Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4H6J3_LEIBR

TriTrypDb:

LbrM.11.0470 , LBRM2903_110009700

Length:

575

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 101
NetGPI	no	yes: 0, no: 101

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	96
GO:0110165	cellular anatomical entity	1	96

Expansion

Sequence features

A4H6J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6J3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	44
GO:0022857	transmembrane transporter activity	2	44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	560	564	PF00656	0.560
CLV_C14_Caspase3-7	570	574	PF00656	0.569
CLV_NRD_NRD_1	116	118	PF00675	0.357
CLV_NRD_NRD_1	375	377	PF00675	0.381
CLV_NRD_NRD_1	514	516	PF00675	0.344
CLV_NRD_NRD_1	571	573	PF00675	0.506
CLV_PCSK_KEX2_1	116	118	PF00082	0.372
CLV_PCSK_KEX2_1	272	274	PF00082	0.408
CLV_PCSK_KEX2_1	375	377	PF00082	0.365
CLV_PCSK_KEX2_1	571	573	PF00082	0.553
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.371
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.384
CLV_PCSK_PC7_1	268	274	PF00082	0.402
CLV_PCSK_SKI1_1	408	412	PF00082	0.517
CLV_PCSK_SKI1_1	515	519	PF00082	0.365
DEG_MDM2_SWIB_1	448	456	PF02201	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.357
DEG_ODPH_VHL_1	64	76	PF01847	0.328
DOC_CYCLIN_RxL_1	405	415	PF00134	0.189
DOC_CYCLIN_yClb5_NLxxxL_5	492	501	PF00134	0.207
DOC_MAPK_DCC_7	482	491	PF00069	0.212
DOC_MAPK_gen_1	116	123	PF00069	0.524
DOC_MAPK_gen_1	237	245	PF00069	0.371
DOC_MAPK_gen_1	375	384	PF00069	0.560
DOC_MAPK_gen_1	470	480	PF00069	0.404
DOC_MAPK_MEF2A_6	208	217	PF00069	0.483
DOC_MAPK_MEF2A_6	377	386	PF00069	0.561
DOC_MAPK_MEF2A_6	482	491	PF00069	0.270
DOC_MAPK_RevD_3	258	273	PF00069	0.509
DOC_PP2B_LxvP_1	403	406	PF13499	0.419
DOC_PP4_FxxP_1	388	391	PF00568	0.404
DOC_PP4_FxxP_1	41	44	PF00568	0.319
DOC_SPAK_OSR1_1	86	90	PF12202	0.318
DOC_USP7_MATH_1	224	228	PF00917	0.349
DOC_USP7_MATH_1	4	8	PF00917	0.272
DOC_USP7_MATH_1	406	410	PF00917	0.403
DOC_USP7_MATH_1	425	429	PF00917	0.330
DOC_USP7_MATH_1	531	535	PF00917	0.675
DOC_USP7_UBL2_3	438	442	PF12436	0.546
DOC_USP7_UBL2_3	473	477	PF12436	0.428
DOC_WW_Pin1_4	143	148	PF00397	0.334
DOC_WW_Pin1_4	328	333	PF00397	0.393
LIG_14-3-3_CanoR_1	26	34	PF00244	0.331
LIG_14-3-3_CanoR_1	363	369	PF00244	0.374
LIG_14-3-3_CanoR_1	381	387	PF00244	0.408
LIG_14-3-3_CanoR_1	515	524	PF00244	0.607
LIG_BRCT_BRCA1_1	147	151	PF00533	0.206
LIG_BRCT_BRCA1_1	330	334	PF00533	0.369
LIG_BRCT_BRCA1_1	6	10	PF00533	0.302
LIG_BRCT_BRCA1_1	97	101	PF00533	0.409
LIG_FHA_1	224	230	PF00498	0.334
LIG_FHA_1	247	253	PF00498	0.367
LIG_FHA_1	296	302	PF00498	0.523
LIG_FHA_1	304	310	PF00498	0.453
LIG_FHA_1	338	344	PF00498	0.377
LIG_FHA_1	390	396	PF00498	0.333
LIG_FHA_1	496	502	PF00498	0.400
LIG_FHA_2	285	291	PF00498	0.589
LIG_FHA_2	45	51	PF00498	0.468
LIG_FHA_2	568	574	PF00498	0.668
LIG_GBD_Chelix_1	120	128	PF00786	0.427
LIG_GBD_Chelix_1	453	461	PF00786	0.383
LIG_LIR_Apic_2	288	294	PF02991	0.561
LIG_LIR_Apic_2	385	391	PF02991	0.379
LIG_LIR_Apic_2	50	54	PF02991	0.467
LIG_LIR_Gen_1	253	264	PF02991	0.352
LIG_LIR_Gen_1	308	317	PF02991	0.338
LIG_LIR_Gen_1	323	332	PF02991	0.430
LIG_LIR_Gen_1	47	57	PF02991	0.418
LIG_LIR_Gen_1	502	513	PF02991	0.387
LIG_LIR_Gen_1	7	17	PF02991	0.291
LIG_LIR_Nem_3	148	154	PF02991	0.251
LIG_LIR_Nem_3	308	313	PF02991	0.307
LIG_LIR_Nem_3	315	320	PF02991	0.293
LIG_LIR_Nem_3	323	327	PF02991	0.400
LIG_LIR_Nem_3	331	337	PF02991	0.304
LIG_LIR_Nem_3	367	372	PF02991	0.574
LIG_LIR_Nem_3	47	52	PF02991	0.373
LIG_LIR_Nem_3	502	508	PF02991	0.334
LIG_LIR_Nem_3	7	13	PF02991	0.279
LIG_LIR_Nem_3	75	79	PF02991	0.305
LIG_LYPXL_SIV_4	44	52	PF13949	0.269
LIG_MLH1_MIPbox_1	147	151	PF16413	0.209
LIG_NRBOX	346	352	PF00104	0.225
LIG_NRBOX	457	463	PF00104	0.296
LIG_NRBOX	496	502	PF00104	0.475
LIG_Pex14_2	324	328	PF04695	0.411
LIG_Pex14_2	448	452	PF04695	0.355
LIG_SH2_CRK	45	49	PF00017	0.325
LIG_SH2_PTP2	291	294	PF00017	0.539
LIG_SH2_PTP2	505	508	PF00017	0.355
LIG_SH2_SRC	505	508	PF00017	0.487
LIG_SH2_STAP1	8	12	PF00017	0.294
LIG_SH2_STAT3	199	202	PF00017	0.539
LIG_SH2_STAT5	150	153	PF00017	0.326
LIG_SH2_STAT5	199	202	PF00017	0.558
LIG_SH2_STAT5	210	213	PF00017	0.314
LIG_SH2_STAT5	222	225	PF00017	0.313
LIG_SH2_STAT5	291	294	PF00017	0.542
LIG_SH2_STAT5	372	375	PF00017	0.582
LIG_SH2_STAT5	40	43	PF00017	0.303
LIG_SH2_STAT5	505	508	PF00017	0.338
LIG_SH2_STAT5	51	54	PF00017	0.487
LIG_SH2_STAT5	58	61	PF00017	0.326
LIG_SH3_2	536	541	PF14604	0.753
LIG_SH3_3	218	224	PF00018	0.316
LIG_SH3_3	258	264	PF00018	0.366
LIG_SH3_3	482	488	PF00018	0.287
LIG_SH3_3	533	539	PF00018	0.640
LIG_SH3_3	60	66	PF00018	0.274
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.361
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.377
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.374
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.315
LIG_SUMO_SIM_anti_2	426	431	PF11976	0.336
LIG_SUMO_SIM_par_1	392	398	PF11976	0.309
LIG_SUMO_SIM_par_1	428	434	PF11976	0.290
LIG_SUMO_SIM_par_1	92	98	PF11976	0.336
LIG_TRFH_1	40	44	PF08558	0.367
LIG_TYR_ITIM	43	48	PF00017	0.341
LIG_UBA3_1	333	339	PF00899	0.380
MOD_CK1_1	137	143	PF00069	0.380
MOD_CK1_1	146	152	PF00069	0.275
MOD_CK1_1	22	28	PF00069	0.266
MOD_CK1_1	30	36	PF00069	0.334
MOD_CK1_1	303	309	PF00069	0.516
MOD_CK1_1	335	341	PF00069	0.344
MOD_CK1_1	511	517	PF00069	0.572
MOD_CK1_1	554	560	PF00069	0.709
MOD_CK1_1	95	101	PF00069	0.366
MOD_CK2_1	364	370	PF00069	0.395
MOD_GlcNHglycan	13	16	PF01048	0.469
MOD_GlcNHglycan	131	134	PF01048	0.321
MOD_GlcNHglycan	226	229	PF01048	0.343
MOD_GlcNHglycan	276	281	PF01048	0.460
MOD_GlcNHglycan	334	337	PF01048	0.520
MOD_GlcNHglycan	347	350	PF01048	0.310
MOD_GlcNHglycan	358	361	PF01048	0.286
MOD_GSK3_1	108	115	PF00069	0.346
MOD_GSK3_1	170	177	PF00069	0.477
MOD_GSK3_1	22	29	PF00069	0.282
MOD_GSK3_1	246	253	PF00069	0.376
MOD_GSK3_1	267	274	PF00069	0.537
MOD_GSK3_1	296	303	PF00069	0.559
MOD_GSK3_1	328	335	PF00069	0.348
MOD_GSK3_1	339	346	PF00069	0.346
MOD_GSK3_1	495	502	PF00069	0.385
MOD_GSK3_1	567	574	PF00069	0.709
MOD_N-GLC_1	328	333	PF02516	0.551
MOD_N-GLC_1	495	500	PF02516	0.320
MOD_NEK2_1	123	128	PF00069	0.397
MOD_NEK2_1	154	159	PF00069	0.294
MOD_NEK2_1	209	214	PF00069	0.348
MOD_NEK2_1	300	305	PF00069	0.529
MOD_NEK2_1	337	342	PF00069	0.347
MOD_NEK2_1	343	348	PF00069	0.328
MOD_NEK2_1	364	369	PF00069	0.398
MOD_NEK2_1	423	428	PF00069	0.342
MOD_NEK2_1	495	500	PF00069	0.332
MOD_NEK2_1	551	556	PF00069	0.670
MOD_NEK2_1	72	77	PF00069	0.299
MOD_NEK2_2	44	49	PF00069	0.486
MOD_PIKK_1	198	204	PF00454	0.596
MOD_PIKK_1	370	376	PF00454	0.558
MOD_PIKK_1	95	101	PF00454	0.411
MOD_PKA_2	267	273	PF00069	0.551
MOD_PKA_2	508	514	PF00069	0.477
MOD_Plk_1	19	25	PF00069	0.259
MOD_Plk_1	343	349	PF00069	0.332
MOD_Plk_1	495	501	PF00069	0.342
MOD_Plk_2-3	284	290	PF00069	0.677
MOD_Plk_4	102	108	PF00069	0.326
MOD_Plk_4	123	129	PF00069	0.372
MOD_Plk_4	146	152	PF00069	0.294
MOD_Plk_4	154	160	PF00069	0.257
MOD_Plk_4	238	244	PF00069	0.340
MOD_Plk_4	247	253	PF00069	0.365
MOD_Plk_4	296	302	PF00069	0.529
MOD_Plk_4	305	311	PF00069	0.477
MOD_Plk_4	349	355	PF00069	0.314
MOD_Plk_4	364	370	PF00069	0.368
MOD_Plk_4	390	396	PF00069	0.325
MOD_Plk_4	425	431	PF00069	0.323
MOD_Plk_4	44	50	PF00069	0.377
MOD_Plk_4	59	65	PF00069	0.265
MOD_Plk_4	80	86	PF00069	0.275
MOD_ProDKin_1	143	149	PF00069	0.334
MOD_ProDKin_1	328	334	PF00069	0.392
MOD_SUMO_for_1	524	527	PF00179	0.495
MOD_SUMO_rev_2	185	191	PF00179	0.569
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.318
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.378
TRG_ENDOCYTIC_2	150	153	PF00928	0.296
TRG_ENDOCYTIC_2	210	213	PF00928	0.367
TRG_ENDOCYTIC_2	40	43	PF00928	0.312
TRG_ENDOCYTIC_2	45	48	PF00928	0.325
TRG_ENDOCYTIC_2	49	52	PF00928	0.485
TRG_ENDOCYTIC_2	505	508	PF00928	0.392
TRG_ENDOCYTIC_2	510	513	PF00928	0.524
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	39%	90%
A0A0N1HT40	Leptomonas seymouri	74%	100%
A0A0N1HZC2	Leptomonas seymouri	30%	92%
A0A0N1IKC5	Leptomonas seymouri	49%	95%
A0A0N1PAX2	Leptomonas seymouri	22%	100%
A0A0N1PB63	Leptomonas seymouri	26%	87%
A0A0S4IIJ4	Bodo saltans	23%	100%
A0A0S4JR45	Bodo saltans	31%	100%
A0A1X0NKK0	Trypanosomatidae	32%	95%
A0A1X0NL32	Trypanosomatidae	33%	92%
A0A1X0NM09	Trypanosomatidae	33%	94%
A0A1X0NRW5	Trypanosomatidae	40%	82%
A0A1X0NV13	Trypanosomatidae	50%	88%
A0A1X0NV19	Trypanosomatidae	48%	96%
A0A1X0NV27	Trypanosomatidae	48%	96%
A0A1X0NVH8	Trypanosomatidae	45%	87%
A0A1X0NVM7	Trypanosomatidae	53%	89%
A0A1X0NWQ1	Trypanosomatidae	45%	90%
A0A1X0NZE6	Trypanosomatidae	32%	96%
A0A1X0NZU2	Trypanosomatidae	28%	89%
A0A1X0NZU5	Trypanosomatidae	33%	98%
A0A1X0NZW1	Trypanosomatidae	28%	96%
A0A1X0P0M7	Trypanosomatidae	32%	97%
A0A3Q8I7Y9	Leishmania donovani	88%	100%
A0A3Q8IF95	Leishmania donovani	28%	91%
A0A3Q8ISY9	Leishmania donovani	37%	91%
A0A3R7JPZ0	Trypanosoma rangeli	27%	100%
A0A3R7JSQ9	Trypanosoma rangeli	28%	100%
A0A3R7KKN8	Trypanosoma rangeli	30%	96%
A0A3R7MAQ7	Trypanosoma rangeli	35%	81%
A0A3R7N415	Trypanosoma rangeli	29%	96%
A0A3R7N921	Trypanosoma rangeli	28%	100%
A0A3R7R443	Trypanosoma rangeli	29%	96%
A0A3R7R6N6	Trypanosoma rangeli	28%	100%
A0A3S7WRJ4	Leishmania donovani	48%	90%
A0A3S7WRJ5	Leishmania donovani	40%	82%
A0A3S7WRL4	Leishmania donovani	84%	92%
A0A3S7WSR4	Leishmania donovani	46%	95%
A0A3S7WWU1	Leishmania donovani	27%	87%
A0A3S7XB11	Leishmania donovani	30%	95%
A0A422MSE4	Trypanosoma rangeli	47%	100%
A0A422MSP6	Trypanosoma rangeli	33%	100%
A0A422MST9	Trypanosoma rangeli	28%	96%
A0A422MU68	Trypanosoma rangeli	29%	100%
A4H6J0	Leishmania braziliensis	47%	100%
A4H6J1	Leishmania braziliensis	45%	100%
A4HC19	Leishmania braziliensis	27%	89%
A4HHG3	Leishmania braziliensis	30%	89%
A4HJW3	Leishmania braziliensis	38%	90%
A4HPE2	Leishmania braziliensis	30%	94%
A4HUX5	Leishmania infantum	48%	90%
A4HUX6	Leishmania infantum	41%	82%
A4HUX7	Leishmania infantum	83%	92%
A4HUX8	Leishmania infantum	83%	98%
A4HZF5	Leishmania infantum	28%	91%
A4HZJ4	Leishmania infantum	27%	87%
A4I7C5	Leishmania infantum	37%	91%
A4ICI3	Leishmania infantum	30%	95%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	98%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	97%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	95%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	96%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	96%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	84%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	92%
E9AGK5	Leishmania infantum	46%	95%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	90%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	88%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	95%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	97%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	87%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	91%
Q4Q1E4	Leishmania major	30%	100%
Q4Q5T8	Leishmania major	37%	100%
Q4QC27	Leishmania major	28%	100%
Q4QC28	Leishmania major	29%	100%
Q4QFY5	Leishmania major	46%	100%
Q4QH10	Leishmania major	86%	100%
Q4QH11	Leishmania major	86%	100%
Q4QH12	Leishmania major	86%	100%
Q4QH13	Leishmania major	86%	100%
Q4QH14	Leishmania major	42%	100%
Q4QH15	Leishmania major	47%	100%
V5B647	Trypanosoma cruzi	48%	91%
V5B983	Trypanosoma cruzi	32%	98%
V5BBB1	Trypanosoma cruzi	47%	97%
V5BFV8	Trypanosoma cruzi	30%	86%
V5BQY6	Trypanosoma cruzi	38%	81%
V5BVP0	Trypanosoma cruzi	47%	97%
V5DT25	Trypanosoma cruzi	54%	93%