Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein Associated with Differentiation, putative

Species:

Leishmania braziliensis

UniProt:

A4H6J0_LEIBR

TriTrypDb:

LbrM.11.0430 , LBRM2903_110009100

Length:

643

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 121
NetGPI	no	yes: 0, no: 121

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	114
GO:0110165	cellular anatomical entity	1	114
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A4H6J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6J0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	54
GO:0022857	transmembrane transporter activity	2	54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.709
CLV_NRD_NRD_1	303	305	PF00675	0.394
CLV_NRD_NRD_1	308	310	PF00675	0.431
CLV_NRD_NRD_1	459	461	PF00675	0.369
CLV_NRD_NRD_1	561	563	PF00675	0.512
CLV_NRD_NRD_1	599	601	PF00675	0.357
CLV_PCSK_KEX2_1	303	305	PF00082	0.411
CLV_PCSK_KEX2_1	459	461	PF00082	0.353
CLV_PCSK_KEX2_1	561	563	PF00082	0.553
CLV_PCSK_KEX2_1	599	601	PF00082	0.352
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.357
CLV_PCSK_PC7_1	595	601	PF00082	0.402
CLV_PCSK_SKI1_1	235	239	PF00082	0.333
CLV_PCSK_SKI1_1	245	249	PF00082	0.262
CLV_PCSK_SKI1_1	27	31	PF00082	0.243
CLV_PCSK_SKI1_1	304	308	PF00082	0.453
CLV_PCSK_SKI1_1	348	352	PF00082	0.358
CLV_PCSK_SKI1_1	517	521	PF00082	0.292
CLV_PCSK_SKI1_1	599	603	PF00082	0.369
DEG_APCC_DBOX_1	244	252	PF00400	0.497
DEG_APCC_DBOX_1	26	34	PF00400	0.459
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.246
DOC_MAPK_gen_1	459	468	PF00069	0.533
DOC_MAPK_MEF2A_6	461	470	PF00069	0.533
DOC_MAPK_MEF2A_6	566	575	PF00069	0.317
DOC_MAPK_RevD_3	294	310	PF00069	0.620
DOC_PP1_RVXF_1	275	281	PF00149	0.267
DOC_PP2B_LxvP_1	487	490	PF13499	0.418
DOC_PP2B_LxvP_1	49	52	PF13499	0.365
DOC_PP2B_LxvP_1	494	497	PF13499	0.299
DOC_PP4_FxxP_1	78	81	PF00568	0.312
DOC_USP7_MATH_1	129	133	PF00917	0.172
DOC_USP7_MATH_1	15	19	PF00917	0.611
DOC_USP7_MATH_1	261	265	PF00917	0.356
DOC_USP7_MATH_1	342	346	PF00917	0.731
DOC_USP7_MATH_1	427	431	PF00917	0.398
DOC_USP7_UBL2_3	522	526	PF12436	0.529
DOC_WW_Pin1_4	327	332	PF00397	0.566
LIG_14-3-3_CanoR_1	21	28	PF00244	0.576
LIG_14-3-3_CanoR_1	447	453	PF00244	0.298
LIG_14-3-3_CanoR_1	57	65	PF00244	0.342
LIG_14-3-3_CanoR_1	593	598	PF00244	0.580
LIG_APCC_ABBAyCdc20_2	605	611	PF00400	0.587
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_deltaCOP1_diTrp_1	393	399	PF00928	0.363
LIG_eIF4E_1	597	603	PF01652	0.410
LIG_FHA_1	119	125	PF00498	0.293
LIG_FHA_1	136	142	PF00498	0.367
LIG_FHA_1	199	205	PF00498	0.368
LIG_FHA_1	232	238	PF00498	0.438
LIG_FHA_1	261	267	PF00498	0.327
LIG_FHA_1	273	279	PF00498	0.286
LIG_FHA_1	282	288	PF00498	0.377
LIG_FHA_1	389	395	PF00498	0.496
LIG_FHA_1	414	420	PF00498	0.316
LIG_FHA_1	430	436	PF00498	0.270
LIG_FHA_1	46	52	PF00498	0.310
LIG_FHA_1	467	473	PF00498	0.463
LIG_FHA_1	474	480	PF00498	0.316
LIG_FHA_1	584	590	PF00498	0.401
LIG_FHA_1	68	74	PF00498	0.331
LIG_FHA_2	336	342	PF00498	0.731
LIG_FHA_2	350	356	PF00498	0.775
LIG_FHA_2	368	374	PF00498	0.596
LIG_LIR_Apic_2	373	379	PF02991	0.551
LIG_LIR_Apic_2	87	91	PF02991	0.471
LIG_LIR_Gen_1	185	195	PF02991	0.285
LIG_LIR_Gen_1	408	417	PF02991	0.354
LIG_LIR_Nem_3	163	167	PF02991	0.331
LIG_LIR_Nem_3	174	179	PF02991	0.317
LIG_LIR_Nem_3	185	190	PF02991	0.257
LIG_LIR_Nem_3	35	39	PF02991	0.350
LIG_LIR_Nem_3	408	412	PF02991	0.323
LIG_LIR_Nem_3	451	455	PF02991	0.530
LIG_LIR_Nem_3	549	553	PF02991	0.324
LIG_LIR_Nem_3	87	92	PF02991	0.491
LIG_NRBOX	430	436	PF00104	0.215
LIG_Pex14_2	175	179	PF04695	0.314
LIG_Pex14_2	190	194	PF04695	0.359
LIG_Pex14_2	246	250	PF04695	0.327
LIG_Pex14_2	405	409	PF04695	0.352
LIG_Pex14_2	43	47	PF04695	0.346
LIG_Pex14_2	452	456	PF04695	0.549
LIG_Pex14_2	78	82	PF04695	0.405
LIG_PTB_Apo_2	411	418	PF02174	0.313
LIG_REV1ctd_RIR_1	177	187	PF16727	0.281
LIG_SH2_CRK	291	295	PF00017	0.466
LIG_SH2_SRC	216	219	PF00017	0.574
LIG_SH2_SRC	498	501	PF00017	0.340
LIG_SH2_STAP1	45	49	PF00017	0.334
LIG_SH2_STAP1	551	555	PF00017	0.277
LIG_SH2_STAT3	236	239	PF00017	0.457
LIG_SH2_STAT3	551	554	PF00017	0.330
LIG_SH2_STAT5	149	152	PF00017	0.477
LIG_SH2_STAT5	187	190	PF00017	0.321
LIG_SH2_STAT5	236	239	PF00017	0.468
LIG_SH2_STAT5	259	262	PF00017	0.293
LIG_SH2_STAT5	269	272	PF00017	0.277
LIG_SH2_STAT5	376	379	PF00017	0.556
LIG_SH2_STAT5	498	501	PF00017	0.315
LIG_SH2_STAT5	551	554	PF00017	0.297
LIG_SH2_STAT5	597	600	PF00017	0.499
LIG_SH2_STAT5	88	91	PF00017	0.476
LIG_SH3_3	255	261	PF00018	0.312
LIG_SH3_3	293	299	PF00018	0.352
LIG_SH3_3	566	572	PF00018	0.317
LIG_SH3_4	8	15	PF00018	0.511
LIG_Sin3_3	47	54	PF02671	0.178
LIG_SUMO_SIM_par_1	29	35	PF11976	0.428
LIG_SUMO_SIM_par_1	92	98	PF11976	0.332
LIG_TYR_ITIM	267	272	PF00017	0.283
LIG_WRC_WIRS_1	172	177	PF05994	0.370
LIG_WRC_WIRS_1	33	38	PF05994	0.425
LIG_WRC_WIRS_1	449	454	PF05994	0.246
MOD_CDC14_SPxK_1	330	333	PF00782	0.555
MOD_CDK_SPxK_1	327	333	PF00069	0.562
MOD_CK1_1	219	225	PF00069	0.533
MOD_CK1_1	35	41	PF00069	0.305
MOD_CK1_1	67	73	PF00069	0.320
MOD_CK1_1	98	104	PF00069	0.339
MOD_CK2_1	349	355	PF00069	0.757
MOD_CK2_1	448	454	PF00069	0.367
MOD_CMANNOS	395	398	PF00535	0.351
MOD_GlcNHglycan	15	18	PF01048	0.424
MOD_GlcNHglycan	168	171	PF01048	0.324
MOD_GlcNHglycan	263	266	PF01048	0.334
MOD_GlcNHglycan	281	284	PF01048	0.467
MOD_GlcNHglycan	343	347	PF01048	0.409
MOD_GlcNHglycan	424	427	PF01048	0.573
MOD_GlcNHglycan	442	445	PF01048	0.315
MOD_GlcNHglycan	532	535	PF01048	0.287
MOD_GlcNHglycan	581	584	PF01048	0.357
MOD_GSK3_1	129	136	PF00069	0.379
MOD_GSK3_1	145	152	PF00069	0.498
MOD_GSK3_1	268	275	PF00069	0.300
MOD_GSK3_1	304	311	PF00069	0.588
MOD_GSK3_1	35	42	PF00069	0.327
MOD_GSK3_1	422	429	PF00069	0.357
MOD_GSK3_1	474	481	PF00069	0.331
MOD_GSK3_1	532	539	PF00069	0.326
MOD_GSK3_1	579	586	PF00069	0.371
MOD_LATS_1	591	597	PF00433	0.605
MOD_N-GLC_1	198	203	PF02516	0.358
MOD_N-GLC_1	312	317	PF02516	0.532
MOD_N-GLC_1	413	418	PF02516	0.549
MOD_N-GLC_1	58	63	PF02516	0.510
MOD_N-GLC_2	326	328	PF02516	0.377
MOD_N-GLC_2	388	390	PF02516	0.219
MOD_NEK2_1	13	18	PF00069	0.623
MOD_NEK2_1	160	165	PF00069	0.390
MOD_NEK2_1	197	202	PF00069	0.288
MOD_NEK2_1	229	234	PF00069	0.470
MOD_NEK2_1	270	275	PF00069	0.266
MOD_NEK2_1	32	37	PF00069	0.302
MOD_NEK2_1	397	402	PF00069	0.263
MOD_NEK2_1	422	427	PF00069	0.335
MOD_NEK2_1	448	453	PF00069	0.365
MOD_NEK2_1	485	490	PF00069	0.323
MOD_NEK2_1	530	535	PF00069	0.293
MOD_NEK2_1	536	541	PF00069	0.297
MOD_NEK2_1	579	584	PF00069	0.321
MOD_OFUCOSY	301	308	PF10250	0.281
MOD_PIKK_1	15	21	PF00454	0.608
MOD_PIKK_1	454	460	PF00454	0.523
MOD_PIKK_1	508	514	PF00454	0.365
MOD_PIKK_1	58	64	PF00454	0.250
MOD_PKA_2	20	26	PF00069	0.582
MOD_PKA_2	308	314	PF00069	0.596
MOD_Plk_1	354	360	PF00069	0.672
MOD_Plk_1	413	419	PF00069	0.318
MOD_Plk_4	142	148	PF00069	0.277
MOD_Plk_4	171	177	PF00069	0.372
MOD_Plk_4	381	387	PF00069	0.534
MOD_Plk_4	413	419	PF00069	0.302
MOD_Plk_4	433	439	PF00069	0.334
MOD_Plk_4	448	454	PF00069	0.292
MOD_Plk_4	475	481	PF00069	0.317
MOD_Plk_4	532	538	PF00069	0.302
MOD_Plk_4	95	101	PF00069	0.296
MOD_ProDKin_1	327	333	PF00069	0.567
MOD_SUMO_rev_2	631	640	PF00179	0.640
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.357
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.314
TRG_ENDOCYTIC_2	187	190	PF00928	0.293
TRG_ENDOCYTIC_2	269	272	PF00928	0.261
TRG_ENDOCYTIC_2	291	294	PF00928	0.305
TRG_ENDOCYTIC_2	86	89	PF00928	0.483
TRG_ER_diArg_1	302	304	PF00400	0.669
TRG_ER_diArg_1	599	601	PF00400	0.566
TRG_ER_diArg_1	605	608	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	544	549	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	39%	100%
A0A0N1HT40	Leptomonas seymouri	45%	100%
A0A0N1HZC2	Leptomonas seymouri	29%	100%
A0A0N1IKC5	Leptomonas seymouri	54%	100%
A0A0N1PB63	Leptomonas seymouri	26%	97%
A0A0N1PD04	Leptomonas seymouri	25%	100%
A0A0N1PFR4	Leptomonas seymouri	26%	97%
A0A0S4JR45	Bodo saltans	28%	100%
A0A1X0NKK0	Trypanosomatidae	31%	100%
A0A1X0NM09	Trypanosomatidae	30%	100%
A0A1X0NRW5	Trypanosomatidae	39%	92%
A0A1X0NV13	Trypanosomatidae	49%	99%
A0A1X0NV19	Trypanosomatidae	49%	100%
A0A1X0NV27	Trypanosomatidae	50%	100%
A0A1X0NVH8	Trypanosomatidae	42%	97%
A0A1X0NVM7	Trypanosomatidae	48%	100%
A0A1X0NWQ1	Trypanosomatidae	47%	100%
A0A1X0NZE6	Trypanosomatidae	31%	100%
A0A1X0NZU2	Trypanosomatidae	31%	100%
A0A1X0NZU5	Trypanosomatidae	35%	100%
A0A1X0NZW1	Trypanosomatidae	27%	100%
A0A1X0P0M7	Trypanosomatidae	29%	100%
A0A381MMW5	Leishmania infantum	30%	98%
A0A3Q8I7Y9	Leishmania donovani	47%	100%
A0A3Q8IEC4	Leishmania donovani	30%	99%
A0A3Q8IF95	Leishmania donovani	28%	100%
A0A3Q8IIT5	Leishmania donovani	25%	96%
A0A3Q8ISY9	Leishmania donovani	40%	100%
A0A3R7JSQ9	Trypanosoma rangeli	26%	100%
A0A3R7KKN8	Trypanosoma rangeli	27%	100%
A0A3R7MAQ7	Trypanosoma rangeli	34%	91%
A0A3R7N3S6	Trypanosoma rangeli	24%	100%
A0A3R7N415	Trypanosoma rangeli	26%	100%
A0A3R7N921	Trypanosoma rangeli	28%	100%
A0A3R7R443	Trypanosoma rangeli	28%	100%
A0A3S7WRJ4	Leishmania donovani	83%	100%
A0A3S7WRJ5	Leishmania donovani	53%	92%
A0A3S7WRL4	Leishmania donovani	45%	100%
A0A3S7WRS3	Leishmania donovani	25%	100%
A0A3S7WSR4	Leishmania donovani	53%	100%
A0A3S7WWU1	Leishmania donovani	26%	97%
A0A3S7X2G0	Leishmania donovani	30%	98%
A0A3S7X2K5	Leishmania donovani	30%	100%
A0A3S7XB11	Leishmania donovani	31%	100%
A0A422MSE4	Trypanosoma rangeli	48%	100%
A0A422MSP6	Trypanosoma rangeli	33%	100%
A0A422MST9	Trypanosoma rangeli	27%	100%
A0A422MU68	Trypanosoma rangeli	28%	100%
A4H6J1	Leishmania braziliensis	56%	98%
A4H6J3	Leishmania braziliensis	47%	100%
A4H6Q5	Leishmania braziliensis	24%	100%
A4HC19	Leishmania braziliensis	28%	100%
A4HHG2	Leishmania braziliensis	25%	95%
A4HHG3	Leishmania braziliensis	32%	99%
A4HHG4	Leishmania braziliensis	32%	98%
A4HJW3	Leishmania braziliensis	40%	100%
A4HPE2	Leishmania braziliensis	29%	100%
A4HUX5	Leishmania infantum	83%	100%
A4HUX6	Leishmania infantum	53%	92%
A4HUX7	Leishmania infantum	45%	100%
A4HUX8	Leishmania infantum	46%	100%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	26%	97%
A4I4L2	Leishmania infantum	25%	96%
A4I7C5	Leishmania infantum	40%	100%
A4ICI3	Leishmania infantum	31%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	94%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AE01	Leishmania major	29%	99%
E9AE09	Leishmania major	25%	99%
E9AE10	Leishmania major	25%	99%
E9AE11	Leishmania major	31%	100%
E9AGK5	Leishmania infantum	53%	100%
E9AHJ0	Leishmania infantum	30%	99%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	98%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	97%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4Q1E4	Leishmania major	31%	100%
Q4Q5T8	Leishmania major	40%	100%
Q4QC27	Leishmania major	26%	100%
Q4QC28	Leishmania major	28%	100%
Q4QFY5	Leishmania major	52%	99%
Q4QGU8	Leishmania major	25%	100%
Q4QH10	Leishmania major	46%	95%
Q4QH11	Leishmania major	46%	92%
Q4QH12	Leishmania major	46%	92%
Q4QH13	Leishmania major	46%	92%
Q4QH14	Leishmania major	53%	100%
Q4QH15	Leishmania major	82%	100%
V5B647	Trypanosoma cruzi	46%	100%
V5B983	Trypanosoma cruzi	32%	100%
V5BBB1	Trypanosoma cruzi	44%	100%
V5BFV8	Trypanosoma cruzi	30%	96%
V5BQY6	Trypanosoma cruzi	35%	91%
V5BVP0	Trypanosoma cruzi	49%	100%
V5DT25	Trypanosoma cruzi	48%	100%