Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6J6_LEIBR

TriTrypDb:

LbrM.11.0500 , LBRM2903_110010000

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.541
CLV_NRD_NRD_1	203	205	PF00675	0.701
CLV_NRD_NRD_1	434	436	PF00675	0.477
CLV_NRD_NRD_1	466	468	PF00675	0.506
CLV_NRD_NRD_1	500	502	PF00675	0.553
CLV_NRD_NRD_1	531	533	PF00675	0.619
CLV_NRD_NRD_1	55	57	PF00675	0.507
CLV_PCSK_FUR_1	181	185	PF00082	0.517
CLV_PCSK_KEX2_1	183	185	PF00082	0.498
CLV_PCSK_KEX2_1	203	205	PF00082	0.709
CLV_PCSK_KEX2_1	406	408	PF00082	0.351
CLV_PCSK_KEX2_1	42	44	PF00082	0.616
CLV_PCSK_KEX2_1	433	435	PF00082	0.489
CLV_PCSK_KEX2_1	466	468	PF00082	0.489
CLV_PCSK_KEX2_1	502	504	PF00082	0.518
CLV_PCSK_KEX2_1	531	533	PF00082	0.526
CLV_PCSK_KEX2_1	55	57	PF00082	0.401
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.351
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.616
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.434
CLV_PCSK_PC7_1	179	185	PF00082	0.464
CLV_PCSK_PC7_1	527	533	PF00082	0.514
CLV_PCSK_SKI1_1	375	379	PF00082	0.606
CLV_PCSK_SKI1_1	419	423	PF00082	0.524
CLV_PCSK_SKI1_1	467	471	PF00082	0.516
CLV_PCSK_SKI1_1	483	487	PF00082	0.393
CLV_PCSK_SKI1_1	61	65	PF00082	0.643
DEG_APCC_DBOX_1	167	175	PF00400	0.588
DEG_APCC_DBOX_1	522	530	PF00400	0.572
DEG_SPOP_SBC_1	253	257	PF00917	0.543
DEG_SPOP_SBC_1	26	30	PF00917	0.649
DOC_CKS1_1	312	317	PF01111	0.754
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.722
DOC_MAPK_gen_1	108	118	PF00069	0.359
DOC_MAPK_gen_1	133	143	PF00069	0.591
DOC_MAPK_MEF2A_6	136	143	PF00069	0.594
DOC_MAPK_NFAT4_5	136	144	PF00069	0.594
DOC_PP1_RVXF_1	112	119	PF00149	0.456
DOC_PP2B_LxvP_1	303	306	PF13499	0.696
DOC_USP7_MATH_1	214	218	PF00917	0.767
DOC_USP7_MATH_1	248	252	PF00917	0.669
DOC_USP7_MATH_1	265	269	PF00917	0.789
DOC_USP7_MATH_1	275	279	PF00917	0.700
DOC_USP7_MATH_1	32	36	PF00917	0.675
DOC_USP7_MATH_1	72	76	PF00917	0.649
DOC_WW_Pin1_4	196	201	PF00397	0.713
DOC_WW_Pin1_4	254	259	PF00397	0.740
DOC_WW_Pin1_4	283	288	PF00397	0.743
DOC_WW_Pin1_4	311	316	PF00397	0.685
LIG_14-3-3_CanoR_1	351	355	PF00244	0.572
LIG_14-3-3_CanoR_1	358	368	PF00244	0.566
LIG_14-3-3_CanoR_1	401	408	PF00244	0.550
LIG_14-3-3_CanoR_1	43	48	PF00244	0.582
LIG_14-3-3_CanoR_1	446	450	PF00244	0.510
LIG_14-3-3_CanoR_1	523	527	PF00244	0.536
LIG_Actin_WH2_2	404	421	PF00022	0.554
LIG_CaM_IQ_9	47	63	PF13499	0.482
LIG_eIF4E_1	20	26	PF01652	0.504
LIG_FHA_1	138	144	PF00498	0.553
LIG_FHA_1	149	155	PF00498	0.621
LIG_FHA_1	221	227	PF00498	0.656
LIG_FHA_1	328	334	PF00498	0.637
LIG_FHA_1	99	105	PF00498	0.524
LIG_FHA_2	361	367	PF00498	0.600
LIG_FHA_2	379	385	PF00498	0.343
LIG_GBD_Chelix_1	486	494	PF00786	0.609
LIG_LIR_Gen_1	112	122	PF02991	0.608
LIG_LIR_Nem_3	112	118	PF02991	0.613
LIG_LYPXL_SIV_4	81	89	PF13949	0.547
LIG_LYPXL_yS_3	452	455	PF13949	0.576
LIG_PTB_Apo_2	301	308	PF02174	0.721
LIG_PTB_Phospho_1	301	307	PF10480	0.717
LIG_RPA_C_Fungi	179	191	PF08784	0.391
LIG_SH2_NCK_1	20	24	PF00017	0.506
LIG_SH2_SRC	20	23	PF00017	0.505
LIG_SH2_STAP1	475	479	PF00017	0.465
LIG_SH2_STAT3	307	310	PF00017	0.727
LIG_SH2_STAT5	115	118	PF00017	0.615
LIG_SH2_STAT5	372	375	PF00017	0.549
LIG_SH2_STAT5	441	444	PF00017	0.401
LIG_SH2_STAT5	82	85	PF00017	0.408
LIG_SH3_3	306	312	PF00018	0.641
LIG_SUMO_SIM_anti_2	384	393	PF11976	0.596
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.532
LIG_SUMO_SIM_par_1	330	339	PF11976	0.601
LIG_TRAF2_1	421	424	PF00917	0.580
LIG_TRAF2_1	542	545	PF00917	0.687
LIG_TYR_ITIM	533	538	PF00017	0.626
MOD_CDK_SPxxK_3	196	203	PF00069	0.571
MOD_CK1_1	137	143	PF00069	0.580
MOD_CK1_1	193	199	PF00069	0.609
MOD_CK1_1	24	30	PF00069	0.650
MOD_CK1_1	282	288	PF00069	0.712
MOD_CK1_1	319	325	PF00069	0.714
MOD_CK1_1	45	51	PF00069	0.560
MOD_CK2_1	228	234	PF00069	0.744
MOD_CK2_1	67	73	PF00069	0.660
MOD_Cter_Amidation	181	184	PF01082	0.552
MOD_GlcNHglycan	185	188	PF01048	0.552
MOD_GlcNHglycan	240	243	PF01048	0.568
MOD_GlcNHglycan	250	253	PF01048	0.584
MOD_GlcNHglycan	290	293	PF01048	0.656
MOD_GlcNHglycan	475	478	PF01048	0.503
MOD_GlcNHglycan	73	77	PF01048	0.645
MOD_GlcNHglycan	78	81	PF01048	0.601
MOD_GSK3_1	21	28	PF00069	0.658
MOD_GSK3_1	238	245	PF00069	0.722
MOD_GSK3_1	248	255	PF00069	0.626
MOD_GSK3_1	259	266	PF00069	0.720
MOD_GSK3_1	275	282	PF00069	0.706
MOD_GSK3_1	317	324	PF00069	0.525
MOD_GSK3_1	72	79	PF00069	0.569
MOD_NEK2_1	25	30	PF00069	0.623
MOD_NEK2_1	279	284	PF00069	0.669
MOD_NEK2_1	522	527	PF00069	0.596
MOD_NEK2_1	64	69	PF00069	0.664
MOD_NEK2_2	265	270	PF00069	0.651
MOD_NEK2_2	37	42	PF00069	0.622
MOD_PIKK_1	27	33	PF00454	0.500
MOD_PIKK_1	67	73	PF00454	0.566
MOD_PKA_1	183	189	PF00069	0.402
MOD_PKA_1	42	48	PF00069	0.587
MOD_PKA_2	148	154	PF00069	0.595
MOD_PKA_2	183	189	PF00069	0.520
MOD_PKA_2	193	199	PF00069	0.729
MOD_PKA_2	350	356	PF00069	0.546
MOD_PKA_2	360	366	PF00069	0.540
MOD_PKA_2	379	385	PF00069	0.283
MOD_PKA_2	400	406	PF00069	0.548
MOD_PKA_2	42	48	PF00069	0.587
MOD_PKA_2	445	451	PF00069	0.581
MOD_PKA_2	522	528	PF00069	0.597
MOD_PKB_1	181	189	PF00069	0.600
MOD_Plk_1	137	143	PF00069	0.580
MOD_Plk_1	155	161	PF00069	0.362
MOD_Plk_1	21	27	PF00069	0.746
MOD_Plk_1	390	396	PF00069	0.556
MOD_Plk_1	72	78	PF00069	0.647
MOD_Plk_2-3	228	234	PF00069	0.723
MOD_Plk_2-3	540	546	PF00069	0.652
MOD_Plk_4	155	161	PF00069	0.391
MOD_Plk_4	21	27	PF00069	0.663
MOD_ProDKin_1	196	202	PF00069	0.716
MOD_ProDKin_1	254	260	PF00069	0.739
MOD_ProDKin_1	283	289	PF00069	0.741
MOD_ProDKin_1	311	317	PF00069	0.687
MOD_SUMO_for_1	118	121	PF00179	0.553
MOD_SUMO_for_1	494	497	PF00179	0.553
MOD_SUMO_rev_2	505	515	PF00179	0.641
TRG_DiLeu_BaEn_1	21	26	PF01217	0.620
TRG_DiLeu_BaEn_1	298	303	PF01217	0.696
TRG_DiLeu_BaEn_1	482	487	PF01217	0.515
TRG_DiLeu_BaEn_4	338	344	PF01217	0.491
TRG_DiLeu_BaEn_4	505	511	PF01217	0.514
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.505
TRG_ENDOCYTIC_2	115	118	PF00928	0.615
TRG_ENDOCYTIC_2	452	455	PF00928	0.576
TRG_ENDOCYTIC_2	535	538	PF00928	0.597
TRG_ER_diArg_1	181	184	PF00400	0.497
TRG_ER_diArg_1	203	205	PF00400	0.754
TRG_ER_diArg_1	433	435	PF00400	0.525
TRG_ER_diArg_1	501	504	PF00400	0.537
TRG_ER_diArg_1	531	533	PF00400	0.619
TRG_NES_CRM1_1	416	432	PF08389	0.509
TRG_NES_CRM1_1	511	524	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P310	Leptomonas seymouri	53%	100%
A0A0S4IYQ0	Bodo saltans	27%	100%
A0A1X0NVG8	Trypanosomatidae	32%	100%
A0A3Q8IB95	Leishmania donovani	80%	100%
A0A3R7L4W3	Trypanosoma rangeli	32%	100%
A4HUY1	Leishmania infantum	81%	100%
E9ANL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QH07	Leishmania major	81%	100%
V5C199	Trypanosoma cruzi	32%	100%