PUF nine target 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PUF nine target 1

Gene product:

PUF nine target 1

Species:

Leishmania braziliensis

UniProt:

A4H6J7_LEIBR

TriTrypDb:

LbrM.11.0510 , LBRM2903_110010100

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	583	587	PF00656	0.699
CLV_C14_Caspase3-7	602	606	PF00656	0.633
CLV_NRD_NRD_1	339	341	PF00675	0.480
CLV_NRD_NRD_1	351	353	PF00675	0.698
CLV_NRD_NRD_1	358	360	PF00675	0.730
CLV_NRD_NRD_1	500	502	PF00675	0.556
CLV_PCSK_KEX2_1	339	341	PF00082	0.385
CLV_PCSK_KEX2_1	351	353	PF00082	0.698
CLV_PCSK_KEX2_1	357	359	PF00082	0.731
CLV_PCSK_KEX2_1	4	6	PF00082	0.456
CLV_PCSK_KEX2_1	499	501	PF00082	0.583
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.517
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.631
CLV_PCSK_SKI1_1	320	324	PF00082	0.401
CLV_PCSK_SKI1_1	35	39	PF00082	0.359
CLV_PCSK_SKI1_1	392	396	PF00082	0.682
CLV_PCSK_SKI1_1	495	499	PF00082	0.534
CLV_PCSK_SKI1_1	500	504	PF00082	0.558
CLV_PCSK_SKI1_1	536	540	PF00082	0.531
DOC_CDC14_PxL_1	278	286	PF14671	0.459
DOC_CYCLIN_RxL_1	387	397	PF00134	0.668
DOC_CYCLIN_RxL_1	4	16	PF00134	0.472
DOC_MAPK_gen_1	181	188	PF00069	0.289
DOC_MAPK_gen_1	299	308	PF00069	0.561
DOC_MAPK_gen_1	32	42	PF00069	0.361
DOC_MAPK_gen_1	4	12	PF00069	0.357
DOC_MAPK_gen_1	495	506	PF00069	0.513
DOC_PP4_FxxP_1	182	185	PF00568	0.271
DOC_PP4_FxxP_1	258	261	PF00568	0.586
DOC_USP7_MATH_1	247	251	PF00917	0.710
DOC_USP7_MATH_1	379	383	PF00917	0.738
DOC_USP7_MATH_1	404	408	PF00917	0.688
DOC_USP7_MATH_1	44	48	PF00917	0.349
DOC_USP7_MATH_1	524	528	PF00917	0.531
DOC_USP7_MATH_1	545	549	PF00917	0.512
DOC_USP7_MATH_1	87	91	PF00917	0.326
DOC_USP7_UBL2_3	495	499	PF12436	0.571
DOC_USP7_UBL2_3	503	507	PF12436	0.591
DOC_USP7_UBL2_3	60	64	PF12436	0.517
DOC_WW_Pin1_4	515	520	PF00397	0.626
DOC_WW_Pin1_4	615	620	PF00397	0.747
DOC_WW_Pin1_4	623	628	PF00397	0.533
LIG_14-3-3_CanoR_1	109	113	PF00244	0.353
LIG_14-3-3_CanoR_1	231	235	PF00244	0.469
LIG_14-3-3_CanoR_1	277	282	PF00244	0.671
LIG_14-3-3_CanoR_1	339	343	PF00244	0.390
LIG_14-3-3_CanoR_1	35	43	PF00244	0.457
LIG_14-3-3_CanoR_1	410	419	PF00244	0.772
LIG_14-3-3_CanoR_1	568	576	PF00244	0.644
LIG_14-3-3_CanoR_1	609	615	PF00244	0.553
LIG_14-3-3_CanoR_1	621	626	PF00244	0.731
LIG_Actin_WH2_2	264	281	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_BRCT_BRCA1_1	379	383	PF00533	0.619
LIG_FHA_1	147	153	PF00498	0.276
LIG_FHA_1	208	214	PF00498	0.271
LIG_FHA_1	328	334	PF00498	0.559
LIG_FHA_1	538	544	PF00498	0.445
LIG_FHA_1	610	616	PF00498	0.736
LIG_FHA_2	162	168	PF00498	0.289
LIG_FHA_2	204	210	PF00498	0.341
LIG_FHA_2	474	480	PF00498	0.534
LIG_Integrin_RGD_1	202	204	PF01839	0.404
LIG_LIR_Apic_2	180	185	PF02991	0.271
LIG_LIR_Apic_2	233	238	PF02991	0.625
LIG_LIR_Apic_2	256	261	PF02991	0.656
LIG_LIR_Gen_1	101	110	PF02991	0.388
LIG_LIR_Gen_1	123	133	PF02991	0.317
LIG_LIR_Gen_1	167	176	PF02991	0.335
LIG_LIR_Gen_1	204	213	PF02991	0.271
LIG_LIR_Gen_1	448	458	PF02991	0.340
LIG_LIR_Gen_1	479	487	PF02991	0.548
LIG_LIR_Gen_1	75	81	PF02991	0.460
LIG_LIR_Nem_3	101	105	PF02991	0.332
LIG_LIR_Nem_3	123	129	PF02991	0.317
LIG_LIR_Nem_3	167	171	PF02991	0.335
LIG_LIR_Nem_3	233	237	PF02991	0.545
LIG_LIR_Nem_3	448	453	PF02991	0.347
LIG_LIR_Nem_3	624	628	PF02991	0.575
LIG_LIR_Nem_3	75	80	PF02991	0.411
LIG_LIR_Nem_3	90	94	PF02991	0.214
LIG_PCNA_yPIPBox_3	501	515	PF02747	0.568
LIG_PDZ_Class_1	633	638	PF00595	0.616
LIG_Pex14_2	131	135	PF04695	0.289
LIG_Pex14_2	80	84	PF04695	0.342
LIG_RPA_C_Fungi	354	366	PF08784	0.684
LIG_SH2_CRK	235	239	PF00017	0.617
LIG_SH2_CRK	625	629	PF00017	0.565
LIG_SH2_CRK	66	70	PF00017	0.526
LIG_SH2_NCK_1	229	233	PF00017	0.434
LIG_SH2_NCK_1	235	239	PF00017	0.484
LIG_SH2_PTP2	102	105	PF00017	0.463
LIG_SH2_STAP1	466	470	PF00017	0.419
LIG_SH2_STAT5	102	105	PF00017	0.330
LIG_SH2_STAT5	151	154	PF00017	0.277
LIG_SH2_STAT5	196	199	PF00017	0.271
LIG_SH2_STAT5	219	222	PF00017	0.312
LIG_SH2_STAT5	328	331	PF00017	0.418
LIG_SH2_STAT5	625	628	PF00017	0.576
LIG_SH2_STAT5	91	94	PF00017	0.288
LIG_SH3_1	279	285	PF00018	0.656
LIG_SH3_2	435	440	PF14604	0.485
LIG_SH3_3	279	285	PF00018	0.624
LIG_SH3_3	427	433	PF00018	0.535
LIG_SH3_3	483	489	PF00018	0.538
LIG_Sin3_3	126	133	PF02671	0.335
LIG_SUMO_SIM_par_1	286	291	PF11976	0.626
LIG_SUMO_SIM_par_1	321	327	PF11976	0.390
LIG_TRAF2_1	238	241	PF00917	0.503
LIG_TRAF2_1	424	427	PF00917	0.557
LIG_TRAF2_1	442	445	PF00917	0.531
LIG_UBA3_1	322	326	PF00899	0.453
MOD_CDC14_SPxK_1	618	621	PF00782	0.560
MOD_CDK_SPK_2	515	520	PF00069	0.626
MOD_CDK_SPxK_1	615	621	PF00069	0.570
MOD_CK1_1	177	183	PF00069	0.303
MOD_CK1_1	280	286	PF00069	0.546
MOD_CK1_1	327	333	PF00069	0.599
MOD_CK1_1	378	384	PF00069	0.619
MOD_CK1_1	481	487	PF00069	0.533
MOD_CK1_1	577	583	PF00069	0.499
MOD_CK2_1	251	257	PF00069	0.489
MOD_CK2_1	280	286	PF00069	0.711
MOD_CK2_1	312	318	PF00069	0.508
MOD_CK2_1	439	445	PF00069	0.484
MOD_CK2_1	473	479	PF00069	0.515
MOD_CMANNOS	23	26	PF00535	0.354
MOD_Cter_Amidation	355	358	PF01082	0.700
MOD_GlcNHglycan	176	179	PF01048	0.272
MOD_GlcNHglycan	279	282	PF01048	0.535
MOD_GlcNHglycan	290	293	PF01048	0.622
MOD_GlcNHglycan	372	375	PF01048	0.711
MOD_GlcNHglycan	377	380	PF01048	0.643
MOD_GlcNHglycan	435	438	PF01048	0.636
MOD_GlcNHglycan	441	444	PF01048	0.444
MOD_GlcNHglycan	479	483	PF01048	0.637
MOD_GlcNHglycan	526	529	PF01048	0.589
MOD_GlcNHglycan	547	550	PF01048	0.767
MOD_GlcNHglycan	595	598	PF01048	0.582
MOD_GlcNHglycan	635	638	PF01048	0.616
MOD_GSK3_1	170	177	PF00069	0.319
MOD_GSK3_1	203	210	PF00069	0.332
MOD_GSK3_1	247	254	PF00069	0.547
MOD_GSK3_1	370	377	PF00069	0.684
MOD_GSK3_1	44	51	PF00069	0.355
MOD_GSK3_1	574	581	PF00069	0.620
MOD_GSK3_1	587	594	PF00069	0.612
MOD_GSK3_1	628	635	PF00069	0.703
MOD_LATS_1	144	150	PF00433	0.314
MOD_N-GLC_1	174	179	PF02516	0.404
MOD_N-GLC_1	587	592	PF02516	0.629
MOD_N-GLC_1	609	614	PF02516	0.610
MOD_NEK2_1	13	18	PF00069	0.362
MOD_NEK2_1	208	213	PF00069	0.219
MOD_NEK2_1	251	256	PF00069	0.435
MOD_NEK2_1	288	293	PF00069	0.674
MOD_NEK2_1	473	478	PF00069	0.457
MOD_NEK2_1	491	496	PF00069	0.502
MOD_NEK2_1	576	581	PF00069	0.755
MOD_NEK2_1	591	596	PF00069	0.624
MOD_PIKK_1	294	300	PF00454	0.557
MOD_PK_1	461	467	PF00069	0.569
MOD_PKA_2	108	114	PF00069	0.404
MOD_PKA_2	230	236	PF00069	0.482
MOD_PKA_2	294	300	PF00069	0.573
MOD_PKA_2	338	344	PF00069	0.530
MOD_PKA_2	574	580	PF00069	0.770
MOD_PKA_2	608	614	PF00069	0.742
MOD_PKB_1	357	365	PF00069	0.705
MOD_PKB_1	566	574	PF00069	0.536
MOD_Plk_1	174	180	PF00069	0.361
MOD_Plk_1	18	24	PF00069	0.422
MOD_Plk_1	203	209	PF00069	0.349
MOD_Plk_1	247	253	PF00069	0.543
MOD_Plk_1	426	432	PF00069	0.614
MOD_Plk_1	478	484	PF00069	0.538
MOD_Plk_1	587	593	PF00069	0.652
MOD_Plk_2-3	48	54	PF00069	0.484
MOD_Plk_4	230	236	PF00069	0.463
MOD_Plk_4	324	330	PF00069	0.425
MOD_Plk_4	461	467	PF00069	0.569
MOD_Plk_4	526	532	PF00069	0.690
MOD_ProDKin_1	515	521	PF00069	0.625
MOD_ProDKin_1	615	621	PF00069	0.748
MOD_ProDKin_1	623	629	PF00069	0.526
MOD_SUMO_rev_2	315	322	PF00179	0.516
MOD_SUMO_rev_2	488	497	PF00179	0.531
TRG_DiLeu_BaEn_1	318	323	PF01217	0.450
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.324
TRG_ENDOCYTIC_2	102	105	PF00928	0.349
TRG_ENDOCYTIC_2	168	171	PF00928	0.335
TRG_ENDOCYTIC_2	480	483	PF00928	0.584
TRG_ENDOCYTIC_2	625	628	PF00928	0.707
TRG_ENDOCYTIC_2	66	69	PF00928	0.391
TRG_ER_diArg_1	299	302	PF00400	0.659
TRG_ER_diArg_1	351	353	PF00400	0.697
TRG_ER_diArg_1	357	359	PF00400	0.729
TRG_ER_diArg_1	566	569	PF00400	0.731
TRG_NLS_MonoExtC_3	498	503	PF00514	0.628
TRG_NLS_MonoExtN_4	496	503	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	568	573	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q1	Leptomonas seymouri	74%	98%
A0A1X0NV07	Trypanosomatidae	48%	100%
A0A3S5H6I9	Leishmania donovani	80%	98%
A0A422NQF9	Trypanosoma rangeli	50%	100%
A4HUY2	Leishmania infantum	81%	98%
D0A7G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ANL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QH06	Leishmania major	80%	100%
V5BRS7	Trypanosoma cruzi	50%	100%