This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 12 |
| NetGPI | no | yes: 0, no: 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 12 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
Related structures:
AlphaFold database: A4H6J2
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005488 | binding | 1 | 7 |
| GO:0020037 | heme binding | 4 | 7 |
| GO:0046906 | tetrapyrrole binding | 3 | 7 |
| GO:0097159 | organic cyclic compound binding | 2 | 7 |
| GO:1901363 | heterocyclic compound binding | 2 | 7 |
| GO:0043167 | ion binding | 2 | 6 |
| GO:0043169 | cation binding | 3 | 6 |
| GO:0046872 | metal ion binding | 4 | 6 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| DOC_MAPK_DCC_7 | 115 | 125 | PF00069 | 0.523 |
| DOC_USP7_MATH_1 | 83 | 87 | PF00917 | 0.690 |
| DOC_USP7_UBL2_3 | 90 | 94 | PF12436 | 0.697 |
| DOC_WW_Pin1_4 | 95 | 100 | PF00397 | 0.689 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.653 |
| LIG_BRCT_BRCA1_1 | 72 | 76 | PF00533 | 0.463 |
| LIG_FHA_1 | 66 | 72 | PF00498 | 0.533 |
| LIG_FHA_2 | 104 | 110 | PF00498 | 0.737 |
| LIG_FHA_2 | 16 | 22 | PF00498 | 0.502 |
| LIG_LIR_Gen_1 | 10 | 15 | PF02991 | 0.533 |
| LIG_LIR_Gen_1 | 21 | 32 | PF02991 | 0.439 |
| LIG_LIR_Nem_3 | 10 | 14 | PF02991 | 0.463 |
| LIG_LIR_Nem_3 | 57 | 63 | PF02991 | 0.442 |
| LIG_NRBOX | 136 | 142 | PF00104 | 0.427 |
| LIG_Pex14_1 | 24 | 28 | PF04695 | 0.442 |
| LIG_SH2_CRK | 28 | 32 | PF00017 | 0.442 |
| LIG_SH2_STAT5 | 139 | 142 | PF00017 | 0.470 |
| LIG_SUMO_SIM_par_1 | 30 | 35 | PF11976 | 0.442 |
| LIG_TRAF2_1 | 107 | 110 | PF00917 | 0.666 |
| LIG_TYR_ITIM | 26 | 31 | PF00017 | 0.442 |
| LIG_UBA3_1 | 136 | 142 | PF00899 | 0.322 |
| MOD_CDK_SPxxK_3 | 95 | 102 | PF00069 | 0.701 |
| MOD_CK1_1 | 104 | 110 | PF00069 | 0.661 |
| MOD_CK1_1 | 59 | 65 | PF00069 | 0.434 |
| MOD_CK2_1 | 103 | 109 | PF00069 | 0.724 |
| MOD_CK2_1 | 7 | 13 | PF00069 | 0.463 |
| MOD_GSK3_1 | 59 | 66 | PF00069 | 0.448 |
| MOD_NEK2_1 | 32 | 37 | PF00069 | 0.438 |
| MOD_NEK2_1 | 54 | 59 | PF00069 | 0.533 |
| MOD_NEK2_1 | 70 | 75 | PF00069 | 0.510 |
| MOD_PKA_1 | 94 | 100 | PF00069 | 0.735 |
| MOD_PKA_2 | 15 | 21 | PF00069 | 0.478 |
| MOD_Plk_1 | 83 | 89 | PF00069 | 0.539 |
| MOD_ProDKin_1 | 95 | 101 | PF00069 | 0.688 |
| TRG_ENDOCYTIC_2 | 28 | 31 | PF00928 | 0.442 |
| TRG_Pf-PMV_PEXEL_1 | 36 | 40 | PF00026 | 0.276 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IJC6 | Leptomonas seymouri | 68% | 100% |
| A0A0S4J0V9 | Bodo saltans | 47% | 100% |
| A0A0S4J2K9 | Bodo saltans | 54% | 100% |
| A0A0S4JCD1 | Bodo saltans | 28% | 100% |
| A0A1X0NV37 | Trypanosomatidae | 50% | 100% |
| A0A3Q8I926 | Leishmania donovani | 82% | 100% |
| A0A3S7WQZ7 | Leishmania donovani | 32% | 100% |
| A0A422MYR2 | Trypanosoma rangeli | 46% | 100% |
| A4H5X6 | Leishmania braziliensis | 29% | 100% |
| A4HU71 | Leishmania infantum | 32% | 100% |
| A4HUW0 | Leishmania infantum | 82% | 100% |
| B7GCG7 | Phaeodactylum tricornutum (strain CCAP 1055/1) | 32% | 100% |
| C9ZRS4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 29% | 78% |
| D0A7I2 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 46% | 100% |
| E9AJH1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 67% |
| E9AN01 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9ANK3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 81% | 100% |
| O04354 | Borago officinalis | 34% | 100% |
| O48845 | Arabidopsis thaliana | 30% | 100% |
| P00171 | Bos taurus | 35% | 100% |
| P49096 | Musca domestica | 29% | 100% |
| P49097 | Cuscuta reflexa | 35% | 100% |
| P49098 | Nicotiana tabacum | 32% | 100% |
| P49099 | Nicotiana tabacum | 33% | 100% |
| P49100 | Oryza sativa subsp. japonica | 34% | 100% |
| Q4QH22 | Leishmania major | 80% | 100% |
| Q4QHM6 | Leishmania major | 32% | 100% |
| Q9FDW8 | Arabidopsis thaliana | 36% | 100% |
| Q9HFV1 | Rhizopus stolonifer | 33% | 100% |
| Q9V4N3 | Drosophila melanogaster | 29% | 100% |
| Q9Y706 | Mortierella alpina | 33% | 100% |
| Q9ZNV4 | Arabidopsis thaliana | 34% | 100% |
| Q9ZWT2 | Arabidopsis thaliana | 31% | 100% |
| V5BRX2 | Trypanosoma cruzi | 48% | 100% |