Protein grainyhead

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein grainyhead

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6J9_LEIBR

TriTrypDb:

LbrM.11.0530 , LBRM2903_110010300

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6J9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.613
CLV_NRD_NRD_1	228	230	PF00675	0.435
CLV_NRD_NRD_1	332	334	PF00675	0.580
CLV_NRD_NRD_1	423	425	PF00675	0.406
CLV_PCSK_KEX2_1	208	210	PF00082	0.469
CLV_PCSK_KEX2_1	228	230	PF00082	0.507
CLV_PCSK_KEX2_1	326	328	PF00082	0.583
CLV_PCSK_KEX2_1	332	334	PF00082	0.539
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.613
CLV_PCSK_SKI1_1	283	287	PF00082	0.483
CLV_PCSK_SKI1_1	63	67	PF00082	0.507
CLV_PCSK_SKI1_1	90	94	PF00082	0.557
CLV_Separin_Metazoa	165	169	PF03568	0.462
DEG_APCC_DBOX_1	300	308	PF00400	0.734
DOC_MAPK_gen_1	414	422	PF00069	0.409
DOC_MAPK_gen_1	424	432	PF00069	0.359
DOC_USP7_MATH_1	139	143	PF00917	0.668
DOC_USP7_MATH_1	257	261	PF00917	0.535
DOC_WW_Pin1_4	215	220	PF00397	0.714
DOC_WW_Pin1_4	293	298	PF00397	0.692
DOC_WW_Pin1_4	371	376	PF00397	0.635
LIG_14-3-3_CanoR_1	101	108	PF00244	0.528
LIG_14-3-3_CanoR_1	129	138	PF00244	0.500
LIG_14-3-3_CanoR_1	228	232	PF00244	0.647
LIG_14-3-3_CanoR_1	298	308	PF00244	0.716
LIG_Actin_WH2_2	390	407	PF00022	0.612
LIG_BRCT_BRCA1_1	217	221	PF00533	0.470
LIG_CSL_BTD_1	216	219	PF09270	0.631
LIG_CtBP_PxDLS_1	263	267	PF00389	0.605
LIG_FHA_1	276	282	PF00498	0.519
LIG_FHA_1	339	345	PF00498	0.610
LIG_FHA_1	389	395	PF00498	0.572
LIG_FHA_1	415	421	PF00498	0.589
LIG_FHA_2	198	204	PF00498	0.548
LIG_FHA_2	228	234	PF00498	0.645
LIG_FHA_2	245	251	PF00498	0.702
LIG_FHA_2	27	33	PF00498	0.553
LIG_FHA_2	277	283	PF00498	0.435
LIG_FHA_2	376	382	PF00498	0.665
LIG_FHA_2	388	394	PF00498	0.641
LIG_FHA_2	40	46	PF00498	0.704
LIG_FHA_2	84	90	PF00498	0.734
LIG_Integrin_isoDGR_2	48	50	PF01839	0.506
LIG_LIR_Apic_2	150	155	PF02991	0.709
LIG_LIR_Gen_1	337	345	PF02991	0.663
LIG_LIR_Nem_3	215	220	PF02991	0.596
LIG_PDZ_Class_2	439	444	PF00595	0.455
LIG_Pex14_1	217	221	PF04695	0.694
LIG_PTB_Apo_2	313	320	PF02174	0.634
LIG_SH2_CRK	152	156	PF00017	0.669
LIG_SH2_STAP1	31	35	PF00017	0.542
LIG_SH2_STAT5	295	298	PF00017	0.486
LIG_SH2_STAT5	339	342	PF00017	0.629
LIG_SH2_STAT5	85	88	PF00017	0.575
LIG_SH3_3	160	166	PF00018	0.702
LIG_SH3_3	353	359	PF00018	0.545
LIG_SH3_3	8	14	PF00018	0.609
MOD_CDK_SPK_2	293	298	PF00069	0.631
MOD_CK1_1	201	207	PF00069	0.573
MOD_CK1_1	312	318	PF00069	0.616
MOD_CK2_1	197	203	PF00069	0.541
MOD_CK2_1	244	250	PF00069	0.742
MOD_CK2_1	318	324	PF00069	0.701
MOD_CK2_1	375	381	PF00069	0.677
MOD_CK2_1	387	393	PF00069	0.648
MOD_GlcNHglycan	103	106	PF01048	0.625
MOD_GlcNHglycan	132	135	PF01048	0.652
MOD_GlcNHglycan	56	59	PF01048	0.548
MOD_GSK3_1	139	146	PF00069	0.572
MOD_GSK3_1	197	204	PF00069	0.571
MOD_GSK3_1	22	29	PF00069	0.642
MOD_GSK3_1	240	247	PF00069	0.693
MOD_GSK3_1	262	269	PF00069	0.557
MOD_GSK3_1	296	303	PF00069	0.753
MOD_GSK3_1	308	315	PF00069	0.731
MOD_GSK3_1	340	347	PF00069	0.567
MOD_GSK3_1	371	378	PF00069	0.719
MOD_GSK3_1	410	417	PF00069	0.677
MOD_N-GLC_1	213	218	PF02516	0.693
MOD_N-GLC_1	222	227	PF02516	0.688
MOD_N-GLC_2	232	234	PF02516	0.652
MOD_NEK2_1	23	28	PF00069	0.550
MOD_NEK2_1	266	271	PF00069	0.571
MOD_NEK2_1	275	280	PF00069	0.516
MOD_NEK2_1	387	392	PF00069	0.451
MOD_NEK2_2	400	405	PF00069	0.580
MOD_PIKK_1	252	258	PF00454	0.572
MOD_PK_1	428	434	PF00069	0.576
MOD_PK_1	88	94	PF00069	0.663
MOD_PKA_2	100	106	PF00069	0.527
MOD_PKA_2	201	207	PF00069	0.481
MOD_PKA_2	227	233	PF00069	0.722
MOD_PKA_2	300	306	PF00069	0.639
MOD_PKA_2	368	374	PF00069	0.689
MOD_Plk_1	213	219	PF00069	0.628
MOD_Plk_1	76	82	PF00069	0.635
MOD_Plk_1	88	94	PF00069	0.535
MOD_Plk_4	143	149	PF00069	0.726
MOD_Plk_4	201	207	PF00069	0.584
MOD_Plk_4	23	29	PF00069	0.585
MOD_Plk_4	240	246	PF00069	0.533
MOD_Plk_4	340	346	PF00069	0.573
MOD_Plk_4	418	424	PF00069	0.421
MOD_Plk_4	76	82	PF00069	0.502
MOD_ProDKin_1	215	221	PF00069	0.714
MOD_ProDKin_1	293	299	PF00069	0.695
MOD_ProDKin_1	371	377	PF00069	0.624
TRG_ENDOCYTIC_2	339	342	PF00928	0.629
TRG_ER_diArg_1	207	210	PF00400	0.463
TRG_ER_diArg_1	332	334	PF00400	0.568
TRG_ER_diArg_1	60	63	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P309	Leptomonas seymouri	59%	100%
A0A0S4JRC7	Bodo saltans	28%	100%
A0A1X0ND00	Trypanosomatidae	42%	100%
A0A3S5H6J0	Leishmania donovani	79%	100%
A0A422NQE0	Trypanosoma rangeli	41%	100%
A4HUY4	Leishmania infantum	79%	100%
D0A7G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QH04	Leishmania major	80%	100%
V5DT29	Trypanosoma cruzi	40%	100%