
LIG_eIF4E_1	73	79	PF01652	0.333
LIG_FAT_LD_1	186	194	PF03623	0.682
LIG_FHA_1	110	116	PF00498	0.509
LIG_FHA_1	179	185	PF00498	0.636
LIG_FHA_2	34	40	PF00498	0.427
LIG_FHA_2	51	57	PF00498	0.456
LIG_LIR_Apic_2	164	169	PF02991	0.639
LIG_SH2_STAP1	34	38	PF00017	0.492
LIG_SH2_STAP1	9	13	PF00017	0.477
LIG_SH2_STAT3	9	12	PF00017	0.524
LIG_SH2_STAT5	111	114	PF00017	0.511
LIG_SH2_STAT5	166	169	PF00017	0.603
LIG_SH2_STAT5	34	37	PF00017	0.388
LIG_SH3_3	101	107	PF00018	0.607
LIG_SH3_3	133	139	PF00018	0.656
LIG_Sin3_3	76	83	PF02671	0.436
MOD_CK1_1	117	123	PF00069	0.823
MOD_CK1_1	19	25	PF00069	0.391
MOD_CK1_1	43	49	PF00069	0.568
MOD_CK2_1	33	39	PF00069	0.420
MOD_CK2_1	50	56	PF00069	0.461
MOD_GlcNHglycan	121	124	PF01048	0.632
MOD_GlcNHglycan	152	155	PF01048	0.747
MOD_GlcNHglycan	83	86	PF01048	0.474
MOD_GSK3_1	144	151	PF00069	0.767
MOD_NEK2_1	102	107	PF00069	0.669
MOD_PIKK_1	148	154	PF00454	0.790
MOD_Plk_4	128	134	PF00069	0.700
MOD_ProDKin_1	109	115	PF00069	0.656
MOD_ProDKin_1	144	150	PF00069	0.715
MOD_ProDKin_1	96	102	PF00069	0.607
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.499
TRG_ER_diArg_1	58	60	PF00400	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I225	Leptomonas seymouri	62%	98%
A0A1X0NDQ9	Trypanosomatidae	42%	98%
A0A3Q8I937	Leishmania donovani	74%	97%
A0A3R7KJF9	Trypanosoma rangeli	42%	100%
A4HUY5	Leishmania infantum	74%	97%
D0A7G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ANM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	97%
Q4QH03	Leishmania major	71%	100%