ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies), putative

Species:

Leishmania braziliensis

UniProt:

A4H6J4_LEIBR

TriTrypDb:

LbrM.11.0480 , LBRM2903_110009800

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6J4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	124	130	PF00089	0.378
CLV_NRD_NRD_1	207	209	PF00675	0.452
CLV_PCSK_KEX2_1	209	211	PF00082	0.440
CLV_PCSK_KEX2_1	213	215	PF00082	0.390
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.462
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.416
CLV_PCSK_SKI1_1	62	66	PF00082	0.304
CLV_Separin_Metazoa	143	147	PF03568	0.463
CLV_Separin_Metazoa	181	185	PF03568	0.210
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DOC_USP7_UBL2_3	209	213	PF12436	0.439
DOC_WW_Pin1_4	199	204	PF00397	0.409
DOC_WW_Pin1_4	44	49	PF00397	0.322
DOC_WW_Pin1_4	77	82	PF00397	0.387
LIG_14-3-3_CanoR_1	114	120	PF00244	0.525
LIG_eIF4E_1	161	167	PF01652	0.414
LIG_FHA_1	162	168	PF00498	0.320
LIG_FHA_2	15	21	PF00498	0.360
LIG_HCF-1_HBM_1	95	98	PF13415	0.536
LIG_LIR_Gen_1	11	21	PF02991	0.419
LIG_LIR_Gen_1	121	128	PF02991	0.323
LIG_LIR_Nem_3	11	16	PF02991	0.299
LIG_LIR_Nem_3	121	125	PF02991	0.316
LIG_PCNA_yPIPBox_3	208	219	PF02747	0.291
LIG_SH2_CRK	122	126	PF00017	0.316
LIG_SH2_NCK_1	122	126	PF00017	0.240
LIG_SH2_STAT3	107	110	PF00017	0.634
LIG_SH2_STAT5	12	15	PF00017	0.400
LIG_SH2_STAT5	205	208	PF00017	0.451
LIG_SH2_STAT5	82	85	PF00017	0.469
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.388
LIG_UBA3_1	93	99	PF00899	0.418
MOD_CK1_1	109	115	PF00069	0.671
MOD_CK1_1	8	14	PF00069	0.533
MOD_CK2_1	82	88	PF00069	0.473
MOD_GlcNHglycan	130	133	PF01048	0.322
MOD_GlcNHglycan	84	87	PF01048	0.511
MOD_N-GLC_1	5	10	PF02516	0.659
MOD_NEK2_1	115	120	PF00069	0.525
MOD_NEK2_1	128	133	PF00069	0.325
MOD_NEK2_2	101	106	PF00069	0.541
MOD_PIKK_1	106	112	PF00454	0.662
MOD_Plk_1	101	107	PF00069	0.548
MOD_Plk_1	120	126	PF00069	0.168
MOD_Plk_1	8	14	PF00069	0.493
MOD_Plk_4	120	126	PF00069	0.421
MOD_Plk_4	23	29	PF00069	0.243
MOD_Plk_4	8	14	PF00069	0.493
MOD_ProDKin_1	199	205	PF00069	0.411
MOD_ProDKin_1	44	50	PF00069	0.322
MOD_ProDKin_1	77	83	PF00069	0.385
TRG_DiLeu_BaEn_1	143	148	PF01217	0.378
TRG_DiLeu_BaEn_1	59	64	PF01217	0.421
TRG_DiLeu_LyEn_5	143	148	PF01217	0.463
TRG_ENDOCYTIC_2	122	125	PF00928	0.319
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU29	Leptomonas seymouri	78%	100%
A0A0S4JTV5	Bodo saltans	28%	85%
A0A1X0NV32	Trypanosomatidae	55%	100%
A0A3S7WRN0	Leishmania donovani	91%	100%
A0A422NQB4	Trypanosoma rangeli	52%	100%
A4HUX9	Leishmania infantum	91%	100%
E9ANL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O75832	Homo sapiens	28%	100%
P77736	Escherichia coli (strain K12)	34%	100%
Q17QS6	Bos taurus	29%	69%
Q2KI79	Bos taurus	24%	72%
Q4QH09	Leishmania major	92%	100%
Q4ULZ2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	25%	74%
Q502M6	Danio rerio	26%	76%
Q5UPA0	Acanthamoeba polyphaga mimivirus	26%	69%
Q6AFL2	Leifsonia xyli subsp. xyli (strain CTCB07)	39%	89%
Q862Z2	Oryctolagus cuniculus	28%	69%
Q8N6D5	Homo sapiens	23%	75%
Q8VBX0	Mus musculus	28%	81%
Q8WWX0	Homo sapiens	28%	69%
Q8WXK3	Homo sapiens	29%	81%
Q8ZWC4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	28%	88%
Q96DX5	Homo sapiens	25%	77%
Q99PE2	Mus musculus	25%	72%
Q9CQ31	Mus musculus	28%	70%
Q9D1A4	Mus musculus	28%	69%
Q9H9E1	Homo sapiens	24%	72%
Q9WV06	Mus musculus	28%	69%
Q9Z2X2	Mus musculus	27%	98%
Q9Z2X3	Rattus norvegicus	29%	98%
V5BBG1	Trypanosoma cruzi	53%	100%